1. Christoph K. Hitzenberger

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    1. Mentioned In 136 Articles

    2. Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

      Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope
      We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for investigating ex-vivo brain tissue of patients diagnosed with Alzheimers disease (AD) and of a mouse model of AD. A submicrometer axial resolution in tissue was achieved using a broad visible light spectrum. The use of various objective lenses enabled reaching micrometer transversal resolution and the acquisition of images of microscopic brain features, such as cell structures, vessels, and white ...
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    3. Adaptable switching schemes for time-encoded multichannel optical coherence tomography

      Adaptable switching schemes for time-encoded multichannel optical coherence tomography
      We introduce the approach of variable time encoding for multichannel optical coherence tomography (OCT). High-speed fiber optical switches are applied for sequential sample arm switching to enable quasisimultaneous image acquisition from three different orientation angles. In comparison with previous multichannel OCT (using simultaneous sample illumination), time-encoded multichannel OCT has no need for division of illumination power among the respective channels to satisfy laser safety requirements. Especially for ophthalmic applicationsin particular ...
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    4. In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography

      In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography
      Purpose : To investigate the early development of spontaneous retinal neovascularization in the murine retina by a multifunctional optical coherence tomography approach. To characterize involved tissue changes in vivo and describe structural and functional changes over time. Methods : A multifunctional optical coherence tomography (OCT) system providing 3-fold contrast comprising reflectivity, polarization sensitivity, and OCT angiography (OCTA) was utilized to image very-low-density lipoprotein receptor (VLDLR) knockout mice. Baseline measurements were acquired as ...
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    5. Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography

      Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography
      Adaptive Optics (AO) retinal imaging is revealing microscopic structures of the eye in a non-invasive way. Due to anisoplanatism, conventional AO systems are efficient on small 1x1 field of view (FoV). We present a lens-based AO scanning laser ophthalmoscope (SLO) set-up with 2 deformable mirrors (DM), providing high-resolution retinal imaging on a 4x4 FoV, for an eye pupil diameter of 7 mm. The first DM is in a pupil plane ...
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    6. White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina

      White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina
      A white light polarization sensitive optical coherence tomography system has been developed, using a supercontinuum laser as the light source. By detecting backscattered light from 400700 nm, an axial resolution of 1.0 m in air was achieved. The system consists of a free-space interferometer and two homemade spectrometers that detect orthogonal polarization states. Following system specifications, images of a healthy murine retina as acquired by this non-contact system are ...
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    7. Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

      Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy
      One major hallmark of Alzheimers disease (AD) and cerebral amyloid angiopathy (CAA) is the deposition of extracellular senile plaques and vessel wall deposits composed of amyloid-beta (A ). In AD, degeneration of neurons is preceded by the formation of A plaques, which show different morphological forms. Most of them are birefringent owing to the parallel arrangement of amyloid fibrils. Here, we present polarization sensitive optical coherence microscopy (PS-OCM) for imaging mature ...
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    8. Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure

      Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure
      A multi-functional optical coherence tomography (OCT) approach is presented to determine ocular fundus pulsations as an axial displacement between the retina and the chorioscleral complex in the albino rat eye. By combining optical coherence elastography and OCT angiography (OCTA), we measure subtle deformations in the nanometer range within the eye and simultaneously map retinal and choroidal perfusion. The conventional OCT reflectivity contrast serves as a backbone to segment the retina ...
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    9. Polarization-sensitive optical coherence tomography in the anterior mouse eye

      Polarization-sensitive optical coherence tomography in the anterior mouse eye
      Polarization-sensitive optical coherence tomography (PS-OCT) provides intrinsic contrast related to tissue microstructure. In the past, PS-OCT has been successfully used for imaging the anterior eye of humans in a variety of pathologic conditions. Here, we present PS-OCT imaging of the anterior eye in mice. Spectral domain PS-OCT centered at a wavelength of 840 nm was performed in anaesthetized laboratory mice. Three dimensional data sets were acquired at a 70 kHz ...
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    10. IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To examine the involvement of the retinal pigment epithelium (RPE) in the presence of vitelliform macular lesions (VML) in Best vitelliform macular dystrophy (BVMD), autosomal recessive bestrophinopathy, and adult-onset vitelliform macular degeneration using polarization-sensitive optical coherence tomography (PS-OCT). Methods: A total of 35 eyes of 18 patients were imaged using a PS-OCT system and blue light fundus autofluorescence imaging. Pathogenic mutations in the BEST1 gene, 3 of which were ...
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    11. Beyond backscattering: Optical neuroimaging by BRAD

      Beyond backscattering: Optical neuroimaging by BRAD
      Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked ...
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    12. Digital scan of the eye provides accurate picture of a person’s general health

      Digital scan of the eye provides accurate picture of a person’s general health
      Personalized medicine or "precision medicine" is the most significant trend in 21st century medicine. "Its all about the right treatment for the right patient at the right time," says Ursula Schmidt-Erfurth, Head of MedUni Vienna's Department of Ophthalmology and Optometry. And looking into the eye using digital techniques and analysing Big Data also provides an accurate picture of a person's general medical condition, facilitates early diagnosis and treatment ...
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    13. Multi-directional optical coherence tomography for retinal imaging

      Multi-directional optical coherence tomography for retinal imaging
      We introduce multi-directional optical coherence tomography (OCT), a technique for investigation of the scattering properties of directionally reflective tissue samples. By combining the concepts of multi-channel and directional OCT, this approach enables simultaneous acquisition of multiple reflectivity depth-scans probing a mutual sample location from differing angular orientations. The application of multi-directional OCT in retinal imaging allows for in-depth investigations on the directional reflectivity of the retinal nerve fiber layer, Henles ...
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    14. Adolf Friedrich Fercher: a pioneer of biomedical optics

      Adolf Friedrich Fercher: a pioneer of biomedical optics
      Adolf Friedrich Fercher, an outstanding pioneer of biomedical optics, passed away earlier this year. He was a brilliant and visionary researcher who pioneered various fields of biomedical optics, such as laser speckle flowgraphy, tissue interferometry, and optical coherence tomography (OCT). On the occasion of the 25th anniversary of OCT, this paper reviews and commemorates Ferchers pioneering work.
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    15. Polarisation-sensitive optical coherence tomography for material

      Polarisation-sensitive optical coherence tomography for material
      Optical Coherence Tomography (OCT) is an emerging technology for high-resolution non-contact imaging of semi-transparent structures. Originally developed for medical diagnostics, we extend the OCT-technique to problems posed in material testing and characterisation. Layer thickness and refractive indices as well as internal structures of polymer parts have been determined within this study. An extension of OCT, namely polarisation-sensitive OCT (PS-OCT) has been used to identify regions of increased anisotropy within injection-moulded ...
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    16. 1-15 of 136 1 2 3 4 5 6 7 8 9 »
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  2. About Christoph K. Hitzenberger

    Christoph K. Hitzenberger

    Christoph Hitzenberger is vice chair of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna. He co-founded, with Adolf F. Fercher, the university’s biomedical optics research group, and developed the heterodyne low-coherence interferometry (LCI) system for measuring intraocular distances (axial eye length, retinal thickness). This work led to the development of the first commercial LCI ocular biometry system, and the technology was expanded to record OCT images, the first in vivo retinal images of the human eye. He also demonstrated, with Fercher, the first application of spectral domain LCI to intraocular ranging, enabling rapid 3-D imaging and revolutionizing retinal diagnostics. Hitzenberger received the award of the Hoechst Foundation for Advancement of Medical Research in Austria and is a fellow of the International Society for Optics and Photonics and the Optical Society. In addition to serving as editor-in-chief of Biomedical Optics Express , he is the author or co-author of some 150 peer-reviewed scientific publications.