1. Christoph K. Hitzenberger

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    1. Mentioned In 146 Articles

    2. Generating large field of view en-face projection images from intra-acquisition motion compensated volumetric optical coherence tomography data

      Generating large field of view en-face projection images from intra-acquisition motion compensated volumetric optical coherence tomography data
      A technique to generate large field of view projection maps of arbitrary optical coherence tomography (OCT) data is described. The technique is divided into two stages - an image acquisition stage that features a simple to use fast and robust retinal tracker to get motion free retinal OCT volume scans - and a stitching stage where OCT data from different retinal locations is first registered against a reference image using a custom ...
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    3. Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT

      Analysis of retinal nerve fiber layer birefringence in patients with glaucoma and diabetic retinopathy by polarization sensitive OCT
      The retinal nerve fiber layer (RNFL) is a fibrous tissue that shows form birefringence. This optical tissue property is related to the microstructure of the nerve fiber axons that carry electrical signals from the retina to the brain. Ocular diseases that are known to cause neurologic changes, like glaucoma or diabetic retinopathy (DR), might alter the birefringence of the RNFL, which could be used for diagnostic purposes. In this pilot ...
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    4. Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography

      Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography
      Using adaptive optics optical coherence tomography, human photoreceptors and retinal pigment epithelium (RPE) cells are typically visualized on a small field of view of 1 to 2. In addition, volume averaging is required for visualizing the RPE cell mosaic. To increase the imaging area, we introduce a lens based spectral domain AO-OCT system that shows low aberrations within an extended imaging area of 44 while maintaining a high (theoretical) transverse ...
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    5. Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice

      Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice
      Purpose : The retinal phenotype of popular mouse models mimicking ophthalmic diseases, such as the superoxide dismutase 1 (SOD1) knockout (KO) mouse model, has mainly been assessed by ex vivo histology and in vivo fundus photography. We used multifunctional optical coherence tomography (OCT) to characterize the retinas of SOD1 KO mice in vivo. Methods : The custom-made ophthalmoscope featured a combination of conventional OCT, polarization-sensitive OCT, and OCT angiography. Seven SOD1 KO ...
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    6. Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography

      Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography
      We present a polarization-sensitive (PS) extension for bright- and dark-field (BRAD) optical coherence tomography imaging. Using a few-mode fiber detection scheme, the light backscattered at different angles is separated, and the BRAD images of tissue scattering are generated. A calibration method to correct for the fiber birefringence is proposed. Since particle scattering profiles are polarization dependent, a PS detection extends the capabilities for investigating the scattering properties of biological tissues ...
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    7. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix

      Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix
      ...me,” Ann. Diagn. Pathol. 11(4), 258–261 (2007). [Crossref] [PubMed] B. Baumann, E. Götzinger, M. Pircher, and C. K. Hitzenberger, “Measurements of depolarization distribution in the healthy human macula by polarization s...
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    8. Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

      Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography
      One key hallmark of Alzheimers disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining of different brain regions, is required. Here, we present optical coherence tomography (OCT) as a tissue-preserving imaging modality for the visualization of amyloid-beta plaques and compare their contrast in intensity- and polarization-sensitive (PS) OCT. Human brain samples ...
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    9. Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography

      Investigating spontaneous retinal venous pulsation using Doppler optical coherence tomography
      We demonstrate the advantages of optical coherence tomography (OCT) imaging for investigation of spontaneous retinal venous pulsation (SRVP). The pulsatile changes in venous vessel caliber are analyzed qualitatively and quantitatively using conventional intensity-based OCT as well as the functional extension Doppler OCT (DOCT). Single-channel and double-channel line scanning protocols of our multi-channel OCT prototype are employed to investigate venous pulsatile caliber oscillations as well as venous flow pulsatility in the ...
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    10. Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern

      Mapping of Corneal Layer Thicknesses With Polarization-Sensitive Optical Coherence Tomography Using a Conical Scan Pattern
      Purpose : We demonstrate segmentation and mapping of corneal layers (epithelium, Bowman's layer, and stroma) across the entire cornea (limbus to limbus), using additional contrast provided by polarization-sensitive optical coherence tomography (PS-OCT) and analyze the reproducibility of the procedure. Methods : A custom built PS-OCT system operating at 1045 nm central wavelength with conical scanning was used for image acquisition. Conical scanning allows for almost perpendicular beam incidence on the corneal ...
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    11. Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

      Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope
      We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for investigating ex-vivo brain tissue of patients diagnosed with Alzheimers disease (AD) and of a mouse model of AD. A submicrometer axial resolution in tissue was achieved using a broad visible light spectrum. The use of various objective lenses enabled reaching micrometer transversal resolution and the acquisition of images of microscopic brain features, such as cell structures, vessels, and white ...
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    12. Beyond backscattering: optical neuroimaging by BRAD

      Beyond backscattering: optical neuroimaging by BRAD
      Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked ...
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    13. Adaptable switching schemes for time-encoded multichannel optical coherence tomography

      Adaptable switching schemes for time-encoded multichannel optical coherence tomography
      We introduce the approach of variable time encoding for multichannel optical coherence tomography (OCT). High-speed fiber optical switches are applied for sequential sample arm switching to enable quasisimultaneous image acquisition from three different orientation angles. In comparison with previous multichannel OCT (using simultaneous sample illumination), time-encoded multichannel OCT has no need for division of illumination power among the respective channels to satisfy laser safety requirements. Especially for ophthalmic applicationsin particular ...
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    14. In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography

      In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography
      Purpose : To investigate the early development of spontaneous retinal neovascularization in the murine retina by a multifunctional optical coherence tomography approach. To characterize involved tissue changes in vivo and describe structural and functional changes over time. Methods : A multifunctional optical coherence tomography (OCT) system providing 3-fold contrast comprising reflectivity, polarization sensitivity, and OCT angiography (OCTA) was utilized to image very-low-density lipoprotein receptor (VLDLR) knockout mice. Baseline measurements were acquired as ...
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    15. Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography

      Large field of view adaptive optics scanning laser ophthalmoscopy and optical coherence tomography
      Adaptive Optics (AO) retinal imaging is revealing microscopic structures of the eye in a non-invasive way. Due to anisoplanatism, conventional AO systems are efficient on small 1x1 field of view (FoV). We present a lens-based AO scanning laser ophthalmoscope (SLO) set-up with 2 deformable mirrors (DM), providing high-resolution retinal imaging on a 4x4 FoV, for an eye pupil diameter of 7 mm. The first DM is in a pupil plane ...
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  2. About Christoph K. Hitzenberger

    Christoph K. Hitzenberger

    Christoph Hitzenberger is vice chair of the Center for Medical Physics and Biomedical Engineering at the Medical University of Vienna. He co-founded, with Adolf F. Fercher, the university’s biomedical optics research group, and developed the heterodyne low-coherence interferometry (LCI) system for measuring intraocular distances (axial eye length, retinal thickness). This work led to the development of the first commercial LCI ocular biometry system, and the technology was expanded to record OCT images, the first in vivo retinal images of the human eye. He also demonstrated, with Fercher, the first application of spectral domain LCI to intraocular ranging, enabling rapid 3-D imaging and revolutionizing retinal diagnostics. Hitzenberger received the award of the Hoechst Foundation for Advancement of Medical Research in Austria and is a fellow of the International Society for Optics and Photonics and the Optical Society. In addition to serving as editor-in-chief of Biomedical Optics Express , he is the author or co-author of some 150 peer-reviewed scientific publications.