1. Christine P. Hendon

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    1. Mentioned In 55 Articles

    2. Characterization of the human myocardium by optical coherence tomography

      Characterization of the human myocardium by optical coherence tomography
      Optical coherence tomography can provide high‐resolution imaging of the human heart valuable for treating cardiovascular disease. However, comprehensive optical coherence tomography imaging data in the human heart is lacking. This study provides imaging data from a large sample size of human hearts, and qualitative and quantitative imaging features corresponding to a variety of cardiac tissue types are described, providing guidance to future cardiac applications of optical coherence tomography.
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    3. Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method

      Fully Automated Postlumpectomy Breast Margin Assessment Utilizing Convolutional Neural Network Based Optical Coherence Tomography Image Classification Method
      Background The purpose of this study was to develop a deep learning classification approach to distinguish cancerous from noncancerous regions within optical coherence tomography (OCT) images of breast tissue for potential use in an intraoperative setting for margin assessment. Methods A custom ultrahigh-resolution OCT (UHR-OCT) system with an axial resolution of 2.7 m and a lateral resolution of 5.5 m was used in this study. The algorithm used ...
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    4. Chip-based frequency comb sources for optical coherence tomography

      Chip-based frequency comb sources for optical coherence tomography
      Optical coherence tomography (OCT) is a powerful interferometric imaging technique widely used in medical fields such as ophthalmology, cardiology and dermatology. Superluminescent diodes (SLDs) are widely used as light sources in OCT. Recently integrated chip-based frequency combs have been demonstrated in numerous platforms and the possibility of using these broadband chip-scale combs for OCT has been raised extensively over the past few years. However, the use of these chip-based frequency ...
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    5. Optical coherence tomography imaging of cardiac substrates

      Optical coherence tomography imaging of cardiac substrates
      Cardiovascular disease is the leading cause of morbidity and mortality in the United States. Knowledge of a patients heart structure will help to plan procedures, potentially identifying arrhythmia substrates, critical structures to avoid, detect transplant rejection, and reduce ambiguity when interpreting electrograms and functional measurements. Similarly, basic research of numerous cardiac diseases would greatly benefit from structural imaging at cellular scale. For both applications imaging on the scale of a ...
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    6. Real-time assessment of catheter contact and orientation using an integrated optical coherence tomography cardiac ablation catheter

      Real-time assessment of catheter contact and orientation using an integrated optical coherence tomography cardiac ablation catheter
      The efficacy of catheter ablation treatment for atrial fibrillation is directly impacted by the quality of lesion formation. Two parameters that are critical for maximizing energy delivery are sustained catheter contact and orientation. Currently, these parameters must be inferred indirectly through tactile feedback or measurements of bioelectrical impedance and tip force. In this work, we propose a method for discerning contact and orientation based on direct endomyocardial imaging mediated by ...
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    7. Chip-based frequency combs sources for optical coherence tomography

      Chip-based frequency combs sources for optical coherence tomography
      The Optical coherence tomography (OCT) is a powerful interferometric imaging technique widely used in medical fields such as ophthalmology, cardiology and dermatology, for which footprint and cost are becoming increasingly important. Here we present a platform for miniaturized sources for OCT based on chip-scale lithographically defined microresonators. We show that the proposed platform is compatible with standard commercial spectral domain (SD) OCT systems and enable imaging of human tissue with ...
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    8. Scanning optical coherence tomography probe for in vivo imaging and displacement measurements in the cochlea

      Scanning optical coherence tomography probe for in vivo imaging and displacement measurements in the cochlea
      We developed a spectral domain optical coherence tomography (SDOCT) fiber optic probe for imaging and sub-nanometer displacement measurements inside the mammalian cochlea. The probe, 140 m in diameter, can scan laterally up to 400 m by means of a piezoelectric bender. Two different sampling rates are used, 10 kHz for high-resolution B-scan imaging, and 100 kHz for displacement measurements in order to span the auditory frequency range of gerbil (~50 ...
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    9. Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph

      Compressed sensing-enabled phase-sensitive swept-source optical coherence tomograph
      Here we present a novel phase-sensitive swept-source optical coherence tomography (PhS-SS-OCT) system. The simultaneously recorded calibration signal, which is commonly used in SS-OCT to stabilize the phase, is randomly sub-sampled during the acquisition, and it is later reconstructed based on the Compressed Sensing (CS) theory. We first mathematically investigated the method, and verified it through computer simulations. We then conducted a vibrational frequency test and a flow velocity measurement in ...
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    10. Adapting a commercial spectral domain optical coherence tomography system for time-locked displacement and physiological measurements

      Adapting a commercial spectral domain optical coherence tomography system for time-locked displacement and physiological measurements
      Measuring vibration within the cochlear partition is important to understand sound transduction and nonlinear amplification within the cochlea. Here we describe the customization of a commercially available Spectral Domain Optical Coherence Tomography system, the Thorlabs Telesto, for displacement measurements in the cochlea using a technique called Spectral Domain Phase Microscopy (SDPM). The paper describes the SDOCT data analysis pipeline composed of background subtraction, interpolation, and spectral shaping of the raw ...
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    11. Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography

      Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography
      Computational models and experimental optical mapping of cardiac electrophysiology serve as powerful tools to investigate the underlying mechanisms of arrhythmias . Modeling can also aid the interpretation of optical mapping signals, which may have different characteristics with respect to the underlying electrophysiological signals they represent. However, despite the prevalence of atrial arrhythmias such as atrial fibrillation , models of optical electrical mapping incorporating realistic structure of the atria are lacking. Therefore, we ...
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    12. Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography

      Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography
      The regional heterogeneity study of cervical ultrastructure is critical to understand the cervical functions like cervical softening and dilation. To better understand why the internal os initiates the premature remodeling, we present the heterogeneity study of collagen fiber network, tissue optical property, and mechanical property between the internal os and external os using optical coherence tomography (OCT) and indentation test. Pregnant (n=1) and non-pregnant patients (n=8) were consented ...
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    13. High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)

      High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)
      In the past decades, the performance of swept source optical coherence tomography (SS-OCT) has experienced an unprecedented improvement which is mainly driven by the rapidly evolving laser technologies: the state-of-art SS-OCT is now tens of dB more sensitive, six orders of magnitude faster, and seeing ten times deeper than the original version of time domain OCT. Regardless of the abovementioned progress, the phase instability is always considered the biggest weakness ...
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    14. Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)

      Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)
      Over the past 25 years of development and innovation, optical coherence tomography (OCT) has successfully fills the gap between the ex vivo high-resolution optical microscopy technologies and in vivo low-resolution medical imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (US). Ultrahigh resolution (UHR) OCT categorizes OCT systems with an axial resolution below 3 m in tissue. With the improved resolution, UHR OCT may impart the knowledge of ...
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    15. 1-15 of 55 1 2 3 4 »
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  2. About Christine P. Hendon

    Christine P. Hendon

    Christine P. Fleming Hendon is an assistant professor in the Department of Electrical Engineering at Columbia University. Her research objective is to develop high-resolution optical imaging and spectroscopy instruments in conjunction with real-time image analysis for diagnosis and therapy monitoring of diseases of the heart. She completed a Research Fellowship at the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School (2010-2012). Dr. Fleming received her B.S. in Electrical Engineering and Computer Science from Massachusetts Institute of Technology in 2004, and her M.S. and Ph.D. in Biomedical Engineering from Case Western Reserve University in 2007 and 2010, respectively.

  3. Quotes

    1. I am very pleased and honored that my work has received such recognition from the NIH.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    2. We aim to demonstrate that Optical Coherence Tomography (OCT) can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    3. I am thrilled to receive such a notable recognition of my work.... I hope this will draw attention to cardiovascular disease, which is the leading cause of mortality in the United States—it's critical that we continue to develop technologies to detect abnormalities at early stages and develop effective therapies to treat this pervasive illness.
      In Christine Fleming named to MIT Technology Review's annual Innovators Under 35 list