1. Christine Hendon

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    1. Mentioned In 40 Articles

    2. Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)

      Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)
      Over the past 25 years of development and innovation, optical coherence tomography (OCT) has successfully fills the gap between the ex vivo high-resolution optical microscopy technologies and in vivo low-resolution medical imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (US). Ultrahigh resolution (UHR) OCT categorizes OCT systems with an axial resolution below 3 m in tissue. With the improved resolution, UHR OCT may impart the knowledge of ...
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    3. Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment—A Multi-reader Study

      Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment—A Multi-reader Study
      Rationale and Objectives This study aimed to assess whether different breast cancer subspecialty physicians can be trained to distinguish non-suspicious from suspicious areas of post-lumpectomy specimen margin in patients with breast cancer using optical coherence tomography (OCT) images (a near-infrared based imaging technique) with final histology as the reference standard. Materials and Methods This institutional review board-exempt, Health Insurance Portability and Accountability Act-compliant study was performed on 63 surgically excised ...
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    4. Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography
      A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multi-contrast imaging of human myocardium in one-shot measurement. The intensity contrast and functional contrasts, including the ratio between the cross- and co- polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate micro-structures in the myocardium ...
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    5. Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images

      Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
      According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation ...
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    6. Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging

      Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging
      Sparse representation theory is an exciting area of research with recent applications in medical imaging and detection, segmentation, and quantitative analysis of biological processes. We present a variant on the robust-principal component analysis (RPCA) algorithm, called frequency constrained RPCA (FC-RPCA), for selectively segmenting dynamic phenomena that exhibit spectra within a user-defined range of frequencies. The algorithm lacks subjective parameter tuning and demonstrates robust segmentation in datasets containing multiple motion sources ...
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    7. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector
      The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed systems performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and ...
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    8. Phase-noise analysis of swept-source optical coherence tomography systems

      Phase-noise analysis of swept-source optical coherence tomography systems
      We propose a new model to characterize the phase noise in swept-source optical coherence tomography (SS-OCT). The new model explicitly incorporates scanning variability, timing jitter, and sample location in addition to intensity noise (shot noise). The model was analyzed and validated by using both Monte Carlo methods and experiments. We suggest that the proposed model can be used as a guideline for future SS-OCT experimental designs.
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    9. Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT

      Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT
      Background and Objective Breast cancer is one of the most common cancers, and recognized as the third leading cause of mortality in women. Optical coherence tomography (OCT) enables three dimensional visualization of biological tissue with micrometer level resolution at high speed, and can play an important role in early diagnosis and treatment guidance of breast cancer. In particular, ultra-high resolution (UHR) OCT provides images with better histological correlation. This paper ...
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    10. Automated fiber tracking and tissue characterization of the anterior cruciate ligament with optical coherence tomography

      Automated fiber tracking and tissue characterization of the anterior cruciate ligament with optical coherence tomography
      The directionality of collagen fibers across the anterior cruciate ligament (ACL) as well as the insertion of this key ligament into bone are important for understanding the mechanical integrity and functionality of this complex tissue. Quantitative analysis of three-dimensional fiber directionality is of particular interest due to the physiological, mechanical, and biological heterogeneity inherent across the ACL-to-bone junction, the behavior of the ligament under mechanical stress, and the usefulness of ...
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    11. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography
      Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly ...
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    12. Mapping the human atria with optical coherence tomography

      Mapping the human atria with optical coherence tomography
      Atrial structure plays an important role in the mechanisms of atrial disease. However, detailed imaging of human atria remains limited due to many imaging modalities lacking sufficient resolution. We propose the use of optical coherence tomography (OCT), which has micrometer resolution and millimeter-scale imaging depth well-suited for the atria, combined with image stitching algorithms, to develop large, detailed atria image maps. Human atria samples (n = 7) were obtained under approved ...
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    13. Characterization of ventricular endomyocardial tissue using optical coherence tomography

      Characterization of ventricular endomyocardial tissue using optical coherence tomography
      We present an initial study to describe the potential of optical coherence tomography (OCT) for characterizing endomyocardial tissue. We obtained ventricular OCT images from 15 fresh human hearts. Layer thickness measurements and texture features were extracted from volumetric datasets with endocardial thickening, normal myocardium, myocardium with interstitial fibrosis, normal endocardium, and adipose tissue. Within our datasets, we observed that the thickness of endocardium was not different within samples with normal ...
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    14. Signal competition in optical coherence tomography and its relevance for cochlear vibrometry

      Signal competition in optical coherence tomography and its relevance for cochlear vibrometry
      The usual technique for measuring vibration within the cochlear partition is heterodyne interferometry. Recently, spectral domain phase microscopy (SDPM) was introduced and offers improvements over standard heterodyneinterferometry. In particular, it has a penetration depth of several mm due to working in the infrared range, has narrow and steep optical sectioning due to using a wideband light source, and is able to measure from several cochlear layers simultaneously. However, SDPM is ...
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  2. About Christine Hendon

    Christine Hendon

    Christine P. Fleming Hendon is an assistant professor in the Department of Electrical Engineering at Columbia University. Her research objective is to develop high-resolution optical imaging and spectroscopy instruments in conjunction with real-time image analysis for diagnosis and therapy monitoring of diseases of the heart. She completed a Research Fellowship at the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School (2010-2012). Dr. Fleming received her B.S. in Electrical Engineering and Computer Science from Massachusetts Institute of Technology in 2004, and her M.S. and Ph.D. in Biomedical Engineering from Case Western Reserve University in 2007 and 2010, respectively.

  3. Quotes

    1. I am very pleased and honored that my work has received such recognition from the NIH.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    2. We aim to demonstrate that Optical Coherence Tomography (OCT) can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    3. I am thrilled to receive such a notable recognition of my work.... I hope this will draw attention to cardiovascular disease, which is the leading cause of mortality in the United States—it's critical that we continue to develop technologies to detect abnormalities at early stages and develop effective therapies to treat this pervasive illness.
      In Christine Fleming named to MIT Technology Review's annual Innovators Under 35 list