1. Christine Hendon

    0 Comments Leave a Comment

    1-15 of 45 1 2 3 »
    1. Mentioned In 45 Articles

    2. Adapting a commercial spectral domain optical coherence tomography system for time-locked displacement and physiological measurements

      Adapting a commercial spectral domain optical coherence tomography system for time-locked displacement and physiological measurements
      Measuring vibration within the cochlear partition is important to understand sound transduction and nonlinear amplification within the cochlea. Here we describe the customization of a commercially available Spectral Domain Optical Coherence Tomography system, the Thorlabs Telesto, for displacement measurements in the cochlea using a technique called Spectral Domain Phase Microscopy (SDPM). The paper describes the SDOCT data analysis pipeline composed of background subtraction, interpolation, and spectral shaping of the raw ...
      Read Full Article
    3. Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography

      Tissue-Specific Optical Mapping Models of Swine Atria Informed by Optical Coherence Tomography
      Computational models and experimental optical mapping of cardiac electrophysiology serve as powerful tools to investigate the underlying mechanisms of arrhythmias . Modeling can also aid the interpretation of optical mapping signals, which may have different characteristics with respect to the underlying electrophysiological signals they represent. However, despite the prevalence of atrial arrhythmias such as atrial fibrillation , models of optical electrical mapping incorporating realistic structure of the atria are lacking. Therefore, we ...
      Read Full Article
    4. Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography

      Heterogeneity study of the human cervix between the internal os and the external os using optical coherence tomography
      The regional heterogeneity study of cervical ultrastructure is critical to understand the cervical functions like cervical softening and dilation. To better understand why the internal os initiates the premature remodeling, we present the heterogeneity study of collagen fiber network, tissue optical property, and mechanical property between the internal os and external os using optical coherence tomography (OCT) and indentation test. Pregnant (n=1) and non-pregnant patients (n=8) were consented ...
      Read Full Article
    5. High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)

      High-speed phase-stable swept source optical coherence tomography: functional imaging and biomedical applications (Thesis)
      In the past decades, the performance of swept source optical coherence tomography (SS-OCT) has experienced an unprecedented improvement which is mainly driven by the rapidly evolving laser technologies: the state-of-art SS-OCT is now tens of dB more sensitive, six orders of magnitude faster, and seeing ten times deeper than the original version of time domain OCT. Regardless of the abovementioned progress, the phase instability is always considered the biggest weakness ...
      Read Full Article
    6. Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)

      Ultrahigh resolution spectral domain optical coherence tomography and its functional extension for human myocardium and breast tissue imaging (Thesis)
      Over the past 25 years of development and innovation, optical coherence tomography (OCT) has successfully fills the gap between the ex vivo high-resolution optical microscopy technologies and in vivo low-resolution medical imaging modalities, including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound (US). Ultrahigh resolution (UHR) OCT categorizes OCT systems with an axial resolution below 3 m in tissue. With the improved resolution, UHR OCT may impart the knowledge of ...
      Read Full Article
    7. Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment—A Multi-reader Study

      Optical Coherence Tomography: A Novel Imaging Method for Post-lumpectomy Breast Margin Assessment—A Multi-reader Study
      Rationale and Objectives This study aimed to assess whether different breast cancer subspecialty physicians can be trained to distinguish non-suspicious from suspicious areas of post-lumpectomy specimen margin in patients with breast cancer using optical coherence tomography (OCT) images (a near-infrared based imaging technique) with final histology as the reference standard. Materials and Methods This institutional review board-exempt, Health Insurance Portability and Accountability Act-compliant study was performed on 63 surgically excised ...
      Read Full Article
    8. Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography

      Multi-contrast Endomyocardial Imaging By Single-channel High Resolution Cross-polarization Optical Coherence Tomography
      A single-channel high-resolution cross-polarization (CP) optical coherence tomography (OCT) system is presented for multi-contrast imaging of human myocardium in one-shot measurement. The intensity contrast and functional contrasts, including the ratio between the cross- and co- polarization channels as well as the cumulative retardation, are reconstructed from the CP-OCT readout. By comparing the CP-OCT results with histological analysis, it is shown that the system can successfully delineate micro-structures in the myocardium ...
      Read Full Article
    9. Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images

      Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
      According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation ...
      Read Full Article
    10. Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging

      Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging
      Sparse representation theory is an exciting area of research with recent applications in medical imaging and detection, segmentation, and quantitative analysis of biological processes. We present a variant on the robust-principal component analysis (RPCA) algorithm, called frequency constrained RPCA (FC-RPCA), for selectively segmenting dynamic phenomena that exhibit spectra within a user-defined range of frequencies. The algorithm lacks subjective parameter tuning and demonstrates robust segmentation in datasets containing multiple motion sources ...
      Read Full Article
    11. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector
      The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed systems performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and ...
      Read Full Article
    12. Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector

      Highly phase-stable 200 kHz swept-source optical coherence tomography based on KTN electro-optic deflector
      The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed systems performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and ...
      Read Full Article
    13. Phase-noise analysis of swept-source optical coherence tomography systems

      Phase-noise analysis of swept-source optical coherence tomography systems
      We propose a new model to characterize the phase noise in swept-source optical coherence tomography (SS-OCT). The new model explicitly incorporates scanning variability, timing jitter, and sample location in addition to intensity noise (shot noise). The model was analyzed and validated by using both Monte Carlo methods and experiments. We suggest that the proposed model can be used as a guideline for future SS-OCT experimental designs.
      Read Full Article
    14. Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT

      Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT
      Background and Objective Breast cancer is one of the most common cancers, and recognized as the third leading cause of mortality in women. Optical coherence tomography (OCT) enables three dimensional visualization of biological tissue with micrometer level resolution at high speed, and can play an important role in early diagnosis and treatment guidance of breast cancer. In particular, ultra-high resolution (UHR) OCT provides images with better histological correlation. This paper ...
      Read Full Article
    15. Automated fiber tracking and tissue characterization of the anterior cruciate ligament with optical coherence tomography

      Automated fiber tracking and tissue characterization of the anterior cruciate ligament with optical coherence tomography
      The directionality of collagen fibers across the anterior cruciate ligament (ACL) as well as the insertion of this key ligament into bone are important for understanding the mechanical integrity and functionality of this complex tissue. Quantitative analysis of three-dimensional fiber directionality is of particular interest due to the physiological, mechanical, and biological heterogeneity inherent across the ACL-to-bone junction, the behavior of the ligament under mechanical stress, and the usefulness of ...
      Read Full Article
    16. 1-15 of 45 1 2 3 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Christine Hendon

    Christine Hendon

    Christine P. Fleming Hendon is an assistant professor in the Department of Electrical Engineering at Columbia University. Her research objective is to develop high-resolution optical imaging and spectroscopy instruments in conjunction with real-time image analysis for diagnosis and therapy monitoring of diseases of the heart. She completed a Research Fellowship at the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School (2010-2012). Dr. Fleming received her B.S. in Electrical Engineering and Computer Science from Massachusetts Institute of Technology in 2004, and her M.S. and Ph.D. in Biomedical Engineering from Case Western Reserve University in 2007 and 2010, respectively.

  3. Quotes

    1. I am very pleased and honored that my work has received such recognition from the NIH.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    2. We aim to demonstrate that Optical Coherence Tomography (OCT) can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    3. I am thrilled to receive such a notable recognition of my work.... I hope this will draw attention to cardiovascular disease, which is the leading cause of mortality in the United States—it's critical that we continue to develop technologies to detect abnormalities at early stages and develop effective therapies to treat this pervasive illness.
      In Christine Fleming named to MIT Technology Review's annual Innovators Under 35 list