1. Christine Hendon

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    1. Mentioned In 34 Articles

    2. Phase-noise analysis of swept-source optical coherence tomography systems

      Phase-noise analysis of swept-source optical coherence tomography systems
      We propose a new model to characterize the phase noise in swept-source optical coherence tomography (SS-OCT). The new model explicitly incorporates scanning variability, timing jitter, and sample location in addition to intensity noise (shot noise). The model was analyzed and validated by using both Monte Carlo methods and experiments. We suggest that the proposed model can be used as a guideline for future SS-OCT experimental designs.
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    3. Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT

      Visualization and tissue classification of human breast cancer images using ultrahigh-resolution OCT
      Background and Objective Breast cancer is one of the most common cancers, and recognized as the third leading cause of mortality in women. Optical coherence tomography (OCT) enables three dimensional visualization of biological tissue with micrometer level resolution at high speed, and can play an important role in early diagnosis and treatment guidance of breast cancer. In particular, ultra-high resolution (UHR) OCT provides images with better histological correlation. This paper ...
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    4. Automated fiber tracking and tissue characterization of the anterior cruciate ligament with optical coherence tomography

      Automated fiber tracking and tissue characterization of the anterior cruciate ligament with optical coherence tomography
      The directionality of collagen fibers across the anterior cruciate ligament (ACL) as well as the insertion of this key ligament into bone are important for understanding the mechanical integrity and functionality of this complex tissue. Quantitative analysis of three-dimensional fiber directionality is of particular interest due to the physiological, mechanical, and biological heterogeneity inherent across the ACL-to-bone junction, the behavior of the ligament under mechanical stress, and the usefulness of ...
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    5. Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography

      Ex vivo visualization of human ciliated epithelium and quantitative analysis of induced flow dynamics by using optical coherence tomography
      Background and Objective Cilia-driven mucociliary clearance is an important self-defense mechanism of great clinical importance in pulmonary research. Conventional light microscopy possesses the capability to visualize individual cilia and its beating pattern but lacks the throughput to assess the global ciliary activities and flow dynamics. Optical coherence tomography (OCT), which provides depth-resolved cross-sectional images, was recently introduced to this area. Materials and Methods Fourteen de-identified human tracheobronchial tissues are directly ...
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    6. Mapping the human atria with optical coherence tomography

      Mapping the human atria with optical coherence tomography
      Atrial structure plays an important role in the mechanisms of atrial disease. However, detailed imaging of human atria remains limited due to many imaging modalities lacking sufficient resolution. We propose the use of optical coherence tomography (OCT), which has micrometer resolution and millimeter-scale imaging depth well-suited for the atria, combined with image stitching algorithms, to develop large, detailed atria image maps. Human atria samples (n = 7) were obtained under approved ...
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    7. Characterization of ventricular endomyocardial tissue using optical coherence tomography

      Characterization of ventricular endomyocardial tissue using optical coherence tomography
      We present an initial study to describe the potential of optical coherence tomography (OCT) for characterizing endomyocardial tissue. We obtained ventricular OCT images from 15 fresh human hearts. Layer thickness measurements and texture features were extracted from volumetric datasets with endocardial thickening, normal myocardium, myocardium with interstitial fibrosis, normal endocardium, and adipose tissue. Within our datasets, we observed that the thickness of endocardium was not different within samples with normal ...
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    8. Signal competition in optical coherence tomography and its relevance for cochlear vibrometry

      Signal competition in optical coherence tomography and its relevance for cochlear vibrometry
      The usual technique for measuring vibration within the cochlear partition is heterodyne interferometry. Recently, spectral domain phase microscopy (SDPM) was introduced and offers improvements over standard heterodyneinterferometry. In particular, it has a penetration depth of several mm due to working in the infrared range, has narrow and steep optical sectioning due to using a wideband light source, and is able to measure from several cochlear layers simultaneously. However, SDPM is ...
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      Mentions: Christine Hendon
    9. Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Wome

      Collagen Fiber Orientation and Dispersion in the Upper Cervix of Non-Pregnant and Pregnant Wome
      The structural integrity of the cervix in pregnancy is necessary for carrying a pregnancy until term, and the organization of human cervical tissue collagen likely plays an important role in the tissues structural function. Collagen fibers in the cervical extracellular matrix exhibit preferential directionality, and this collagen network ultrastructure is hypothesized to reorient and remodel during cervical softening and dilation at time of parturition. Within the cervix, the upper half ...
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    10. Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography

      Myocardial imaging using ultrahigh-resolution spectral domain optical coherence tomography
      We present an ultrahigh-resolution spectral domain optical coherence tomography (OCT) system in 800 nm with a low-noise supercontinuum source (SC) optimized for myocardial imaging. The system was demonstrated to have an axial resolution of 2.72 m with a large imaging depth of 1.78 mm and a 6-dB falloff range of 0.89 mm. The lateral resolution ( 5.52m ) was compromised to enhance the image penetration required for myocardial ...
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    11. Automated classification of optical coherence tomography images of human atrial tissue

      Automated classification of optical coherence tomography images of human atrial tissue
      Tissue composition of the atria plays a critical role in the pathology of cardiovascular disease, tissue remodeling, and arrhythmogenic substrates. Optical coherence tomography (OCT) has the ability to capture the tissue composition information of the human atria. In this study, we developed a region-based automated method to classify tissue compositions within human atria samples within OCT images. We segmented regional information without prior information about the tissue architecture and subsequently ...
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    12. Characterizing Ablation Lesions Using Optical Coherence Tomography (OCT)

      Characterizing Ablation Lesions Using Optical Coherence Tomography (OCT)
      Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.
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    13. “How Does Breast Cancer Develop?” Pilot Grants Awarded to Multidisciplinary Teams Using the Intraductal Approach to Advance Breast Cancer Prevention

      “How Does Breast Cancer Develop?” Pilot Grants Awarded to Multidisciplinary Teams Using the Intraductal Approach to Advance Breast Cancer Prevention
      Dr. Sheldon Feldman and Dr. Fatih Balci study intraductal approaches to breast cancer. They are currently investigating the effectiveness of optical coherence tomography (OCT), which is used in cardiology to look at blood vessels from the inside using light instead of sound (as an ultrasound does) to create three-dimensional images. OCT may be able to identify early changes in the breast duct before ductal carcinoma in situ (DCIS) or cancer ...
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    14. 1-15 of 34 1 2 3 »
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  2. About Christine Hendon

    Christine Hendon

    Christine P. Fleming Hendon is an assistant professor in the Department of Electrical Engineering at Columbia University. Her research objective is to develop high-resolution optical imaging and spectroscopy instruments in conjunction with real-time image analysis for diagnosis and therapy monitoring of diseases of the heart. She completed a Research Fellowship at the Wellman Center for Photomedicine at Massachusetts General Hospital and Harvard Medical School (2010-2012). Dr. Fleming received her B.S. in Electrical Engineering and Computer Science from Massachusetts Institute of Technology in 2004, and her M.S. and Ph.D. in Biomedical Engineering from Case Western Reserve University in 2007 and 2010, respectively.

  3. Quotes

    1. I am very pleased and honored that my work has received such recognition from the NIH.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    2. We aim to demonstrate that Optical Coherence Tomography (OCT) can address unmet clinical needs of cardiac imaging by providing cellular-level imaging of the myocardium.
      In Prof. Christine Hendon Wins $2.4 Million in Funding with NIH 2014 New Innovator Award | Electrical Engineering
    3. I am thrilled to receive such a notable recognition of my work.... I hope this will draw attention to cardiovascular disease, which is the leading cause of mortality in the United States—it's critical that we continue to develop technologies to detect abnormalities at early stages and develop effective therapies to treat this pervasive illness.
      In Christine Fleming named to MIT Technology Review's annual Innovators Under 35 list