1. Chris K. S. Leung

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    1. Mentioned In 50 Articles

    2. Optical coherence tomography angiography in glaucoma: a mini-review

      Optical coherence tomography angiography in glaucoma: a mini-review
      The advent of optical coherence tomography angiography (OCT-A) provides a new opportunity to visualize the retinal vasculature in a non-invasive and dye-free manner which may help identify vascular abnormalities in glaucoma. While a reduction in retinal and optic nerve head vessel densities and blood flow indexes measured by OCT-A has been demonstrated in patients with glaucoma in many studies, it is unclear whether OCT-A provides additional information for the detection ...
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    3. Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography

      Evaluation of Retinal Nerve Fiber Layer Thinning With Fourier-Domain Optical Coherence Tomography
      Retinal nerve fiber layer (RNFL) defects are a defining feature of optic neuropathies and have been implicated in a few neurodegenerative disorders, including multiple sclerosis, 1 Alzheimer disease, 2 and Parkinson disease. 3 Ashina et al 4 conducted a prospective study observing 1406 children recruited from the Cophenhagen Child Cohort over 10 years. They showed that children of mothers with a history of smoking during pregnancy had a mean reduction ...
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    4. Optical Coherence Tomography Imaging for Glaucoma – Today and Tomorrow

      Optical Coherence Tomography Imaging for Glaucoma – Today and Tomorrow
      Abstract: Digital imaging technologies for glaucoma diagnostics have evolved rapidly over the recent years. From time-domain optical coherence tomography (OCT) to spectral-domain and swept-source OCTs, the application of OCT for analysis of the anterior chamber angle and the optic nerve head (ONH) is expanding. The second-generation anterior segment swept-source OCT is able to image the configuration of the anterior chamber angle in 3 dimensions in less than 1 second and ...
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    5. Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography

      Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography
      Purpose To investigate the impact of retinal blood vessels and retinal nerve fibre layer (RNFL) segmentation errors on RNFL measurement. Methods One eye of 180 subjects (60 normal, 66 mild-to-moderate and 54 advanced glaucoma subjects) was randomly selected for RNFL imaging with a spectral-domain OCT. The boundaries of the RNFL detected by the instrument software were checked, and the segmentation errors were corrected by a customized computer program. The differences ...
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    6. Diagnosing progression with optical coherence tomography

      Diagnosing progression with optical coherence tomography
      Purpose of review: Optical coherence tomography (OCT) imaging of the retinal nerve fiber layer (RNFL), optic nerve head (ONH) and macula has gained popularity in recent years to detect and monitor glaucoma. With significant improvement in scan speed and scan resolution, spectral-domain OCT has become an efficient platform to evaluate progressive RNFL thinning and ONH remodeling. This review summarizes the recent progress of OCT RNFL, ONH and macular measurements for ...
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    7. Imaging the Iris with Swept-Source Optical Coherence Tomography: Relationship between Iris Volume and Primary Angle Closure

      Imaging the Iris with Swept-Source Optical Coherence Tomography: Relationship between Iris Volume and Primary Angle Closure
      ...BM, * Christopher Kai-Shun Leung, MD, MB, ChB Affiliations + Corresponding Author Information Correspondence: Christopher Kai-Shun Leung, MD, MB, ChB, Department of Ophthalmology & Visual Sciences, The Chinese University...
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    8. Corneal thickness and elevation measurements using swept source optical coherence tomography and slit scanning topography in normal and keratoconic eyes

      Corneal thickness and elevation measurements using swept source optical coherence tomography and slit scanning topography in normal and keratoconic eyes
      Background Optical coherence tomography is being used increasingly for corneal measurements. The current study compared corneal thickness and corneal elevation using SS-OCT (Casia, Tomey, Nagoya, Japan) and slit scanning topography (Orbscan IIz, Bausch Lomb, Rochester, New York). Design Prospective study Participants 41 normal and 46 keratoconus subjects Methods All eyes were imaged using SS-OCT and slit scanning tomography during the same visit. Mean central (CCT) and thinnest (TCT) corneal thickness ...
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    9. Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: Measuring Peripheral Anterior Synechia in Glaucoma

      Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: Measuring Peripheral Anterior Synechia in Glaucoma
      Objective To investigate the use of swept-source optical coherence tomography (OCT) for measuring the area and degree of peripheral anterior synechia (PAS) involvement in patients with angle-closure glaucoma. Design Cross-sectional study. Participants Twenty-three eyes with PAS (detected by indentation gonioscopy) from 20 patients with angle-closure glaucoma (20 eyes had primary angle-closure glaucoma and 3 eyes had angle-closure glaucoma secondary to chronic anterior uveitis [n = 2] and AxenfeldRieger syndrome [n = 1 ...
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    10. Anterior Chamber Angle Imaging With Swept-Source Optical Coherence Tomography: Detecting the Scleral Spur, Schwalbe's Line, and Schlemm's Canal

      Anterior Chamber Angle Imaging With Swept-Source Optical Coherence Tomography: Detecting the Scleral Spur, Schwalbe's Line, and Schlemm's Canal
      Objective: To determine the visibility of the scleral spur (SS), Schwalbe's line (SL), and Schlemm's canal (SC) imaged by a swept-source optical coherence tomographer (OCT). Methods: One eye from each individual was randomly selected from 30 normal subjects and 30 patients with primary open-angle glaucoma for anterior segment imaging with a swept-source OCT. The angles were imaged with 2 protocols: (1) high-density (HD, a raster of 64 B-scans ...
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    11. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Interpreting the RNFL maps in Healthy Myopic Eyes

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Interpreting the RNFL maps in Healthy Myopic Eyes
      Objective: To investigate the association between the distribution profile of the retinal nerve fiber layer (RNFL) bundles and myopia and its impact on interpretation of the RNFL map imaged by a spectral-domain optical coherence tomography (OCT). Methods: The RNFL of 189 myopic eyes from 103 normal healthy myopic participants was imaged by the Cirrus HD-OCT. The angle between the long axes of the superotemporal and inferotemporal RNFL bundles determined in ...
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    12. Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph
      ...Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, PR China , * Christopher Kai-shun Leung, MD, MB ChB Affiliations + Department of Ophthalmology and Visual Sciences, The Chi...
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    13. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography A Prospective Analysis of Age-Related Loss

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography A Prospective Analysis of Age-Related Loss
      Objective To investigate age-related changes of the retinal nerve fiber layer (RNFL) imaged by a spectral-domain optical coherence tomography (OCT). Design Prospective, cross-sectional, and longitudinal studies. Participants One hundred normal individuals were recruited for cross-sectional analysis, 35 of whom were randomly selected for longitudinal analysis. Methods The circumpapillary average and quadrant RNFL thicknesses were measured by the Cirrus HD-OCT. In the longitudinal study, participants were followed at 4-month intervals for ...
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    14. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Impact of Signal Strength on Analysis of the RNFL Map

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Impact of Signal Strength on Analysis of the RNFL Map
      Purpose: The objective of the study was to investigate the influence of signal strength (SS) on retinal nerve fiber layer (RNFL) measurement and interpretation of the RNFL thickness deviation map obtained with a spectral-domain optical coherence tomography. Design: Cross-sectional study. Methods: Thirty-seven eyes from 37 normal subjects were included. Six cube scans, each with 200 × 200 RNFL measurement pixels covering an area of 6 × 6 mm2 at the optic disc ...
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    15. Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects

      Determinants of Quantitative Optic Nerve Measurements using Spectral Domain Optical Coherence Tomography in a Population-based Sample of Non-glaucomatous Subjects
      Purpose: To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods: Adults aged 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. Cirrus high-definition OCT (Carl Zeiss Meditec Inc, Dublin, CA) was used to measure ONH and RNFL parameters. A total of ...
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  2. About Chris K. S. Leung

    Chris K. S. Leung

    Chris K. S. Leung is at the Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital.

  3. Quotes

    1. At a comparable level of specificity, Spectralis OCT RNFL measurement attained a higher sensitivity than HRT optic disc measurement.
      In Delving into glaucoma