1. Chinese Academy of Sciences

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    1. Mentioned In 109 Articles

    2. Multi-scale pathological fluid segmentation in OCT with a novel curvature loss in convolutional neural network

      Multi-scale pathological fluid segmentation in OCT with a novel curvature loss in convolutional neural network
      The segmentation of pathological fluid lesions in optical coherence tomography (OCT), including intraretinal fluid, subretinal fluid, and pigment epithelial detachment, is of great importance for the diagnosis and treatment of various eye diseases such as neovascular age-related macular degeneration and diabetic macular edema. Although significant progress has been achieved with the rapid development of fully convolutional neural networks (FCN) in recent years, some important issues remain unsolved. First, pathological fluid ...
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    3. Retinal Microvascular Alterations Detected by Optical Coherence Tomography Angiography in Nonfunctioning Pituitary Adenomas

      Retinal Microvascular Alterations Detected by Optical Coherence Tomography Angiography in Nonfunctioning Pituitary Adenomas
      Purpose: Visual impairment assessment plays a significant role in diagnosis and clinical decisions in nonfunctioning pituitary adenoma (NFPA). Retinal microvascular alterations may potentially reflect the visual impairment. The purpose of this study was to evaluate fundus microvascular alterations in patients with NFPA. Methods: Comparisons of visual field, retinal structure, and microcirculation were conducted between patients with NFPA and age- and sex-matched healthy controls. Multivariate regression modeling was used to assess ...
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    4. Prediction of effective Lens position using anterior segment optical coherence tomography in Chinese subjects with angle closure

      Prediction of effective Lens position using anterior segment optical coherence tomography in Chinese subjects with angle closure
      Purpose: To assess the accuracy of biometric parameters measured by anterior segment optical coherence tomography (AS-OCT) and partial coherence interferometry (PCI) in prediction of effective lens position (ELP) compared with previous formulas in PACG patients. Methods: 121 PACG eyes were randomly divided into training set (85 eyes) and validation set (36 eyes) with same procedure including AS-OCT, PCI, phacoemulsification and IOL implantation surgery. Preoperative anterior chamber depth (pre-ACD), scleral spur ...
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    5. Association Between the Severity of Diabetic Retinopathy and Optical Coherence Tomography Angiography Metrics

      Association Between the Severity of Diabetic Retinopathy and Optical Coherence Tomography Angiography Metrics
      Diabetic retinopathy, the most serious ocular complication of diabetes, imposes a serious economic burden on society. Automatic and objective assessment of vessel changes can effectively manage diabetic retinopathy and prevent blindness. Optical coherence tomography angiography (OCTA) metrics have been confirmed to be used to assess vessel changes. The accuracy and reliability of OCTA metrics are restricted by vessel segmentation methods. In this study, a multi-branch retinal vessel segmentation method is ...
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    6. Associations Between Diabetic Retinal Microvasculopathy and Neuronal Degeneration Assessed by Swept-Source OCT and OCT Angiography

      Associations Between Diabetic Retinal Microvasculopathy and Neuronal Degeneration Assessed by Swept-Source OCT and OCT Angiography
      Purpose: To provide clinical evidence of the associations between retinal neuronal degeneration and microvasculopathy in diabetic retinopathy (DR). Methods: This case-control study included 76 patients (76 eyes) with type 2 diabetes mellitus (DM), and refraction error between -3.0 and +3.0 D. The eyes were assigned into DM (without DR), non-proliferative DR (NPDR), and proliferative DR (PDR) groups. Age-, sex-, and refractive error-matched normal subjects were enrolled as controls ...
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    7. Wide-field swept source optical coherence tomography evaluation of posterior segment changes in highly myopic eyes

      Wide-field swept source optical coherence tomography evaluation of posterior segment changes in highly myopic eyes
      Background: To investigate the features in the posterior pole of highly myopic (HM) eyes using a wide-field high-resolution swept source optical coherence tomography (SS OCT). Methods: This observational cross-sectional study involved 262 eyes of 139 patients, who were diagnosed as HM and had consecutively been examined by SS OCT in the Ophthalmology Department of the Peking Union Medical College Hospital between March 2019 and December 2019. The characteristics of OCT ...
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    8. High myopia and macular vascular density: an optical coherence tomography angiography study

      High myopia and macular vascular density: an optical coherence tomography angiography study
      Objective: To investigate whether there are differences inmacular vascular density (VD) between patients with high-myopia (HM) and those with non-high myopia (NHM) using Optical Coherence Tomography Angiography (OCTA). Method: OCTA was performed on 35 eyes with HM with spherical equivalence (SE) - 6.00D and 35 eyes with NHM with SE -6.00D. Vascular densities of the macula (overall macula, fovea, parafovea, superior hemi and inferior hemi) were measured in each ...
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    9. Flattening the curve: Nano-film enhanced supercontinuum edition

      Flattening the curve: Nano-film enhanced supercontinuum edition
      Providing light with tailored properties through ultrafast supercontinuum generation represents an active field of nonlinear science research. A German-Australian research collaboration has presented a new concept that includes a longitudinally varying thickness nano-films in microstructured exposed core fibers. This offers low input energy, broadband and spectrally flattened spectra in the near infrared with high pulse-to-pulse stability, establishing a novel class of light sources for fields such as biophotonics, medical diagnostics ...
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    10. Quantitative assessment of vascular features in port wine stains through optical coherence tomography angiography

      Quantitative assessment of vascular features in port wine stains through optical coherence tomography angiography
      Background: Vascular lesions such as port wine stains (PWS) lead to facial and psychological problems, which require careful and precise treatments. The key point of treating PWS is to selectively destroy the abnormal blood vessels. Hence, the in vivo monitoring of targeted vessels is crucial. Optical coherence tomography angiography (OCTA), an emerging label-free imaging tool, facilitates the evaluation of skin structure and vasculature at a high resolution. In this study ...
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    11. Optical coherence tomography angiography characteristics and correlated factors with visual acuity in retinal arterial occlusion

      Optical coherence tomography angiography characteristics and correlated factors with visual acuity in retinal arterial occlusion
      Purpose: To reveal the characteristics of vascular changes in retinal arterial occlusion (RAO) using optical coherence tomography angiography (OCTA) and determine the correlated factors with best-corrected visual acuity (BCVA). Methods: This retrospective study recruited 54 RAO patients and 27 healthy individuals. Ophthalmic examinations including BCVA and OCTA were performed in all the patients and individuals. The OCTA outcomes were analyzed using SPSS software, and the characteristics of vascular changes and ...
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    12. Unsupervised domain adaptation model for lesion detection in retinal OCT images

      Unsupervised domain adaptation model for lesion detection in retinal OCT images
      Background and objective Optical Coherence Tomography (OCT) is one of the most used retinal imaging modalities in the clinic as it can provide high-resolution anatomical images. The huge number of OCT images has significantly advanced the development of deep learning methods for automatic lesion detection to ease the doctor's workload. However, it has been frequently revealed that the deep neural network (DNN) model has difficulty handling the domain discrepancies ...
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    13. Widefield Swept-Source Optical Coherence Tomography Angiography Assessment of Choroidal Changes in Vogt-Koyanagi-Harada Disease

      Widefield Swept-Source Optical Coherence Tomography Angiography Assessment of Choroidal Changes in Vogt-Koyanagi-Harada Disease
      Purpose: To investigate choroidal changes in patients with Vogt-Koyanagi-Harada disease (VKH) using widefield swept-source optical coherence tomography angiography (SS-OCTA). Methods: In this cross-sectional study, 133 eyes of 69 patients with VKH (52 eyes of 28 active VKH patients and 81 eyes of 41 inactive VKH patients) and 104 eyes of 52 age and sex matched healthy volunteers were imaged using a widefield SS-OCTA instrument. On 12 mm 12 mm OCTA ...
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    14. Correction of refractive and scattered image distortions in optical coherence tomography based on scalpel

      Correction  of  refractive  and  scattered  image  distortions  in optical coherence tomography based on scalpel
      Optical coherence tomography (OCT) is a non-invasive imaging te chnique, which has high resolution and high sensitivity. Due to its real-time, cross-sectional, an d micrometer-scale imaging capabilities, OCT has been widely used in ophthalmology [1]. In ophthalmic im aging, OCT allowed for not only the analysis of anterior segment structures like cornea and iri s, but also the visualization of details like trabecular meshwork and Schlemms canal. Clinically, real-time OCT ...
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    15. Capillary stall quantification from optical coherence tomography angiogram maximum intensity projections

      Capillary stall quantification from optical coherence tomography angiogram maximum intensity projections
      Optical coherence tomography (OCT) is applicable to the study of cerebral microvasculature in vivo. Optimised acquisition schemes enable the generation of three-dimensional OCT angiograms, i.e., volumetric images of red blood cell flux in capillary networks, currently at a repetition rate of up to 1/10 seconds. This makes testable a new class of hypotheses that strive to bridge the gap between microscopic phenomena occurring at the spatial scale of ...
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    16. Weakly supervised anomaly segmentation in retinal OCT images using an adversarial learning approach

      Weakly supervised anomaly segmentation in retinal OCT images using an adversarial learning approach
      Lesion detection is a critical component of disease diagnosis, but the manual segmentation of lesions in medical images is time-consuming and experience-demanding. These issues have recently been addressed through deep learning models. However, most of the existing algorithms were developed using supervised training, which requires time-intensive manual labeling and prevents the model from detecting unaware lesions. As such, this study proposes a weakly supervised learning network based on CycleGAN for ...
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  2. About Chinese Academy of Sciences

    Chinese Academy of Sciences

    Chinese Academy of Sciences (CAS) is a leading academic institution and comprehensive research and development center in natural science, technological science and high-tech innovation in China. It was founded in Beijing on 1st November 1949 on the basis of the former Academia Sinica (Central Academy of Sciences) and Peiping Academy of Sciences.