1. Chao Zhou

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    1. Mentioned In 59 Articles

    2. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...n for engineering and business. For more information, visit http://www.lehigh.edu/ . About Dr. Chao Zhou: Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked wi...
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    3. Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue

      Computer-Aided Diagnosis of Label-Free 3-D Optical Coherence Microscopy Images of Human Cervical Tissue
      : Ultrahigh-resolution optical coherence microscopy (OCM) has recently demonstrated its potential for accurate diagnosis of human cervical diseases. One major challenge for clinical adoption, however, is the steep learning curve clinicians need to overcome to interpret OCM images. Developing an intelligent technique for computer-aided diagnosis (CADx) to accurately interpret OCM images will facilitate clinical adoption of the technology and improve patient care. Methods: 497 high-resolution 3-D OCM volumes (600 cross-sectional images ...
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    4. Integrating optical coherence tomography with gravimetric and video analysis (OCT-Gravimetry-Video method) for studying the drying process of polystyrene latex system

      Integrating optical coherence tomography with gravimetric and video analysis (OCT-Gravimetry-Video method) for studying the drying process of polystyrene latex system
      Latex, an aqueous dispersion of sub-micron polymer particles, is widely used as polymer binder in waterborne coatings and adhesives. Drying of a latex is inhomogeneous, during which the spatial distribution of particles is non-uniform and changes with time, usually resulting in a compromise of the integrity of a dried film. To study drying inhomogeneity of latex, we developed a system integrating optical coherence tomography (OCT) with gravimetric and video analysis ...
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    5. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...n for engineering and business. For more information, visit http://www.lehigh.edu/ . About Dr. Chao Zhou: Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked wi...
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    6. Feature Of The Week 10/15/2017: Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Feature Of The Week 10/15/2017: Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids
      ...howing great potential for high-throughput drug screening. For more information see recent Article . Courtesy Chao Zhou from Lehigh University . Three-dimensional (3D) tumor spheroid models have gained increased recognit...
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    7. Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device

      Wide-field high-speed space-division multiplexing optical coherence tomography using an integrated photonic device
      Space-division multiplexing optical coherence tomography (SDM-OCT) is a recently developed parallel OCT imaging method in order to achieve multi-fold speed improvement. However, the assembly of fiber optics components used in the first prototype system was labor-intensive and susceptible to errors. Here, we demonstrate a high-speed SDM-OCT system using an integrated photonic chip that can be reliably manufactured with high precisions and low per-unit cost. A three-layer cascade of 1 2 ...
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    8. Integrated Local Binary Pattern Texture Features for Classification of Breast Tissue Imaged by Optical Coherence Microscopy

      Integrated Local Binary Pattern Texture Features for Classification of Breast Tissue Imaged by Optical Coherence Microscopy
      This paper proposes a texture analysis technique that can effectively classify different types of human breast tissue imaged by Optical Coherence Microscopy (OCM). OCM is an emerging imaging modality for rapid tissue screening and has the potential to provide high resolution microscopic images that approach those of histology. OCM images, acquired without tissue staining, however, pose unique challenges to image analysis and pattern classification. We examined multiple types of texture ...
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    9. Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids

      Optical coherence tomography detects necrotic regions and volumetrically quantifies multicellular tumor spheroids
      hree-dimensional (3D) tumor spheroid models have gained increased recognition as important tools in cancer research and anti-cancer drug development. However, currently available imaging approaches employed in high-throughput screening drug discovery platforms e.g. bright field, phase contrast, and fluorescence microscopies, are unable to resolve 3D structures deep inside (50 m) tumor spheroids. In this study, we established a label-free, non-invasive optical coherence tomography (OCT) imaging platform to characterize 3D morphological ...
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    10. Optical Coherence Tomography for Brain Imaging and Developmental Biology

      Optical Coherence Tomography for Brain Imaging and Developmental Biology
      Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its noninvasiveness nature, OCT enables longitudinal imaging ...
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    11. Apparatus and method for space-division multiplexing optical coherence tomography

      Apparatus and method for space-division multiplexing optical coherence tomography
      A space-division multiplexing optical coherence tomography apparatus and system is provided. In one embodiment, the system includes a light source, a reference arm, and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned ...
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    12. Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography

      Label-Free Imaging of Eosinophilic Esophagitis Mouse Models Using Optical Coherence Tomography
      Eosinophilic esophagitis (EoE) is an immune-mediated disorder characterized by esophageal inflammation and related structural changes causing symptoms such as feeding difficulties and food impaction. The pathophysiological mechanisms underlying EoE remain poorly understood. Preclinical studies using mouse models have been critical in comprehending human disease mechanisms and associated pathways. In this chapter, we describe an experimental method using a noninvasive label-free optical imaging technique, optical coherence tomography, to characterize the pathophysiological ...
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    13. Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics/Biomedical Optical Imaging at Lehigh University
      ...ofessors, and a staff of 1,255. For more information, visit http://www.lehigh.edu/ . About Dr. Chao Zhou: Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked wi...
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    14. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ofessors, and a staff of 1,255. For more information, visit http://www.lehigh.edu/ . About Dr. Chao Zhou: Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked wi...
      Read Full Article
    15. Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University

      Post-doctoral Associate Position in Biophotonics / Biomedical Optical Imaging at Lehigh University
      ...ofessors, and a staff of 1,255. For more information, visit http://www.lehigh.edu/ . About Dr. Chao Zhou: Dr. Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked wi...
      Read Full Article
    16. 1-15 of 59 1 2 3 4 »
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    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Chao Zhou

    Chao Zhou

    Chao Zhou obtained his Ph.D. degree in physics in 2007 from the University of Pennsylvania, where he worked with Professor Arjun G. Yodh on the development of diffuse optical spectroscopy and imaging techniques. In August 2007, he joined Professor James G. Fujimoto's Laser Medicine and Medical Imaging Group at the Massachusetts Institute of Technology as a postdoctoral associate. Since then, he has been working on the development of Optical Coherence Tomography (OCT) and Optical Coherence Microscopy (OCM) technologies. In June 2012, he joined the faculty at Lehigh University as an assistant professor in electrical engineering and bioengineering. He has extensive experience in the field of biomedical optical imaging and has contributed to the development and validation of novel modalities for the imaging of humans and animals with various applications ranging from measuring the brain function to monitoring cancer treatments. He has published over 45 peer-reviewed journal articles, and is a member of the International Society for Optical Engineering, American Heart Association and the International Society for Cerebral Blood flow and Metabolism. He is also a peer reviewer for Optics Letters, Optics Express, Biomedical Optics Express, Applied Optics, Journal of Optical Society of America - A, Journal of Biomedical Optics, Medical Physics, Physics in Medicine and Biology, Physiological Measurement, Journal of Selected Topics in Quantum Electronics and several conferences.

  3. Quotes

    1. We’re also using OCT and OCM to look at developmental biology...In current practice, if you want to examine a developing embryo or animal, you have to sacrifice it and cut it up. Our goal is to be able to image embryonic structures in a less destructive way...We can image [interior cross-sections of] the systolic and diastolic rhythms of an embryonic fly's heart, and compare a normal heart to one with cardio-arrhythmia...OCT, when combined with OCM, can get in vivo , 3-D structural and functional images without needing to remove and process tissues.
      In A more accurate and noninvasive look at cancerous tumors