1. Chao-Wei Chen

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    1. Mentioned In 15 Articles

    2. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography

      Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography
      Early detection of neoplastic changes remains a critical challenge in clinical cancer diagnosis and treatment. Many cancers arise from epithelial layers such as those of the gastrointestinal (GI) tract. Current standard endoscopic technology is difficult to detect the subsurface lesions. In this research, we investigated the feasibility of a novel multi-modal optical imaging approach including high-resolution optical coherence tomography (OCT) and high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and ...
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    3. Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus

      Optical Coherence Tomographic Elastography Reveals Mesoscale Shear Strain Inhomogeneities in the Annulus Fibrosus
      Study Design. Basic science study using in vitro tissue testing and imaging to characterize local strains in annulus fibrosus (AF) tissue. Objective. To characterize mesoscale strain inhomogeneities between lamellar and inter-/translamellar (ITL) matrix compartments during tissue shear loading. Summary of Background Data. The intervertebral disc (IVD) is characterized by significant heterogeneities in tissue structure and plays a critical role in load distribution and force transmission in the spine. In ...
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    4. Three dimensional mesoscale analysis of translamellar cross-bridge morphologies in the annulus fibrosus using optical coherence tomography

      Three dimensional mesoscale analysis of translamellar cross-bridge morphologies in the annulus fibrosus using optical coherence tomography
      ...ross-bridge morphologies in the annulus fibrosus using optical coherence tomography 1. Sang Kuy Han^1,2, 2. Chao-Wei Chen^1, 3. Jerry Wierwille^1, 4. Yu Chen^1 and 5. Adam H. Hsieh^1,3,* Article first published onlin...
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    5. Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection

      Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection
      Optical Coherence Tomography (OCT) offers high-resolution imaging of the tissue microstructure. But there are numerous limitations to OCT including providing direct molecular imaging capability. A popular research thrust has recently been to combine OCT with other imaging technology such as Raman, Fluorescence, and other molecular imaging techniques to achieve a multi-modality imaging capability. This multi-modality imaging offers improved capabilities including all the normal OCT benefits as well as allowing the ...
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    6. Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography

      Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography
      Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabricated to locate and image adenomatous polyps in APCMin/+ mice. The biomarker α-l-fucose covalently joins the liposomal conjugated lectin Ulexeuropaeus agglutinin (UEA-1), via glycosidic linkage to the polyp mucin layer. Multispectral optical imaging (MSI) corroborated ...
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    7. Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging

      Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging
      ...for macroscopic imaging methods to resolve.For more information see recent Article1 and Article2. Courtesy of Chao-Wei Chen and Yu Chen from the University of Maryland Feature Of The Week 9/26/10: Multimodal imaging repr...
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    8. Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT) for Depth-Resolved Subsurface Cancer Imaging

      Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT) for Depth-Resolved Subsurface Cancer Imaging
      ...ptical Tomography (FLOT) for Depth-Resolved Subsurface Cancer Imaging Yu Chen, Shuai Yuan, Jerry Wierwille, Chao-Wei Chen, Tiffany Blackwell, Paul Winnard, Venu Raman, and Kristine Glunde » View Full Text: Acrobat PDF ...
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    9. Investigation of pore structure and cell distribution in EH-PEG hydrogel scaffold using optical coherence tomography and fluorescence microscopy

      Investigation of pore structure and cell distribution in EH-PEG hydrogel scaffold using optical coherence tomography and fluorescence microscopy
      ...ing and Regenerative Medicine IV Conference Chairs: Sean J. Kirkpatrick, Ruikang Wang ABSTRACT REFERENCES (6) Chao-Wei Chen, Martha W. Betz, John P. Fisher, and Andrew Paek Univ. of Maryland, College Park (USA) James Jia...
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    10. Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging

      Abstract. Optical coherence tomography (OCT) provides high-resolution, cross-sectional imaging of tissue microstructure in situ and in real time, while fluorescence molecular imaging (FMI) enables the visualization of basic molecular processes. There is a great deal of interest in combining these two modalities so that the tissue's structural and molecular information can be obtained simultaneously. This could greatly benefit biomedical applications such as detecting early diseases and monitoring therapeutic interventions ...
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    11. Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography

      Feature Of The Week 9/6/09: Automated Quantification of Microstructural Dimensions of the Human Kidney using Optical Coherence Tomography
      Feature Of The Week 9/6/09: Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can non-invasively provide cross-sectional, high-resolution images of tissue morphology in situ and in real-time. Recent development in high-speed OCT enables the acquisition of a large amount of three-dimensional image d
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    12. 1-15 of 15
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  2. About Chao-Wei Chen

    Chao-Wei Chen

    Chao-Wei Chen is with the Fischell Department of Bioengineering at the University of Maryland, College Park.  Dr. Chen received his BS degree at Department of Electrical Engineering, National Taiwan University in 2005 MS degree at Graduate Institute of Photonics and Optoelectronics, National Taiwan University in 2007. His master study was about Current-Voltage characteristics of carrier transport in Organic LEDs. He contributed an analytic solution to a specific carrier transport model in 2008. For his interest in display research and image processing, he continued to pursue Ph.D degree at University of Maryland since 2007. His current research includes optical coherence tomography/elastography and fluorescence laminar optical tomography.