1. Chang Gung University

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    1. Mentioned In 71 Articles

    2. Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser

      Ultrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser
      In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and ...
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    3. Correlation between pigmented arc and epithelial thickness (COPE) study in orthokeratology-treated patients using OCT measurements

      Correlation between pigmented arc and epithelial thickness (COPE) study in orthokeratology-treated patients using OCT measurements
      Purpose To determine the intensity of corneal pigmented arc in orthokeratology (ortho-k)-treated children, and its correlation with key epithelial thickness measurements obtained by anterior segment optical coherence tomography (AS-OCT). Methods This study is a retrospective case series. Medical records of children who received ortho-k treatment for myopia control in our hospital were reviewed. Intensity of ortho-k-associated pigmented arc and its correlation with key epithelial thickness parameters in the central ...
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    4. Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II

      Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II
      Precis: 3D spectral domain OCT volume scans of the optic nerve head and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Purpose: To report the use of spectral domain optical coherence tomography (OCT) in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Methods: Observational case series. Four consecutive patients with ...
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    5. Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software

      Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
      Prcis: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. Purpose: To compare the diagnostic capability of three-dimensional (3D) peripapillary retinal volume (RV) versus two-dimensional (2D) peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma . Patients and Methods: A retrospective cross-sectional analysis was conducted. A total of 180 subjects [113 open-angle glaucomas (OAG), 67 normal ...
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    6. Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma

      Segmental inner macular layer analysis with spectral-domain optical coherence tomography for early detection of normal tension glaucoma
      Purpose To segment the inner macular layers (IML) and compare the discriminating abilities of the macular and peripapillary retinal nerve fiber layer (mRNFL and pRNFL, respectively) thicknesses in patients with early-stage normal tension glaucoma (NTG). Design Cross-sectional study Methods Forty-nine normal subjects and 69 preperimetric glaucoma (PPG) and 60 NTG patients were enrolled. Spectral-domain optical coherence tomography (SD-OCT) was used to obtain pRNFL and macular thickness parameters and segment the ...
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    7. Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography

      Non-Invasive Quantification of the Growth of Cancer Cell Colonies by a Portable Optical Coherence Tomography
      Investigation of tumor development is essential in cancer research. In the laboratory, living cell culture is a standard bio-technology for studying cellular response under tested conditions to predict in vivo cellular response. In particular, the colony formation assay has become a standard experiment for characterizing the tumor development in vitro. However, quantification of the growth of cell colonies under a microscope is difficult because they are suspended in a three-dimensional ...
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    8. In vivo detection of UV-induced acute skin effects using optical coherence tomography

      In vivo detection of UV-induced acute skin effects using optical coherence tomography
      Ultraviolet (UV) rays have been identified as a carcinogen with long-term irradiation and are an important risk factor for skin cancer. Here, we report the use of optical coherence tomography/optical coherence tomography angiography (OCT/OCTA) to study acute UV-induced effects on skin in vivo . To understand the relationship between the acute effects and irradiated UV power density, three groups were irradiated with different power densities in our experiments. Furthermore ...
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    9. Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma

      Analysis of peripapillary retinal nerve fiber layer and inner macular layers by spectral-domain optical coherence tomography for detection of early glaucoma
      AIM : To analyze the diagnostic capabilities of peripapillary retinal nerve fiber layer (pRNFL) thickness and segmented inner macular layer (IML) thickness measured by spectral-domain optical coherence tomography for detection of early glaucoma. METHODS : Fifty-three patients with primary open angle glaucoma (POAG), 60 patients with normal tension glaucoma (NTG) and 32 normal control subjects were enrolled. Thicknesses of pRNFL, total macular layers (TML), and the IML, including macular RNFL (mRNFL) and ...
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    10. NOVEL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BIOMARKER IN BRANCH RETINAL VEIN OCCLUSION MACULAR EDEMA

      NOVEL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY BIOMARKER IN BRANCH RETINAL VEIN OCCLUSION MACULAR EDEMA
      Purpose: To evaluate the association between deepsuperficial flow ratio (DSFR) and the treatment response of macular edema in branch retinal vein occlusion . Methods: Thirty eyes from 30 patients with branch retinal vein occlusion who had received optical coherence tomography angiography examination were included. Seventeen normal fellow eyes acted as the control group. Patients were classified into the good response group and the refractory group by absence or presence of macular ...
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    11. Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design

      Extending the depth of focus of fiber-optic optical coherence tomography using a chromatic dual-focus design
      We report a dual-focus fiber-optic probe designed to extend depth of focus (DOF) in high-resolution endoscopic optical coherence tomography. We exploited the broad spectral bandwidth of a supercontinuum source and, in the fiber probe, the foci of the 7501000 nm and 11001450 nm inputs were axially chromatically shifted. The interference signals from the two spectral bands were measured with a Si camera-based spectrometer and an InGaAs camera-based spectrometer, respectively. We ...
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    12. The relationship between age, axial length and retinal nerve fiber layer thickness in the normal elderly population in Taiwan: The Chiayi eye study in Taiwan

      The relationship between age, axial length and retinal nerve fiber layer thickness in the normal elderly population in Taiwan: The Chiayi eye study in Taiwan
      ...-Yuan, Taiwan Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan, College of Medicine, Chang Gung University, Tao-Yuan, Taiwan Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Tai...
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    13. Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography

      Assessment of temporary cerebral effects induced by focused ultrasound with optical coherence tomography angiography
      Focused ultrasound (FUS) in combination with microbubbles temporally and locally increases the permeability of the blood-brain barrier (BBB) for facilitating drug delivery. However, the temporary effects of FUS on the brain microstructure and microcirculation need to be addressed. We used label-free optical coherence tomography (OCT) and OCT angiography (OCTA) to investigate the morphological and microcirculation changes in mouse brains due to FUS exposure at different power levels. Additionally, the recovery ...
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    14. Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography

      Noninvasive structural and microvascular anatomy of oral mucosae using handheld optical coherence tomography
      In this study, we demonstrated the feasibility of using a handheld optical coherence tomography (OCT) for in vivo visualizations of the microstructural and microvascular features of various oral mucosal types. To scan arbitrary locations of the oral mucosa, a scanning probe was developed, composed of a probe body fabricated by a 3D printer, miniaturized two-axis galvanometer, relay lenses, and reflective prism. With a 3D printing technique, the probe weight and ...
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    15. Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia

      Diagnostic capability of peripapillary retinal nerve fiber layer parameters in time-domain versus spectral-domain optical coherence tomography for assessing glaucoma in high myopia
      AIM : To evaluate and compare the diagnostic capabilities of peripapillary retinal nerve fiber layer (p-RNFL) parameters of Spectralis optical coherence tomography (OCT) versus Stratus OCT to detect glaucoma in patients with high myopia. METHODS : This is a retrospective, cross-sectional study. Sixty highly myopic eyes of 60 patients were enrolled, with 30 eyes in the glaucoma group and 30 eyes in the control group. All eyes received peripapillary imaging of the ...
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    16. Optical Coherence Tomography Angiography of the Superficial Microvasculature in the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes

      Optical Coherence Tomography Angiography of the Superficial Microvasculature in the Macular and Peripapillary Areas in Glaucomatous and Healthy Eyes
      Purpose : To quantitatively evaluate the superficial microvasculature in the macular and peripapillary areas in glaucomatous and healthy eyes using optical coherence tomography angiography (OCT-A). Methods : We enrolled 26 eyes of medically managed primary open-angle glaucoma patients and 27 eyes of healthy subjects were enrolled in this prospective study. Measurements of OCT-A vessel density were acquired both in the macular and peripapillary areas. We compared vessel density values, the circumpapillary retinal ...
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  2. About Chang Gung University

    Chang Gung University

    Chang Gung University currently consists of the College of Medicine, College of Engineering, and College of Management. Our University has approximately 490 full-time and 340 part-time faculty members, and has more than 6,100 students enrolled. We have been striving for excellence in both instruction and research area since the establishment of our institution. In taking advantage of Formosa Plastics Group's abundant manufacturing and medical service resources, Chang Gung University aims to be a first-rate internationally renowned university that prepares high standard professional talents in the fields of medical science, high technology, and knowledge management.