1. Center for Ophthalmic Optics and Lasers

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    1. Mentioned In 243 Articles

    2. Billions of dollars saved with eye imaging technology co-invented by OHSU physician

      Billions of dollars saved with eye imaging technology co-invented by OHSU physician
      A non-invasive imaging technology used to evaluate eye health has saved the U.S. government and patients billions of dollars, a new study reveals. Medicare and its patients saved a combined $11.2 billion between 2008 and 2015 by using optical coherence tomography , also known as OCT, according to a paper published in the American Journal of Ophthalmology . The cost savings are a result of physicians being able to provide ...
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    3. Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy

      Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy
      Purpose To compare patient and Medicare savings from the use of optical coherence tomography (OCT) in guiding therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in developing OCT by the National Institutes of Health (NIH) and the National Science Foundation (NSF). Design Observational cohort study. Methods Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology codes on intravitreal injections (67028), retinal OCT ...
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    4. New Study Finds Federally-Funded Technology Saved Medicare $9 Billion

      New Study Finds Federally-Funded Technology Saved Medicare $9 Billion
      A new study quantifying a 21-fold return on investment suggests an efficient and non-partisan method to cut healthcare spending is to invest in basic research. The paper tracks how a new technology aids doctors in reducing the number of unnecessary drug injections used to treat a blinding condition called wet age-related macular degeneration (AMD). According to the study, Medicare has enjoyed $9 billion in savings over an eight year period ...
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    5. Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography

      Polarization-multiplexed, dual-beam swept source optical coherence tomography angiography
      A polarization-multiplexed, dual-beam setup is proposed to expand the field of view for a swept source optical coherence tomography angiography (OCTA) system. This method used a Wollaston prism to split sample path light into two orthogonal-polarized beams. This allowed two beams to shine on the cornea at an angle separation of ~ 14 degrees, which led to a separation of ~ 4.2 mm on the retina. A 3-mm glass plate was ...
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    6. Imaging of Iris Lesions With High-Speed Optical Coherence Tomography

      Imaging of Iris Lesions With High-Speed Optical Coherence Tomography
      n BACKGROUND AND OBJECTIVES:To image and measure iris tumors with optical coherence tomography (OCT). n PATIENTS AND METHODS:High-speed(2,000 4,000 axial-scan/sec and 416 frames/sec) 1.3-micron wavelength anterior segment OCT prototypes were used to image 6 eyes of 6 patients with a variety of iris lesions, including focal iris nevus, diffuse iris nevus, amelanotic iris nevus, iris melanocytosis, and iris melanoma. OCT images were ...
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    7. Automated detection of photoreceptor disruption in mild diabetic retinopathy on volumetric optical coherence tomography

      Automated detection of photoreceptor disruption in mild diabetic retinopathy on volumetric optical coherence tomography
      Diabetic retinopathy is a pathology where microvascular circulation abnormalities ultimately result in photoreceptor disruption and, consequently, permanent loss of vision. Here, we developed a method that automatically detects photoreceptor disruption in mild diabetic retinopathy by mapping ellipsoid zone reflectance abnormalities from en face optical coherence tomography images. The algorithm uses a fuzzy c-means scheme with a redefined membership function to assign a defect severity level on each pixel and generate ...
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    8. Optical Coherence Tomography Angiography in Neuro-Ophthalmology

      Optical Coherence Tomography Angiography in Neuro-Ophthalmology
      Optical coherence tomography (OCT) has become the most commonly performed imaging procedure in ophthalmology (1,2). Conventional OCT provides high-resolution structural information of the retina and optic nerve. More recent functional extensions such as Doppler OCT (3) and OCT angiography (OCTA) (4) have emerged as useful tools for vascular evaluation of eye diseases, including optic neuropathies. This issue of the Journal of Neuro-Ophthalmology has 2 articles (5,6) demonstrating the ...
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    9. Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography

      Assessment Of Retinal Blood Flow In Diabetic Retinopathy Using Doppler FOURIER-DOMAIN Optical Coherence Tomography
      Purpose: To evaluate retinal blood flow measurements in normal eyes and eyes with varying levels of diabetic retinopathy (DR) using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: Twenty-two eyes of 19 subjects, 10 with severe nonproliferative DR (NPDR) and 12 with proliferative DR (PDR), were compared with 44 eyes of 40 healthy control subjects. All eyes were scanned by RTvue FD-OCT. Color disk photographs and cube/volume scans of the ...
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    10. OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia

      OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia
      Purpose Use projection-resolved OCT angiography to investigate the autoregulatory response in the 3 parafoveal retinal plexuses under hyperoxia. Design Prospective cohort study. Participants Nine eyes from 9 healthy participants. Methods One eye from each participant was scanned using a commercial spectral-domain OCT system. Two repeated macular scans (3 3 mm 2 ) were acquired at baseline and during oxygen breathing. The split-spectrum amplitude-decorrelation algorithm was used to detect blood flow. The ...
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    11. Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography

      Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography
      We introduce a method to automatically detect drusen in dry age-related macular degeneration (AMD) from optical coherence tomography with minimum need for layer segmentation. The method is based on the en face detection of drusen areas in C-scans at certain distances above the Bruchs membrane, circumventing the difficult task of pathologic retinal pigment epithelium segmentation. All types of drusen can be detected, including the challenging subretinal drusenoid deposits (pseudodrusen). The ...
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    12. Projection-resolved optical coherence tomography angiography exhibiting early flow prior to clinically observed retinal angiomatous proliferation

      Projection-resolved optical coherence tomography angiography exhibiting early flow prior to clinically observed retinal angiomatous proliferation
      Purpose The purpose of this study is to analyze early retinal angiomatous proliferation (RAP) utilizing a novel imaging modality, Projection-Resolved Optical Coherence Tomography Angiography (PR-OCTA). Observations Five months prior to the diagnosis of a RAP lesion, cross-sectional PR-OCTA demonstrated flow in the outer retina contiguous with the deep retinal capillary plexus (DCP) and adjacent to a small pigment epithelial detachment. After development of a clinically visible RAP lesion, cross-sectional PR-OCTA ...
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    13. Oregon Health & Science University Receives NIH Grant for Functional and Structural Optical Coherence Tomography for Glaucoma

      Oregon Health & Science University Receives NIH Grant  for Functional and Structural Optical Coherence Tomography for Glaucoma
      Oregon Health Science University Receives a 2017 NIH Grant for $559,269 for Functional and Structural Optical Coherence Tomography for Glaucoma. The principal investigator is David Huang. The program began in 2013 and ends in 2021. Below is a summary of the proposed work. Glaucoma is a leading cause of blindness. Early diagnosis and close monitoring of glaucoma are important because the onset is insidious and the damage is irreversible ...
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    14. Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

      Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field
      Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment Method We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as ...
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    15. Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis

      Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis
      Background Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS). Objective To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS. Methods Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. The ONH-FI was defined as flow signal averaged over the optic ...
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  2. About Center for Ophthalmic Optics and Lasers

    Center for Ophthalmic Optics and Lasers

    The Center for Ophthalmic Optics and Lasers (COOL) at Doheny Eye Institute, University of Southern California (USC) is a state of the art research center focusing on the application of biomedical optics in clinical medicine. COOL lab emcompass an extensive range of research areas in both optics and ophthalmology. The mission of the center is to: "Conserve, improve and restore vision through advances in laser and optical technology".