1. Center for Ophthalmic Optics and Lasers

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    1. Mentioned In 304 Articles

    2. Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

      Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
      Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower ...
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    3. Oregon Health & Science University Receives a NIH Grant for Wide-Field and Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy

      Oregon Health & Science University Receives a NIH Grant  for Wide-Field and Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy
      Oregon Health Science University Receives a 2020 NIH Grant for $424,803 for Wide-Field and Projection-Resolved Optical Coherence Tomography Angiography in Diabetic Retinopathy. The principal investigator is Yali Jia. Below is a summary of the proposed work. Our group has demonstrated that optical coherence tomography angiography (OCTA) can address many of the disadvantages of fluorescein angiography (FA) in diabetic retinopathy (DR). OCTA uses the intrinsic contrast of blood cell motion ...
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    4. Sensorless adaptive-optics optical coherence tomographic angiography

      Sensorless adaptive-optics optical coherence tomographic angiography
      Optical coherence tomographic angiography (OCTA) can image the retinal blood flow but visualization of the capillary caliber is limited by the low lateral resolution. Adaptive optics (AO) can be used to compensate ocular aberrations when using high numerical aperture (NA), and thus improve image resolution. However, previously reported AO-OCTA instruments were large and complex, and have a small sub-millimeter field of view (FOV) that hinders the extraction of biomarkers with ...
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    5. Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography

      Depth-resolved optimization of a real-time sensorless adaptive optics optical coherence tomography
      Sensorless adaptive optics optical coherence tomography (AO-OCT) is a technology to image retinal tissue with high resolution by compensating ocular aberrations without wavefront sensors. In this Letter, a fast and robust hill-climbing algorithm is developed to optimize five Zernike modes in AO-OCT with a numerical aperture between that of conventional AO and commercial OCT systems. The merit function is generated in real time using graphics processing unit while axially tracking ...
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    6. Optical coherence tomography angiography avascular area association with one-year treatment requirement and disease progression in diabetic retinopathy

      Optical coherence tomography angiography avascular area association with one-year treatment requirement and disease progression in diabetic retinopathy
      Purpose To assess the association between optical coherence tomography angiography (OCTA) quantified avascular areas (AA) and diabetic retinopathy (DR) severity, progression and treatment requirement in the following year. Design Prospective cohort study. Methods We recruited diabetic patients from tertiary academic retina practice and obtained 3x3-mm macular OCTA scans with AngioVue system and standard 7-field color photographs at baseline and 1-year visit. A masked grader determined the DR severity from the ...
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    7. Systems and methods to remove shadowgraphic flow projections on OCT angiography

      Systems and methods to remove shadowgraphic flow projections on OCT angiography
      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.
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    8. Bulk motion subtraction in optical coherence tomography angiography

      Bulk motion subtraction in optical coherence tomography angiography
      Described herein is an algorithm to remove decorrelation noise due to bulk motion in optical coherence tomography angiography (OCTA). OCTA B-frames are divided into segments within which the bulk motion velocity could be assumed constant. This velocity is recovered using linear regression of decorrelation versus the logarithm of reflectance in axial lines (A-lines) identified as bulk tissue by percentile analysis. The fitting parameters are used to calculate a reflectance-adjusted threshold ...
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    9. Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      Oregon Health and Science University Receives NIH Grant for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases
      Oregon Health and Science University Receives a 2020 NIH Grant for $493,238 for Application of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and precise measurements in the anterior segment of the ...
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    10. Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization

      Application of Corneal Optical Coherence Tomography Angiography for Assessment of Vessel Depth in Corneal Neovascularization
      Purpose: To map and measure the depths of corneal neovascularization (NV) using 3-dimensional optical coherence tomography angiography (OCTA) at 2 different wavelengths. Methods: Corneal NV of varying severity, distribution, and underlying etiology was examined. Average NV depth and vessel density were measured using 840-nm spectral-domain OCTA and 1050-nm swept-source OCTA. The OCTA results were compared with clinical slit-lamp estimation of NV depth. Results: Twelve eyes with corneal NV from 12 ...
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    11. Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients

      Estimating Visual Field Mean Deviation using Optical Coherence Tomographic Nerve Fiber Layer Measurements in Glaucoma Patients
      To construct an optical coherence tomography (OCT) nerve fiber layer (NFL) parameter that has maximal correlation and agreement with visual field (VF) mean deviation (MD). The NFL_MD parameter in dB scale was calculated from the peripapillary NFL thickness profile nonlinear transformation and VF area-weighted averaging. From the Advanced Imaging for Glaucoma study, 245 normal, 420 pre-perimetric glaucoma (PPG), and 289 perimetric glaucoma (PG) eyes were selected. NFL_MD had significantly higher ...
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    12. Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma

      Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma
      Purpose To simulate 24-2 visual field (VF) using optical coherence tomographic angiography (OCTA) for glaucoma evaluation. Design Cross-sectional study. Methods One eye each of 39 glaucoma and 31 age-matched normal participants was scanned using 4.5-mm OCTA scans centered on the disc. The peripapillary retinal nerve fiber layer plexus capillary density (NFLP_CD, %area) was measured. The NFLP_CD and 24-2 VF maps were divided into 8 corresponding sectors using an extension ...
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    13. Quantification of local circulation with OCT angiography

      Quantification of local circulation with OCT angiography
      Impaired intraocular blood flow within vascular beds in the human eye is associated with certain ocular diseases including, for example, glaucoma, diabetic retinopathy and age-related macular degeneration. A reliable method to quantify blood flow in the various intraocular vascular beds could provide insight into the vascular component of ocular disease pathophysiology. Using ultrahigh-speed optical coherence tomography (OCT), a new 3D angiography algorithm called split-spectrum amplitude-decorrelation angiography (SSADA) was developed for ...
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    14. Measuring Glaucomatous Focal Perfusion Loss in the Peripapillary Retina using Optical Coherence Tomographic Angiography

      Measuring Glaucomatous Focal Perfusion Loss in the Peripapillary Retina using Optical Coherence Tomographic Angiography
      Purpose To measure low perfusion areas (LPA) and focal perfusion loss (FPL) in the peripapillary retina using optical coherence tomographic angiography (OCTA) in glaucoma. Design Prospective observation study. Participants Forty-seven primary open angle glaucoma (POAG) patients and 36 normal subjects were analyzed. Methods One eye of each subject was scanned using AngioVue 4.5-mm OCTA scan centered on the disc. En face nerve fiber layer plexus angiogram was generated. Using ...
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    15. The Bruno Lumbroso Lecture at the 7th International Congress on OCT Angiography

      The Bruno Lumbroso Lecture at the 7th International Congress on OCT Angiography
      Dear Colleagues: As you know, the International Congress on OCT Angiography, En Face OCT and Advances in OCT that Professor Bruno Lumbroso initiated few years ago will be in its 7th Year this December 2019 in Rome. Certainly, this global Congress has become one of the most successful, most-attended, and most educational meetings in the field of retinal imaging. Every December during the past six years, more than 1,000 ...
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    16. Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography

      Longitudinal Detection of Radiation-Induced Peripapillary and Macular Retinal Capillary Ischemia Using Optical Coherence Tomography Angiography
      Purpose To study longitudinal changes in retinal capillary circulation in eyes treated with iodine 125 (I-125) plaque brachytherapy for uveal melanoma using optical coherence tomography angiography (OCTA). Design Longitudinal prospective study of 21 subjects undergoing treatment for uveal melanoma with I-125 plaque brachytherapy. Eyes with melanoma were imaged with OCTA prior to treatment and at 12 month intervals until 2 years post-brachytherapy. Participants After IRB-approval, participants were enrolled prospectively from ...
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  2. About Center for Ophthalmic Optics and Lasers

    Center for Ophthalmic Optics and Lasers

    The Center for Ophthalmic Optics and Lasers (COOL) at Doheny Eye Institute, University of Southern California (USC) is a state of the art research center focusing on the application of biomedical optics in clinical medicine. COOL lab emcompass an extensive range of research areas in both optics and ophthalmology. The mission of the center is to: "Conserve, improve and restore vision through advances in laser and optical technology".