1. Center for Ophthalmic Optics and Lasers

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    1. Mentioned In 273 Articles

    2. Systems and methods to remove shadowgraphic flow projections in OCT angiography

      Systems and methods to remove shadowgraphic flow projections in OCT angiography
      Methods and systems for suppressing shadowgraphic flow projection artifacts in OCT angiography images of a sample are disclosed. In one example approach, normalized OCT angiography data is analyzed at the level of individual A-scans to classify signals as either flow or projection artifact. This classification information is then used to suppress projection artifacts in the three dimensional OCT angiography dataset.
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    3. Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition

      Real-time cross-sectional and en face OCT angiography guiding high-quality scan acquisition
      Defocusing, vignetting, and bulk motion degrade the image quality of optical coherence tomography angiography (OCTA) more significantly than structural OCT. The assessment of focus, alignment conditions, and stability of imaging subjects in commercially available OCTA systems are currently based on OCT signal quality alone, without knowledge of OCTA signal quality. This results in low yield rates for further quantification. In this Letter, we developed a novel OCTA platform based on ...
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    4. Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University

      Visual Optics Postdoctoral/Research Fellow Opening at Oregon Health & Science University
      A postdoctoral research fellow position is available in the Center for Ophthalmic Optics Lasers Lab ( www.coollab.net ), Casey Eye Institute, Oregon Health Science University. This is an outstanding opportunity for a candidate to use optical coherence tomography to conduct visual optics research in an academic ophthalmology setting. The researcher on this position will work with a team of scientists, engineers and physicians to develop ultrahigh-performance OCT systems for comprehensive ...
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    5. DETECTION OF CLINICALLY UNSUSPECTED RETINAL NEOVASCULARIZATION WITH WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

      DETECTION OF CLINICALLY UNSUSPECTED RETINAL NEOVASCULARIZATION WITH WIDE-FIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
      Purpose: To evaluate wide-field optical coherence tomography angiography (OCTA) for detection of clinically unsuspected neovascularization (NV) in diabetic retinopathy (DR). Methods: This prospective observational single-center study included adult patients with a clinical diagnosis of nonproliferative DR. Participants underwent a clinical examination, standard 7-field color photography, and OCTA with commercial and prototype swept-source devices. The wide-field OCTA was achieved by montaging five 6 10-mm scans from a prototype device into a ...
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    6. OSHU Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases

      OSHU Receives NIH Grant for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases
      Oregon Health Science University Receives a 2019 NIH Grant for $496,687 for Applications of Ultrahigh-Speed Long-Range Wide-Field OCT in Anterior Eye Diseases. The principal investigator is David Huang. The program began in 2018 and ends in 2023. Below is a summary of the proposed work. Optical coherence tomography (OCT) is uniquely able to achieve micron depth resolution while imaging a large 3-dimensional (3D) volume. This enables 3D imaging and ...
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    7. Systems and methods for retinal layer segmentation in OCT imaging and OCT angiography

      Systems and methods for retinal layer segmentation in OCT imaging and OCT angiography
      Disclosed herein are methods and systems for segmenting, visualizing, and quantifying the layered structure of retina in optical coherence tomography datasets. The disclosed methods have particular application to OCT angiography data, where specific retina layers have distinct vascular structures and characteristics that can be altered in various pathological conditions of the eye.
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    8. Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography

      Rodent retinal circulation organization and oxygen metabolism revealed by visible-light optical coherence tomography
      Visible light optical coherence tomography (vis-OCT) is an emerging label-free and high-resolution 3-dimensional imaging technique that can provide retinal oximetry, angiography, and flowmetry in one modality. In this paper, we studied the organization of the arterial and venous retinal circulation in rats using vis-OCT. Arterioles were found predominantly in the superficial vascular plexus whereas veins tended to drain capillaries from the deep capillary plexus. After that, we determined the oxygen ...
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    9. Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report

      Quantitative evaluation of retinal artery occlusion using optical coherence tomography angiography: A case report
      Rationale: Retinal artery occlusion (RAO) results in painless, catastrophic vision loss in a period of seconds. Optical coherence tomography angiography (OCTA) can image retinal microcirculation, which is helpful to evaluate treatment response during the follow-up period. Using a single case with central RAO, we report its retinal perfusion changes before and after treatment using OCTA. Patient concerns: A 36-year-old Chinese man came to our clinic with a sudden, painless loss ...
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    10. Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University

      Postdoctoral Fellowship/Research Associate Position at the Casey Eye Institute, Oregon Health & Science University
      ... be submitted. A postdoctoral research fellowship/research associate position is immediately available in the Center for Ophthalmic Optics and Lasers www.COOLLab.net, Casey Eye Institute, Oregon Health & Science Universi...
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    11. Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography

      Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography
      Advances in the retinal layer segmentation of structural optical coherence tomography (OCT) images have allowed the separation of capillary plexuses in OCT angiography (OCTA). With the increased scanning speeds of OCT devices and wider field images (10 mm on fast-axis), greater retinal curvature and anatomic variations have introduced new challenges. In this study, we developed a novel automated method to segment seven retinal layer boundaries and two retinal plexuses in ...
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    12. Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography

      Classification of Choroidal Neovascularization Using Projection-Resolved Optical Coherence Tomographic Angiography
      Purpose : To evaluate if projection-resolved optical coherence tomographic angiography (PR-OCTA) reduces projection artifact with less attenuation of choroidal neovascularization (CNV) flow signal compared to conventional OCTA with slab subtraction. Methods : In this retrospective cross-sectional study, participants with subfoveal treatment-nave CNV secondary to age-related macular degeneration underwent OCTA. Scans were exported for custom processing including manual segmentation as necessary, application of slab subtraction and PR-OCTA algorithm, and calculation of CNV vascular ...
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    13. Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases

      Deep learning for the segmentation of preserved photoreceptors on en face optical coherence tomography in two inherited retinal diseases
      The objective quantification of photoreceptor loss in inherited retinal degenerations (IRD) is essential for measuring disease progression, and is now especially important with the growing number of clinical trials. Optical coherence tomography (OCT) is a non-invasive imaging technology widely used to recognize and quantify such anomalies. Here, we implement a versatile method based on a convolutional neural network to segment the regions of preserved photoreceptors in two different IRDs (choroideremia ...
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    14. Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes

      Automated Quantification of Nonperfusion Areas in 3 Vascular Plexuses With Optical Coherence Tomography Angiography in Eyes of Patients With Diabetes
      Importance Diabetic retinopathy (DR) is a leading cause of vision loss that is managed primarily through qualitative clinical examination of the retina. Optical coherence tomography angiography (OCTA) may offer an objective and quantitative method of evaluating DR. Objective To quantify capillary nonperfusion in 3 vascular plexuses in the macula of eyes patients with diabetes of various retinopathy severity using projection-resolved OCTA (PR-OCTA). Design, Setting, and Participants Cross-sectional study at a ...
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  2. About Center for Ophthalmic Optics and Lasers

    Center for Ophthalmic Optics and Lasers

    The Center for Ophthalmic Optics and Lasers (COOL) at Doheny Eye Institute, University of Southern California (USC) is a state of the art research center focusing on the application of biomedical optics in clinical medicine. COOL lab emcompass an extensive range of research areas in both optics and ophthalmology. The mission of the center is to: "Conserve, improve and restore vision through advances in laser and optical technology".