1. Case Western Reserve University

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    1. Mentioned In 298 Articles

    2. Optical coherence tomography diagnostic signs in posterior uveitis

      Optical coherence tomography diagnostic signs in posterior uveitis
      A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into personalized medicine. Many new diagnostic signs are being developed that involve imaging technology. Optical coherence ...
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    3. Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University

      Postdoc Opening in Coronary Artery, Intravascular OCT Computational Imaging at Case Western Reserve University
      ...rans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply. Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants...
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    4. Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration

      Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration
      Purpose: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). Methods: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 5099 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis ...
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    5. Case Western Reserve University Receives NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Case Western Reserve University Receives NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects
      ...arlier detection strategies, and potentially to treat CHDs more effectively .

      Case Western Reserve University Receives a 2019 NIH Grant for $493,857 for Optical Tools to Assess the Role of...

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    6. The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction

      The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction
      Background Patients with ST-elevation Myocardial Infarction treated by primary percutaneous coronary intervention (PPCI) experience drastic hemodynamic systemic changes (i.e., blood pressure) during the different phases of the procedure. Optical coherence tomography is often used to unveil the underlying cause of STEMI (pre-PCI) and to optimize stent implantation (post-PCI). The impact of blood pressure variability on coronary lumen remains uncertain. This study aimed to investigate the relationship between blood pressure ...
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    7. Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT
      ...ft from empirical planning and risk analysis to patient-specific strategies .

      Case Western Reserve University Receives a 2019 NIH Grant for $396,887 for Noninvasive Assessment of the Corne...

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    8. Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity

      Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity
      ims: A novel method for computation of fractional flow reserve (FFR) from optical coherence tomography (OCT) was developed recently. This study aimed to evaluate the diagnostic accuracy of a new OCT-based FFR (OFR) computational approach, using wire-based FFR as the reference standard. Methods and results: Patients who underwent both OCT and FFR prior to intervention were analysed. The lumen of the interrogated vessel and the ostia of the side branches ...
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    9. Case Western Reserve University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western Reserve University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions
      ...ll build on expertise in interventions, quantitative image analysis of IVOCT, and finite element modeling.

      Case Western Reserve University Receives a 2019 NIH Grant for $732,934 for Computer Assisted Coronary Artery S...

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    10. Title Automated Plaque Characterization of Intravascular Optical Coherence Tomography (IVOCT) Images Using 3D Cryo-image/Histology Validation (Thesis)

      Title Automated Plaque Characterization of Intravascular Optical Coherence Tomography (IVOCT) Images Using 3D Cryo-image/Histology Validation (Thesis)
      Intravascular optical coherence tomography (IVOCT) is a high-resolution (10-20 m), high-contrast, catheter-based imaging technology that can identify major coronary plaques types (fibrous, lipid, and calcium). However, with 500 images generated in a single 2.5 second scan, automation is needed to facilitate live-time clinical use and off-line assessment of drug therapeutics. Therefore, we developed machine learning approaches for automated plaque characterization using cryo-imaging/histology for validation. However, we confronted a ...
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    11. Automated analysis of intravascular OCT image volumes

      Automated analysis of intravascular OCT image volumes
      This disclosure provides systems and methods to automatically classify stent struts as covered or uncovered and to measure the thickness of tissue coverage. As one example, the method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus and detecting struts based on analysis of the image data. Image data corresponding to each of the detected struts is further analyzed automatically to compute an indication of ...
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    12. Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects

      Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects
      Background/Aims Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing. Methods Data from patients with chronic HCQ exposure was obtained from seven tertiary care ...
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    13. Analysis of optical tomography (OCT) images

      Analysis of optical tomography (OCT) images
      A method includes storing three-dimensional image data acquired intravascularly via an optical coherence tomography (OCT) apparatus. The image data is analyzed to compute a probability estimate of stent presence at support positions appearing in an A-line. Stent strut locations are located in three-dimensional space based on the computed probability estimate of stent presence.
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    14. SLIME: robust, high-speed 3D microvascular mapping

      SLIME: robust, high-speed 3D microvascular mapping
      Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes ...
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    15. Feasibility of a porcine arteriovenous shunt model for assessment of acute thrombogenicity in bifurcation stenting technique by optical coherence tomography

      Feasibility of a porcine arteriovenous shunt model for assessment of acute thrombogenicity in bifurcation stenting technique by optical coherence tomography
      Background Double kissing (DK) crush stenting has been reported as a superior bifurcation stenting strategy compared to culotte stenting. However, the mechanism associated with the reduction of clinical events by DK crush stenting remains unclear. We therefore investigated the thrombogenicity of DK crush stenting and culotte stenting with both bare-metal stents (BMS) and drug-eluting stents (DES) and the feasibility of a novel porcine arteriovenous shunt model. Methods High-resolution intracoronary imaging ...
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    16. Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography

      Noninvasive Assessment of Corneal Crosslinking With Phase-Decorrelation Optical Coherence Tomography
      Purpose : There is strong evidence that abnormalities in corneal biomechanical play a causal role in corneal ectasias, such as keratoconus. Additionally, corneal crosslinking (CXL) treatment, which halts progression of keratoconus, directly appeals to corneal biomechanics. However, existing methods of corneal biomechanical assessment have various drawbacks: dependence on IOP, long acquisition times, or limited resolution. Here, we present a method that may avoid these limitations by using optical coherence tomography (OCT ...
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  2. About Case Western Reserve University

    Case Western Reserve University

    Case Western Reserve University. Case Western Reserve University is a private research university located in Cleveland, Ohio, United States, with some residence halls on the south end of campus located in Cleveland Heights. Biophotonics Imaging Laboratory at Case Western Reserve University.   Here at the BIL our researchers focus on the development of optical imaging technologies with focus on the development of solutions to specific clinical or research applications. Our primary tool of optical imaging is optical coherence tomography (OCT).