1. Case Western Reserve University

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    1. Mentioned In 328 Articles

    2. Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine

      Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine
      Radiofrequency ablation (RFA) is commonly used to treat atrial fibrillation (AF). However, the outcome is often compromised due to the lack of direct real-time feedback to assess lesion transmurality. In this work, we evaluated the ability of polarization-sensitive optical coherence tomography (PSOCT) to measure cardiac wall thickness and assess RF lesion transmurality during left atrium (LA) RFA procedures. Quantitative transmural lesion criteria using PSOCT images were determined ex vivo using ...
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    3. Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy

      Comparison of the Effect of Pan-Retinal Photocoagulation and Intravitreal Conbercept Treatment on the Change of Retinal Vessel Density Monitored by Optical Coherence Tomography Angiography in Patients with Proliferative Diabetic Retinopathy
      Background: This study compares the change of retinal vessel density (VD) after pan-retinal photocoagulation (PRP) and intravitreal conbercept (IVC) treatment in proliferative diabetic retinopathy (PDR) eyes with optical coherence tomography angiography (OCTA). Methods: A total of 55 treatment-nave PDR eyes were included in this retrospective study. Of these, 29 eyes were divided into a PRP group, and 26 eyes were divided into an IVC group based on the treatment they ...
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    4. Case Western Reserve University ReceivesNIH Grant for Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart disease

      Case Western Reserve University ReceivesNIH Grant for Identifying and protecting alcohol-sensitive epigenetic changes in congenital heart disease
      ...ls through structured mentorship, hands-on laboratory experiences, didactic teaching, and formal classwork at Case Western Reserve University, FAES at the NIH, and Jackson Laboratories. Dr. Michael Jenkins, a pioneer in ...
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    5. Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation

      Case Western Reserve University Receives NIH Grant for Optically guided catheter ablation of atrial fibrillation
      ...Dr. Marboe). Our team's long-term goal is to develop innovative technologies to improve AF ablation outcomes. Case Western Reserve University Receives a 2021 NIH Grant for $683,321 for Optically guided catheter ablation ...
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    6. Multi-Compartment Spatially-derived Radiomics from Optical Coherence Tomography Predict Anti-VEGF Treatment Durability in Macular Edema Secondary to Retinal Vascular Disease

      Multi-Compartment Spatially-derived Radiomics from Optical Coherence Tomography Predict Anti-VEGF Treatment Durability in Macular Edema Secondary to Retinal Vascular Disease
      Objective: Diabetic macular edema (DME) and retinal vein occlusion (RVO) are the leading causes of visual impairments across the world. Vascular endothelial growth factor (VEGF) stimulates breakdown of blood-retinal barrier that causes accumulation of fluid within macula. Anti-VEGF therapy is the first-line treatment for both the diseases; however, the degree of response varies for individual patients. The main objective of this work was to identify the (i) texture-based radiomics features ...
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    7. Phase-decorrelation optical coherence tomography-based parameter measurement

      Phase-decorrelation optical coherence tomography-based parameter measurement
      One example includes a scanning system. The system includes a phase-decorrelation optical coherence tomography (PhD-OCT) scanner configured to implement a scanning sequence via an optical signal on a sample medium. The system also includes a scanning controller configured to provide control signals to the PhD-OCT scanner to implement the scanning sequence and to obtain phase and amplitude information associated with a reflected version of the optical signal. The phase and ...
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    8. An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis

      An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis
      Purpose: To analyse vitreous anatomy patients with anterior uveitis (AU) using swept source optical coherence tomography (SS-OCT). Methods: Patients with newly diagnosed AU and healthy participants were scanned using 16-mm SS-OCT B-scans and 12 12 mm cube centred at the fovea. Linear SS-OCT scans were evaluated to identify the premacular bursa (PB) above the macula and the Cloquet's canal above the optic disc. A dynamic evaluation of the 12 ...
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    9. Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart

      Prenatal ethanol exposure impairs the conduction delay at the atrioventricular junction in the looping heart
      The etiology of ethanol-related congenital heart defects has been the focus of much study, but most research has concentrated on cellular and molecular mechanisms. We have shown with optical coherence tomography (OCT) that ethanol exposure led to increased retrograde flow and smaller atrioventricular (AV) cushions compared to controls. Since AV cushions play a role in patterning the conduction delay at the atrioventricular junction (AVJ), this study aims to investigate whether ...
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    10. Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT

      Case Western Reserve University Receives NIH Grant for Noninvasive Assessment of the Cornea by Diffusion OCT
      ...impact the field by driving a shift from empirical planning and risk analysis to patient-specific strategies. Case Western Reserve University Receives a 2021 NIH Grant for $381,543 for Noninvasive Assessment of the Corne...
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    11. Case Western University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions

      Case Western University Receives NIH Grant for Computer Assisted Coronary Artery Stent Interventions
      Case Western University Receives a 2021 NIH Grant for $484,748 for Computer Assisted Coronary Artery Stent Interventions. The principal investigator is David Wilson. Below is a summary of the proposed work Computer assisted coronary artery stent interventions Summary When treating highly calcified coronary artery lesions with stents, interventional cardiologists, with limited information, make stressful treatment decisions, which can lead to inadequate stent deployment and poor outcomes, or even rare ...
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    12. Automatic Segmentation in Multiple OCT Layers For Stargardt Disease Characterization Via Deep Learning

      Automatic Segmentation in Multiple OCT Layers For Stargardt Disease Characterization Via Deep Learning
      Purpose : This study sought to perform automated segmentation of 11 retinal layers and Stargardt-associated features on spectral-domain optical coherence tomography (SD-OCT) images and to analyze differences between normal eyes and eyes diagnosed with Stargardt disease. Methods : Automated segmentation was accomplished through application of the deep learningshortest path (DL-SP) framework, a shortest path segmentation approach that is enhanced by a deep learning fully convolutional neural network. To compare normal eyes and ...
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    13. Learning With Fewer Images via Image Clustering: Application to Intravascular OCT Image Segmentation

      Learning With Fewer Images via Image Clustering: Application to Intravascular OCT Image Segmentation
      Deep learning based methods are routinely used to segment various structures of interest in varied medical imaging modalities. Acquiring annotations for a large number of images requires a skilled analyst, and the process is both time consuming and challenging. Our approach to reduce effort is to reduce the number of images needing detailed annotation. For intravascular optical coherence tomography (IVOCT) image pullbacks, we tested 10% to 100% of training images ...
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    14. Optically Empty Choroidal Spaces In High Hyperopia

      Optically Empty Choroidal Spaces In High Hyperopia
      Purpose: To describe the progressive optical coherence tomography findings of atypical choroidal cavitation in the inner choroid. Methods: Case report. Results: A 29-year-old asymptomatic woman was noted to display two flat translucent whitish subretinal lesions along the superotemporal arcade of the right eye, during routine retinal examination. Cross-sectional spectral domain optical coherence tomography of the choroid illustrated two hyporeflective lesions consistent with atypical choroidal cavitation of the Sattler layer, associated ...
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    15. Standardization of optical coherence tomography angiography nomenclature in retinal vascular diseases: first survey results

      Standardization of optical coherence tomography angiography nomenclature in retinal vascular diseases: first survey results
      Purpose: To develop a consensus nomenclature for optical coherence tomography angiography (OCTA) findings in retinal vascular diseases. Design: Online survey using Delphi Method SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Members of The Retina Society, European Society of Retina Specialists (EURETINA) and the Japanese Retina and Vitreous Society (JRVS). Methods, intervention, or testing: An online questionnaire on OCTA terminology in retinal vascular diseases was sent to members of The Retina Society, EURETINA ...
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  2. About Case Western Reserve University

    Case Western Reserve University

    Case Western Reserve University. Case Western Reserve University is a private research university located in Cleveland, Ohio, United States, with some residence halls on the south end of campus located in Cleveland Heights. Biophotonics Imaging Laboratory at Case Western Reserve University.   Here at the BIL our researchers focus on the development of optical imaging technologies with focus on the development of solutions to specific clinical or research applications. Our primary tool of optical imaging is optical coherence tomography (OCT).