1. Case Western Reserve University

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    1. Mentioned In 218 Articles

    2. In Vivo Characterization of Carotid Neointimal Hyperplasia by use of Optical Coherence Tomography: Before and After Cutting Balloon Angioplasty

      In Vivo Characterization of Carotid Neointimal Hyperplasia by use of Optical Coherence Tomography: Before and After Cutting Balloon Angioplasty
      ...s of Cleveland, Case Western Reserve University, Cleveland, OH Neurology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH Carotid stenosis; optical coherence tomography; angiography ...
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    3. Feature Of The Week 02/22/15: Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      Feature Of The Week 02/22/15:  Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure
      ...y of experimental/disease models. For more information see recent Article . Courtesy of Ganga Karunamuni from Case Western Reserve University . The most commonly used method to analyze congenital heart defects involves s...
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    4. Machine Learning Based Analysis of Coronary Stent Images in Intravascular Optical Coherence Tomography Pullbacks (Thesis)

      Machine Learning Based Analysis of Coronary Stent Images in Intravascular Optical Coherence Tomography Pullbacks (Thesis)
      ...ink: http://rave.ohiolink.edu/etdc/view?acc_num=case1415548044 Year and Degree 2015, Doctor of Philosophy, Case Western Reserve University, Biomedical Engineering. Abstract Coronary artery disease (CAD) is the most co...
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    5. Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography

      Ethnic Differences in Trabecular Meshwork Height by Optical Coherence Tomography

      Importance Differences in ocular anatomy may contribute to ethnic differences in glaucoma risk. Because the trabecular meshwork (TM) plays an important role in aqueous outflow, its anatomy in relation to at-risk populations may provide insight into a potential contributor to elevated intraocular pressure and thus to probability of glaucoma development. Objective To investigate whether differences exist in TM height between ethnic groups. Design, Setting, and Participants This prospective study took place from January 1, 2012, to December 31, 2013. Adult patients who self-reported as being of white, Asian, Hispanic, or African American ethnicity were recruited from ophthalmology clinics at the ...

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    6. Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography

      Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography

      We developed robust, three-dimensional methods, as opposed to traditional A-line analysis, for estimating the optical properties of calcified, fibrotic, and lipid atherosclerotic plaques from in vivo coronary artery intravascular optical coherence tomography clinical pullbacks. We estimated attenuation μ t and backscattered intensity I 0 from small volumes of interest annotated by experts in 35 pullbacks. Some results were as follows: noise reduction filtering was desirable, parallel line (PL) methods outperformed individual line methods, root mean square error was the best goodness-of-fit, and α -trimmed PL ( α -T-PL) was the best overall method. Estimates of μ t were calcified ( 3.84 ± 0.95     mm − 1 ...

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    7. Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure

      Using optical coherence tomography to rapidly phenotype and quantify congenital heart defects associated with prenatal alcohol exposure
      ...ent of Pediatrics, Case Western Reserve University, Cleveland, OH, USA Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA National Institute of Health. Grant Numbers: R01HL083048,...
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    8. Proximal optimization technique and kissing balloon inflations with the bioresorbable vascular scaffold for coronary bifurcation percutaneous coronary intervention

      Proximal optimization technique and kissing balloon inflations with the bioresorbable vascular scaffold for coronary bifurcation percutaneous coronary intervention

      Proximal optimization technique and final kissing balloon inflations with noncompliant balloons facilitate success with coronary bifurcation intervention. The use of bioresorbable vascular scaffolds has been postulated to reduce the risk of in-stent restenosis, a particular problem with bifurcation intervention. We present a case of bifurcation intervention in a 49-year-old woman, using for the first time, proximal optimization and kissing balloon inflation within bioresorbable vascular scaffolds, using optical coherence tomography guidance.

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    9. Optical coherence tomography imaging of the patent ductus arteriosus: First known uses in congenital heart disease

      Optical coherence tomography imaging of the patent ductus arteriosus: First known uses in congenital heart disease

      Background: Angiography is used to assess ductal morphology and caliber during interventional closure of the ductus arteriosus. We are evaluating the use of optical coherence tomography (OCT) to evaluate ductal anatomy given the potential benefit of superior resolution and lower radiation. Methods: Standard angiograms were performed on two patients with patent ductus arteriosus prior to device occlusion. OCT was then used to obtain high-resolution three-dimensional vessel reconstructions. Devices were chosen based on angiographic measurements. Results: OCT resulted in excellent three-dimensional anatomic definition, with elliptical narrowest lumenal measurements of 2.2 x 3.1 mm and 1.6 x 2.3 ...

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    10. Differences determined by optical coherence tomography volumetric analysis in non-culprit lesion morphology and inflammation in ST-segment elevation myocardial infarction and stable angina pectoris patients

      Differences determined by optical coherence tomography volumetric analysis in non-culprit lesion morphology and inflammation in ST-segment elevation myocardial infarction and stable angina pectoris patients

      Background: While the current methodology for determining fibrous cap (FC) thickness of lipid plaques is based on manual measurements of arbitrary points, which could lead to high variability and decreased accuracy, it ignores the three-dimensional (3-D) morphology of coronary artery disease. Objective: To compare, utilizing optical coherence tomography (OCT) assessments, volumetric quantification of FC and macrophage detection using both visual assessment and automated image processing algorithms in non-culprit lesions of STEMI and stable angina pectoris (SAP) patients. Methods: Lipid plaques were selected from 67 consecutive patients (1 artery/patient). FC was manually delineated by a computer-aided method and automatically classified ...

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    11. New Insights on acute expansion and longitudinal elongation of bioresorbable vascular scaffolds In-Vivo and at bench test: A note of caution on reliance to compliance charts and nominal length

      New Insights on acute expansion and longitudinal elongation of bioresorbable vascular scaffolds In-Vivo and at bench test: A note of caution on reliance to compliance charts and nominal length

      Objectives : We performed systematic optical coherence tomography (OCT) analyses after BVS implantation in a “real world” setting aiming at evaluating scaffold expansion and longitudinal integrity. Background : A comprehensive elucidation of bioresorbable vascular scaffolds´ (BVS) acute performance in the “real-world” setting is lacking Methods : Acute BVS expansion compared with compliance chart information and longitudinal integrity were assessed in 29 patients (32 lesions) by OCT. In addition, bench experiments with 4 scaffolds were performed with different combinations of deployment pressures and tube stiffness. Results : Scaffold underexpansion, using compliance chart information as reference, was observed in 97% of OCT cross-sections in vivo; however ...

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  2. About Case Western Reserve University

    Case Western Reserve University

    Case Western Reserve University. Case Western Reserve University is a private research university located in Cleveland, Ohio, United States, with some residence halls on the south end of campus located in Cleveland Heights. Biophotonics Imaging Laboratory at Case Western Reserve University.   Here at the BIL our researchers focus on the development of optical imaging technologies with focus on the development of solutions to specific clinical or research applications. Our primary tool of optical imaging is optical coherence tomography (OCT).