1. Case Western Reserve University

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    1. Mentioned In 342 Articles

    2. Fractional Flow Reserve (FFR) Estimation from OCT-Based CFD Simulations: Role of Side Branches

      Explore MDPI Open Access Journals Platform Cardiology
      Fractional Flow Reserve (FFR) Estimation from OCT-Based CFD Simulations: Role of Side Branches
      The computational fluid dynamic method has been widely used to quantify the hemodynamic alterations in a diseased artery and investigate surgery outcomes. The artery model reconstructed based on optical coherence tomography (OCT) images generally does not include the side branches. However, the side branches may significantly affect the hemodynamic assessment in a clinical setting, i.e., the fractional flow reserve (FFR), defined as the ratio of mean distal coronary pressure ...
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      Mentions: Case Western Reserve University University of South Florida

    3. OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration

      Explore ScienceDirect Ophthalmology
      OCT-Derived Radiomic Features Predict Anti–VEGF Response and Durability in Neovascular Age-Related Macular Degeneration
      No established biomarkers currently exist for therapeutic efficacy and durability of antiVEGF therapy in neovascular age-related macular degeneration (nAMD). This study evaluated radiomic-based quantitative OCT biomarkers that may be predictive of anti-VEGF treatment response and durability. Design Assessment of baseline biomarkers using machine learning (ML) classifiers to predict tolerance to anti-VEGF therapy. Participants Eighty-one participants with treatment-nave nAMD from the OSPREY study, including 15 super responders (patients who achieved and ...
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      Mentions: Case Western Reserve University Cleveland Clinic

    4. Automated endocardial cushion segmentation and cellularization quantification in developing hearts using optical coherence tomography

      Explore Optica Publishing Group Cardiology , Developmental Biology
      Automated endocardial cushion segmentation and cellularization quantification in developing hearts using optical coherence tomography
      Of all congenital heart defects (CHDs), anomalies in heart valves and septa are among the most common and contribute about fifty percent to the total burden of CHDs. Progenitors to heart valves and septa are endocardial cushions formed in looping hearts through a multi-step process that includes localized expansion of cardiac jelly, endothelial-to-mesenchymal transition, cell migration and proliferation. To characterize the development of endocardial cushions, previous studies manually measured cushion ...
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      Mentions: Case Western Reserve University

    5. Automated segmentation of microvessels in intravascular OCT images using deep learning

      Explore arxiv.org Cardiology
      Automated segmentation of microvessels in intravascular OCT images using deep learning
      To analyze this characteristic of vulnerability, we developed an automated deep learning method for detecting mi- crovessels in intravascular optical coherence tomography (IVOCT) images. A total of 8,403 IVOCT image frames from 85 lesions and 37 normal segments were analyzed. Manual annotation was done using a dedicated software (OCTOPUS) previously developed by our group. Data augmentation in the polar ( r , ) domain was applied to raw IVOCT images to ensure ...
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      Mentions: Case Western Reserve University

    7. The Vitreous in Uveitis: Characterizing the Invisible with Optical Coherence Tomography

      Explore Taylor & Francis Online Ophthalmology
      The Vitreous in Uveitis: Characterizing the Invisible with Optical Coherence Tomography
      Purpose The current gold standard to grade vitreous inflammation is the Nussenblatt scale based in clinical examination, published in 1985. Nowadays a big effort is undergoing to come out with more objective and reliable methods based in optical coherence (OCT) imaging analysis. Methods A systematic review was done to identify the articles that quantify or assess qualitatively vitreous inflammation with OCT. Results Twelve papers were included. Only one paper analyzed ...
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      Mentions: Case Western Reserve University

    8. A SYSTEMATIC REVIEW OF DEEP LEARNING APPLICATIONS FOR OPTICAL COHERENCE TOMOGRAPHY IN AGE-RELATED MACULAR DEGENERATION

      Explore LWW Online Ophthalmology
      A SYSTEMATIC REVIEW OF DEEP LEARNING APPLICATIONS FOR OPTICAL COHERENCE TOMOGRAPHY IN AGE-RELATED MACULAR DEGENERATION
      Purpose: To survey the current literature regarding applications of deep learning to optical coherence tomography in age-related macular degeneration (AMD). Methods: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review was conducted from January 1, 2000, to May 9, 2021, using PubMed and EMBASE databases. Original research investigations that applied deep learning to optical coherence tomography in patients with AMD or features of AMD (choroidal neovascularization, geographic atrophy ...
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      Mentions: Brigham and Women’s Hospital Case Western Reserve University Harvard University

    11. Assessment of post-dilatation strategies for optimal stent expansion in calcified coronary lesions: Ex vivo analysis with optical coherence tomography

      Explore ScienceDirect Cardiology
      Assessment of post-dilatation strategies for optimal stent expansion in calcified coronary lesions: Ex vivo analysis with optical coherence tomography
      Introduction: Interventional cardiologists make adjustments in the presence of coronary calcifications known to limit stent expansion, but proper balloon sizing, plaque-modification approaches, and high-pressure regimens are not well established. Intravascular optical coherence tomography (IVOCT) provides high-resolution images of coronary tissues, including detailed imaging of calcifications, and accurate measurements of stent deployment, providing a means for detailed study of stent deployment. Objective: Evaluate stent expansion in an ex vivo model of ...
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      Mentions: Case Western Reserve University

    12. Optical Coherence Tomography Findings in Infectious Posterior Uveitis

      Explore Taylor & Francis Online Ophthalmology
      Optical Coherence Tomography Findings in Infectious Posterior Uveitis
      Purpose To describe and illustrate the main optical coherence tomography (OCT) findings of infectious uveitis. Methods Narrative review. Results Posterior segment OCT in patients with infectious uveitis reveals posterior hyaloid face precipitates, superficial retinal precipitates and infiltrates, foveolitis, retinitis, neuro-retinitis, choroidal granulomas, and choroiditis as main imaging biomarkers. Some of these features are specific to the underlying causing etiology and may support the diagnosis and the initiation of treatment. Some ...
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      Mentions: Case Western Reserve University Cleveland Clinic Università Vita-Salute San Raffaele

    13. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Explore ScienceDirect Ophthalmology
      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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      Mentions: University of Wisconsin University of Chicago University of Toronto

    14. COMPUTATIONAL IMAGING AS APPLIED TO CORONARY ARTERY OPTICAL COHERENCE TOMOGRAPHY

      Explore OhioLINK ETD Center Cardiology , Student Theses
      COMPUTATIONAL IMAGING AS APPLIED TO CORONARY ARTERY OPTICAL COHERENCE TOMOGRAPHY
      Patients with inadequate stent expansion are at high risk for adverse outcomes, including stent thrombosis as well as in-stent restenosis. Both are well-described complication usually causing acute coronary syndromes and, in the worst-case scenario, sudden cardiac death. Once a stent is deployed in atherosclerotic tissue that is highly resistant to dilation, it is often tricky to fully expand the implanted stent, even using a noncompliant balloon. Careful evaluation of these ...
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      Mentions: Case Western Reserve University

    15. Characterizing ablation lesions using optical coherence tomography (OCT)

      Explore uspto.gov Cardiology , Patents
      Characterizing ablation lesions using optical coherence tomography (OCT)
      Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.
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      Mentions: Case Western Reserve University

    16. Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine

      Explore Nature Publishing Group Cardiology
      Polarization-sensitive optical coherence tomography monitoring of percutaneous radiofrequency ablation in left atrium of living swine
      Radiofrequency ablation (RFA) is commonly used to treat atrial fibrillation (AF). However, the outcome is often compromised due to the lack of direct real-time feedback to assess lesion transmurality. In this work, we evaluated the ability of polarization-sensitive optical coherence tomography (PSOCT) to measure cardiac wall thickness and assess RF lesion transmurality during left atrium (LA) RFA procedures. Quantitative transmural lesion criteria using PSOCT images were determined ex vivo using ...
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      Mentions: Case Western Reserve University
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  4. About Case Western Reserve University

    Case Western Reserve University

    Case Western Reserve University. Case Western Reserve University is a private research university located in Cleveland, Ohio, United States, with some residence halls on the south end of campus located in Cleveland Heights. Biophotonics Imaging Laboratory at Case Western Reserve University.   Here at the BIL our researchers focus on the development of optical imaging technologies with focus on the development of solutions to specific clinical or research applications. Our primary tool of optical imaging is optical coherence tomography (OCT).

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