1. Case Western Reserve University

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    1. Mentioned In 253 Articles

    2. Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis

      Explore Circulation Cardiology
      Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis
      Background There are few clinical studies on the pathophysiological mechanisms of very late stent thrombosis (VLST). We report optical coherence tomography findings in patients with VLST and compare the findings between bare-metal stents (BMS) and drug-eluting stents (DES). Methods and Results We conducted a registry of stent thrombosis at 4 North American centers with optical coherence tomography imaging programs SAFE registry (The Study of Late Stent Failure Evaluated by OCT ...
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      Mentions: University of Pittsburgh Case Western Reserve University University of British Columbia

    3. Optical Imaging Measurement of Intravascular Solution Efficacy Trial (OPTIMISE)

      Explore Home - ClinicalTrials.gov Cardiology , Clinical Trials
      Optical Imaging Measurement of Intravascular Solution Efficacy Trial (OPTIMISE)
      Iodinated contrast is the current gold standard for infrainguinal angiography imaging in patients without renal insufficiency and has also been used with intravascular Optical Coherence Tomography (iOCT) to improve image quality in human coronary arteries as well as carotid arteries. The current debate in the literature for iOCT medium is between iodinated contrast and dextran and CO2 may offer a superior method of iOCT imaging during lower extremity occlusive disease ...
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      Mentions: Case Western Reserve University

    4. Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries

      Explore Journal of Endovascular Therapy Cardiology
      Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries
      Purpose: To examine the hypothesis that alternative flush media could be used for lower extremity optical coherence tomography (OCT) imaging in long lesions that would normally require excessive use of contrast. Methods: The OPTical Imaging Measurement of Intravascular Solution Efficacy (OPTIMISE) trial was a single-center, prospective study ( ClinicalTrials.gov identifier NCT01743872 ) that enrolled 23 patients (mean age 6811 years; 14 men) undergoing endovascular intervention involving the superficial femoral artery. Four ...
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      Mentions: Case Western Reserve University Hiram G. Bezerra

    5. Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects

      Explore Optical Coherence Tomography News Funding
      Case Western Reserve University Receives 2016 NIH Grant for Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart Defects
      ...earlier detection strategies, and potentially to treat CHDs more effectively.

      Case Western Reserve University Receives a 2016 NIH Grant for $483,717 for Optical Tools to Assess the Role of...

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      Mentions: National Institutes of Health Case Western Reserve University Michael W. Jenkins

    6. Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation

      Explore SPIE | Journal Cardiology
      Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
      Evidence suggests high-resolution, high-contrast, 100 frames / s 100frames/s intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and three-dimensional (3-D) registration methods to provide validation of IVOCT pullback volumes using microscopic, color, and fluorescent cryo-image volumes with optional registered cryo-histology. A specialized registration method matched IVOCT pullback images acquired in the catheter reference frame to a ...
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      Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha

    7. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Explore Optical Coherence Tomography News Developmental Biology , Funding
      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart
      ...rategies based on FA/MI prevention of birth defects to benefit public health.

      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and ...

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      Mentions: Andrew M. Rollins National Institutes of Health Case Western Reserve University

    8. AUTOMATED MACHINE LEARNING BASED ANALYSIS OF INTRAVASCULAR OPTICAL COHERENCE TOMOGRAPHY IMAGES (Thesis)

      Explore OhioLINK ETD Center Cardiology , Student Theses
      AUTOMATED MACHINE LEARNING BASED ANALYSIS OF INTRAVASCULAR OPTICAL COHERENCE TOMOGRAPHY IMAGES (Thesis)
      Coronary artery disease (CAD) is the leading cause of death in the world. Most acute coronary events (e.g. heart attacks) are due to the rupture of atherosclerotic plaques inside the arteries, however, calcified lesion is the most widely treatable, typically, by stent implantation via percutaneous coronary intervention (PCI). Intravascular Optical Coherence Tomography (IVOCT) imaging has the resolution, contrast, and penetration depth to characterize coronary artery plaques. Conventional manual evaluation ...
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      Mentions: Case Western Reserve University

    10. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

      Explore SPIE | Journal Cardiology
      Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
      Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame ...
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      Mentions: Andrew M. Rollins Case Western Reserve University Guy Lamouche

    11. CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart

      Explore Wiley Online Library Developmental Biology
      CUG-BP, Elav-like family member 1 (CELF1) is required for normal myofibrillogenesis, morphogenesis, and contractile function in the embryonic heart
      Background : CUG-BP, Elav-like family member 1 (CELF1) is a multifunctional RNA binding protein found in a variety of adult and embryonic tissues. In the heart, CELF1 is found exclusively in the myocardium. However, the roles of CELF1 during cardiac development have not been completely elucidated. Results : Myofibrillar organization is disrupted and proliferation is reduced following knockdown of CELF1 in cultured chicken primary embryonic cardiomyocytes. In vivo knockdown of Celf1 in ...
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      Mentions: Case Western Reserve University

    12. 3D registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation

      Explore Conference Proceedings Cardiology
      3D registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
      High resolution, 100 frames/sec intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and 3D registration methods, to provide validation of IVOCT pullback volumes using microscopic, brightfield and fluorescent cryoimage volumes, with optional, exactly registered cryo-histology. The innovation was a method to match an IVOCT pullback images, acquired in the catheter reference frame, to a true ...
      Read Full Article
      Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha

    14. Classification of calcium in intravascular OCT images for the purpose of intervention planning

      Explore Conference Proceedings Cardiology
      Classification of calcium in intravascular OCT images for the purpose of intervention planning
      The presence of extensive calcification is a primary concern when planning and implementing a vascular percutaneous intervention such as stenting. If the balloon does not expand, the interventionalist must blindly apply high balloon pressure, use an atherectomy device, or abort the procedure. As part of a project to determine the ability of Intravascular Optical Coherence Tomography (IVOCT) to aid intervention planning, we developed a method for automatic classification of calcium ...
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      Mentions: Case Western Reserve University David L. Wilson Hiram G. Bezerra

    15. Optical coherence tomography: A pathway from research to clinical practice

      Explore cardiorevascmed.com Cardiology
      Optical coherence tomography: A pathway from research to clinical practice
      For more than half a century, coronary angiography has been the goldstandard diagnostic test for the assessment of coronary artery disease, but it does not provide information about the components of the vascular wall, atherosclerosic disease burden, or the interaction of local devices with coronary artery walls. The development of intracoronary imaging techniques, such as optical coherence tomography (OCT), was conceived with the objective to overcome coronary angiography limitations.
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      Mentions: Case Western Reserve University Hector M. Garcia-Garcia Salvatore Brugaletta

    16. Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Explore Conference Proceedings Ophthalmology
      Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) benefit clinical diagnostic imaging in ophthalmology by enabling in vivo noninvasive en face and volumetric visualization of retinal structures, respectively. Spectrally encoding methods enable confocal imaging through fiber optics and reduces system complexity. Previous applications in ophthalmic imaging include spectrally encoded confocal scanning laser ophthalmoscopy (SECSLO) and a combined SECSLO-OCT system for image guidance, tracking, and registration. However, spectrally encoded imaging ...
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      Mentions: Andrew M. Rollins Case Western Reserve University Axsun Technologies
    17. 1-15 of 253 1 2 3 4 ... 15 16 17 »
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  4. About Case Western Reserve University

    Case Western Reserve University

    Case Western Reserve University. Case Western Reserve University is a private research university located in Cleveland, Ohio, United States, with some residence halls on the south end of campus located in Cleveland Heights. Biophotonics Imaging Laboratory at Case Western Reserve University.   Here at the BIL our researchers focus on the development of optical imaging technologies with focus on the development of solutions to specific clinical or research applications. Our primary tool of optical imaging is optical coherence tomography (OCT).

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