BACKGROUND AND OBJECTIVE: To noninvasively evaluate the retinal microvasculature in healthy human subjects with optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Cross-sectional, observational study of five healthy subjects. OCTA was performed on 3 × 3 mm(2) sections centered on the fovea, nasal macula, and temporal macula. Retinal vasculature was assessed within three horizontal slabs consisting of the inner, middle, and outer retina. The vasculature within each retinal slab was reconstructed using phase-based and intensity contrast-based algorithms and visualized as separate en face images. RESULTS: OCTA in healthy subjects demonstrates capillary networks consistent with previous histological studies. No retinal vessels ...
Advances in retinal pharmacology have significantly improved outcomes for patients with a range of chronic retinal conditions, including age-related macular degeneration, macular edema, retinal vascular disorders and diseases of the vitreomacular interface. Maximizing the efficacy of available treatments requires the appropriate use of optical coherence tomography (OCT) to diagnose these conditions and to monitor the efficacy of treatment. In this webinar series, leading clinicians and researchers will discuss the role of OCT in detecting structural changes associated with a range of retinal diseases and provide clinical pearls on using tools such as thickness maps, automated change analysis and angiography in ...
Purpose:To test the capability of a novel dual-beam Doppler optical coherence tomography (OCT) technique for simultaneous in vivo measurement of the Doppler angle and, thus, the absolute retinal blood velocity and the retinal flow rate, without the influence of motion artifacts. Methods:A novel dual-beam Doppler spectral domain OCT (SD-OCT) was developed. The two probing beams are separated with a controllable distance along an arbitrary direction, both of which are controlled by two independent 2D optical scanners. Two sets of optical Doppler tomography (ODT) images are acquired simultaneously. The Doppler angle of each blood vessel segment was calculated from ...
A system, method and apparatus for anatomical mapping utilizing optical coherence tomography. In the present invention, 3-dimensional fundus intensity imagery can be acquired from a scanning of light back-reflected from an eye. The scanning can include spectral domain scanning, as an example. A fundus intensity image can be acquired in real-time. The 3-dimensional data set can be reduced to generate an anatomical mapping, such as an edema mapping and a thickness mapping. Optionally, a partial fundus intensity image can be produced from the scanning of the eye to generate an en face view of the retinal structure of the eye ...
Optical coherence tomography (OCT) is a promising technique for clinical diagnosis of various types of tissue, because high-resolution tomography is easily obtained by its compact imaging optics. The fundamental principles of OCT evolved from optical one-dimensional low-coherence reflectometry, which uses a Michelson interferometer and a broadband light source. Due to the additional transverse scanning (B-scan), two-dimensional imaging was obtained, and this technique was named OCT by Fujimoto and rapidly expanded to numerous biomedical and clinical applications
This fourth annual supplement to Ophthalmic Surgery, Lasers & Imaging devoted to optical coherence tomography (OCT) is a testament to the unique status and evolution of perhaps the single most important development of the era in ophthalmic imaging. Presented here are the latest reports of diagnosis and treatment challenges utilizing OCT to study and solve the problem and benefit the patient. They describe the most recent technological innovations and applications of the technique first described in 1991 in the journal Science , 1 and as a group represent the broad range of relevance of this imaging technique. Original clinical and experimental studies ...
Dr. Carmen A. Puliafito was appointed dean and holder of the May S. and John Hooval Dean’s Chair at the Keck School of Medicine of USC effective November 1, 2007. He also serves as a professor of ophthalmology and health management. Before joining USC, Puliafito was chair of the Department of Ophthalmology and director of the Bascom Palmer Eye Institute at the University of Miami’s Miller School of Medicine. There, he oversaw a twofold increase in faculty size, a rise from 34th to 14th in National Institutes of Health funding within a three-year span, and the reclaiming of the top position in U.S. News & World Report’s eye-hospital rankings from the Wilmer Eye Institute at Johns Hopkins University. He also guided fundraising and the development of a $22 million, seven-acre, state-of-the-art campus in Palm Beach Gardens. Puliafito earned his medical degree, magna cum laude, at Harvard Medical School. Following a residency and fellowships at the Massachusetts Eye and Ear Infirmary (MEEI), he served on the faculties of both Harvard and MIT and founded MEEI’s Morse Laser Center and Laboratory. He went on to build an eye program at Tufts University, where he became founding director of the New England Eye Center. An internationally recognized leader in ophthalmic laser technology, Puliafito has served as president of the American Society for Laser Medicine and Surgery and as trustee and president of the Association for Research in Vision and Ophthalmology, the world’s largest eye-research organization. He holds two U.S. patents and has written more than 120 peer-reviewed scientific articles as well as six books. In addition to his MD from Harvard University, Puliafito has an MBA from the Wharton School of the University of Pennsylvania.
The USC Eye Institute is pioneering the development of novel treatments for eye diseases that cause vision loss and contributing critical scientific knowledge to advance the field of ophthalmology.In USC Eye Institute Adds 12 Faculty Physician Scientists in 2014
OCT has revolutionized the treatment of eye disease on a global basis, and it is now routinely used to make clinical decisions about treating patients with blinding diseases such as macular degeneration, diabetic retinopathy and glaucoma.In Cirrus HD-OCT Record Number of 10,000 Installations and Prestigious Award for OCT Inventors
OCT is a case study in the power of collaboration between engineering and medicine in the development of new technologies that can dramatically improve patient care...I am deeply honored to receive the award and proud to have been at the forefront of such an important contribution to the field of vision medicine.In Puliafito honored with international Vision Award in Portugal
We can evaluate underlying pathology and monitor disease response, retinal thickness, cystoid macular edema, vitreoretinal traction and track subretinal fluid.In Spectral domain OCT useful as research tool, clinical adjunct
This last point may be a little counterintuitive. The patients that need the most careful macular exam, the most careful scrutiny with OCT, are the patients with relatively good vision that you're considering operating on because they actually in many ways have the most to lose by the cataract operation.In Surgeon suggests using OCT for preop cataract evaluation to protect patient, physician