1. Carl Zeiss Meditec

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    1. Mentioned In 1301 Articles

    2. Reproducibility of Spectral-domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

      Reproducibility of Spectral-domain Optical Coherence Tomography RNFL Map for Glaucomatous and Fellow Normal Eyes in Unilateral Glaucoma

      Purpose: To compare the reproducibility of the optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness map between glaucomatous and fellow normal eyes of unilateral glaucoma patients. Methods: In this prospective case-control study, Cirrus HD-OCT was performed for 79 unilateral glaucoma patients 3 times on the first visit and on 3 subsequent visits within a 2-month period. Test-retest standard deviation (TRT-SD) and tolerance limit based on the 1.645x[square root]2xTRT-SD formula were derived for RNFL thicknesses at the respective superpixels of the RNFL thickness map. Results: The TRT-SDs and tolerance limits of the glaucomatous eyes (TRT-SD: 2 ...

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    3. Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting

      Wide-Field OCT Angiography at 400 KHz Utilizing Spectral Splitting

      Optical angiography systems based on optical coherence tomography (OCT) require dense sampling in order to maintain good vascular contrast. We demonstrate a way to gain acquisition speed and spatial sampling by using spectral splitting with a swept source OCT system. This method splits the recorded spectra into two to several subspectra. Using continuous lateral scanning, the lateral sampling is then increased by the same factor. This allows increasing the field of view of OCT angiography, while keeping the same transverse resolution and measurement time. The performance of our method is demonstrated in vivo at different locations of the human retina ...

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    4. Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

      Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia

      Background The aim was to assess the macular parameters of glaucoma in highly myopic subjects. Methods In a retrospective study, we enrolled 72 highly myopic eyes (spherical equivalent up to -6.00 D), of which 31 had early to moderate glaucoma and 41 formed a control group. The diagnosis of early to moderate glaucoma was based on glaucomatous visual-field defects with a mean deviation better than -12 dB. All patients underwent imaging with Stratus optical coherence tomography. We subsequently performed analysis for macular volume and thickness parameters between two groups. Results Using Stratus optical coherence tomography, we found significantly lower ...

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    5. Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma

      Comparing focal and global responses on multifocal electroretinogram with retinal nerve fibre layer thickness by spectral domain optical coherence tomography in glaucoma

      Purpose To evaluate first and second order responses on multifocal electroretinogram (mfERG) and with retinal nerve fibre layer thickness (RNFL) on Cirrus spectral domain optical coherence tomography (SD-OCT) in glaucoma. Methods Patients (old and new) diagnosed with primary open angle glaucoma, primary angle closure glaucoma or normal tension glaucoma attending glaucoma services from November 2012 to January 2013 were screened. Ninety-seven eyes fulfilling inclusion criteria were evaluated by Humphrey visual field, Cirrus SD-OCT imaging and mfERG (Veris Science 5.1.10X; EDI, Redwood City, California, USA) for this observational cross-sectional study. The global and averaged quadrant-wise peak-to-trough amplitudes and peak ...

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    6. A comprehensive model for correcting RNFL readings of varying signal strengths in CIRRUS Optical Coherence Tomography (OCT)

      A comprehensive model for correcting RNFL readings of varying signal strengths in CIRRUS Optical Coherence Tomography (OCT)

      Purpose. Develop a model for the CIRRUSTM HD-OCT that allows for the comparison of retinal nerve fiber layer (RNFL) thickness measurements with dissimilar signal strengths (SS) and accounts for test-re-test variability. Methods. RNFLs were obtained in normals using the CIRRUSTM optic disc cube 200x200 protocol during a single encounter. Five RNFL scans were obtained with a SS of 9-10. Diffusion lens filters were used to degrade SS to obtain five scans at each SS group of 7-8, 5-6, and 3-4. The relationship between average RNFL thickness and SS was established and an equation was developed to allow for adjustment of ...

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    7. Effect of Angle of Incidence on Anterior Chamber Angle Metrics From Optical Coherence Tomography

      Effect of Angle of Incidence on Anterior Chamber Angle Metrics From Optical Coherence Tomography

      Purpose: To evaluate the local variability of anterior chamber angle (ACA) metrics obtained by time domain (TD) and spectral domain (SD) optical coherence tomography (OCT). Materials and Methods: Anterior-segment OCT imaging was performed on 30 normal eyes using Visante TD-OCT and 40 normal eyes using Cirrus SD-OCT. For Visante OCT, a single 16-mm line scan of the inferior angle with 3 slightly different rotations of 265, 270, and 275 degrees was performed. For Cirrus OCT, a 5-line raster of the inferior angle was performed, centering the third scan line at the 6 o'clock position, with 0.25 mm between ...

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    8. Correlation and Agreement Between Cirrus HD-OCT "RNFL Thickness Map" and Scan Circle Retinal Nerve Fiber Layer Thickness Measurements

      Correlation and Agreement Between Cirrus HD-OCT "RNFL Thickness Map" and Scan Circle Retinal Nerve Fiber Layer Thickness Measurements

      Purpose: To evaluate the correlation and agreement between optical coherence tomography (Cirrus HD-OCT) retinal nerve fiber layer (RNFL) thickness map and scan circle RNFL thickness measurements. Methods: ImageJ and custom Perl scripts were used to derive RNFL thickness measurements from RNFL thickness maps of optic disc scans of healthy and glaucomatous eyes. Average, quadrant, and clock-hour RNFL thickness of the map, and RNFL thickness of the areas inside/outside the scan circle were obtained. Correlation and agreement between RNFL thickness map and scan circle RNFL thickness measurements were evaluated using R2 and Bland-Altman plots, respectively. Results: A total of 104 ...

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    9. Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography

      Reproducibility of Anterior Segment Angle Metrics Measurements Derived From Cirrus Spectral Domain Optical Coherence Tomography

      Purpose: To investigate the reproducibility of anterior segment angle (ACA) metrics measurements in normal subjects on Cirrus spectral domain optical coherence tomography (SD-OCT). Methods: 40 eyes from 20 healthy, normal subjects underwent anterior segment imaging using a Cirrus SD-OCT. For each eye, 2 acquisitions of 5-line raster scans were performed perpendicularly on the inferior (270 degrees) angle. The Schwalbe's line-angle opening distance (SL-AOD) and Schwalbe's line-trabecular-iris space area (SL-TISA) measurements were performed by masked certified reading center graders using customized grading software. Intra-acquisition, intergrader, and intragrader reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass correlation coefficients ...

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    10. Difference in Subfoveal Choroidal Thickness between Two Spectral-Domain Optical Coherence Tomography Systems

      Difference in Subfoveal Choroidal Thickness between Two Spectral-Domain Optical Coherence Tomography Systems

      Purpose To determine the difference in subfoveal choroidal thickness between two spectral-domain optical coherence tomography (SD-OCT) systems in normal eyes and eyes with retinal diseases. Methods Thirty-three normal eyes and 49 eyes with retinal disease (13 eyes with diabetic retinopathy, 28 eyes with epiretinal membrane and eight eyes with macular hole) were enrolled in the study. Subfoveal choroidal thicknesses were measured by 3 observers using the enhanced depth imaging technique of Heidelberg Spectralis® and the high-definition five-line raster scan of Cirrus HD-OCT® using calipers within the program. Differences between the measured values were analyzed with a paired t -test in ...

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  2. About Carl Zeiss Meditec

    Carl Zeiss Meditec

    Carl Zeiss Meditec.  Ophthalmology Systems.  Carl Zeiss Meditec is an integrated medical technology company with two main areas of business activity.  In the field of ophthalmology we offer complete solutions for treating the four main eye ailments: vision defects (refraction), cataract, glaucoma and retinal disorders. Our products support doctors and patients to diagnose and treat these ailments efficiently and precisely, thus giving both of them clear benefits, not least by offering them a comprehensive disease management solution. The acquisition of Carl Zeiss Surgical has strengthened our leading market and competitive position for devices and systems in ophthalmic surgery.  Furthermore, we have secured an outstanding starting position in the growth market of neuro/ENT surgery. As the world‘s leading provider of surgical microscopes and visualisation solutions for these treatments, we will further expand our footprint in this area through organic growth and strategic expansion into adjacent market segments. In doing so, we want to develop into a solution provider in this area as well.  Carl Zeiss Meditec's medical technology portfolio is rounded off by innovative and promising future technologies such as intraoperative radiation therapy, which allows the targeted treatment of breast cancer and brain cancer during the operation stage itself.

  3. Quotes about Carl Zeiss Meditec

    1. I have come to rely on the Carl Zeiss Meditec brand for consistent and reliable technologies that are at the forefront of innovation and patient care.
      Ike K. Ahmed in Carl Zeiss Meditec Introduces New Suite of Ophthalmic Innovations
    2. Mr Taylor has been instrumental in making Meditec one of the leading companies in the field of ophthalmology in the past few years. My sincere thanks are due to him for his effort and dedication. I am pleased that Mr Taylor will continue to support us in the role of independent consultant and that we will be able to draw on his experience in future. Furthermore, I am convinced that we are ideally set with our current team to accelerate the proposed realisation of growth potential of Carl Zeiss Meditec.
      Michael Kaschke in Carl Zeiss Meditec reorganises management of its strategic business units
    3. Carl Zeiss Meditec received the highest overall Frost & Sullivan Competitive Metrics Score in the recently completed Strategic Analysis of Optical Imaging Technologies in U.S. Clinical Diagnostics Markets.
      In Frost & Sullivan Lauds Carl Zeiss Meditec for Dominating the OCT Market for Ophthalmic Applications