1. Cardiovascular Research Foundation

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    1. Mentioned In 160 Articles

    2. Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial

      Explore PubMed Cardiology
      Thin-Cap Fibroatheroma Rather Than Any Lipid Plaques Increases the Risk of Cardiovascular Events in Diabetic Patients: Insights From the COMBINE OCT–FFR Trial
      Background: Autopsy studies have established that thin-cap fibroatheromas (TCFAs) are the most frequent cause of fatal coronary events. In living patients, optical coherence tomography (OCT) has sufficient resolution to accurately differentiate TCFA from thick-cap fibroatheroma (ThCFA) and not lipid rich plaque (non-LRP). However, the impact of OCT-detected plaque phenotype of nonischemic lesions on future adverse events remains unknown. Therefore, we studied the natural history of OCT-detected TCFA, ThCFA, and non-LRP ...
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      Mentions: Columbia University Cardiovascular Research Foundation University of Twente

    3. Optical coherence tomography in coronary atherosclerosis assessment and intervention

      Explore Nature Publishing Group Cardiology
      Optical coherence tomography in coronary atherosclerosis assessment and intervention
      Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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      Mentions: Brigham and Women’s Hospital Johns Hopkins University Massachusetts Institute of Technology

    4. A Multicenter RCT of OCT-Guided Reperfusion in STEMI With Early Infarct Artery Patency

      Explore ScienceDirect Cardiology
      A Multicenter RCT of OCT-Guided Reperfusion in STEMI With Early Infarct Artery Patency
      Objectives The aim of this study was to test whether optical coherence tomographic (OCT) guidance would provide additional useful information beyond that obtained by angiography and lead to a shift in reperfusion strategy and improved clinical outcomes in patients with ST-segment elevation myocardial infarction (STEMI) with early infarct artery patency. Background Angiography is limited in assessing the underlying pathophysiological mechanisms of the culprit lesion. Methods EROSION III (Optical Coherence TomographyGuided ...
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      Mentions: Cardiovascular Research Foundation Capital Medical University Harbin Medical University

    5. Diagnostic performance of fractional flow reserve derived from coronary angiography, intravascular ultrasound, and optical coherence tomography; a meta-analysis

      Explore Journal of Cardiology Cardiology
      Diagnostic performance of fractional flow reserve derived from coronary angiography, intravascular ultrasound, and optical coherence tomography; a meta-analysis
      Background: Little is known about the overall diagnostic performance of computational fractional flow reserve (FFR) derived from angiography (Angio-FFR), intravascular ultrasound (IVUS-FFR), and optical coherence tomography (OCT-FFR) to detect hemodynamically significant coronary artery disease. The present study aimed to evaluate the diagnostic performance of those novel physiologic indices using conventional FFR as the gold standard. Methods: PubMed and Embase were searched in September 2021 for a systematic review and meta-analysis ...
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      Mentions: Cardiovascular Research Foundation Stanford University

    6. Clinical outcomes of suboptimal stent deployment as assessed by optical coherence tomography

      Explore eurointervention.pcronline.com Cardiology
      Clinical outcomes of suboptimal stent deployment as assessed by optical coherence tomography
      Background: Intraprocedural optical coherence tomography (OCT) is a valuable tool for guidance of percutaneous coronary intervention, but long-term follow-up data are lacking. Aims: The aim of this study was to address the long-term (7.5 years) clinical impact of quantitative OCT metrics of suboptimal stent implantation. Methods: This retrospective study includes 391 patients with long-term follow-up (mean 2,737 days; interquartile range 1,301-3,143 days) from the multicentre Centro ...
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      Mentions: Cardiovascular Research Foundation Azienda Ospedaliera San Paolo

    7. Double-kissing nano-crush for bifurcation PCI guided by live OCT imaging: Shedding light on stent positioning

      Explore ScienceDirect Cardiology
      Double-kissing nano-crush for bifurcation PCI guided by live OCT imaging: Shedding light on stent positioning
      Percutaneous coronary intervention (PCI) of bifurcation lesions poses unique challenges and carries a high risk of adverse events on follow-up, mainly driven by repeat revascularization and stent thrombosis . Several techniques exist to tackle bifurcation lesions. Among those, double kissing (DK) crush has emerged in recent years as a safe and effective approach for complex bifurcations requiring a two-stent strategy. In its most recent iteration, the DK nano-crush, minimal (ideally less ...
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      Mentions: Cardiovascular Research Foundation Università Vita-Salute San Raffaele

    8. Focal Geometry and Characteristics of Erosion-Prone Coronary Plaques in vivo Angiography and Optical Coherence Tomography Study

      Explore Frontiers Cardiology
      Focal Geometry and Characteristics of Erosion-Prone Coronary Plaques in vivo Angiography and Optical Coherence Tomography Study
      Objective: This study compared focal geometry and characteristics of culprit plaque erosion (PE) vs. non-culprit plaques in ST-segment elevated myocardial infarction (STEMI) patients in whom optical coherence tomography (OCT) identified PE as the cause of the acute event. Background: Culprit PE is a distinct clinical entity with specific coronary risk factors and its own tailored management strategy. However, not all plaques develop erosion resulting in occlusive thrombus formation. Methods: Between ...
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      Mentions: Cardiovascular Research Foundation Harbin Medical University

    9. Using Optical Coherence Tomography and Intravascular Ultrasound Imaging to Quantify Coronary Plaque Cap Stress/Strain and Progression: A Follow-Up Study Using 3D Thin-Layer Models

      Explore Frontiers Cardiology
      Using Optical Coherence Tomography and Intravascular Ultrasound Imaging to Quantify Coronary Plaque Cap Stress/Strain and Progression: A Follow-Up Study Using 3D Thin-Layer Models
      ...S, OCT, and angiography baseline and follow-up data were collected from nine patients (mean age: 69; m: 5) at Cardiovascular Research Foundation with informed consent obtained. IVUS and OCT slices were coregistered and m...
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      Mentions: Emory University Columbia University Cardiovascular Research Foundation

    10. Clinical determinants of coronary artery disease burden and vulnerability using optical coherence tomography co-registered with intravascular ultrasound

      Explore LWW Online Cardiology
      Clinical determinants of coronary artery disease burden and vulnerability using optical coherence tomography co-registered with intravascular ultrasound
      Objectives: We investigated clinical determinants of disease burden and vulnerability using optical coherence tomography (OCT) co-registered with intravascular ultrasound (IVUS) in a large cohort of patients. Methods: A total of 704 patients [44.5% with acute coronary syndromes (ACS)] underwent coronary intervention. IVUS plaque burden and OCT lipid, macrophage and calcium indices and the presence of thrombus, plaque rupture and thin-cap fibroatheroma (TCFA) were analyzed. Results: Median patient age was ...
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      Mentions: Columbia University Cardiovascular Research Foundation Zhejiang University

    11. What are the PROSPECTs and clinical implications of vulnerable plaque?

      Explore Journals Cardiology
      What are the PROSPECTs and clinical implications of vulnerable plaque?
      Despite the fact that it has been three decades since James Muller and his colleagues first proposed the concept of vulnerable plaque 1 and 18 years since Naghavi et al. published their consensus document summarizing the concepts behind vulnerable patients and vulnerable plaques, including classifications for clinical and pathological evaluation, 2 , 3 we still have much to learn about the clinical implications of vulnerable plaque ( Graphical Abstract ). Feasibility of vulnerable ...
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      Mentions: Imperial College London Cardiovascular Research Foundation

    12. Comparison of 6‐month vascular healing response after bioresorbable polymer versus durable polymer drug‐eluting stent implantation in patients with acute coronary syndromes: A randomized serial optical coherence tomography study

      Explore Wiley Online Library Cardiology
      Comparison of 6‐month vascular healing response after bioresorbable polymer versus durable polymer drug‐eluting stent implantation in patients with acute coronary syndromes: A randomized serial optical coherence tomography study
      Objectives This study was conducted to use optical coherence tomography (OCT) to compare vascular healing between bioresorbable polymer (BP) and durable polymer (DP) everolimus-eluting stents (EES) in patients with acute coronary syndromes (ACS). Background Whether BP-EES induce better vascular healing compared to contemporary DP-EES remains controversial, especially for ACS. Methods In this prospective, randomized, non-inferiority trial, we used OCT to compare 6-month vascular healing in patients with ACS randomized to ...
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      Mentions: National Institutes of Health Columbia University Cardiovascular Research Foundation

    13. Intracoronary optical coherence tomography: state of the art and future directions

      Explore eurointervention.pcronline.com Cardiology
      Intracoronary optical coherence tomography: state of the art and future directions
      Optical coherence tomography (OCT) has been increasingly utilised to guide percutaneous coronary intervention (PCI). Despite the diagnostic utility of OCT, facilitated by its high resolution, the impact of intracoronary OCT on clinical practice has thus far been limited. Difficulty in transitioning from intravascular ultrasound (IVUS), complex image interpretation, lack of a standardised algorithm for PCI guidance, and paucity of data from prospective clinical trials have contributed to the modest adoption ...
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      Mentions: Columbia University Cardiovascular Research Foundation

    14. Optical Coherence Tomography in Acute Coronary Syndromes

      Explore Interventional Cardiology Clinics Cardiology
      Optical Coherence Tomography in Acute Coronary Syndromes
      Advances in intravascular imaging have enabled assessment of the underlying plaque morphology in acute coronary syndromes, which allows for the initiation of individualized therapy. The atherothrombotic substrates for acute coronary syndromes consist of plaque rupture, erosion, and calcified nodule, whereas spontaneous coronary artery dissection, coronary artery spasm, and coronary embolism constitute rarer nonatherothrombotic etiologies. This review provides a brief overview of the data from clinical studies that have used intravascular ...
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      Mentions: Cardiovascular Research Foundation

    15. Predicting plaque vulnerability change using intravascular ultrasound + optical coherence tomography image-based fluid–structure interaction models and machine learning methods with patient follow-up data: a feasibility study

      Explore BioMedical Engineering OnLine Cardiology
      Predicting plaque vulnerability change using intravascular ultrasound + optical coherence tomography image-based fluid–structure interaction models and machine learning methods with patient follow-up data: a feasibility study
      ... from left circumflex coronary artery and right coronary artery (RCA) of one participant (female; age: 80) at Cardiovascular Research Foundation (CRF) using protocol approved by the local institute and informed consents ...
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      Mentions: Cardiovascular Research Foundation Boston Scientific Washington University in St. Louis

    16. Optical coherence tomography detection of vulnerable plaques at high risk of developing acute coronary syndrome

      Explore Journals Cardiology
      Optical coherence tomography detection of vulnerable plaques at high risk of developing acute coronary syndrome
      Aims: The ability of optical coherence tomography (OCT) to detect plaques at high risk of developing acute coronary syndrome (ACS) remains unclear. The aim of this study was to evaluate the association between non-culprit plaques characterized as both lipid-rich plaque (LRP) and thin-cap fibroatheroma (TCFA) by OCT and the risk of subsequent ACS events at the lesion level. Methods and results: In 1378 patients who underwent OCT, 3533 non-culprit plaques ...
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      Mentions: Cardiovascular Research Foundation Wakayama Medical University
    17. 1-15 of 160 1 2 3 4 ... 9 10 11 »
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  4. About Cardiovascular Research Foundation

    Cardiovascular Research Foundation

    Cardiovascular Research Foundation (CRF) strives to improve the quality of life for patients with cardiovascular disease. Our goal is to advance the development and use of safe and effective minimally invasive cardiovascular treatments.  In addition to its world-renowned Core Labs, and the many ground-breaking studies and trials conducted under the Foundation's auspices each year, CRF also sponsors a number of patient-based special projects such as the Women's Health Initiative. Furthermore, through its Data Coordinating and Analysis Center, CRF maintains a vast database of clinical inquiry and outcomes. This important database has been created to track the real-world, long-term effectiveness of new treatment models.
    CRF's dedication to research and education is demonstrated at the annual Transcatheter Cardiovascular Therapeutics (TCT) symposium where CRF's distinguished faculty joins forces with more than 600 of the world's leading cardiologists to teach, share and discuss the latest techniques and developments in the field with over 11,000 symposium participants from across the globe. Where once it took years for such theories and practices to achieve currency in the medical community, TCT now ensures the timely dissemination of this critical body of research and therapeutic practice. It is an exchange, as Dr Leon says, "that influences the way hundreds of thousands of patients are treated every year."

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