1. Cardiovascular Research Foundation

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    1. Mentioned In 81 Articles

    2. Variable underlying morphology of culprit plaques associated with ST-elevation myocardial infarction: an optical coherence tomography analysis from the SMART trial

      Variable underlying morphology of culprit plaques associated with ST-elevation myocardial infarction: an optical coherence tomography analysis from the SMART trial
      Aims The objective was to assess in vivo culprit lesion morphologies that caused ST-segment elevation myocardial infarction (STEMI) using optical coherence tomography (OCT). Methods and results Culprit lesions in 80 patients presenting within 6 h of STEMI onset from the CompariSon of Manual Aspiration with Rheolytic Thrombectomy in patients undergoing primary PCI (SMART) trial were evaluated. Underlying morphology of 64 culprit lesions was identifiable by OCT and included 37 lesions ...
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    3. Intravascular Imaging of Coronary Calcification and Its Clinical Implications

      Intravascular Imaging of Coronary Calcification and Its Clinical Implications
      Calcium impacts the natural history and treatment of coronary artery disease in many ways. Intravascular imaging studies, mostly intravascular ultrasound, but more recently studies using optical coherence tomography, have been instrumental in increasing our understanding of the relationship between calcium and coronary atherosclerosis, the predictors, the natural history of this relationship, and the impact on treatment. On one hand, stable coronary lesions are associated with more calcium than unstable lesions ...
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    4. OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome

      OCT for the Identification of Vulnerable Plaque in Acute Coronary Syndrome
      After 2 decades of development and use in interventional cardiology research, optical coherence tomography (OCT) has now become a core intravascular imaging modality in clinical practice. Its unprecedented spatial resolution allows visualization of the key components of the atherosclerotic plaque that appear to confer vulnerability to rupturenamely the thickness of the fibrous cap, size of the necrotic core, and the presence of macrophages. The utility of OCT in the evaluation ...
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    5. Hypersensitivity Reaction in the US Food and Drug Administration-Approved Second-Generation Drug-Eluting Stents: Histopathological Assessment With Ex Vivo Optical Coherence Tomography

      Hypersensitivity Reaction in the US Food and Drug Administration-Approved Second-Generation Drug-Eluting Stents: Histopathological Assessment With Ex Vivo Optical Coherence Tomography
      A 55-year-old white man received 4 coronary stents, 3 Resolute zotarolimus-eluting stents (R-ZES; Medtronic, Santa Rosa, CA) and 1 XIENCE Xpedition (CoCr-EES; Abbott Vascular, Santa Clara, CA), for unstable angina pectoris 238 days antemortem. The patient was found dead and had recently been seen without any complaints. The patient had a history of hypertension, hyperlipidemia, and smoking. At the time of stent placement, coronary angiography revealed diffuse disease in the ...
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    6. Matching human pathology is essential for validating OCT imaging to detect high-risk plaques

      Matching human pathology is essential for validating OCT imaging to detect high-risk plaques
      We thank Mark Brezinski for his Correspondence ( Capabilities, limitations, and misconceptions of using OCT to assess vulnerable plaques . Nat. Rev. Cardiol. doi:10.1038/nrcardio.2014.62-c1 ) 1 on our Review ( Clinical classification of plaque morphology in coronary disease . Nat. Rev. Cardiol. 11 , 379 389 ; 2014 ), 2 and for his comments and clarifications. We agree that the phenomenon
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    7. Optical coherence tomography assessment of a PLGA-polymer with electro-grafting base layer versus a PLA-polymer sirolimus-eluting stent at three-month follow-up: the BuMA-OCT randomised trial

      Optical coherence tomography assessment of a PLGA-polymer with electro-grafting base layer versus a PLA-polymer sirolimus-eluting stent at three-month follow-up: the BuMA-OCT randomised trial
      Aims: To compare stent strut coverage using optical coherence tomography (OCT) at three-month follow-up between a PLGA-polymer with electro-grafting base layer sirolimus-eluting stent (SES) (BuMA) and a PLA-polymer SES (EXCEL). Methods and results: This prospective, single-centre, non-inferiority randomised BuMA-OCT trial enrolled patients with de novo coronary artery lesions, treated with either the BuMA or the EXCEL stent. The study primary endpoint was OCT-evaluated stent strut coverage at three months. Secondary ...
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    8. Peri-strut low-intensity areas in optical coherence tomography correlate with peri-strut inflammation and neointimal proliferation: an in-vivo correlation study in the familial hypercholesterolemic coronary swine model of in-stent restenosis

      Peri-strut low-intensity areas in optical coherence tomography correlate with peri-strut inflammation and neointimal proliferation: an in-vivo correlation study in the familial hypercholesterolemic coronary swine model of in-stent restenosis
      Background: Peri-strut low-intensity area (PLI) is a common imaging finding during the evaluation of in-stent neointima using optical coherence tomography (OCT). We aimed to determine the biological significance of PLI by comparing in-vivo OCT images with the corresponding histological sections obtained from the familial hypercholesterolemic swine model of coronary stenosis. Methods: A total of 26 coronary vessels of nine familial hypercholesterolemic swine were injured with 30% balloon overstretch and then ...
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    9. Drug-eluting stent implantation in patients with acute coronary syndrome - the Activity of Platelets after Inhibition and Cardiovascular Events: Optical Coherence Tomography (APICE OCT) study

      Drug-eluting stent implantation in patients with acute coronary syndrome - the Activity of Platelets after Inhibition and Cardiovascular Events: Optical Coherence Tomography (APICE OCT) study
      Aims: To our knowledge, no randomised study has compared rates of uncovered stent struts in everolimus (EES) vs. new-generation zotarolimus-eluting (ZES-R) stents in acute coronary syndrome (ACS). The aim of our study was to evaluate the completeness of neointimal coverage with optical coherence tomography (OCT) in ACS patients treated with drug-eluting stents (DES) comparing EES versus new-generation ZES-R. Methods and results: All eligible ACS patients admitted to four Italian centres ...
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    10. Clinical classification of plaque morphology in coronary disease

      Clinical classification of plaque morphology in coronary disease
      In published post-mortem pathological studies, more than two-thirds of acute coronary events are associated with the rupture of lipid-rich, voluminous, and outwardly remodelled plaques covered by attenuated and inflamed fibrous caps in the proximal part of coronary arteries. Superficial erosion of the plaques is responsible for most of the remaining events; the eroded plaques usually do not demonstrate much lipid burden, do not have thin fibrous caps, are not positively ...
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    11. Expectations and limitations of contemporary intravascular imaging: lessons learned from pathology

      Expectations and limitations of contemporary intravascular imaging: lessons learned from pathology
      Acute coronary syndrome is the leading cause of death worldwide and plaque rupture is the most common underlying mechanism of coronary thrombosis. During the last 2 decades the understanding of atherosclerotic plaque progression advanced dramatically and pathology studies provided fundamental insights of underlying plaque morphology, which paved the way for invasive imaging modalities, which bring a new area of atherosclerotic plaque characterization in vivo. The development of intravascular ultrasound (IVUS ...
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  2. About Cardiovascular Research Foundation

    Cardiovascular Research Foundation

    Cardiovascular Research Foundation (CRF) strives to improve the quality of life for patients with cardiovascular disease. Our goal is to advance the development and use of safe and effective minimally invasive cardiovascular treatments.  In addition to its world-renowned Core Labs, and the many ground-breaking studies and trials conducted under the Foundation's auspices each year, CRF also sponsors a number of patient-based special projects such as the Women's Health Initiative. Furthermore, through its Data Coordinating and Analysis Center, CRF maintains a vast database of clinical inquiry and outcomes. This important database has been created to track the real-world, long-term effectiveness of new treatment models.
    CRF's dedication to research and education is demonstrated at the annual Transcatheter Cardiovascular Therapeutics (TCT) symposium where CRF's distinguished faculty joins forces with more than 600 of the world's leading cardiologists to teach, share and discuss the latest techniques and developments in the field with over 11,000 symposium participants from across the globe. Where once it took years for such theories and practices to achieve currency in the medical community, TCT now ensures the timely dissemination of this critical body of research and therapeutic practice. It is an exchange, as Dr Leon says, "that influences the way hundreds of thousands of patients are treated every year."