1. California Institute of Technology

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    1. Mentioned In 51 Articles

    2. Advanced Monte Carlo Simulation and Machine Learning for Frequency Domain Optical Coherence Tomography

      Advanced Monte Carlo Simulation and Machine Learning for Frequency Domain Optical Coherence Tomography
      Optical Coherence Tomography(OCT) is a popular, rapidly growing imaging technique with an increasing number of bio-medical applications due to its noninvasive nature. However, there are three major challenges in understanding and improving an OCT system: (1) Obtaining an OCT image is not easy. It either takes a real medical experiment or requires days of computer simulation. Without much data, it is difficult to study the physical processes underlying OCT ...
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    3. Optical Coherence Tomography (OCT) System With Improved Motion Contrast

      Optical Coherence Tomography (OCT) System With Improved Motion Contrast
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly relates to motion contrast methods for such OCT systems.
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    4. Optical Coherence Tomography (OCT) System With PHASE-SENSITIVE B-SCAN Registration

      Optical Coherence Tomography (OCT) System With PHASE-SENSITIVE B-SCAN Registration
      This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan registration method. In this disclosure, an OCT system may have a configuration that scans a physical object, acquires OCT signals to form B-scans, uses these B-scans to determine an optimal shift in an axial direction by using total phase error between B-scans ...
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    5. Compressive sensing optical coherence tomography using randomly accessible lasers

      Compressive sensing optical coherence tomography using randomly accessible lasers
      We propose and demonstrate a novel a compressive sensing swept source optical coherence tomography (SSOCT) system that enables high speed images to be taken while maintaining the high resolution offered from a large bandwidth sweep. Conventional SSOCT systems sweep the optical frequency of a laser (t) to determine the depth of the reflectors at a given lateral location. A scatterer located at delay appears as a sinusoid cos ((t) ) at ...
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    6. Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)

      Improved in vivo imaging of human blood circulation in the chorioretinal complex using phase variance method with new phase stabilized 1 μm swept-source optical coherence tomography (pv-SSOCT)
      We demonstrate the feasibility of our newly developed phase stabilized high-speed (100 kHz A-scans/s) 1 m sweptsource optical coherence tomography (SSOCT) system with the phase-variance based motion contrast method for visualization of human chorioretinal complex microcirculation. Compared to our previously reported spectral domain (spectrometer based) phase-variance (pv)-SDOCT system it has advantages of higher sensitivity, reduced fringe washout for high blood flow speeds and deeper penetration in choroid. High ...
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    7. Swept-frequency semiconductor laser coupled to microfabricated biomolecular sensor and methods related thereto

      Swept-frequency semiconductor laser coupled to microfabricated biomolecular sensor and methods related thereto
      An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described. Biomolecular sensors with optical resonator microfabricated with integrated waveguide operation can be in a microfluidic flow cell.
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    8. Acoustic assisted phase conjugate optical tomography

      Acoustic assisted phase conjugate optical tomography
      A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical ...
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    9. Visualization of human retinal and choroidal vascular networks with phase-variance optical coherence tomography

      Visualization of human retinal and choroidal vascular networks with phase-variance optical coherence tomography
      We present in vivo noninvasive retinal and choroidal perfusion maps with phase-variance optical coherence tomography (pvOCT). We acquired a pvOCT volumetric data set of a normal subject and visualized blood circulation in the retina and the choroid. En face projection views of the retina as well as the choroid were generated from a manually segmented volumetric data set. In addition, the processed pvOCT images were compared to current standard imaging ...
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    10. Optical imaging techniques in microfluidics and their applications

      Optical imaging techniques in microfluidics and their applications
      Microfluidic devices have undergone rapid development in recent years and provide a lab-on-a-chip solution for many biomedical and chemical applications. Optical imaging techniques are essential in microfluidics for observing and extracting information from biological or chemical samples. Traditionally, imaging in microfluidics is achieved by bench-top conventional microscopes or other bulky imaging systems. More recently, many novel compact microscopic techniques have been developed to provide a low-cost and portable solution. In ...
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    11. Image reconstruction by position and motion tracking

      Image reconstruction by position and motion tracking
      A system, method, and apparatus provide the ability to reconstruct an image from an object. A hand-held image acquisition device is configured to acquire local image information from a physical object. A tracking system obtains displacement information for the hand-held acquisition device while the device is acquiring the local image information. An image reconstruction system computes the inverse of the displacement information and combines the inverse with the local image ...
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  2. About California Institute of Technology

    California Institute of Technology

    California Institute of Technology is a private research university located in Pasadena, California. The Institute maintains a strong emphasis on the natural sciences and engineering, and operates and manages NASA's neighboring Jet Propulsion Laboratory. Caltech is a small school, with only about 2100 students (about 900 undergraduates and 1200 graduate students), but it is ranked number 2 in the world according to Global University Ranking and in the top ten universities worldwide by metrics such as Science Watch, Nobel Prizes, and general university rankings.