1. Brown University

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    1. Mentioned In 20 Articles

    2. Noninvasive diagnostic techniques of port wine stain

      Noninvasive diagnostic techniques of port wine stain
      Port‐wine stain (PWS) is a benign capillary malformation that most commonly occurs in the head and neck. It is present at birth and progresses over time. It is formed by progressive dilatation of post‐capillary venules and is associated with hypertrophy and nodularity with increasing age, leading to cosmetic disfigurement and psychological aggravation. It is caused by genetic mosaicism in GNAQ and GNA11 genes. Histopathology is the gold standard ...
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      Mentions: Brown University
    3. Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice

      Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice
      We report optical coherence tomography (OCT) imaging of localized fast optical signals (FOSs) arising from whisker stimulation in awake mice. The activated voxels were identified by fitting the OCT intensity signal time course with a response function over a time scale of a few hundred milliseconds after the whisker stimulation. The significantly activated voxels were shown to be localized to the expected brain region for whisker stimulation. The ability to ...
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    4. Design and optimization of line-field optical coherence tomography at visible wavebands

      Design and optimization of line-field optical coherence tomography at visible wavebands
      Parallel line-field Fourier-domain optical coherence tomography (LF-FDOCT) has emerged to enable relatively higher speeds than the conventional FDOCT system. In the LF-FDOCT, one B-scan is captured at a time instead of scanning the beam to acquire hundreds of A-scans. On the other hand, spectroscopic OCT using the visible waveband provides absorption information over multiple wavelengths at each voxel. This information of spectral absorption enables quantitative measurement of blood oxygenation, voxel ...
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      Mentions: Brown University
    5. Epidemiology, Diagnosis, Staging and Multimodal Therapy of Esophageal and Gastric Tumors

      Epidemiology, Diagnosis, Staging and Multimodal Therapy of Esophageal and Gastric Tumors
      Gastric and esophageal tumors are diverse neoplasms that involve mucosal and submucosal tissue layers and include squamous cell carcinomas, adenocarcinomas, spindle cell neoplasms, neuroendocrine tumors, marginal B cell lymphomas, along with less common tumors. The worldwide burden of esophageal and gastric malignancies is significant, with esophageal and gastric cancer representing the ninth and fifth most common cancers, respectively. The approach to diagnosis and staging of these lesions is multimodal and ...
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      Mentions: Brown University
    6. Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms

      Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms
      Optical coherence tomography angiography (OCTA) is becoming increasingly popular for neuroscientific study, but it remains challenging to objectively quantify angioarchitectural properties from 3D OCTA images. This is mainly due to projection artifacts or tails underneath vessels caused by multiple-scattering, as well as the relatively low signal-to-noise ratio compared to fluorescence-based imaging modalities. Here, we propose a set of deep learning approaches based on convolutional neural networks (CNNs) to automated enhancement ...
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      Mentions: Brown University
    7. Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography

      Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography
      Background To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes. Methods In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-nave diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and ...
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    8. Intravascular Imaging for Venous Interventions

      Intravascular Imaging for Venous Interventions
      Purpose of Review This review surveys the clinical landscape of intravascular imaging for endovenous interventions. Recent Findings Endovascular imaging has become increasingly important for diagnosing venous pathology and guiding venous interventions. In particular, intravascular ultrasound (IVUS) provides 3D high-resolution cross-sectional imaging of vessel and surrounding tissues, often in anatomic locations inaccessible to surface ultrasound, namely the superior vena cava, inferior vena cava, and caval-iliac veins. Summary Current well-established indications for ...
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    9. Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography

      Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography
      Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations ...
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    10. Diversity in optical coherence tomography normative databases: moving beyond race

      Diversity in optical coherence tomography normative databases: moving beyond race
      Normative databases of optical coherence tomography (OCT) metrics, such as retinal nerve fiber layer (RNFL) and macular thickness, are critical to clinical use of OCT imaging. In order to accurately represent the range of normal variation in patient populations, these normative databases must themselves be adequately diverse. Thus far, diversity in OCT normative databases has largely been defined as racial diversity. However, this has largely been based on self-reported race ...
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    11. Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy

      Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy
      Optimal coronary stent implantation is among the few successful strategies in preventing stent failures, notably in-stent restenosis and stent thrombosis. 1 Understanding the intravascular milieu is a prerequisite for optimization of percutaneous coronary intervention (PCI). Calcified lesions limit stent expansion, the most robust predictor of target lesion revascularization, and are thus associated with worst outcomes. 2 Coronary angiography is a poor discriminator of calcium distribution and thickness. Reliance on angiography ...
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    12. Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography

      Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography
      Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements ...
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    13. Optical coherence tomography imaging of capillary reperfusion after ischemic stroke

      Optical coherence tomography imaging of capillary reperfusion after ischemic stroke
      Although progress has been made for recanalization therapies after ischemic stroke, post-treatment imaging studies show that tissue reperfusion cannot be attained despite satisfactory recanalization in a significant percentage of patients. Hence, investigation of microcirculatory changes in both surface and deep cortical levels after ischemia reperfusion is important for understanding the post-stroke blood flow dynamics. In this study, we applied optical coherence tomography (OCT) imaging of cerebral blood flow for the ...
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  2. About Brown University

    Brown University

    Brown University is a private , Ivy League university located in Providence, Rhode Island.