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    1. Mentioned In 23 Articles

    3. Deep Learning and Simulation for the Estimation of Red Blood Cell Flux With Optical Coherence Tomography

      Explore Frontiers
      Deep Learning and Simulation for the Estimation of Red Blood Cell Flux With Optical Coherence Tomography
      We present a deep learning and simulation-based method to measure cortical capillary red blood cell (RBC) flux using Optical Coherence Tomography (OCT). This method is more accurate than the traditional peak-counting method and avoids any user parametrization, such as a threshold choice. We used data that was simultaneously acquired using OCT and two-photon microscopy to uncover the distribution of parameters governing the height, width, and inter-peak time of peaks in ...
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      Mentions: Brown University

    4. OCTA reveals remodeling of the peripheral capillary free zones in normal aging

      Explore Nature Publishing Group Ophthalmology
      OCTA reveals remodeling of the peripheral capillary free zones in normal aging
      The retinal neurovascular unit consists of blood vessel endothelial cells, pericytes, neurons, astrocytes, and Mller cells that form the inner retinal blood barrier. A peripheral capillary free zone (pCFZ) represents the distance that oxygen and nutrients must diffuse to reach the neural retina, and serves as a metric of retinal tissue oxygenation. The pCFZs are formed based on oxygen saturation in the retinal arterioles and venules. Because retinal arterioles contain ...
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      Mentions: Brown University

    5. Noninvasive diagnostic techniques of port wine stain

      Explore Wiley Online Library Dermatology
      Noninvasive diagnostic techniques of port wine stain
      Port‐wine stain (PWS) is a benign capillary malformation that most commonly occurs in the head and neck. It is present at birth and progresses over time. It is formed by progressive dilatation of post‐capillary venules and is associated with hypertrophy and nodularity with increasing age, leading to cosmetic disfigurement and psychological aggravation. It is caused by genetic mosaicism in GNAQ and GNA11 genes. Histopathology is the gold standard ...
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      Mentions: Brown University

    6. Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice

      Explore OSA | OSA Publishing Neurology
      Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice
      We report optical coherence tomography (OCT) imaging of localized fast optical signals (FOSs) arising from whisker stimulation in awake mice. The activated voxels were identified by fitting the OCT intensity signal time course with a response function over a time scale of a few hundred milliseconds after the whisker stimulation. The significantly activated voxels were shown to be localized to the expected brain region for whisker stimulation. The ability to ...
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      Mentions: Boston University Brown University

    8. Design and optimization of line-field optical coherence tomography at visible wavebands

      Explore OSA | OSA Publishing
      Design and optimization of line-field optical coherence tomography at visible wavebands
      Parallel line-field Fourier-domain optical coherence tomography (LF-FDOCT) has emerged to enable relatively higher speeds than the conventional FDOCT system. In the LF-FDOCT, one B-scan is captured at a time instead of scanning the beam to acquire hundreds of A-scans. On the other hand, spectroscopic OCT using the visible waveband provides absorption information over multiple wavelengths at each voxel. This information of spectral absorption enables quantitative measurement of blood oxygenation, voxel ...
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      Mentions: Brown University

    9. Epidemiology, Diagnosis, Staging and Multimodal Therapy of Esophageal and Gastric Tumors

      Explore MDPI Open Access Journals Platform Gastroenterology
      Epidemiology, Diagnosis, Staging and Multimodal Therapy of Esophageal and Gastric Tumors
      Gastric and esophageal tumors are diverse neoplasms that involve mucosal and submucosal tissue layers and include squamous cell carcinomas, adenocarcinomas, spindle cell neoplasms, neuroendocrine tumors, marginal B cell lymphomas, along with less common tumors. The worldwide burden of esophageal and gastric malignancies is significant, with esophageal and gastric cancer representing the ninth and fifth most common cancers, respectively. The approach to diagnosis and staging of these lesions is multimodal and ...
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      Mentions: Brown University

    10. Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms

      Explore OSA | OSA Publishing
      Deep learning toolbox for automated enhancement, segmentation, and graphing of cortical optical coherence tomography microangiograms
      Optical coherence tomography angiography (OCTA) is becoming increasingly popular for neuroscientific study, but it remains challenging to objectively quantify angioarchitectural properties from 3D OCTA images. This is mainly due to projection artifacts or tails underneath vessels caused by multiple-scattering, as well as the relatively low signal-to-noise ratio compared to fluorescence-based imaging modalities. Here, we propose a set of deep learning approaches based on convolutional neural networks (CNNs) to automated enhancement ...
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      Mentions: Brown University

    11. Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography

      Explore Eye and Vision Ophthalmology
      Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography
      Background To examine the baseline morphological characteristics and alterations in intraretinal microvascular abnormalities (IRMAs) in response to anti-vascular endothelial growth factor (anti-VEGF) treatment, documented by optical coherence tomography angiography (OCTA) in diabetic eyes. Methods In this retrospective study, IRMAs were evaluated with multimodal imaging (fundus photography, fluorescein angiography, OCTA) in treatment-nave diabetic eyes before and after anti-VEGF treatment for diabetic macular edema (DME) and/or proliferative diabetic retinopathy (PDR) and ...
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      Mentions: Yale University Tufts University Brown University

    12. Intravascular Imaging for Venous Interventions

      Explore Home - Springer Cardiology
      Intravascular Imaging for Venous Interventions
      Purpose of Review This review surveys the clinical landscape of intravascular imaging for endovenous interventions. Recent Findings Endovascular imaging has become increasingly important for diagnosing venous pathology and guiding venous interventions. In particular, intravascular ultrasound (IVUS) provides 3D high-resolution cross-sectional imaging of vessel and surrounding tissues, often in anatomic locations inaccessible to surface ultrasound, namely the superior vena cava, inferior vena cava, and caval-iliac veins. Summary Current well-established indications for ...
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      Mentions: Beth Israel Deaconess Medical Center Yale University Harvard University

    13. Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography

      Explore journalretinavitreous.biomedcentral.com Ophthalmology
      Topographic analysis of macular choriocapillaris flow deficits in diabetic retinopathy using swept–source optical coherence tomography angiography
      Background The purpose of this study was to investigate the association between diabetic retinopathy (DR) severity and macular choriocapillaris (CC) flow deficit percentage (FD %) in different macular regions using swept-source optical coherence tomography angiography (SS-OCTA). Methods Diabetic patients with SS-OCTA images were graded by severity and retrospectively assessed. CC FD % was calculated in four different regions of the OCTA image: inner, middle, outer, and full-field region. The generalized estimating equations ...
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      Mentions: Massachusetts Institute of Technology Yale University Tufts University

    14. Diversity in optical coherence tomography normative databases: moving beyond race

      Explore Home - Springer Ophthalmology
      Diversity in optical coherence tomography normative databases: moving beyond race
      Normative databases of optical coherence tomography (OCT) metrics, such as retinal nerve fiber layer (RNFL) and macular thickness, are critical to clinical use of OCT imaging. In order to accurately represent the range of normal variation in patient populations, these normative databases must themselves be adequately diverse. Thus far, diversity in OCT normative databases has largely been defined as racial diversity. However, this has largely been based on self-reported race ...
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      Mentions: Tufts University Brown University

    15. Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy

      Explore Circulation Cardiology
      Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy
      Optimal coronary stent implantation is among the few successful strategies in preventing stent failures, notably in-stent restenosis and stent thrombosis. 1 Understanding the intravascular milieu is a prerequisite for optimization of percutaneous coronary intervention (PCI). Calcified lesions limit stent expansion, the most robust predictor of target lesion revascularization, and are thus associated with worst outcomes. 2 Coronary angiography is a poor discriminator of calcium distribution and thickness. Reliance on angiography ...
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      Mentions: Case Western Reserve University Brown University

    16. Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography

      Explore SPIE Digital Library
      Measurement of shear-induced diffusion of red blood cells using dynamic light scattering-optical coherence tomography
      Dynamic Light Scattering-Optical Coherence Tomography (DLS-OCT) takes the advantages of using DLS to measure particle flow and diffusion within an OCT resolution-constrained 3D volume, enabling the simultaneous measurements of absolute RBC velocity and diffusion coefficient with high spatial resolution. In this work, we applied DLS-OCT to measure both RBC velocity and the shear-induced diffusion coefficient within penetrating venules of the somatosensory cortex of anesthetized mice. Blood flow laminar profile measurements ...
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      Mentions: Massachusetts General Hospital Harvard University Boston University
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  4. About Brown University

    Brown University

    Brown University is a private , Ivy League university located in Providence, Rhode Island.

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