1. British Columbia Cancer Agency

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    1. Mentioned In 44 Articles

    2. Systems for optical imaging of biological tissues

      Systems for optical imaging of biological tissues
      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment ...
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    3. Depth-multiplexed optical coherence tomography dual-beam manually-actuated distortion-corrected imaging (DMDI) with a micromotor catheter

      Depth-multiplexed optical coherence tomography dual-beam manually-actuated distortion-corrected imaging (DMDI) with a micromotor catheter
      We present a new micromotor catheter implementation of dual-beam manually-actuated distortion-corrected imaging (DMDI). The new catheter called a depth-multiplexed dual-beam micromotor catheter, or mDBMC, maintains the primary advantage of unlimited field-of-view distortion-corrected imaging along the catheter axis. The mDBMC uses a polarization beam splitter and cube mirror to create two beams that scan circularly with approximately constant separation at the catheter surface. This arrangement also multiplexes both imaging channels into ...
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    4. Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer

      Dual-beam manually actuated distortion-corrected imaging (DMDI): two dimensional scanning with a single-axis galvanometer
      We recently demonstrated a new two-dimensional imaging paradigm called dual-beam manually actuated distortion-corrected imaging (DMDI). This technique uses a single mechanical scanner and two spatially separated beams to determine relative sample velocity and simultaneously corrects image distortions due to manual actuation. DMDI was first demonstrated using a rotating dual-beam micromotor catheter. Here, we present a new implementation of DMDI using a single axis galvanometer to scan a pair of beams ...
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    5. Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration

      Correction of motion artifacts in endoscopic optical coherence tomography and autofluorescence images based on azimuthal en face image registration
      We present a method for the correction of motion artifacts present in two- and three-dimensionalin vivoendoscopic images produced by rotary-pullback catheters. This method can correct for cardiac/breathing-based motion artifacts and catheter-based motion artifacts such as nonuniform rotational distortion (NURD). This method assumes thaten facetissue imaging contains slowly varying structures that are roughly parallel to the pullback axis. The method reduces motion artifacts using a dynamic time warping solution through ...
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    6. Early Cancer Detection (Book Chapter)

      Early Cancer Detection (Book Chapter)
      Lung cancer is the leading cause of cancer deaths worldwide as the majority of patient shave advanced disease at diagnosis. Detection and early treatment of pre-invasive and minimally invasive lung cancer can significantly improve the current 5-year survival of 18%, Endoscopic optical imaging (such as autoflourescence imaging), NBI, and OCT provide sensitive means to rapidly scan the central airways , in order to detect early lung cancer for biopsy confirmation and ...
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    7. Optical Coherence Tomography: A Review (Book Chapter)

      Optical Coherence Tomography: A Review (Book Chapter)
      Optical coherence tomography (OCT), with polarization-sensitive (PS), Doppler, and autofluorescence (AF) capabilities, is emerging as a promising bronchoscopic diagnostic tool. In the upper and central airways, it allows accurate real-time airway measurements to assist bronchoscopic assessment of obstructive sleep apnea, severity of tracheomalacia, airway stenosis, or extent of tumor involvement into the bronchial wall or distally beyond the bronchoscopic view. OCT can visualize cellular and extracellular structures at and below ...
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    8. Dual-beam manually-actuated distortion-corrected imaging (DMDI) with micromotor catheters

      Dual-beam manually-actuated distortion-corrected imaging (DMDI) with micromotor catheters
      e present a new paradigm for performing two-dimensional scanning called dual-beam manually-actuated distortion-corrected imaging (DMDI). DMDI operates by imaging the same object with two spatially-separated beams that are being mechanically scanned rapidly in one dimension with slower manual actuation along a second dimension. Registration of common features between the two imaging channels allows remapping of the images to correct for distortions due to manual actuation. We demonstrate DMDI using a ...
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    9. Massachusetts Life Sciences Center Announces Six New Grants to Support R&D Collaborations

      Massachusetts Life Sciences Center Announces Six New Grants to Support R&D Collaborations
      LX Medical (Westwood, MA) was granted $70,000 for collaboration with BC Cancer Agency Research Center in Vancouver, Canada. LX Medical is developing a probe device that will enable real time biopsy of lung tissue. This device will increase accuracy of biopsy sampling by using optical coherence tomography and with autofluoresence, thereby enabling earlier detection and treatment especially in early stage lung cancer. The collaboration will focus on biopsy testing ...
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    10. Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

      Sex Differences in Airway Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease
      Rationale: Adjusting for the amount of smoking, women have a 50% increased risk of COPD compared with men. It is not known what the anatomic basis/mechanism(s) of these sex-related differences in COPD might be. Objective: To characterize the impact of female sex hormones on chronic cigarette smoke-induced airway remodeling and emphysema in a mouse model of COPD. Methods: Airway remodeling and emphysema were determined morphometrically in male, female ...
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    11. Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature

      Endoscopic Doppler optical coherence tomography and autofluorescence imaging of peripheral pulmonary nodules and vasculature
      We present the first endoscopic Doppler optical coherence tomography and co-registered autofluorescence imaging (DOCT-AFI) of peripheral pulmonary nodules and vascular networks in vivo using a small 0.9 mm diameter catheter. Using exemplary images from volumetric data sets collected from 31 patients during flexible bronchoscopy, we demonstrate how DOCT and AFI offer complementary information that may increase the ability to locate and characterize pulmonary nodules. AFI offers a sensitive visual ...
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    12. Systems For Optical Imaging Of Biological Tissues

      Systems For Optical Imaging Of Biological Tissues
      A fiber-based polarization sensitive optical coherence tomography (PS-OCT) system uses a new polarization diversity detection (PDD) scheme and requires no active polarization modulating components. Retardation of the sample can be determined from amplitudes of arbitrarily-oriented x- and y-components of the reflected light. A hybrid custom 50/50 coupler with single-mode fiber inputs and polarization maintaining (PM) fiber outputs combines light from sample and reference arms of an interferometer. Another embodiment ...
      Read Full Article
    13. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components
      Polarization Sensitive Optical Coherence Tomography (PSOCT) is a functional extension of Optical Coherence Tomography (OCT) that is sensitive to well-structured, birefringent tissue such as scars, smooth muscle and cartilage. In this work, we present a novel completely fiber based swept source PSOCT system using a fiber-optic rotary pullback catheter. This PSOCT implementation uses only passive optical components and requires no calibration while adding minimal additional cost to a standard structural ...
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    14. 1-15 of 44 1 2 3 »
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  2. About British Columbia Cancer Agency

    British Columbia Cancer Agency

    The BC Cancer Research Centre (BCCRC) is located in Vancouver, British Columbia, Canada. Scientists and researchers perform basic, epidemiologic, and clinical research on cancer prevention, early diagnosis of cancer, the molecular and genetic characteristics of the cancer process, and basic research related to new treatments for cancer. With direct links to the cancer centres across the province, discoveries at the BCCRC are quickly translated into clinical applications.