1. Brian J. F. Wong

    0 Comments Leave a Comment

    1-15 of 46 1 2 3 »
    1. Mentioned In 46 Articles

    2. Anatomically correct visualization of the human upper airway using a high-speed long range optical coherence tomography system with an integrated positioning sensor

      Anatomically correct visualization of the human upper airway using a high-speed long range optical coherence tomography system with an integrated positioning sensor
      The upper airway is a complex tissue structure that is prone to collapse. Current methods for studying airway obstruction are inadequate in safety, cost, or availability, such as CT or MRI, or only provide localized qualitative information such as flexible endoscopy. Long range optical coherence tomography (OCT) has been used to visualize the human airway in vivo , however the limited imaging range has prevented full delineation of the various shapes ...
      Read Full Article
    3. Biomedical Optics in Otorhinolaryngology (Textbook)

      Biomedical Optics in Otorhinolaryngology (Textbook)
      Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery gives an overview of current technology in biomedical optics relevant to the field of Otorhinolaryngology and head and neck surgery. It provides a comprehensive source of knowledge for researchers and active clinicians seeking information on the principles and practical use of novel diagnostic and therapeutic technology. While most books focus exclusively on laser surgery, which has been largely unchanged for the past ...
      Read Full Article
    4. Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography

      Diagnosis of subglottic stenosis in a rabbit model using long-range optical coherence tomography
      Objectives/Hypothesis Current imaging modalities lack the necessary resolution to diagnose subglottic stenosis. The aim of this study was to use optical coherence tomography (OCT) to evaluate nascent subglottic mucosal injury and characterize mucosal thickness and structural changes using texture analysis in a simulated intubation rabbit model. Study Design Prospective animal study in rabbits. Methods Three-centimeter-long sections of endotracheal tubes (ETT) were endoscopically placed in the subglottis and proximal trachea ...
      Read Full Article
    5. Quantitative Evaluation of Adult Subglottic Stenosis Using Intraoperative Long-range Optical Coherence Tomography

      Quantitative Evaluation of Adult Subglottic Stenosis Using Intraoperative Long-range Optical Coherence Tomography
      Objectives: To determine the feasibility of long-range optical coherence tomography (LR-OCT) as a tool to intraoperatively image and measure the subglottis and trachea during suspension microlaryngoscopy before and after endoscopic treatment of subglottic stenosis (SGS). Methods: Long-range optical coherence tomography of the adult subglottis and trachea was performed during suspension microlaryngoscopy before and after endoscopic treatment for SGS. The anteroposterior and transverse diameters, cross-sectional area (CSA), distance from the vocal ...
      Read Full Article
    6. Measurement of ciliary beat frequency using ultra-high resolution optical coherence tomography

      Measurement of ciliary beat frequency using ultra-high resolution optical coherence tomography
      Ciliated epithelial cells populate up to 80% of the surface area of the human airway and are responsible for mucociliary transport, which is the key protective mechanism that provides the first line of defense in the respiratory tract. Cilia beat in a rhythmic pattern and may be easily affected by allergens, pollutants, and pathogens, altering ciliary beat frequency (CBF) subsequently. Diseases including cystic fibrosis, chronic obstructive pulmonary disease, and primary ...
      Read Full Article
    7. In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography

      In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography
      Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have ...
      Read Full Article
    8. Long-Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Long-Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury
      Rationale: Subglottic edema and acquired subglottic stenosis are potentially airway-compromising sequelae in neonates following endotracheal intubation. At present, no imaging modality is capable of in vivo diagnosis of subepithelial airway wall pathology as signs of intubation-related injury. Objectives: To use Fourier domain long-range optical coherence tomography (LR-OCT) to acquire micrometer-resolution images of the airway wall of intubated neonates in a neonatal intensive care unit setting and to analyze images for ...
      Read Full Article
    9. Imaging of the internal nasal valve using long-range Fourier domain optical coherence tomography

      Imaging of the internal nasal valve using long-range Fourier domain optical coherence tomography
      Objectives/Hypothesis To evaluate for the first time the feasibility and methodology of long-range Fourier domain optical coherence tomography (LR-OCT) imaging of the internal nasal valve (INV) area in healthy individuals. Study Design Prospective individual cohort study. Methods For 16 individuals, OCT was performed in each nare. The angle and the cross-sectional area of the INV were measured. OCT images were compared to corresponding digital pictures recorded with a flexible ...
      Read Full Article
    10. Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema

      Spatiotemporal correlation of optical coherence tomography in-vivo images of rabbit airway for the diagnosis of edema
      Detection of an early stage of subglottic edema is vital for airway management and prevention of stenosis, a life-threatening condition in critically ill neonates. As an observer for the task of diagnosing edema in vivo , we investigated spatiotemporal correlation (STC) of full-range optical coherence tomography (OCT) images acquired in the rabbit airway with experimentally simulated edema. Operating the STC observer on OCT images generates STC coefficients as test statistics for ...
      Read Full Article
    11. Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury

      Long Range Optical Coherence Tomography of the Neonatal Upper Airway for Early Diagnosis of Intubation-related Subglottic Injury
      Subglottic edema and acquired subglottic stenosis are potentially airway -compromising sequelae in neonates following endotracheal intubation . At present, no imaging modality is capable of in vivo diagnosis of subepithelial airway wall pathology as signs of intubation - related injury . OBJECTIVES: To use Fourier domain long - range optical coherence tomography (LR-OCT) to acquire micrometer-resolution images of the airway wall of intubated neonates in a neonatal intensive care unit (NICU) setting and to ...
      Read Full Article
    12. Measurement of ciliary beat frequency using Doppler optical coherence tomography

      Measurement of ciliary beat frequency using Doppler optical coherence tomography
      Background Measuring ciliary beat frequency (CBF) is a technical challenge and difficult to perform in vivo. Doppler optical coherence tomography (D-OCT) is a mesoscopic noncontact imaging modality that provides high-resolution tomographic images and detects micromotion simultaneously in living tissues. In this work we used D-OCT to measure CBF in ex vivo tissue as the first step toward translating this technology to clinical use. Methods Fresh ex vivo samples of rabbit ...
      Read Full Article
    13. Intraoperative long range optical coherence tomography as a novel method of imaging the pediatric upper airway before and after adenotonsillectomy

      Intraoperative long range optical coherence tomography as a novel method of imaging the pediatric upper airway before and after adenotonsillectomy
      Background/Objectives While upper airway obstruction is a common problem in the pediatric population, the first-line treatment, adenotonsillectomy, fails in up to 20% of patients. The decision to proceed to surgery is often made without quantitative anatomic guidance. We evaluated the use of a novel technique, long-range optical coherence tomography (LR-OCT), to image the upper airway of children under general anesthesia immediately before and after tonsillectomy and/or adenoidectomy. We ...
      Read Full Article
    14. Long-range Fourier domain optical coherence tomography of the pediatric subglottis

      Long-range Fourier domain optical coherence tomography of the pediatric subglottis
      Background Acquired subglottic stenosis (SGS) most commonly results from prolonged endotracheal intubation and is a diagnostic challenge in the intubated child. At present, no imaging modality allows for in vivo characterization of subglottic microanatomy to identify early signs of acquired SGS while the child remains intubated. Fourier domain optical coherence tomography (FD-OCT) is a minimally invasive, light-based imaging modality which provides high resolution, three dimensional (3D) cross-sectional images of biological ...
      Read Full Article
    15. Pediatric Sleep-Related Breathing Disorders: Advances in imaging and computational modeling.

      Pediatric Sleep-Related Breathing Disorders: Advances in imaging and computational modeling.
      We understand now that sleep of sufficient length and quality is required for good health. This is particularly true for infants and children, who have the added physiologic task of growth and development, as compared to their adult counterparts. Sleep-related breathing disorders (SRBDs) are common in childhood and if unrecognized and not treated can result in significant morbidity. For example, children with obstructive sleep apnea (OSA) can exhibit behavioral, mood ...
      Read Full Article
    16. 1-15 of 46 1 2 3 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Brian J. F. Wong

    Brian J. F. Wong

    Brian J. F. Wong, MD, is with the Department of Otolaryngology – Head and Neck Surgery, and with the Beckman Laser Institute, and the Department of Biomedical Engineering at the University of California at Irvine.