1. Brian C. Wilson

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    1. Mentioned In 18 Articles

    2. Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography

      Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography
      Melanoma is the most aggressive type of skin cancer, with significant risk of fatality. Due to its pigmentation, light-based imaging and treatment techniques are limited to near the tumor surface, which is inadequate, for example, to evaluate the microvascular density that is associated with prognosis. White-light diffuse reflectance spectroscopy (DRS) and near-infrared optical coherence tomography (OCT) were used to evaluate the effect of a topically applied optical clearing agent (OCA ...
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    3. Method for identifying malignancies in barrett's esophagus using white light endoscopy

      Method for identifying malignancies in barrett's esophagus using white light endoscopy
      A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume T.sub.HB and oxygenation SO.sub.2. A pull-back approach of spectral data ...
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    4. Wide-field optical coherence tomography (WF-OCT) for near real-time, point-of-care assessment of margin status in breast-conserving surgery specimens: Results of a feasibility study at a high-volume single-centre

      Wide-field optical coherence tomography (WF-OCT) for near real-time, point-of-care assessment of margin status in breast-conserving surgery specimens: Results of a feasibility study at a high-volume single-centre
      Wide-Field Optical Coherence Tomography (WF-OCT) is a non-destructive, non-contact light imaging modality capable of label-free visualization of the internal microscopic architecture of breast tissue specimens. Its unique combination of high-resolution imaging in near real-time with tissue penetration depths approaching 2-mm makes it a promising imaging modality for obtaining detailed surgical margin status in breast-conserving surgery (BCS) specimens. A prototype WF-OCT imaging platform developed by Perimeter Medical Imaging, Inc. (Toronto, Canada ...
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    5. The potential use of Optical Coherence Tomography for intraoperative breast tumour margin width estimation

      The potential use of Optical Coherence Tomography for intraoperative breast tumour margin width estimation
      Total mastectomy and lumpectomy with radiation have been shown to have equivalent patient outcomes, which has likely contributed to the more widespread adoption of breast conserving surgery (BCS) procedures. Assessment of breast lumpectomy margin widths in both an accurate and timely manner is essential to successful breast conservation procedures. Current BCS methodologies have been reported to result in reoperation rates of up to 2060%, which represents a significant and unmet ...
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    6. Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit

      Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit
      Abstract: Advances in swept source laser technology continues to increase the imaging speed of swept-source optical coherence tomography (SS-OCT) systems. These fast imaging speeds are ideal for microvascular detection schemes, such as speckle variance (SV), where interframe motion can cause severe imaging artifacts and loss of vascular contrast. However, full utilization of the laser scan speed has been hindered by the computationally intensive signal processing required by SS-OCT and SV ...
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    7. Optical Coherence Tomography Used $500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What’s to Come?

      Optical Coherence Tomography Used $500M of Federally Funded Research Over The Past Decade: How was it Used, What was Accomplished, and What’s to Come?
      The field of optical coherence tomography (OCT) has blossomed dramatically since some of the first work by various researchers around the world in the late 1980s and early 1990s. Since then there have been dozens of companies created, hundreds of research groups working on OCT, thousands of research articles published, millions of patients scanned with OCT, hundreds of millions of venture capital and corporate R&D dollars invested, hundreds of ...
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    8. Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010

      Optical Coherence Tomography in Canada One-Day Symposium September 28, 2010
      The Industrial Materials Institute (IMI) organizes a one-day symposium on Optical Coherence Tomography (OCT) on Tuesday September 28, 2010, at Université Laval (Quebec City). The goals of the symposium are to increase networking between research groups and to provide interested parties an overview of the current status of OCT research in Canada.
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    9. Postdoctoral Fellow Positions at Ryerson University

      Postdoctoral Fellow Positions at Ryerson University
      Two Postdoctoral Fellow positions are offered jointly by the Biophotonics and Bioengineering Laboratory at Dept. Electrical & Computer Engineering, Ryerson University, and the Division of Biophysics and Imaging at Ontario Cancer Institute, University Health Network, under the supervision of Drs. Victor Yang and Brian Wilson. The positions are funded by the Canada Research Chair program and the Canadian Foundation of Innovation to support development of translational biomedical engineering technologies involving photonics ...
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    10. Interstitial Doppler Optical Coherence Tomography as a Local Tumor Necrosis Predictor in Photodynamic Therapy of Prostatic Carcinoma: An In vivo Study

      ...University, and 5 Imaging Research, Sunnybrook Health Sciences Center, Toronto, Canada Requests for reprints: Brian C. Wilson, Ontario Cancer Institute/University Health Network, Department of Medical Biophysics, Univers...
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    11. Advanced Photodynamic Therapy

      Photodynamic therapy (PDT) is the use of drugs (photosensitizers) that are activated by visible or near infrared light to produce specific biological effects in cells or tissues [1]. The basic steps in a PDT treatment are application of the photosensitizer (systemically or topically), a time interval to allow for photosensitizer accumulation in the target diseased tissue or cells, and illumination of the target area or volume with light of an ...
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    12. 1-15 of 18 1 2 »
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  2. About Brian C. Wilson

    Brian C. Wilson

    Dr. Brian C. Wilson is a professor at the Department of Medical Biophysics at the University of Toronto and also involved with Ontario Cancer Institute / Princess Margaret Hospital.