1. Brett E. Bouma

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    1. Mentioned In 198 Articles

    2. Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium

      Quantitative depolarization measurements for fiber‐based polarization‐sensitive optical frequency domain imaging of the retinal pigment epithelium
      A full quantitative evaluation of the depolarization of light may serve to assess concentrations of depolarizing particles in the retinal pigment epithelium and to investigate their role in retinal diseases in the human eye. Optical coherence tomography (OCT) and optical frequency domain imaging (OFDI) use spatial incoherent averaging to compute depolarization. Depolarization depends on accurate measurements of the polarization states at the receiver but also on the polarization state incident ...
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    3. Volumetric non-local-means based speckle reduction for optical coherence tomography

      Volumetric non-local-means based speckle reduction for optical coherence tomography
      We present a novel tomographic non-local-means based despeckling technique, TNode, for optical coherence tomography. TNode is built upon a weighting similarity criterion derived for speckle in a three-dimensional similarity window. We present an implementation using a two-dimensional search window, enabling the despeckling of volumes in the presence of motion artifacts, and an implementation using a three-dimensional window with improved performance in motion-free volumes. We show that our technique provides effective ...
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    4. NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer

      NinePoint Medical Appoints Eman Namati, Ph.D., to Chief Executive Officer
      ...ging systems at Massachusetts General Hospital. He worked with Professors Guillermo Tearney, M.D., Ph.D., and Brett Bouma, Ph.D. on the OCT technology that was licensed to NinePoint Medical. Dr. Namati holds a Ph.D. in B...
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    5. Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography

      Robust wavenumber and dispersion calibration for Fourier-domain optical coherence tomography
      Many Fourier-domain optical coherence tomography (FD-OCT) systems sample the interference fringes with a non-uniform wavenumber ( k ) interval, introducing a chirp to the signal that depends on the path length difference underlying each fringe. A dispersion imbalance between sample and reference arms also generates a chirp in the fringe signal which, in contrast, is independent of depth. Fringe interpolation to obtain a signal linear in k and compensate dispersion imbalance is ...
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    6. Complex differential variance angiography with noise-bias correction for optical coherence tomography of the retina

      Complex differential variance angiography with noise-bias correction for optical coherence tomography of the retina
      Complex differential variance (CDV) provides phase-sensitive angiographic imaging for optical coherence tomography (OCT) with immunity to phase-instabilities of the imaging system and small-scale axial bulk motion. However, like all angiographic methods, measurement noise can result in erroneous indications of blood flow that confuse the interpretation of angiographic images. In this paper, a modified CDV algorithm that corrects for this noise-bias is presented. This is achieved by normalizing the CDV signal ...
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    7. Symposium on Advances in Biomedical Polarimetry, March 12, 2018 in Boston

      Symposium on Advances in Biomedical Polarimetry, March 12, 2018 in Boston
      The Center for Biomedical OCT and Research (CBORT) is hosting the Advances in Biomedical Polarimetry with OCT symposium, taking place on Monday March 12, 2018 in Boston. The 1-day program is designed to provide an understanding of the latest PS-OCT instrumentation and signal processing techniques as well as present the use of PS-OCT in numerous biomedical application areas. We anticipate an interdisciplinary group of approximately 125 scientists, engineers, physicists, clinicians ...
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    8. Prediction of scar size in rats six months after burns based on early post injury polarization-sensitive optical frequency domain imaging

      Prediction of scar size in rats six months after burns based on early post injury polarization-sensitive optical frequency domain imaging
      Hypertrophic scars remain a major clinical problem in the rehabilitation of burn survivors and lead to physical, aesthetic, functional, psychological, and social stresses. Prediction of healing outcome and scar formation is critical for deciding on the best treatment plan. Both subjective and objective scales have been devised to assess scar severity. Whereas scales of the first type preclude cross-comparison between observers, those of the second type are based on imaging ...
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    9. Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images

      Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
      According to an exemplary embodiment of the present disclosure, apparatus and method can be provided for generating information for at least one structure. For example, using at least one first arrangement, it is possible to receive at least one first radiation from the at least one structure and at least one second radiation from a reference, and interfere the first and second radiations to generate at least one third radiation ...
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    10. Depolarization signatures map gold nanorods within biological tissue

      Depolarization signatures map gold nanorods within biological tissue
      Owing to their electromagnetic properties, tunability and biocompatibility, gold nanorods are being investigated as multifunctional probes for a range of biomedical applications. However, detection beyond the reach of traditional fluorescence and two-photon approaches and quantitation of their concentration in biological tissue remain challenging tasks in microscopy. Here, we show how the size and aspect ratio that impart gold nanorods with their plasmonic properties also make them a source of entropy ...
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    11. Diagnostic Capability of Peripapillary 3D Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans

      Diagnostic Capability of Peripapillary 3D Retinal Nerve Fiber Layer Volume for Glaucoma Using Optical Coherence Tomography Volume Scans
      Purpose To determine the diagnostic capability of peripapillary 3-dimensional (3D) retinal nerve fiber layer (RNFL) volume measurements from spectral domain optical coherence tomography (OCT) volume scans for open angle glaucoma (OAG). Design Assessment of diagnostic accuracy. Methods Setting: Academic clinical setting. Study population : 180 patients (113 OAG and 67 normal subjects). Observation procedures : One eye per subject was included. Peripapillary 3D RNFL volumes were calculated for global, quadrant, and sector ...
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    12. Massachusetts General Hospital Receives NIH Grant for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant for Low Risk In VIvo Optical Diagnosis of IPF with Optical Imaging
      ...lly dedicated to supporting Dr. Hariri in this proposal and her transition to independence. In addition, Drs. Brett Bouma and Thomas Colby will serve on Dr. Hariri's research advisory committee and provide further respec...
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    13. Intravascular imaging for characterization of coronary atherosclerosis

      Intravascular imaging for characterization of coronary atherosclerosis
      This short review surveys recent developments in coronary intravascular imaging technologies. We present an outline of the applications of intravascular imaging for guidance of percutaneous coronary interventions and imaging of atherosclerosis, along with emerging clinical evidence for use. Imaging of tissue composition is important for understanding the relation between the presence of a lesion and clinical sequelae. We describe the recent innovations to enable imaging of unstable atherosclerotic plaques, focusing ...
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    14. 1-15 of 198 1 2 3 4 ... 12 13 14 »
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  2. About Brett E. Bouma

    Brett E. Bouma

    Brett E. Bouma is an Associate Professor at the Wellman Center for Photomedicine at the Massachusetts General Hospital. Research focus is on the development of novel optical instrumentation and methods that address challenges in clinical medicine and basic biological research. Light is uniquely well suited for non-invasively interrogating the microscopic structure, molecular composition, and biomechanical properties of biological tissues. Realizing these capabilities in a practical instrument requires a multidisciplinary approach, focused on specific challenges, that integrates advanced concepts from physics, engineering and material science with biology and clinical experience. The location of our laboratory on the campus of a major clinical research hospital fosters regular interaction across these disciplinary areas.

  3. Quotes

    1. We expect to see commercial devices available in a one- to two-year time frame.
      In America wakes up to 3-D human coronary artery imaging
    2. For diagnosing early-stage disease, the clinician has been basically looking for a needle in a haystack; so sampling only a few microscopic points of an organ, as we could with OCT, is clearly not sufficient.
      In Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces
    3. One of the most exciting concepts would be to directly link OFDI with the delivery of therapy, such as laser treatment for early cancer.
      In Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces