1. Brett E. Bouma

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    1. Mentioned In 224 Articles

    2. Noise and bias in optical coherence tomography intensity signal decorrelation

      Noise and bias in optical coherence tomography intensity signal decorrelation
      Functional optical coherence tomography (OCT) imaging based on the decorrelation of the intensity signal has been used extensively in angiography and is finding use in flowmetry and therapy monitoring. In this work, we present a rigorous analysis of the autocorrelation function, introduce the concepts of contrast bias, statistical bias and variability, and identify the optimal definition of the second-order autocorrelation function (ACF) g (2) to improve its estimation from limited ...
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    3. Forward multiple scattering dominates speckle decorrelation in whole-blood flowmetry using optical coherence tomography

      Forward multiple scattering dominates speckle decorrelation in whole-blood flowmetry using optical coherence tomography
      Quantitative blood flow measurements using optical coherence tomography (OCT) have a wide potential range of medical research and clinical applications. Flowmetry based on the temporal dynamics of the OCT signal may have the ability to measure three-dimensional flow profiles regardless of the flow direction. State-of-the-art models describing the OCT signal temporal statistics are based on dynamic light scattering (DLS), a model which is inherently limited to single scattering regimes. DLS ...
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    4. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume

      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume
      Purpose : To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT) Methods : Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for ...
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    5. Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm

      Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm
      In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 m wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these ...
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    6. Intravascular Polarimetry in Patients With Coronary Artery Disease

      Intravascular Polarimetry in Patients With Coronary Artery Disease
      Objectives The aims of this first-in-human pilot study of intravascular polarimetry were to investigate polarization properties of coronary plaques in patients and to examine the relationship of these features with established structural characteristics available to conventional optical frequency domain imaging (OFDI) and with clinical presentation. Background Polarization-sensitive OFDI measures birefringence and depolarization of tissue together with conventional cross-sectional optical frequency domain images of subsurface microstructure. Methods Thirty patients undergoing polarization-sensitive ...
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    7. Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis

      Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis
      The microscopic tissue structure and organization influence the polarization of light. Intravascular polarimetry leverages this compelling intrinsic contrast mechanism by using polarization-sensitive optical frequency domain imaging to measure the polarization properties of the coronary arterial wall. Tissues rich in collagen and smooth muscle cells appear birefringent, while the presence of lipid causes depolarization, offering quantitative metrics related to the presence of important components of coronary atherosclerosis. Here, we review the ...
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    8. Highly-stable, multi-megahertz circular-ranging optical coherence tomography at 1.3 µm based on a chirped fiber Bragg grating

      Highly-stable, multi-megahertz circular-ranging optical coherence tomography at 1.3 µm based on a chirped fiber Bragg grating
      In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 m wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these ...
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    9. Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography

      Constrained polarization evolution simplifies depth-resolved retardation measurements with polarization-sensitive optical coherence tomography
      We observed that the polarization state of light after round-trip propagation through a birefringent medium frequently aligns with the employed input polarization state mirrored by the horizontal plane of the Poincar sphere. We explored the predisposition for this mirror state and evidence that it constrains the evolution of polarization states as a function of the round-trip depth into weakly scattering birefringent samples, as measured with polarization-sensitive optical coherence tomography (PS-OCT ...
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    10. Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography

      Distinguishing Tumor from Associated Fibrosis to Increase Diagnostic Biopsy Yield with Polarization-Sensitive Optical Coherence Tomography
      Purpose: With recent advancements in personalized medicine, biopsies must contain sufficient tumor for histologic diagnosis and molecular testing. However, inadvertent biopsy of tumor-associated fibrosis compromises tumor yield, resulting in delayed diagnoses and/or repeat procedures when additional tumor is needed. The ability to differentiate tumor from fibrosis intraprocedurally during biopsy could significantly increase tumor yield. Polarization-sensitive optical coherence tomography (PS-OCT) is an imaging modality that is endoscope- and/or needle-compatible ...
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    11. Massachusetts General Hospital Receives NIH Grant for Low Risk In Vivo Diagnosis of IPF with Optical Imaging

      Massachusetts General Hospital Receives NIH Grant  for Low Risk In Vivo Diagnosis of IPF with Optical Imaging
      ...lly dedicated to supporting Dr. Hariri in this proposal and her transition to independence. In addition, Drs. Brett Bouma and Thomas Colby will serve on Dr. Hariri's research advisory committee and provide further respec...
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    12. Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobroncial Optical Coherence Tomography
      ...esearch, having been directly involved in seminal studies aimed at translating OCT imaging to the clinic. Dr. Brett Bouma, co-primary mentor, of the Wellman Center for Photomedicine at MGH is one of the key progenitors o...
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    13. Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix

      Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix
      ...IEEE Photonics J. 10(2), 1–12 (2018). [Crossref] N. Lippok, B. Braaf, M. Villiger, W. Y. Oh, B. J. Vakoc, and B. E. Bouma, “Quantitative depolarization measurements for fiber-based polarization-sensitive optical frequenc...
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    14. 1-15 of 224 1 2 3 4 ... 13 14 15 »
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  2. About Brett E. Bouma

    Brett E. Bouma

    Brett E. Bouma is an Associate Professor at the Wellman Center for Photomedicine at the Massachusetts General Hospital. Research focus is on the development of novel optical instrumentation and methods that address challenges in clinical medicine and basic biological research. Light is uniquely well suited for non-invasively interrogating the microscopic structure, molecular composition, and biomechanical properties of biological tissues. Realizing these capabilities in a practical instrument requires a multidisciplinary approach, focused on specific challenges, that integrates advanced concepts from physics, engineering and material science with biology and clinical experience. The location of our laboratory on the campus of a major clinical research hospital fosters regular interaction across these disciplinary areas.

  3. Quotes

    1. We expect to see commercial devices available in a one- to two-year time frame.
      In America wakes up to 3-D human coronary artery imaging
    2. For diagnosing early-stage disease, the clinician has been basically looking for a needle in a haystack; so sampling only a few microscopic points of an organ, as we could with OCT, is clearly not sufficient.
      In Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces
    3. One of the most exciting concepts would be to directly link OFDI with the delivery of therapy, such as laser treatment for early cancer.
      In Optical Technique Provides Improved 'Virtual Biopsies' Of Internal Surfaces