1. Brendan F. Kennedy

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    1. Mentioned In 45 Articles

    2. OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery

      OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery
      ...as the potential to accurately delineate malignant tissue at the microscopic level. The engineers include Dr. Brendan Kennedy, Dr. Robert McLaughlin, Dr. Kelsey Kennedy and Professor David Sampson from the School of Elec...
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    3. Microscale imaging of breast tumor margins using optical coherence elastography

      Microscale imaging of breast tumor margins using optical coherence elastography
      A variant of optical coherence elastography offers a promising method of distinguishing between tumor and breast tissue in lumpectomy specimens in an intraoperative time frame. 1 May 2017, SPIE Newsroom. DOI: 10.1117/2.1201702.006873 Breast-conserving surgery is the most common surgical procedure used in the treatment of early-stage breast cancer. 1 The aim of this surgery is to remove all malignant tissue such that the surgical margin is ...
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    4. The emergence of optical elastography in biomedicine

      The emergence of optical elastography in biomedicine
      Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields ...
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    5. Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

      Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
      Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the ...
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    6. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes
      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale ...
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    7. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins
      Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a ...
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    8. Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer

      Promising New Imaging Tool Allows Surgeons to Detect Malignant Tissue During Breast-Conserving Surgery for Breast Cancer
      ...n, Lixin Chin, Philip Wijesinghe, Rodney W. Kirk, Bruce Latham, David D. Sampson, Christobel M. Saunders, and Brendan F. Kennedy, "Wide-field optical coherence micro-elastography for intraoperative assessment of human br...
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    9. Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography

      Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography
      Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may ...
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    10. Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment

      Investigation of optical attenuation imaging using optical coherence tomography for monitoring of scars undergoing fractional laser treatment
      En face 2D OCT attenuation coefficient map of a treated immature scar derived from the pre-treatment (top) and the post-treatment (bottom) scans. (Vasculature (black) is masked out.) The scale bars are 0.5 mm. We demonstrate the use of the near-infrared attenuation coefficient, measured using optical coherence tomography (OCT), in longitudinal assessment of hypertrophic burn scars undergoing fractional laser treatment. The measurement method incorporates blood vessel detection by speckle decorrelation ...
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    11. Quantifying the influence of Bessel beams on image quality in optical coherence tomography

      Quantifying the influence of Bessel beams on image quality in optical coherence tomography
      Light scattered by turbid tissue is known to degrade optical coherence tomography (OCT) image contrast progressively with depth. Bessel beams have been proposed as an alternative to Gaussian beams to image deeper into turbid tissue. However, studies of turbid tissue comparing the image quality for different beam types are lacking. We present such a study, using numerically simulated beams and experimental OCT images formed by Bessel or Gaussian beams illuminating ...
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    12. Ultrahigh-resolution optical coherence elastography

      Ultrahigh-resolution optical coherence elastography
      Visualizing stiffness within the local tissue environment at the cellular and subcellular level promises to provide insight into the genesis and progression of disease. In this Letter, we propose ultrahigh-resolution optical coherence elastography (UHROCE), and demonstrate 3D imaging of local axial strain of tissues undergoing compressive loading. We combine optical coherence microscopy (OCM) and phase-sensitive detection of local tissue displacement to produce strain elastograms with resolution (
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    13. Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library

      Optical coherence tomography for longitudinal monitoring of vasculature in scars treated with laser fractionation - Gong - 2015 - Journal of Biophotonics - Wiley Online Library
      En face optical coherence tomography vasculature images pre-treatment (top) and 20 weeks after the first laser treatment (bottom) of a mature burn scar. Arrows mark the same vessel pattern. This study presents the first in vivo longitudinal assessment of scar vasculature in ablative fractional laser treatment using optical coherence tomography (OCT). A method based on OCT speckle decorrelation was developed to visualize and quantify the scar vasculature over the treatment ...
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    14. Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue
      Accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high re-excision rates without resorting to the removal of excess healthy tissue. Optical coherence micro-elastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to micro-scale variations of the mechanical properties ...
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  2. About Brendan F. Kennedy

    Brendan F. Kennedy

    Brendan Kennedy is a researcher at the Optical and Biomedical Engineering Laboratory at the University of Western Australia.  Dr. Kennedy is currently working on techniques to measure the elastic properties of tissue, the investigation of speckle phenomena related to OCT and the development of OCT system technology. His background is in photonics, having completed his Ph.D in Dublin City University, Ireland. His topic was in the field of all-optical signal processing using semiconductor optical amplifiers. Prior to joining OBEL Brendan held a lecturing position in Universidad de Santiago de Chile where his research continued to focus on semiconductor optical amplifiers, concentrating mainly on implementing four-wave mixing as a means to perform all-optically signal processing.