1. Brendan F. Kennedy

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    1. Mentioned In 56 Articles

    2. Method and system for characterising biological tissue

      Method and system for characterising biological tissue
      The present disclosure provides a method for characterizing a region of interest within or between biological tissue. The method comprises inserting at least a portion of a probe into the region of interest and directing electromagnetic radiation to the region of interest and receiving electromagnetic radiation from the region of interest using the probe in a direction that is transversal to a length of the probe. Further, the method comprises ...
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    3. Finger-mounted quantitative micro-elastography

      Finger-mounted quantitative micro-elastography
      We present a finger-mounted quantitative micro-elastography (QME) probe, capable of measuring the elasticity of biological tissue in a format that avails of the dexterity of the human finger. Finger-mounted QME represents the first demonstration of a wearable elastography probe. The approach realizes optical coherence tomography-based elastography by focusing the optical beam into the sample via a single-mode fiber that is fused to a length of graded-index fiber. The fiber is ...
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    4. Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

      Analysis of spatial resolution in phase-sensitive compression optical coherence elastography
      Optical coherence elastography (OCE) is emerging as a method to image the mechanical properties of tissue on the microscale. However, the spatial resolution, a main advantage of OCE, has not been investigated and is not trivial to evaluate. To address this, we present a framework to analyze resolution in phase-sensitive compression OCE that incorporates the three main determinants of resolution: mechanical deformation of the sample, detection of this deformation using ...
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    5. Handheld optical palpation of turbid tissue with motion-artifact correction

      Handheld optical palpation of turbid tissue with motion-artifact correction
      Handheld imaging probes are needed to extend the clinical translation of optical elastography to in vivo applications, yet such probes have received little attention. In this paper, we present the first demonstration of optical palpation using a handheld probe. Optical palpation is a variant of optical elastography that uses three-dimensional optical coherence tomography (3D-OCT) to provide maps of stress at the tissue surface under static compression. Using this technique, stiff ...
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    6. Optical palpation for the visualization of tumor in human breast tissue

      Optical palpation for the visualization of tumor in human breast tissue
      Accurate and effective removal of tumor in one operation is an important goal of breast‐conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low‐resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at ...
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    7. Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review

      Optical Coherence Tomography of the Tympanic Membrane and Middle Ear: A Review
      Objective To evaluate the recent developments in optical coherence tomography (OCT) for tympanic membrane (TM) and middle ear (ME) imaging and to identify what further development is required for the technology to be integrated into common clinical use. Data Sources PubMed, Embase, Google Scholar, Scopus, and Web of Science. Review Methods A comprehensive literature search was performed for English language articles published from January 1966 to January 2018 with the ...
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    8. Wide-field quantitative micro-elastography of human breast tissue

      Wide-field quantitative micro-elastography of human breast tissue
      Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical ...
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    9. Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta

      Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta
      Cellular-scale imaging of the mechanical properties of tissue has helped to reveal the origins of disease; however, cellular-scale resolution is not readily achievable in intact tissue volumes. Here, we demonstrate volumetric imaging of Youngs modulus using ultrahigh-resolution optical coherence elastography, and apply it to characterizing the stiffness of mouse aortas. We achieve isotropic resolution of better than 15 m over a 1-mm lateral field of view through the entire depth ...
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    10. OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery

      OncoRes Medical backed by MRCF to develop innovative imaging technology for breast cancer surgery
      ...as the potential to accurately delineate malignant tissue at the microscopic level. The engineers include Dr. Brendan Kennedy, Dr. Robert McLaughlin, Dr. Kelsey Kennedy and Professor David Sampson from the School of Elec...
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    11. Microscale imaging of breast tumor margins using optical coherence elastography

      Microscale imaging of breast tumor margins using optical coherence elastography
      A variant of optical coherence elastography offers a promising method of distinguishing between tumor and breast tissue in lumpectomy specimens in an intraoperative time frame. 1 May 2017, SPIE Newsroom. DOI: 10.1117/2.1201702.006873 Breast-conserving surgery is the most common surgical procedure used in the treatment of early-stage breast cancer. 1 The aim of this surgery is to remove all malignant tissue such that the surgical margin is ...
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    12. The emergence of optical elastography in biomedicine

      The emergence of optical elastography in biomedicine
      Optical elastography, the use of optics to characterize and map the mechanical properties of biological tissue, involves measuring the deformation of tissue in response to a load. Such measurements may be used to form an image of a mechanical property, often elastic modulus, with the resulting mechanical contrast complementary to the more familiar optical contrast. Optical elastography is experiencing new impetus in response to developments in the closely related fields ...
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  2. About Brendan F. Kennedy

    Brendan F. Kennedy

    Brendan Kennedy is a researcher at the Optical and Biomedical Engineering Laboratory at the University of Western Australia.  Dr. Kennedy is currently working on techniques to measure the elastic properties of tissue, the investigation of speckle phenomena related to OCT and the development of OCT system technology. His background is in photonics, having completed his Ph.D in Dublin City University, Ireland. His topic was in the field of all-optical signal processing using semiconductor optical amplifiers. Prior to joining OBEL Brendan held a lecturing position in Universidad de Santiago de Chile where his research continued to focus on semiconductor optical amplifiers, concentrating mainly on implementing four-wave mixing as a means to perform all-optically signal processing.