1. Brad Fortune

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    1. Mentioned In 29 Articles

    2. Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.

      Glaucoma Specialist Detection of Optical Coherence Tomography Suspicious Rim Tissue in Glaucoma and Glaucoma Suspect Eyes.
      Purpose To assess glaucoma specialists detection of optic nerve head (ONH) rim tissue that is thin by optical coherence tomography (OCT) criteria. Design Reliability analysis Methods 5 clinicians marked the disc margin (DM) and rim margin (RM) on stereo-photos of 151 glaucoma or glaucoma suspect eyes obtained within 3 months of OCT imaging. The photo and OCT infrared image for each eye were colocalized and regionalized into twelve sectors relative ...
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    3. Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma

      Optical coherence tomography evaluation of the optic nerve head neuro‐retinal rim in glaucoma
      Clinical examination of the optic disc is a fundamental component of any ophthalmic evaluation, but it is especially important for diagnosis and management of glaucoma. The purpose of this article is to: (1) review the limitations inherent to clinical examination; (2) outline the rationale for adopting into clinical practice quantitative measures of the optic nerve head neuro‐retinal rim tissue integrity derived from current optical coherence tomography imaging approaches; (3 ...
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    4. A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease

      A Comparison of En Face Optical Coherence Tomography and Fundus Autofluorescence in Stargardt Disease
      Purpose : To compare morphologic changes on en face images derived from wide-field swept-source optical coherence tomography (ssOCT) to hypo- and hyperautofluorescent (hypoAF, hyperAF) areas on short-wavelength autofluorescence (SW-AF), and near-infrared (NIR)-AF in recessive Stargardt disease (STGD1). Methods : Wide-field ssOCT cube scans were obtained from 16 patients (16 eyes). Averaged B-scans and SW-AF images were obtained using Spectralis HRA+OCT. NIR-AF images were obtained from 6 eyes. The inner/outer ...
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    5. Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma

      Automated segmentation errors when using optical coherence tomography to measure retinal nerve fiber layer thickness in glaucoma
      Purpose To characterize the error of optical coherence tomography (OCT) measurements of retinal nerve fiber layer (RNFL) thickness when using automated retinal layer segmentation algorithms without manual refinement. Design: cross-sectional study Methods Setting: glaucoma clinical practice. Study Population: 3490 scans from 412 eyes of 213 individuals with a diagnosis of glaucoma or glaucoma suspect. Observational Procedures: We used spectral domain OCT (Spectralis, Heidelberg Engineering, Heidelberg, Germany) to measure RNFL thickness ...
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    6. In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma

      In Vivo Detection of Laminar and Peripapillary Scleral Hypercompliance in Early Monkey Experimental Glaucoma
      Purpose : To compare optical coherence tomography (OCT) detected, optic nerve head (ONH) compliance within control and experimental glaucoma (EG) eyes of 15 monkeys at EG onset. Methods : Intraocular pressure (IOP) was chronically elevated in one eye of each animal using a laser. Experimental glaucoma onset was identified using confocal scanning laser tomography (CSLT). Optical coherence tomography ONH imaging (40 radial B-scans) was performed at 10 mm Hg before and after ...
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    7. Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma

      Comparing Optic Nerve Head Rim Width, Rim Area, and Peripapillary Retinal Nerve Fiber Layer Thickness to Axon Count in Experimental Glaucoma
      Purpose : We compare spectral-domain optical coherence tomography (SDOCT) measurements of minimum rim width (MRW), minimum rim area (MRA), and peripapillary retinal nerve fiber layer thickness (RNFLT) to complete orbital optic nerve axon counts in nonhuman primates (NHP) with unilateral experimental glaucoma (EG). Methods : Biweekly SDOCT measurements of MRW, MRA, and RNFLT were acquired under manometric IOP control (10 mm Hg) in 51 NHP during baseline (mean SD, 5.0 1 ...
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    8. Changes in Retinal Nerve Fiber Layer Reflectance Intensity as a Predictor of Functional Progression in Glaucoma

      Changes in Retinal Nerve Fiber Layer Reflectance Intensity as a Predictor of Functional Progression in Glaucoma
      Purpose : We determined whether longitudinal changes in retinal nerve fiber layer (RNFL) reflectance provide useful prognostic information about longitudinal changes in function in glaucoma. Methods : The reflectance intensity of each pixel within spectral-domain optical coherence tomography (SD-OCT) circle scans was extracted by custom software. A repeatability cohort comprising 53 eyes of 27 participants (average visual field mean deviation [MD] 1.65 dB) was tested five times within a few weeks ...
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    9. Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps

      Details of Glaucomatous Damage Are Better Seen on OCT En Face Images Than on OCT Retinal Nerve Fiber Layer Thickness Maps
      Purpose : High-resolution images of glaucomatous damage to the retinal nerve fiber layer (RNFL) were obtained with an adaptive optics-scanning light ophthalmoscope (AO-SLO) and used as a basis for comparisons between en face slab images and thickness maps derived from optical coherence tomography (OCT) scans. Methods : Wide-field (9 12 mm) cube scans were obtained with swept-source OCT (DRI-OCT) from six eyes of six patients. All eyes had a deep defect near ...
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    10. Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Age-related Differences in Longitudinal Structural Change by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma
      Purpose. To characterize age-related differences in the magnitude of Spectral Domain Optical Coherence Tomography (SDOCT) structural change in early experimental glaucoma (EG). Methods. Both eyes from 4 young (1.4 - 2.6 yrs) and 4 old (18.6 - 21.9 yrs) rhesus monkeys were imaged at least 3 times at baseline, and then every 2 weeks following laser-induced, chronic, unilateral IOP elevation until the onset of EG (Confocal Scanning Laser ...
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    11. The Effect of Age on Optic Nerve Axon Counts, SDOCT Scan Quality, and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in Rhesus Monkeys

      The Effect of Age on Optic Nerve Axon Counts, SDOCT Scan Quality, and Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in Rhesus Monkeys
      Purpose: To evaluate the effect of age on optic nerve axon counts, spectral-domain optical coherence tomography (SDOCT) scan quality, and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements in healthy monkey eyes. Methods: In total, 83 healthy rhesus monkeys were included in this study (age range: 1.226.7 years). Peripapillary RNFLT was measured by SDOCT. An automated algorithm was used to count 100% of the axons and measure their ...
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    12. Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma

      Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma
      Purpose. To determine if the detection of spectral domain optical coherence tomography (SDOCT) optic nerve head (ONH) change precedes the detection of Confocal Scanning Laser Tomography (CSLT) ONH surface, SDOCT retinal nerve fiber layer (RNFL), Scanning Laser Perimetry (SLP) and multifocal electroretinography (mfERG) change in 8 experimental glaucoma (EG) eyes. Methods. Both eyes from 8 monkeys were tested at least 3 times at baseline, and then every 2 weeks following ...
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    13. Correlating Perimetric Indices With Three Nerve Fiber Layer Thickness Measures

      Correlating Perimetric Indices With Three Nerve Fiber Layer Thickness Measures
      PURPOSE: To determine which of three estimates of retinal nerve fiber layer thickness (RNFLT) correlate best with visual field sensitivity measured using standard automated perimetry (SAP). METHODS: Data were collected from 400 eyes of 209 participants enrolled in the Portland Progression Project. These individuals ranged from high-risk suspects to having non-end-stage glaucoma. In each eye, three measures of average RNFLT (spectral domain optical coherence tomography [SDOCT], scanning laser polarimetry [SLP ...
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    14. Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma

      Onset and Progression of Peripapillary Retinal Nerve Fiber Layer (RNFL) Retardance Changes Occur Earlier Than RNFL Thickness Changes in Experimental Glaucoma
      ...ies, Devers Eye Institute and Legacy Research Institute, Legacy Health, Portland, Oregon 1. Correspondence: Brad Fortune, Associate Scientist, Devers Eye Institute, 1225 NE Second Avenue, Portland, OR 97232; bfortune{a...
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    15. Relationship between Orbital Optic Nerve Axon Counts and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomograph

      Relationship between Orbital Optic Nerve Axon Counts and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomograph
      Purpose: To determine the relationship between total optic nerve axon counts and peripapillary retinal nerve fiber layer thickness (RNFLT) measured in vivo by spectral domain optical coherence tomography (SDOCT). Methods: Twenty-two rhesus macaques had three or more baseline measurements in both eyes of peripapillary RNFLT made by SDOCT (Spectralis, Heidelberg Engineering GmbH). Laser photocoagulation was then applied to the trabecular meshwork of one eye to induce chronic unilateral IOP elevation ...
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  2. About Brad Fortune

    Brad Fortune

    Brad Fortune, O.D. Ph.D., is Director of Electrodiagnostic Services at Devers Eye Institute and Associate Scientist at the Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System. Portland Oregon.