1. Boston University

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    1. Mentioned In 83 Articles

    6. Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography

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      Normalized field autocorrelation function-based optical coherence tomography three-dimensional angiography
      Optical coherence tomography angiography (OCTA) has been widely used for ien face/i visualization of the microvasculature, but is challenged for real three-dimensional (3-D) topologic imaging due to the tail artifacts that appear below large vessels. Further, OCTA is generally incapable of differentiating descending arterioles from ascending venules. We introduce a normalized field autocorrelation function-based OCTA (ig/isub1/sub-OCTA), which minimizes the tail artifacts and is capable of distinguishing penetrating ...
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      Mentions: Boston University David A. Boas

    8. Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography

      Explore OSA | OSA Publishing
      Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography
      Biological functions rely on local microvasculature to deliver oxygen and nutrients and carry away metabolic waste. Alterations to local oxygenation levels are manifested in diseases including cancer, diabetes mellitus, etc. The ability to quantify oxygen saturation (sO 2 ) within microvasculature in vivo to assess local tissue oxygenation and metabolic function is highly sought after. Visible light optical coherence tomography (vis-OCT) angiography has shown promise in reaching this goal. However, achieving ...
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      Mentions: Northwestern University Vadim Backman Boston University

    9. Retinal blood flow reduction after panretinal photocoagulation in Type 2 diabetes mellitus: Doppler optical coherence tomography flowmeter pilot study

      Explore Journals | PLOS Ophthalmology
      Retinal blood flow reduction after panretinal photocoagulation in Type 2 diabetes mellitus: Doppler optical coherence tomography flowmeter pilot study
      ...PLoS ONE 13(11): e0207288. https://doi.org/10.1371/journal.pone.0207288 Editor: Ji Yi, Boston Medical Center, Boston University School of Medicine, UNITED STATES Received: June 17, 2018; Accepted: October 29, 2018; Publi...
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      Mentions: Topcon Medical Systems Masahiro Akiba Boston University

    10. Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21

      Explore Home - Springer Neurology
      Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21
      Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence microscopy (OCM) is higher resolution (i.e., 1.25 m) and is capable of detecting neurons. In a previous report, we compared the correspondence of OCM acquired imaging of neurons with traditional Nissl stained histology in entorhinal cortex layer ...
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      Mentions: Massachusetts Institute of Technology Massachusetts General Hospital Boston University

    12. Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography

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      Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography
      Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms. However, capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo. Here, we demonstrate a novel optical imaging system, Dual-band Dual-scan Inverse Spectroscopic Optical Coherence Tomography (D2- ISOCT), that, for the first time, can simultaneously obtain the following metrics in vivo using endogenous contrast: (1) capillary-level oxygen saturation ...
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      Mentions: Northwestern University Vadim Backman Boston University

    13. Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)

      Explore jove.com Ophthalmology
      Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy (oSLO) and Optical Coherence Tomography (OCT)
      While fluorescence imaging is widely used in ophthalmology, a large field of view (FOV) three-dimensional (3D) fluorescence retinal image is still a big challenge with the state-of-the-art retinal imaging modalities because they would require z-stacking to compile a volumetric dataset. Newer optical coherence tomography (OCT) and OCT angiography (OCTA) systems overcome these restrictions to provide three-dimensional (3D) anatomical and vascular images, but the dye-free nature of OCT cannot visualize leakage ...
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      Mentions: Boston University Ji Yi

    14. Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina

      Explore OSA | OSA Publishing Ophthalmology
      Fiber-based visible and near infrared optical coherence tomography (vnOCT) enables quantitative elastic light scattering spectroscopy in human retina
      Elastic light scattering spectroscopy (ELSS) has been proven a powerful method in measuring tissue structures with exquisite nanoscale sensitivity. However, ELSS contrast in the living human retina has been relatively underexplored, primarily due to the lack of imaging tools with a large spectral bandwidth. Here, we report a simple all fiber-based setup to implement dual-channel visible and near infrared (NIR) optical coherence tomography (vnOCT) for human retinal imaging, bridging over ...
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      Mentions: Boston University Ji Yi

    16. Unified description of three-dimensional optical diffraction microscopy: from transmission microscopy to optical coherence tomography: tutorial

      Explore OSA | OSA Publishing
      Unified description of three-dimensional optical diffraction microscopy: from transmission microscopy to optical coherence tomography: tutorial
      In this tutorial, we present a general model linking the data provided by any optical diffraction microscope to the sample permittivity. Our analysis is applicable to essentially all microscope configurations, in transmission or reflection mode, using scanning or full-field illumination, with or without interferometric measurements. We include also a generalization of our analysis to vector fields.
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      Mentions: Boston University
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  4. About Boston University

    Boston University

    Boston University (BU) is a private research university located in Boston, Massachusetts, United States. With more than 3,000 faculty members and nearly 30,000 students, Boston University is the fourth-largest private university in the United States of America.  Boston University Medical Campus (BUMC) is located in the historic South End of Boston and comprises the Boston University School of Medicine, the Boston University School of Public Health, the Goldman School of Dental Medicine, and the Boston University Graduate School of Medical Sciences. Boston Medical Center is a private, not for profit, 581-licensed bed academic medical center located in Boston's historic South End. The hospital is the primary teaching affiliate for Boston University School of Medicine. Emphasizing community-based care, Boston Medical Center with its mission to provide consistently accessible health services to all is the largest safety net hospital in New England.

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