1. Boston University

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    1. Mentioned In 66 Articles

    2. Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes

      Boston University Receives NIH Grant for Microscopic Imaging of Tissue Oxygen Delivery Altered by Microvascular Changes
      ... compromise tissue oxygenation? We will then relate these findings to clinically relevant imaging biomarkers. Boston University Receives a 2017 NIH Grant for $162,682 for Microscopic Imaging of Tissue Oxygen Delivery Alt...
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    3. Capillary red blood cell velocimetry by phase-resolved optical coherence tomography

      Capillary red blood cell velocimetry by phase-resolved optical coherence tomography
      We present a phase-resolved optical coherence tomography (OCT) method to extend Doppler OCT for the accurate measurement of the red blood cell (RBC) velocity in cerebral capillaries. OCT data were acquired with an M-mode scanning strategy (repeated A-scans) to account for the single-file passage of RBCs in a capillary, which were then high-pass filtered to remove the stationary component of the signal to ensure an accurate measurement of phase shift ...
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    4. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan

      Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan
      Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric structural and molecular imaging with cellular resolution in all three dimensions. Conventional 3D laser scanning fluorescence microscopy requires repeated optical sectioning to create z-stacks in depth. Here, the use ...
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    5. Improving graph-based OCT segmentation for severe pathology in retinitis pigmentosa patients

      Improving graph-based OCT segmentation for severe pathology in retinitis pigmentosa patients
      Three dimensional segmentation of macular optical coherence tomography (OCT) data of subjects with retinitis pigmentosa (RP) is a challenging problem due to the disappearance of the photoreceptor layers, which causes algorithms developed for segmentation of healthy data to perform poorly on RP patients. In this work, we present enhancements to a previously developed graph-based OCT segmentation pipeline to enable processing of RP data. The algorithm segments eight retinal layers in ...
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    6. Optical coherence tomography for non-invasive examination and conservation of cultural heritage objects

      Optical coherence tomography for non-invasive examination and conservation of cultural heritage objects
      Optical coherence tomography (OCT) has great potential for the examination of oil paintings, particularly for celebrated masterpieces by great artists in history. We developed an OCT system for large field of view (FOV), high definition (HD) imaging of oil paintings. To achieve large FOV, we translated the sample using a pair of high-precision linear motors and performed sequential volumetric imaging on adjacent, non-overlapping regions. Through 3D OCT imaging, the surface ...
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    7. High-definition optical coherence tomography imaging for noninvasive examination of heritage works

      High-definition optical coherence tomography imaging for noninvasive examination of heritage works
      Cultural heritage works, such as ancient murals and historical paintings, are examined routinely for the purpose of conservation. Previous works have applied optical coherence tomography (OCT), which is a three-dimensional (3D) microscopic imaging modality in the field of heritage works conservation. The data acquired by OCT provides both 3D surface information of the object and structure information underneath the surface. Therefore, cross-sectional information on the object can be utilized to ...
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    8. Dual-band optical coherence tomography using a single supercontinuum laser source

      Dual-band optical coherence tomography using a single supercontinuum laser source
      We developed a simultaneous visible-light (Vis) and near-infrared (NIR) dual-band optical coherence tomography (OCT) system using a single supercontinuum laser source. The goal was to benchmark our newly developed Vis-OCT against the well-developed NIR-OCT. The Vis-OCT subsystem operated at 91 nm full-width-at-half-maximum (FWHM) bandwidth centered at 566 nm; the NIR-OCT subsystem operated at 93 nm FWHM bandwidth centered at 841 nm. The axial resolutions were 1.8 and 4.4 ...
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    9. Postdoctoral positions open at Boston University School of Medicine

      Postdoctoral positions open at Boston University School of Medicine
      The research is to design, manufacture optical devises, develop novel optical theory and methods for biomedical and clinical applications. The desired experience or interest includes but not limited: light scattering theory, light-tissue interaction, optics design and instrumentation, precision instrumentation, electronics design, programming, fiber optics and endoscopy. Candidate should have PhD degree in physics, optical engineering, biomedical engineering, electronic engineering, mechanical engineering or equivalent training background. Please directly contact PI at ...
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    10. Boston University Receives NIH Grant for Visualizing Cortical Microstructures by Optical Coherence Tomography

      Boston University Receives NIH Grant for Visualizing Cortical Microstructures by Optical Coherence Tomography
      ... imaging (at Massachusetts General Hospital) with expertise in cell type and microstructure analysis (MGH and Boston University School of Medicine). Success will be defined as determining that histological populations ar...
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    11. UV-VIS Spectroscopy in the Clinic – What’s Stopping It?

      UV-VIS Spectroscopy in the Clinic – What’s Stopping It?
      Bigios team isnt the only one to encounter this difficulty in attracting funding. Dr. Adam Waxs group at Duke University has been developing a technique angle-resolved low-coherence interferometry, or a/LCI enabling early detection of cancer and other biomedical applications by measuring the average size of cell nuclei using scattered light. The focus of the a/LCI instrument has been Barretts esophagus, a precursor to esophageal cancer. But Wax is ...
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  2. About Boston University

    Boston University

    Boston University (BU) is a private research university located in Boston, Massachusetts, United States. With more than 3,000 faculty members and nearly 30,000 students, Boston University is the fourth-largest private university in the United States of America.  Boston University Medical Campus (BUMC) is located in the historic South End of Boston and comprises the Boston University School of Medicine, the Boston University School of Public Health, the Goldman School of Dental Medicine, and the Boston University Graduate School of Medical Sciences. Boston Medical Center is a private, not for profit, 581-licensed bed academic medical center located in Boston's historic South End. The hospital is the primary teaching affiliate for Boston University School of Medicine. Emphasizing community-based care, Boston Medical Center with its mission to provide consistently accessible health services to all is the largest safety net hospital in New England.