1. Boston University

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    1. Mentioned In 112 Articles

    2. A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images

      A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images
      Optical coherence tomography (OCT) images of ex vivo human brain tissue are corrupted by multiplicative speckle noise that degrades the contrast to noise ratio (CNR) of microstructural compartments. This work proposes a novel algorithm to reduce noise corruption in OCT images that minimizes the penalized negative log likelihood of gamma distributed speckle noise. The proposed method is formulated as a majorize-minimize problem that reduces to solving an iterative regularized least ...
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    3. Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography

      Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography
      Objective: Serial sectioning optical coherence tomography (OCT) enables distortion-free volumetric reconstruction of several cubic centimeters of human brain samples. We aimed to identify anatomical features of the ex vivo human brain, such as intraparenchymal blood vessels and axonal fiber bundles, from the OCT data in 3D, using intrinsic optical contrast. Methods: We developed an automatic processing pipeline to enable characterization of the intraparenchymal microvascular network in human brain samples. Results ...
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    4. Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development

      Soft-Tissue Material Properties and Mechanogenetics during Cardiovascular Development
      During embryonic development, changes in the cardiovascular microstructure and material properties are essential for an integrated biomechanical understanding. This knowledge also enables realistic predictive computational tools, specifically targeting the formation of congenital heart defects. Material characterization of cardiovascular embryonic tissue at consequent embryonic stages is critical to understand growth, remodeling, and hemodynamic functions. Two biomechanical loading modes, which are wall shear stress and blood pressure, are associated with distinct molecular ...
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    5. Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue

      Refractive-index matching enhanced polarization sensitive optical coherence tomography quantification in human brain tissue
      The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to a low birefringence in the gray matter. In this study, we investigated the effect of refractive index matching by 2,2-thiodiethanol (TDE) immersion on ...
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    6. Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

      Scalable mapping of myelin and neuron density in the human brain with micrometer resolution
      Optical coherence tomography (OCT) is an emerging 3D imaging technique that allows quantification of intrinsic optical properties such as scattering coefficient and back-scattering coefficient, and has proved useful in distinguishing delicate microstructures in the human brain. The origins of scattering in brain tissues are contributed by the myelin content, neuron size and density primarily; however, no quantitative relationships between them have been reported, which hampers the use of OCT in ...
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    7. Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study

      Simultaneous visible light optical coherence tomography and near infrared OCT angiography in retinal pathologies: A case study
      A dual-channel optical coherence tomography system with wavelengths in the visible and near-infrared light ranges can provide both structural and functional information for retinal microvasculature simultaneously. We applied this integrated system in an ongoing clinical study of patients with various retinal pathologies. Here, we present case study results of patients with diabetic retinopathy, central retinal vein occlusion, and sickle cell retinopathy compared to a healthy subject. For the first time ...
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    8. Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue

      Refractive-index matching enhanced polarization-sensitive optical coherence tomography quantification in human brain tissue
      The importance of polarization-sensitive optical coherence tomography (PS-OCT) has been increasingly recognized in human brain imaging. Despite the recent progress of PS-OCT in revealing white matter architecture and orientation, quantification of fine-scale fiber tracts in the human brain cortex has been a challenging problem, due to a low birefringence in the gray matter. In this study, we investigated the effect of refractive index matching by 2,2'-thiodiethanol (TDE) immersion ...
      Read Full Article
    9. MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      MGH Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography
      ...e of the key progenitors of OCT technology and translational OCT. Dr. Kenneth Lutchen, a secondary mentor, of Boston University is a pioneer in the development of experiments aimed at investigating lung physiology, and s...
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    10. Deep Learning in Biomedical Optics

      Deep Learning in Biomedical Optics
      This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging, in vivo microscopy, widefield endoscopy, optical coherence tomography, photoacoustic imaging, diffuse tomography, and functional optical brain imaging. For each of these domains, we summarize how deep learning has been applied and highlight methods by which deep learning can ...
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    11. Scalable mapping of myelin and neuron density in the human brain with micrometer resolution

      Scalable mapping of myelin and neuron density in the human brain with micrometer resolution
      Optical Coherence Tomography (OCT) is an emerging 3D imaging technique that allows quantification of intrinsic optical properties such as scattering coefficient and back-scattering coefficient, and has proved useful in distinguishing delicate microstructures in the human brain. The origins of scattering in brain tissues are contributed by the myelin content, neuron size and density primarily; however, no quantitative relationships between them have been reported, which hampers the use of OCT in ...
      Read Full Article
    12. Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice

      Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice
      We report optical coherence tomography (OCT) imaging of localized fast optical signals (FOSs) arising from whisker stimulation in awake mice. The activated voxels were identified by fitting the OCT intensity signal time course with a response function over a time scale of a few hundred milliseconds after the whisker stimulation. The significantly activated voxels were shown to be localized to the expected brain region for whisker stimulation. The ability to ...
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    13. Measuring myelin content and cell density in the human brain using optical coherence tomography

      Measuring myelin content and cell density in the human brain using optical coherence tomography
      Serial Sectioning Optical Coherence Tomography(serial sectioning OCT) has been widely used to investigate the structural and pathological features of brain samples. OCT is an optical imaging technique that provides both the 3D structure of the tissue as well as the optical properties including the scattering coefficient ( s ) and back-scattering coefficient ( b ). Serial sectioning OCT allows the reconstruction of distortion-free volumetric images at high contrast and high resolution, which has ...
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    14. Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus

      Advanced endoscopic imaging for detecting and guiding therapy of early neoplasias of the esophagus
      Esophageal cancers, largely adenocarcinoma in Western countries and squamous cell cancer in Asia, present a significant burden of disease and remain one of the most lethal of cancers. Key to improving survival is the development and adoption of new imaging modalities to identify early neoplastic lesions, which may be small, multifocal, subsurface, and difficult to detect by standard endoscopy. Such advanced imaging is particularly relevant with the emergence of ablative ...
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    15. Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters

      Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters
      Significance: The optical properties of biological samples provide information about the structural characteristics of the tissue and any changes arising from pathological conditions. Optical coherence tomography (OCT) has proven to be capable of extracting tissue's optical properties using a model that combines the exponential decay due to tissue scattering and the axial point spread function that arises from the confocal nature of the detection system, particularly for higher numerical ...
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    16. Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

      Massachusetts General Hospital Receives NIH Grant for Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography
      ...e of the key progenitors of OCT technology and translational OCT. Dr. Kenneth Lutchen, a secondary mentor, of Boston University is a pioneer in the development of experiments aimed at investigating lung physiology, and s...
      Read Full Article
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  2. About Boston University

    Boston University

    Boston University (BU) is a private research university located in Boston, Massachusetts, United States. With more than 3,000 faculty members and nearly 30,000 students, Boston University is the fourth-largest private university in the United States of America.  Boston University Medical Campus (BUMC) is located in the historic South End of Boston and comprises the Boston University School of Medicine, the Boston University School of Public Health, the Goldman School of Dental Medicine, and the Boston University Graduate School of Medical Sciences. Boston Medical Center is a private, not for profit, 581-licensed bed academic medical center located in Boston's historic South End. The hospital is the primary teaching affiliate for Boston University School of Medicine. Emphasizing community-based care, Boston Medical Center with its mission to provide consistently accessible health services to all is the largest safety net hospital in New England.