1. Stephen A. Boppart

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    1. Mentioned In 209 Articles

    2. Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy

      Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy
      Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i ...
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    3. Introduction to the feature issue on the 25 year anniversary of optical coherence tomography

      Introduction to the feature issue on the 25 year anniversary of optical coherence tomography
      This feature issue commemorates the approximately 25 year history of Optical Coherence Tomography (OCT), one of the most successful biophotonic technologies. While OCT has technological origins traceable to ultrafast laser development and fiber optic system test instrumentation of the 1980s, innovations in low coherence interferometry for optical ranging and imaging for biomedical applications in the U.S., Europe and Japan by the early 1990s led to coinage of the now ...
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    4. Smart phone attachment for 3-D optical coherence tomography imaging

      Smart phone attachment for 3-D optical coherence tomography imaging
      Methods and apparatus for tomographic imaging of a sample. Low-coherence light is split into a sample path and a reference path. A steering optic recombines light in the reference path with light scattered by a sample onto a camera having an areal focal plane array of detector elements such that light in the reference path and light scattered by the sample are characterized by respectively offset propagation vectors at incidence ...
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    5. Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification
      Background and Objective Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from ...
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    6. Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography
      Influenced by both the intrinsic viscoelasticity of the tissue constituents and the time-evolved redistribution of fluid within the tissue, the biomechanical response of skin can reflect not only localized pathology but also systemic physiology of an individual. While clinical diagnosis of skin pathologies typically relies on visual inspection and manual palpation, a more objective and quantitative approach for tissue characterization is highly desirable. Optical coherence tomography (OCT) is an interferometry-based ...
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    7. In vivo 3D imaging of the human tympanic membrane using a wide-field diagonal-scanning optical coherence tomography probe

      In vivo 3D imaging of the human tympanic membrane using a wide-field diagonal-scanning optical coherence tomography probe
      A wide-field optical coherence tomography (OCT) probe was developed that adapts a diagonal-scanning scheme for three-dimensional (3D) in vivo imaging of the human tympanic membrane. The probe consists of a relay lens to enhance the lateral scanning range up to 7 mm. Motion artifacts that occur with the use of handheld probes were found to be decreased owing to the diagonal-scanning pattern, which crosses the center of the sample to ...
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    8. Computational optical coherence tomography [Invited]

      Computational optical coherence tomography [Invited]
      Optical coherence tomography (OCT) has become an important imaging modality with numerous biomedical applications. Challenges in high-speed, high-resolution, volumetric OCT imaging include managing dispersion, the trade-off between transverse resolution and depth-of-field, and correcting optical aberrations that are present in both the system and sample. Physics-based computational imaging techniques have proven to provide solutions to these limitations. This review aims to outline these computational imaging techniques within a general mathematical framework ...
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    9. Low-cost hand-held probe for depth-resolved low-coherence interferometry

      Low-cost hand-held probe for depth-resolved low-coherence interferometry
      We report on the development of a low-cost hand-held low-coherence interferometric imaging system based on the principle of linear optical coherence tomography (Linear OCT), a technique which was first proposed in the early 2000s as a simpler alternative to the conventional time-domain and Fourier-domain OCT. A bench-top implementation of the proposed technique is first presented and validated. The axial resolution, SNR, and sensitivity roll-of of the system was estimated to ...
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    10. UIUC Receives a NIH Grant for Intraoperative Polarization-Sensitive OCT for Assessing Breast Tumor Margins

      UIUC Receives a NIH Grant for Intraoperative Polarization-Sensitive OCT for Assessing Breast Tumor Margins
      University of Illinois at Urbana-Champaign Receives a 2017 NIH Grant for $548,714 for Intraoperative Polarization-Sensitive OCT for Assessing Breast Tumor Margins. The principal investigator is Stephan Boppart. The program began in 2016 and ends in 2021. Below is a summary of the proposed work. Breast cancer is a global healthcare burden, not only for the patients diagnosed with this disease, but also their families and friends. The surgical treatment ...
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    11. Inverse scattering for frequency-scanned full-field optical coherence tomography

      Inverse scattering for frequency-scanned full-field optical coherence tomography
      Full-field optical coherence tomography (OCT) is able to image an entire en face plane of scatterers simultaneously, but typically the focus is scanned through the volume to acquire three-dimensional structure. By solving the inverse scattering problem for full-field OCT, we show it is possible to computationally reconstruct a three-dimensional volume while the focus is fixed at one plane inside the sample. While a low-numerical-aperture (NA) OCT system can tolerate defocus ...
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    12. A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry
      The thickness of the human tympanic membrane (TM) is known to vary considerably across different regions of the TM. Quantitative determination of the thickness distribution and mapping of the TM is of significant importance in hearing research, particularly in mathematical modeling of middle-ear dynamics. Change in TM thickness is also associated with several middle-ear pathologies. Determination of the TM thickness distribution could therefore also enable a more comprehensive diagnosis of ...
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    13. Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range
      ..., USA *Corresponding author: Carney@illinois.edu Yang Xu, Donald Darga, Jason Smid, Adam M. Zysk, Daniel Teh, Stephen A. Boppart, and P. Scott Carney, "Filtering for unwrapping noisy Doppler optical coherence tomography ...
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    14. Automated computational aberration correction method for broadband interferometric imaging techniques

      Automated computational aberration correction method for broadband interferometric imaging techniques
      Numerical correction of optical aberrations provides an inexpensive and simpler alternative to the traditionally used hardware-based adaptive optics techniques. In this Letter, we present an automated computational aberration correction method for broadband interferometric imaging techniques. In the proposed method, the process of aberration correction is modeled as a filtering operation on the aberrant image using a phase filter in the Fourier domain. The phase filter is expressed as a linear ...
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    15. 1-15 of 209 1 2 3 4 ... 12 13 14 »
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  2. About Stephen A. Boppart

    Stephen A. Boppart

    Stephen A. Boppart is a professor in the Biophotonics Imaging Laboratory at the University of Illinois Urbana Champaign.  Dr. Boppart received his Ph.D. from the Massachusetts Institute of Technology in 1998, followed by a M.D. from Harvard Medical School in 2000. Currently Prof. Boppart is a full-time faculty member in the Beckman Institute Nanoelectronics and Biophotonics Group as well as an associate professor in the UIUC Department of Electrical and Computer Engineering and the Bioengineering Department. In January 2007, he was named the Founding Director of the Mills Breast Cancer Institute at Carle Foundation Hospital. Dr. Boppart is also a Clinical Research Physician in the UI College of Medicine-Urbana. His fields of professional interest include optical imaging (specifically in Optical Coherence Tomography) and biophotonics in medicine and biology.

  3. Quotes

    1. Any state of disease will alter the cells and molecules in our body...leaving a distinct optical scattering signature.” The new device senses cancer cells’ unique signatures, letting surgeons know which areas around the tumor are cancerous and which are safe to leave alone.
      In Flashlight-Sized Probe Can Spot Cancer Cells in Real Time
    2. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      In Bringing the human eye into focus
    3. We agree that, given the images we've seen from the hardware [adaptive optics] systems, our computational approaches are equivalent to those...In addition, we think we could do better by correcting the finer aberrations and by being able to manipulate the data post-acquisition, which gives us a lot more flexibility.
      In Bringing the human eye into focus
    4. Jim's innovation, scholarly activities, professional service, entrepreneurial efforts, and impact on the field of biomedical optics typifies the spirit of this award, and reflects the seminal changes that Britton Chance made during his lifetime...Few researchers in the world today have had such a profound impact as a result of their technological work that has literally changed our field, changed the way we practice medicine, and directly improved the lives of perhaps hundreds of thousands of patients (considering ophthalmology and cardiology).
      In Fujimoto Honored with Britton Chance Biomedical Optics Award
    5. We know that antibiotics don’t always work well if you have a biofilm, because the bacteria protect themselves and become resistant...In the presence of a chronic ear infection that has a biofilm, the bacteria may not respond to the usual antibiotics, and you need to stop them. But without being able to detect the biofilm, we have no idea whether or not it’s responding to treatment.
      In Nowhere to hide: New device sees bacteria behind the eardrum
    6. I think it's going to dramatically change things...What we hope is that diagnosis is going to get shifted closer and closer to the point of care...We’re developing techniques to get at molecular changes..So much of medicine and pathology are based on structural changes. If we think of a pathologist looking at a slide, he or she looks at the cells and tissue structures. A radiologist will look at how organs and these anatomical structures are arranged...But with a lot of these techniques, we can get the molecular changes where disease starts. So a pathologist that has molecular information, not just structural, will perhaps catch disease earlier. The same is true for Rohit’s work and Gabi’s work.
      In Positive Results: A New Era for Medical Diagnostics - News from UIUC
    7. It's the same challenge, but instead of imaging through the atmosphere, we're imaging through tissue, and instead of imaging a star, we're imaging a cell.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    8. The effectiveness is striking...Because of the aberrations of the human eye, when you look at the retina without adaptive optics you just see variations of light and dark areas that represent the rods and cones. But when you use adaptive optics, you see the rods and cones as distinct objects...are working to compute the best image possible.
      In Computing the best high-resolution 3-D tissue images - News from Beckman Institute at UIUC
    9. to emphasize the role of medical imaging and how this technology has enabled us to look into the body at many different size scales, how imaging has enabled us to diagnose disease, and how imaging has made a difference in our healthcare...Federal dollars have been used to fund technology that’s going to change and improve health care. They already have. In the area of optics and high-resolution optical imaging, there’s going to be better healthcare, economic development with new companies, new jobs, and new areas of research to investigate...We can now do real-time microscopic imaging in the operating room without waiting for pathology.
      In Boppart Presents at Congressional Briefing
    10. In the end, I expect the cost of this system will be slightly more than what it replaces, but with significantly more capabilities, I do expect the cost of this system to continue to fall as more systems are developed and demand increases...This will be a boon for poorer hospitals and Third World or developing countries...It is essentially a portable imaging system with digital data that can be sent via cell-phone networks for analysis by experts in larger cities/hospitals.
      In Scientists awarded grant to continue developing optical device for medical exams