1. Biwei Yin

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    1. Mentioned In 14 Articles

    2. Extended depth of focus for coherence-based cellular imaging

      Extended depth of focus for coherence-based cellular imaging
      Improving lateral resolution for cross-sectional optical coherence tomography (OCT) imaging is difficult due to the rapid divergence of light once it is focused to a small spot. To overcome this obstacle, we introduce a fiber optics system that generates a coaxially focused multimode (CAFM) beam for depth of focus (DOF) extension. We fabricated a CAFM beam OCT probe and show that the DOF is more than fivefold that of a ...
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    3. Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia

      Flexible, high-resolution micro-optical coherence tomography endobronchial probe toward in vivo imaging of cilia
      We report the design and fabrication of a flexible, longitudinally scanning high-resolution micro-optical coherence tomography (OCT) endobronchial probe, optimized for micro-anatomical imaging in airways. The 2.4 mm diameter and flexibility of the probe allows it to be inserted into the instrument channel of a standard bronchoscope, enabling real-time video guidance of probe placement. To generate a depth-of-focus enhancing annular beam, we utilized a new fabrication method, whereby a hollow ...
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    4. Feature of the Week 04/24/2016: μOCT Imaging Using Depth of Focus Extension by Self-Imaging Wavefront Division in a Common-Path Fiber Optic Probe

      Feature of the Week 04/24/2016: μOCT Imaging Using Depth of Focus Extension by Self-Imaging Wavefront Division in a Common-Path Fiber Optic Probe
      ...aging in catheter/endoscope-based medical imaging devices. For more information see recent Article . Courtesy Biwei Yin from Massachusetts General Hospital . Optical coherence tomography (OCT) is an attractive medical mo...
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    5. μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe

      μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe
      Optical coherence tomography (OCT) is an attractive medical modality due to its ability to acquire high-resolution, cross-sectional images inside the body using flexible, small-diameter, scanning fiber optic probes. Conventional, cross-sectional OCT imaging technologies have approximately 10-m axial resolution and 30-m lateral resolution, specifications that enable the visualization of microscopic architectural morphology. While this resolution is useful for many clinical applications, it is insufficient for resolving individual cells that characterize many ...
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    6. Fourier optics analysis of phase-mask-based path-length-multiplexed optical coherence tomography

      Fourier optics analysis of phase-mask-based path-length-multiplexed optical coherence tomography
      Imaging below fingertip surface might be a useful alternative to the traditional fingerprint sensing since the internal finger features are more reliable than the external ones. One of the most promising subsurface imaging technique is optical coherence tomography (OCT), which, however, has to acquire 3-D data even when a single en face image is required. This makes OCT inherently slow for en face imaging and produce unnecessary large data sets ...
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    7. Detection of plaque structure and composition using OCT combined with two-photon luminescence (TPL) imaging

      Detection of plaque structure and composition using OCT combined with two-photon luminescence (TPL) imaging
      Background and Objectives Atherosclerosis and plaque rupture leads to myocardial infarction and stroke. A novel hybrid optical coherence tomography (OCT) and two-photon luminescence (TPL) fiber-based imaging system was developed to characterize tissue constituents in the context of plaque morphology. Study Design/Materials and Methods Ex vivo coronary arteries (34 regions of interest) from three human hearts with atherosclerotic plaques were examined by OCTTPL imaging. Histological sections (4m in thickness) were ...
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    8. Degradation in the degree of polarization in human retinal nerve fiber layer

      Degradation in the degree of polarization in human retinal nerve fiber layer
      Using a fiber-based swept-source (SS) polarization-sensitive optical coherence tomography (PS-OCT) system, we investigate the degree of polarization (DOP) of light backscattered from the retinal nerve fiber layer (RNFL) in normal human subjects. Algorithms for processing data were developed to analyze the deviation in phase retardation and intensity of backscattered light in directions parallel and perpendicular to the nerve fiber axis (fast and slow axes of RNFL). Considering superior, inferior, and ...
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    9. Feature Of The Week 5/26/2013: University of Texas at Austin Investigates Dual-Wavelength Photothermal OCT for Imaging Microvasculature Blood Oxygen Saturation

      Feature Of The Week 5/26/2013: University of Texas at Austin Investigates Dual-Wavelength Photothermal OCT for Imaging Microvasculature Blood Oxygen Saturation
      ...duces a 3% systematic artifact that over-estimates SO2. For more information see recent Article . Courtesy of Biwei Yin from University of Texas at Austin . A swept-source dual-wavelength photothermal optical coherence t...
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    10. Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

      Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation
      A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation ( SO 2 ) levels in phantom blood vessels with ...
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    11. Optimized retinal nerve fiber layer segmentation based on optical reflectivity and birefringence for polarization-sensitive optical coherence tomography

      Optimized retinal nerve fiber layer segmentation based on optical reflectivity and birefringence for polarization-sensitive optical coherence tomography
      ...ertainty and higher continuity than traditional intensity-based approaches. Bingqing Wang, Amit S. Paranjape, Biwei Yin, Shuang Liu, Mia K. Markey, Thomas E. Milner and H. Grady Rylander III, "Optimized retinal nerve fib...
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    12. 1-14 of 14
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  2. About Biwei Yin

    Biwei Yin

    Biwei Yin, is currently a postdoctoral research fellow in Dr. Tearney’s lab in Wellman Center for Photomedicine, MGH, and Harvard Medical School. He obtained his PhD degree in Electrical and Computer Engineering department in the University of Texas at Austin under Dr. Thomas Milner’s supervision. His research interest lies in optical imaging system development.