1. Bioptigen

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    1. Mentioned In 164 Articles

    2. Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

      Optical coherence tomography (OCT) imaging systems having adaptable lens systems and related methods and computer program products

      OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length ...

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    3. Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

      Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

      Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first ...

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    4. Surgical microscopes using optical coherence tomography and related methods

      Surgical microscopes using optical coherence tomography and related methods

      Some embodiments of the present inventive concept provide optical coherence tomography (OCT) systems for integration with a microscope. The OCT system includes a sample arm coupled to the imaging path of a microscope. The sample arm includes an input beam zoom assembly including at least two movable lenses configured to provide shape control for an OCT signal beam; a scan assembly including at least one scanning mirror and configured for telecentric scanning of the OCT signal beam; and a beam expander configured to set the OCT signal beam diameter incident on the microscope objective. The shape control includes separable controls ...

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    5. Zebrafish as a Model to Study Emmetropization, Refractive Error, and Retinal Substructure using Spectral Domain-Optical Coherence Tomography

      Zebrafish as a Model to Study Emmetropization, Refractive Error, and Retinal Substructure using Spectral Domain-Optical Coherence Tomography
      ...d lens diameter were measured in wild-type and bugeye/lrp2 mutant zebrafish throughout their lifespan using a Bioptigen SD-OCT system. Cone photoreceptor mosaics were visualized using en face summed volume projection (SV...
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    6. Methods, systems and computer program products for collapsing volume data to lower dimensional representations thereof using histogram projection

      Methods, systems and computer program products for collapsing volume data to lower dimensional representations thereof using histogram projection

      Methods of collapsing volume data to a lower dimensional representation of the volume data are provided. The methods include collapsing volume data to a lower dimensional representation of the volume data using histogram projection. Related systems and computer program products are also provided.

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    7. Intra-operative OCT devices for ophthalmic use: an overview

      Intra-operative OCT devices for ophthalmic use: an overview

      It is feasible to bring the currently most used examination method in ophthalmology, optical coherence tomography (OCT), into ophthalmic surgery to enhance information and control for the surgeon and increase outcome for the patient. In this overview, the currently commercially available OCT devices intending intra-operative OCT imaging are described. Further experience with these systems might not only aid in solving current problems but also open our minds to detect processes so far unknown and help answer questions so far unaddressed.

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    8. 3D graph-based automated segmentation of corneal layers in anterior-segment optical coherence tomography images of mice

      3D graph-based automated segmentation of corneal layers in anterior-segment optical coherence tomography images of mice

      Anterior segment optical coherence tomography (AS-OCT) is a non-invasive imaging modality that allows for the quantitative assessment of corneal thicknesses. Automated approaches for these measurements are not readily available and therefore measurements are often obtained manually. While graph-based approaches that enable the optimal simultaneous segmentation of multiple 3D surfaces have been proposed and applied to 3D optical coherence tomography volumes of the back of the eye, such approaches have not been applied for the segmentation of the corneal surfaces. In this work we propose adapting this graph-based method for the automated 3D segmentation of three corneal surfaces in AS-OCT images ...

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  2. About Bioptigen

    Bioptigen

    Bioptigen.  Ophthalmology and General Research Systems.  Bioptigen has pioneered a new class of in vivo optical imaging systems for biomedical applications. These systems enable real-time non-invasive imaging of internal tissue microstructure, advancing critical applications in drug development, genetics research, tissue engineering, and medical vision.  Bioptigen is a spin-out of the Duke University Biomedical Engineering Department. Bioptigen was incorporated in North Carolina in August, 2004, to commercialize technologies originating in the laboratories of Professor Joseph Izatt. Bioptigen technology is based on the science of Optical Coherence Tomography (OCT), an imaging system similar in function to ultrasound, but using low-power light rather than sound waves. OCT offers resolution 100-times finer than standard ultrasound, suitable for analyzing tissue microstructure with features smaller than 10 micrometer.

  3. Quotes about Bioptigen

    1. Bioptigen allows you to sum up multiple images of a particular cut.
      In New Technology: Bioptigen SDOCT Boosts Flexibility
    2. Bioptigen is very pleased to extend its relationship with Case through this new technology agreement.  The intellectual property licensed by Case is fundamental to our ability to provide the highest performance FDOCT imaging system today and to develop new clinical tools that will dramatically extend the clinical value of FDOCT into the future.
      Eric L. Buckland in Case Western Reserve University, University Hospitals Case Medical Center and Bioptigen Establish Exclusive Licensing Agreement
    3. We look forward to working with Bioptigen to incorporate the Case technology and expand their product portfolio to address medical disciplines beyond ocular imaging.
      In Case Western Reserve University, University Hospitals Case Medical Center and Bioptigen Establish Exclusive Licensing Agreement