1. University of Illinois at Urbana-Champaign

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    1. Mentioned In 246 Articles

    2. Volumetric Endoscopic Coherence Microscopy Using A Coherent Fiber Bundle (Wo 2008/091755)

      Volumetric Endoscopic Coherence Microscopy Using A Coherent Fiber Bundle (Wo 2008/091755)
      Methods for employing coherent bundles of optical fibers, whether single- or multi-mode, for optical coherence tomography or optical coherence microscopy. Either a substantially monochromatic source or a broadband source (200) has its spatial coherence reduced and/or is spatially filtered prior to coupling into the fiber bundle for 'illumination of a sample. A scattered signal from features disposed beneath the surface of the sample is interfered with a reference signal ...
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    3. Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues

      Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues
      Magnetic nanoparticles (MNPs) are increasingly important in magnetic resonance and biomedical optical imaging. We describe a method for imaging MNPs by detecting nanoscale displacements using a phase-resolved spectral-domain optical coherence tomography (OCT) system. Biological tissues and phantoms are exposed to ~800 G magnetic fields modulated at 56 and 100 Hz to mechanically actuate embedded iron oxide MNPs (~20 nm diameter). Sensitivity to 27 μg/g (~2 nM) MNPs within tissue ...
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    4. Optical micro-scale mapping of dynamic biomechanical tissue properties

      Optical micro-scale mapping of dynamic biomechanical tissue properties
      Xing Liang, Amy L. Oldenburg, Vasilica Crecea, Eric J. Chaney, Stephen A. Boppart Mechanical forces such as adhesion, shear stress and compression play crucial roles in tissue growth, patterning and development. To understand the role of these mechanical stimuli, it is of great importance to measure biomechanical properties of developing, engineered, and natural tissues. To ... [Opt. Express 16, 11052-11065 (2008)]
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    5. Coherent optical imaging and guided interventions in breast cancer: translating technology into clinical applications

      ...in breast cancer: translating technology into clinical applications Univ. of Illinois at Urbana-Champaign and Mills Breast Cancer Institute (published online Apr. 17, 2008) Breast cancer continues to be one of the most w...
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    6. Stabilization of continuum generation from normally dispersive nonlinear optical fibers for a tunable broad bandwidth source for optical coherence tomography

      Haohua Tu, Daniel L. Marks, Yee Lin Koh, and Stephen A. Boppart Continuum generation from normally dispersive ultrahigh-numerical-aperture fibers deteriorates in relatively short times, limiting its application as a practical optical source for high-resolution optical coherence tomography. We find that reversible light-induced structural modification of fiber optic materials, rather than permanent optical damage, is responsible for this deterioration. By examining how the optical properties of corresponding light-induced waveguides depend on ...
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    7. Interferometric synthetic aperture microscopy: tissue structure inferred by computed imaging techniques

      Interferometric synthetic aperture microscopy: tissue structure inferred by computed imaging techniques
      Daniel L. Marks, Tyler S. Ralston, Brynmor J. Davis et al. Interferometric Synthetic Aperture Microscopy (ISAM) is an optical microscopy computed-imaging technique for measuring the optical properties of three-dimensional structures and biological tissues. In this work, the principle of ISAM is reviewed, and its application to imaging tissue properties in v ... [Proc. SPIE Int. Soc. Opt. Eng. 6864, 686407 (2008)] published Fri Feb 15, 2008.
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    8. Plasmon-resonant gold nanorods provide spectroscopic OCT contrast in excised human breast tumors

      Amy L. Oldenburg, Matthew N. Hansen, Alexander Wei et al. Plasmon-resonant gold nanorods have been demonstrated recently as contrast agents for optical coherence tomography (OCT). To evaluate their ability to produce contrast in a structurally heterogeneous environment, nanorods were injected at discrete locations into an excised sample of human breast inv ... [Proc. SPIE Int. Soc. Opt. Eng. 6867, 68670E (2008)] published Wed Feb 13, 2008.
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    9. Real-time interferometric synthetic aperture microscopy

      Tyler S. Ralston, Daniel L. Marks, P. S. Carney, Stephen A. Boppart. An interferometric synthetic aperture microscopy (ISAM) system design with real-time 2D cross-sectional processing is described in detail. The system can acquire, process, and display the ISAM reconstructed images at frame rates of 2.25 frames per second for 512 X 1024 pixel images. This system ... [Opt. Express 16, 2555-2569 (2008)]
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  2. About University of Illinois at Urbana-Champaign

    University of Illinois at Urbana-Champaign

    The University of Illinois at Urbana-Champaign.  Illinois is a world leader in research, teaching, and public engagement, distinguished by the breadth of its programs, broad academic excellence, and internationally renowned faculty.  Biophotonics Imaging Laboratory at the University of Illinois at Urbana-Champaign. Located in the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign, the Biophotonics Imaging Laboratory, directed by Professor Stephen Boppart, is dedicated to the development of optical biomedical imaging techniques. Mills Breast Cancer Institute is dedicated to the diagnosis, prevention and treatment of breast cancer through collaborative research and excellence in patient care.   Dr. Stephen Boppart, MD, PhD, Founding Director, Mills Breast Cancer Institute.