1. University of Illinois at Urbana-Champaign

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    1. Mentioned In 244 Articles

    2. Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials

      Magnetomotive nanoparticle transducers for optical rheology of viscoelastic materials
      The availability of a real-time non-destructive modality to interrogate the mechanical properties of viscoelastic materials would facilitate many new investigations. We introduce a new optical method for measuring elastic properties of samples which employs magnetite nanoparticles as perturbative agents. Magnetic nanoparticles distributed in silicone-based samples are displaced upon probing with a small external magnetic field gradient and depth-resolved optical coherence phase shifts allow for the tracking of scatterers in the ...
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    3. Dynamic optical coherence elastography and applications

      Dynamic optical coherence elastography, an emerging optical technique to measure material mechanical properties using the non-invasive imaging modality of optical coherence tomography is introduced. Dynamic mechanical excitations were applied to the samples while a spectral domain optical coherence tomography system was used for detection. Based on a simple mechanical model, material mechanical properties such as Young's moduli can be extracted from detected phaseresolved signals. Biological tissues and their biomechanical ...
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    4. Nonlinear interferometric vibrational imaging

      A method of examining a sample, which includes: exposing a reference to a first set of electromagnetic radiation, to form a second set of electromagnetic radiation scattered from the reference; exposing a sample to a third set of electromagnetic radiation to form a fourth set of electromagnetic radiation scattered from the sample; and interfering the second set of electromagnetic radiation and the fourth set of electromagnetic radiation. The first set ...
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    5. Optical Coherence Tomography Identifies Surgical Margins for Breast Cancer Intraoperatively

      PHILADELPHIA -- November 18, 2009 -- Intraoperative optical coherence tomography (OCT) rapidly images larger breast tumour margin areas, dramatically improving the microscopic sampling rate or analysis of the margin, according to research published in the November 15 issue of Cancer Research. "Intraoperative OCT has the potential to provide diagnostically useful information about margin status in real time, at the point of care, rather than relying on postoperative histopathology," said Stephen Boppart, MD ...
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    6. Multi-functional plasmon-resonant contrast agents for optical coherence tomography

      A method of forming an image of a sample, comprising: forming an image of a mixture, by exposing the mixture to electromagnetic radiation; wherein the mixture comprises the sample and plasmon-resonant nanoparticles, and wherein the electromagnetic radiation is in the frequency range of infra-red to ultraviolet light.
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    7. Interferometric synthetic aperture microscopy

      Methods and apparatus for three-dimensional imaging of a sample. A source is provided of a beam of substantially collimated light characterized by a temporally dependent spectrum. The beam is focused in a plane characterized by a fixed displacement along the propagation axis of the beam, and scattered light from the sample is superposed with a reference beam derived from the substantially collimated source onto a focal plane detector array to ...
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    8. Biomechanical Properties of in Vivo Human Skin From Dynamic Optical Coherence Elastography

      Biomechanical Properties of in Vivo Human Skin From Dynamic Optical Coherence Elastography
      Dynamic optical coherence elastography is used to determine in vivoskin biomechanical properties based on mechanical surface wave propagation. Quantitative Youngs moduli are measured on human skin from different sites, orientations, and frequencies. Skin thickness, including measurements from different layers, are also measured simultaneously. Experimental results show significant differences among measurements from different skin sites, between directions parallel and orthogonal to Langers lines, and under different skin hydration states. Results also ...
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    9. Acoustomotive optical coherence elastography for measuring material mechanical properties

      Acoustomotive optical coherence elastography for measuring material mechanical properties
      Acoustomotive optical coherence elastography (AM-OCE), a dynamic and internal excitation optical coherence elastography technique, is reported. Acoustic radiation force was used for internal mechanical excitation, and spectral-domain optical coherence tomography was used for detection. Mechanical properties of gelatin tissue phantoms were measured by AM-OCE and verified using rheometry results. Measured mechanical properties including shear moduli and shear damping parameters of the gelatin samples double when their polymer concentration increases from ...
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    10. Detecting action-potential-correlated scattering changes in single neurons

      Detecting action-potential-correlated scattering changes in single neurons
      Optical coherence microscopy has potential as a tool for noninvasively measuring electrical activity in single neurons based on changes in their intrinsic optical properties. A central goal of neuroscience is to understand how groups of neurons interact to give rise to the myriad functions of the nervous system. This task is extremely difficult in part because of the technical challenge of recording the electrical activity of many neurons simultaneously without ...
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    11. Imaging engineered tissues using structural and functional optical coherence tomography

      As the field of tissue engineering evolves, there will be an increasingly important need to visualize and track the complex dynamic changes that occur within three-dimensional constructs. Optical coherence tomography (OCT), as an emerging imaging technology applied to biological materials, offers a number of significant advantages to visualize these changes. Structural OCT has been used to investigate the longitudinal development of engineered tissues and cell dynamics such as migration, proliferation ...
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    12. Detecting intrinsic scattering changes correlated to neuron action potentials using optical coherence imaging

      Detecting intrinsic scattering changes correlated to neuron action potentials using optical coherence imaging
      We demonstrate how optical coherence imaging techniques can detect intrinsic scattering changes that occur during action potentials in single neurons. Using optical coherence tomography (OCT), an increase in scattering intensity from neurons in the abdominal ganglion of Aplysia californica is observed following electrical stimulation of the connective nerve. In addition, optical coherence microscopy (OCM), with its superior transverse spatial resolution, is used to demonstrate a direct correlation between scattering intensity ...
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    13. Towards freehand image acquisition in optical coherence tomography

      Towards freehand image acquisition in optical coherence tomography
      A new data-capture method could provide increased flexibility for clinical imaging applications. Optical coherence tomography (OCT), a biomedical diagnostic-imaging technique, is currently transitioning from the research laboratory into clinical practice.1 Providing micrometer-scale resolution over millimeter-scale fields of view, OCT is the optical analog of ultrasound. It uses low-coherence interferometry to perform optical ranging in biological tissue. Clinical applications under investigation include optical biopsy2 and detection of tumor margins during ...
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    14. 196-210 of 244 « 1 2 ... 11 12 13 14 15 16 17 »
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  2. About University of Illinois at Urbana-Champaign

    University of Illinois at Urbana-Champaign

    The University of Illinois at Urbana-Champaign.  Illinois is a world leader in research, teaching, and public engagement, distinguished by the breadth of its programs, broad academic excellence, and internationally renowned faculty.  Biophotonics Imaging Laboratory at the University of Illinois at Urbana-Champaign. Located in the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign, the Biophotonics Imaging Laboratory, directed by Professor Stephen Boppart, is dedicated to the development of optical biomedical imaging techniques. Mills Breast Cancer Institute is dedicated to the diagnosis, prevention and treatment of breast cancer through collaborative research and excellence in patient care.   Dr. Stephen Boppart, MD, PhD, Founding Director, Mills Breast Cancer Institute.