1. Bernhard Baumann

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    1. Mentioned In 92 Articles

    2. Optical Coherence Tomography for Brain Imaging (Book Chapter)

      Optical Coherence Tomography for Brain Imaging (Book Chapter)
      Optical coherence tomography (OCT) is an imaging technique based on the detection of light back-reflected or backscattered by tissue. Based on the principles of low-coherence interferometry, OCT provides rapid volumetric imaging with micrometer-scale resolution. OCT has been massively successful in ophthalmology where it became a routine tool for retinal diagnostics. In recent years, however, OCT has also been applied to other fields includingamongst otherscardiovascular imaging, endoscopy of the gastrointestinal tract ...
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      Mentions: Bernhard Baumann
    3. In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography

      In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography
      Purpose : To investigate the early development of spontaneous retinal neovascularization in the murine retina by a multifunctional optical coherence tomography approach. To characterize involved tissue changes in vivo and describe structural and functional changes over time. Methods : A multifunctional optical coherence tomography (OCT) system providing 3-fold contrast comprising reflectivity, polarization sensitivity, and OCT angiography (OCTA) was utilized to image very-low-density lipoprotein receptor (VLDLR) knockout mice. Baseline measurements were acquired as ...
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    4. White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina

      White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina
      A white light polarization sensitive optical coherence tomography system has been developed, using a supercontinuum laser as the light source. By detecting backscattered light from 400700 nm, an axial resolution of 1.0 m in air was achieved. The system consists of a free-space interferometer and two homemade spectrometers that detect orthogonal polarization states. Following system specifications, images of a healthy murine retina as acquired by this non-contact system are ...
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    5. Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy

      Visualization of neuritic plaques in Alzheimer’s disease by polarization-sensitive optical coherence microscopy
      One major hallmark of Alzheimers disease (AD) and cerebral amyloid angiopathy (CAA) is the deposition of extracellular senile plaques and vessel wall deposits composed of amyloid-beta (A ). In AD, degeneration of neurons is preceded by the formation of A plaques, which show different morphological forms. Most of them are birefringent owing to the parallel arrangement of amyloid fibrils. Here, we present polarization sensitive optical coherence microscopy (PS-OCM) for imaging mature ...
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    6. Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure

      Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure
      A multi-functional optical coherence tomography (OCT) approach is presented to determine ocular fundus pulsations as an axial displacement between the retina and the chorioscleral complex in the albino rat eye. By combining optical coherence elastography and OCT angiography (OCTA), we measure subtle deformations in the nanometer range within the eye and simultaneously map retinal and choroidal perfusion. The conventional OCT reflectivity contrast serves as a backbone to segment the retina ...
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    7. Polarization-sensitive optical coherence tomography in the anterior mouse eye

      Polarization-sensitive optical coherence tomography in the anterior mouse eye
      Polarization-sensitive optical coherence tomography (PS-OCT) provides intrinsic contrast related to tissue microstructure. In the past, PS-OCT has been successfully used for imaging the anterior eye of humans in a variety of pathologic conditions. Here, we present PS-OCT imaging of the anterior eye in mice. Spectral domain PS-OCT centered at a wavelength of 840 nm was performed in anaesthetized laboratory mice. Three dimensional data sets were acquired at a 70 kHz ...
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    8. IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY

      IMAGING OF VITELLIFORM MACULAR LESIONS USING POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY
      Purpose: To examine the involvement of the retinal pigment epithelium (RPE) in the presence of vitelliform macular lesions (VML) in Best vitelliform macular dystrophy (BVMD), autosomal recessive bestrophinopathy, and adult-onset vitelliform macular degeneration using polarization-sensitive optical coherence tomography (PS-OCT). Methods: A total of 35 eyes of 18 patients were imaged using a PS-OCT system and blue light fundus autofluorescence imaging. Pathogenic mutations in the BEST1 gene, 3 of which were ...
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    9. Beyond backscattering: Optical neuroimaging by BRAD

      Beyond backscattering: Optical neuroimaging by BRAD
      Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked ...
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    10. Multi-directional optical coherence tomography for retinal imaging

      Multi-directional optical coherence tomography for retinal imaging
      We introduce multi-directional optical coherence tomography (OCT), a technique for investigation of the scattering properties of directionally reflective tissue samples. By combining the concepts of multi-channel and directional OCT, this approach enables simultaneous acquisition of multiple reflectivity depth-scans probing a mutual sample location from differing angular orientations. The application of multi-directional OCT in retinal imaging allows for in-depth investigations on the directional reflectivity of the retinal nerve fiber layer, Henles ...
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    11. Feature Of The Week 09/03/2017: Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      Feature Of The Week 09/03/2017: Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples
      A visible light spectral domain optical coherence microscopy system was developed. A high axial resolution of 0.88 m in tissue was achieved using a broad visible light spectrum (425 685 nm). Healthy human brain tissue was imaged to quantify the difference between white (WM) and grey matter (GM) in intensity and attenuation. The high axial resolution enables the investigation of amyloid-beta plaques of various sizes in human brain tissue ...
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    12. Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples
      A visible light spectral domain optical coherence microscopy system was developed. A high axial resolution of 0.88 m in tissue was achieved using a broad visible light spectrum (425 685 nm). Healthy human brain tissue was imaged to quantify the difference between white (WM) and grey matter (GM) in intensity and attenuation. The high axial resolution enables the investigation of amyloid-beta plaques of various sizes in human brain tissue ...
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    13. Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT

      Conical scan pattern for enhanced visualization of the human cornea using polarization-sensitive OCT
      Conventional imaging of the human cornea with optical coherence tomography (OCT) relies on telecentric scanning optics with sampling beams that are parallel to the optical axis of the eye. Because of the shape of the cornea, the beams have in some areas considerable inclination to the corneal surface which is accompanied by low signal intensities in these areas and thus an inhomogeneous appearance of corneal structures. In addition, alterations in ...
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    14. Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

      Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications
      Polarization sensitive optical coherence tomography (PS-OCT) is an imaging technique based on light scattering. PS-OCT performs rapid two- and three-dimensional imaging of transparent and translucent samples with micrometer scale resolution. PS-OCT provides image contrast based on the polarization state of backscattered light and has been applied in many biomedical fields as well as in non-medical fields. Thereby, the polarimetric approach enabled imaging with enhanced contrast compared to standard OCT and ...
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    15. Visible light spectral domain optical coherence microscopy system for ex vivo imaging

      Visible light spectral domain optical coherence microscopy system for ex vivo imaging
      A visible light spectral domain optical coherence microscopy system operating in the wavelength range of 450-680 nm was developed. The resulting large wavelength range of 230 nm enabled an ultrahigh axial resolution of 0.88m in tissue. The setup consisted of a Michelson interferometer combined with a homemade spectrometer with a spectral resolution of 0.03 nm. Scanning of 1 x 1 mm 2 and 0.5 x 0.5 ...
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    16. Active-passive path-length encoded (APPLE) Doppler OCT

      Active-passive path-length encoded (APPLE) Doppler OCT
      We present a novel active-passive path-length encoded (APPLE) swept source Doppler optical coherence tomography (DOCT) approach, enabling three-dimensional velocity vector reconstruction of moving particles without prior knowledge of the orientation of motion. The developed APPLE DOCT setup allows for non-invasive blood flow measurements in vivo and was primarily designed for quantitative human ocular blood flow investigations. The systems performance was demonstrated by in vitro flow phantom as well as in ...
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  2. About Bernhard Baumann

    Bernhard Baumann

    Bernhard Baumann was born in Vienna, Austria in 1981. He received his Masters in Physics from the University of Vienna in 2006. From 2006 to 2009, Bernhard worked on his doctoral studies under supervision of Prof. Christoph K. Hitzenberger at the Medical University of Vienna. He received a PhD in medical physics in 2009. In 2010, he joined the groups of Prof. James G. Fujimoto at the Research Laboratory of Electronics at the Massachusetts Institute of Technology and Dr. Jay S. Duker at New England Eye Center at Tufts University for a joint post-doctoral fellowship. Since his return to Vienna in 2012, Bernhard has been working as a post-doc at the Medical University of Vienna