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2. Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography
  
  Explore BJO Online Jun 2 2018 Ophthalmology
  
  Aim To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). Methods This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 66mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP ...
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  Mentions: Heidelberg Engineering Carl Zeiss Meditec San Raffaele Scientfic Institute
3. Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren
  
  Explore eurointervention.org Mar 8 2018 Cardiology
  
  Aims: We aimed to assess possible difference of the neointimal quality after everolimus-eluting bioresorbable scaffold (BVS) implantation in comparison with cobalt chromium everolimus-eluting scaffold (CoCr-EES) by optical frequency domain imaging (OFDI). Methods and results: This study is a post-hoc analysis of TROFI II trial assessing neointimal quality 6-month after the implantation of BVS(N=82) and CoCr-EES(N=87) in STEMI patients. Neointimal light property analysis by OFDI full-automatically computed ...
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  Mentions: Imperial College London Leiden University Academic Medical Center at the University of Amsterdam
4. Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration
  
  Explore SAGE Journals Feb 6 2018 Ophthalmology
  
  Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes) from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert (control eyes). Parameters related to ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
5. Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age) (OCTAC)
  
  Explore Home - ClinicalTrials.gov Jan 17 2018 Ophthalmology , Clinical Trials
  
  Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality ...
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  Mentions: Bern University Hospital
6. Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
  
  Explore jove.com Nov 28 2017 Developmental Biology , Ophthalmology
  
  A fascinating difference between teleost and mammals is the lifelong potential of the teleost retina for retinal neurogenesis and regeneration after severe damage. Investigating the regeneration pathways in zebrafish might bring new insights to develop innovative strategies for the treatment of retinal degenerative diseases in mammals. Herein, we focused on the induction of a focal lesion to the outer retina in adult zebrafish by means of a 532 nm diode ...
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  Mentions: University of Bern Volker Enzmann Bern University Hospital
7. In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
  
  Explore jove.com Nov 28 2017 Ophthalmology
  
  Spectral domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO) are extensively used in experimental ophthalmology. In the present protocol, mice expressing green fluorescent protein (gfp) under the promoter of Cx3cr1 (BALB/c-Cx3cr1 gfp/gfp ) were used to image microglia cells in vivo in the retina. Microglia are resident macrophages of the retina and have been implicated in several retinal diseases 1 , 2 , 3 , 4 , 5 , 6 . This protocol ...
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  Mentions: Bern University Hospital Martin S. Zinkernagel
8. In Vivo Imaging of Cx3cr1 Reporter Mice with Spectral-domain Optical Coherence Tomography ...
  
  Explore jove.com Nov 11 2017 Ophthalmology
  
  ...igid gas permeable contact Quantum I, Bausch + Lomb Inc., lens Rochester, NY N/A balanced salt solution (BSS) Inselspital, Bern, Switzerland N/A silicon forceps N/A N/A atipamezole 5 mg/mL (Antisedan) Provet AG, Lyssach,...
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  Mentions: Heidelberg Engineering University of Bern Bern University Hospital
9. Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT
  
  Explore ScienceDirect Oct 3 2017 Cardiology
  
  Objectives The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUSvirtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. Background IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. Methods Anatomic landmarks and endoluminal radiopaque markers ...
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  Mentions: Imperial College London Leiden University Capital Medical University
10. Effect of Post-Dilatation Following Primary PCI With Everolimus-Eluting Bioresorbable Scaffold Versus Everolimus-Eluting Metallic Stent Implantation: An Angiographic and Optical Coherence Tomography TROFI II Substudy
  
  Explore ScienceDirect Sep 24 2017 Cardiology
  
  Objectives This study sought to investigate the effect of post-dilatation on angiographic and intracoronary imaging parameters in the setting of primary percutaneous coronary intervention comparing the everolimus-eluting bioresorbable scaffold (BRS) with the everolimus-eluting metallic stent (EES). Background Routine post-dilatation of BRS has been suggested to improve post-procedural angiographic and subsequent device-related clinical outcomes. Methods In the ABSORB STEMI TROFI II trial, 191 patients with ST-segment elevation myocardial infarction were randomly ...
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  Mentions: Academic Medical Center at the University of Amsterdam Patrick W. Serruys Stephan Windecker
11. OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices
  
  Explore Journals | PLOS May 10 2017
  
  ... study adhered to the tenets of the Declaration of Helsinki and was approved by the local ethics committee at Inselspital. A weaver of informed consent was granted due to the use of anonymized data (KEK number 2016–02100...
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  Mentions: Optovue Heidelberg Engineering Nidek
12. Comparison of 55° Wide-Field Spectral Domain Optical Coherence Tomography and Conventional 30° Optical Coherence Tomography for the Assessment of Diabetic Macular Edema
  
  Explore Karger Publishers Feb 7 2017 Ophthalmology
  
  Purpose: To compare conventional 30 spectral domain optical coherence tomography (SD-OCT) with 55 wide-field SD-OCT for the assessment of diabetic macular edema (DME). Methods: This study included 50 DME patients. Both 55 and 30 SD-OCT was conducted. Two readers evaluated scans according to a standardized grading protocol. Intergrader agreement as well as agreement between 30 and 55 SD-OCT were assessed. Results: Intergrader agreement () was strong and ranged from 0.79 ...
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  Mentions: Bern University Hospital
13. Intracoronary optical coherence tomography: Clinical and research applications and intravascular imaging software overview
  
  Explore Wiley Online Library Jan 21 2017 Cardiology
  
  By providing valuable information about the coronary artery wall and lumen, intravascular imaging may aid in optimizing interventional procedure results and thereby could improve clinical outcomes following percutaneous coronary intervention (PCI). Intravascular optical coherence tomography (OCT) is a light-based technology with a tissue penetration of approximately 1 to 3 mm and provides near histological resolution. It has emerged as a technological breakthrough in intravascular imaging with multiple clinical and research ...
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  Mentions: Imperial College London Leiden University University College London
14. Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy
  
  Explore ScienceDirect Dec 7 2016 Ophthalmology
  
  Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events ...
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  Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel
15. En face Optical Coherence Tomography Imaging for the Detection of Nascent Geographic Atrophy
  
  Explore Elsevier Health Nov 15 2016 Ophthalmology
  
  Purpose To determine if en face optical coherence tomography (OCT) imaging can identify nascent geographic atrophy (nGA) in eyes with intermediate age-related macular degeneration (iAMD). Design Retrospective observational case series. Methods Patients with iAMD from the COMPLETE study at the Bascom Palmer Eye Institute were evaluated to determine if nGA was present at baseline and at follow-up using high density Spectralis OCT B-scans and en face OCT images from the ...
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  Mentions: Giovanni Gregori Philip J. Rosenfeld University of Miami
16. Variability in the measurement of minimum fibrous cap thickness and reproducibility of fibroatheroma classification by optical coherence tomography using manual versus semi-automatic assessment
  
  Explore eurointervention.org Oct 18 2016 Cardiology
  
  Aims: The minimum fibrous cap thickness (FCT) is considered a major criterion of coronary plaque vulnerability according to autopsy studies. We aimed to assess the reproducibility in the measurement of the optical coherence tomography (OCT)-detected minimum FCT and the agreement in the classification of thin-cap fibroatheroma (TCFA), by a software-based semi-automatic method compared with the manual method. Methods and results: A total of 50 frames with fibroatheromas (FA) were ...
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  Mentions: Imperial College London Case Western Reserve University Leiden University
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