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2. Cynomolgus monkey’s choroid reference database derived from hybrid deep learning optical coherence tomography segmentation
  
  Explore Nature Publishing Group Aug 4 2022 Ophthalmology
  
  Cynomolgus monkeys exhibit human-like features, such as a fovea, so they are often used in non-clinical research. Nevertheless, little is known about the natural variation of the choroidal thickness in relation to origin and sex. A combination of deep learning and a deterministic computer vision algorithm was applied for automatic segmentation of foveolar optical coherence tomography images in cynomolgus monkeys. The main evaluation parameters were choroidal thickness and surface area ...
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  Mentions: University Hospital Zurich University of Bonn University of Bern
3. Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode
  
  Explore Home - Springer Jul 24 2022 Neurology , Ophthalmology
  
  Background Optic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS ped ) and myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD ped ) in children6 years. In this study, we investigated retinal atrophy patterns and diagnostic accuracy of optical coherence tomography (OCT) in differentiating between both diseases after the first ON episode. Methods Patients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA ...
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  Mentions: Medical University of Vienna University of Bern Ludwig Maximilian University of Munich
4. Comparison of Indocyanine Green Angiography and Swept-Source Wide-Field Optical Coherence Tomography Angiography in Posterior Uveitis
  
  Explore Frontiers May 23 2022 Ophthalmology
  
  Purpose: To compare indocyanine green angiography (ICGA) and swept-source wide-field optical coherence tomography angiography (SS-OCTA) for the assessment of patients with posterior uveitis. Method: SS-OCTA montage images of 5 x 12 x 12 mm or 2 x 15 x 9 mm, covering ~70-90 degree of the retina of consecutive patients with posterior uveitis were acquired. The choriocapillaries and choroidal slabs were compared to findings on ICGA. Results: Sixty-eight eyes of ...
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  Mentions: University of Bern
5. No optical coherence tomography changes in premanifest Huntington's disease mutation carriers far from disease onset
  
  Explore Wiley Online Library May 8 2022 Neurology , Ophthalmology
  
  Background: Spectral-domain optical coherence tomography (OCT) may detect retinal changes as a biomarker in neurodegenerative diseases like manifest Huntington's disease (HD). We investigate macular retinal layer thicknesses in a premanifest HD (pre-HD) cohort and healthy controls (HC). Methods: Pre-HD mutation carriers underwent standardized ratings and a preset macular OCT scan. Thickness values were determined for each sector of all macular retinal layers, the mean of all sectors and the ...
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  Mentions: University of Bern
6. Outer retinal features in OCT predict visual recovery after primary macula-involving retinal detachment repair
  
  Explore Journals | PLOS May 5 2022 Ophthalmology
  
  Purpose To find predictive markers for the visual potential in optical coherence tomography (OCT) one month after surgical repair of macula-involving rhegmatogenous retinal detachment (miRD) with and without internal limiting membrane (ILM) peeling. Methods This retrospective single-center, single-surgeon cohort study included 74 patients who underwent pars plana vitrectomy (PPV) for primary miRD between January 2013 and August 2020 with follow-up examinations for at least 6 months. Patients developing recurrent detachments ...
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  Mentions: Heidelberg Engineering University of Bern
7. Optical coherence tomography in coronary atherosclerosis assessment and intervention
  
  Explore Nature Publishing Group Apr 30 2022 Cardiology
  
  Since optical coherence tomography (OCT) was first performed in humans two decades ago, this imaging modality has been widely adopted in research on coronary atherosclerosis and adopted clinically for the optimization of percutaneous coronary intervention. In the past 10 years, substantial advances have been made in the understanding of in vivo vascular biology using OCT. Identification by OCT of culprit plaque pathology could potentially lead to a major shift in ...
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  Mentions: Brigham and Women’s Hospital Johns Hopkins University Massachusetts Institute of Technology
8. Effect of Evolocumab on Coronary Plaque Phenotype and Burden in Statin-Treated Patients Following Myocardial Infarction
  
  Explore ScienceDirect Apr 19 2022 Cardiology
  
  Objectives The purpose of this study was to determine the effect of evolocumab on optical coherence tomography (OCT) measures of plaque composition. Background The proprotein convertase subtilisin kexin type-9 inhibitor evolocumab produced coronary atheroma regression in statin-treated patients. Methods Patients with a nonST-segment elevation myocardial infarction were treated with monthly evolocumab 420 mg (n = 80) or placebo (n = 81) for 52 weeks. Patients underwent serial OCT and intravascular ultrasound imaging ...
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  Mentions: Cleveland Clinic University of Bern Semmelweis University
9. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts
  
  Explore ScienceDirect Feb 25 2022 Ophthalmology
  
  Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five ...
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  Mentions: University of Wisconsin University of Chicago University of Toronto
10. High Resolution Optical Coherence Tomography
  
  Explore Home - ClinicalTrials.gov Nov 23 2021 Ophthalmology , Clinical Trials
  
  Comparison of high-resolutionoptical coherence tomography(High-Res-OCT) to conventional imaging modalities for the diagnosis of eye diseases
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  Mentions: University of Bern
11. Towards a better understanding of the posttreatment hemodynamic behaviors in femoropopliteal arteries through personalized computational models based on OCT images
  
  Explore Nature Publishing Group Aug 19 2021 Cardiology
  
  The hemodynamic behavior following endovascular treatment of patients with peripheral arterial disease plays a significant role on the occurrence of restenosis in femoro-popliteal (FP) arteries. The atheroprone flow conditions that are generally accepted to promote restenosis can be calculated by computational fluid dynamics (CFD) analyses, and these results can be used to assess individualized treatment outcomes. However, the impact of endovascular therapy on the flow behaviors of FP arteries are ...
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  Mentions: University of Bern
12. Coronary embolism due to possible thrombosis of prosthetic aortic valve - the role of optical coherence tomography: case report
  
  Explore Journals Aug 12 2021 Cardiology
  
  Background: Coronary embolism is an important non-atherosclerotic cause of acute myocardial infarction (AMI) that requires an individualized diagnostic and therapeutic approach. Although certain angiographic criteria exist that render an embolic origin likely, uncertainty remains. Optical coherence tomography (OCT) is a high-resolution intracoronary imaging technology that enables visualization of thrombus and the underlying coronary vessel wall, which may be helpful to distinguish between an atherosclerotic and non-atherosclerotic origin of AMI. Case ...
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  Mentions: University of Bern
13. Impact of intracoronary optical coherence tomography in routine clinical practice: A contemporary cohort study
  
  Explore ScienceDirect Aug 4 2021 Cardiology
  
  Background/purpose: Guidelines recommend intracoronary optical coherence tomography (OCT) to assess stent failure and guide percutaneous coronary intervention (PCI) but OCT may be useful for other indications in routine clinical practice. Methods/materials: We conducted an international registry of OCT cases at two large tertiary care centers to assess clinical indications and the potential impact on decision making of OCT in clinical routine. Clinical indications, OCT findings, and their impact ...
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  Mentions: University of Bern
14. Evaluating the Safety of the Spectralis Centaurus Device
  
  Explore Home - ClinicalTrials.gov Jul 20 2021 Ophthalmology , Clinical Trials
  
  Optical microsurgery of the retinal pigment epithelium (RPE) requires reliable real-time dosimetry to prevent unwanted overexposure of the neuroretina. The SPECTRALIS CENTAURUS device implements optical coherence tomography (OCT) to detect intentional elimination of RPE cells caused by a prototype laser for selective retina therapy (SRT). Within this clinical trial the safety of the SPECTRALIS CENTAURUS device and its ability to detect RPE cell damage towards selective real-time laser microsurgery will ...
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  Mentions: Heidelberg Engineering University of Bern Bern University of Applied Sciences
15. Discordance in the diagnostic assessment of vulnerable plaques between radiofrequency intravascular ultrasound versus optical coherence tomography among patients with acute myocardial infarction: insights from the IBIS-4 study
  
  Explore Home - Springer Jul 9 2021 Cardiology
  
  We aimed to evaluate the diagnostic agreement between radiofrequency (RF) intravascular ultrasound (IVUS) and optical coherence tomography (OCT) for thin-cap fibroatheroma (TCFA) in non-infarct-related coronary arteries (non-IRA) in patients with ST-segment elevation myocardial infarction (STEMI). In the Integrated Biomarker Imaging Study (IBIS-4), 103 STEMI patients underwent OCT and RF-IVUS imaging of non-IRA after successful primary percutaneous coronary intervention and at 13-month follow-up. A coronary lesion was defined as a segment ...
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  Mentions: Leiden University University of Copenhagen University of Bern
16. Optical Coherence Tomography Findings After Atherectomy Devices | Icr Journal
  
  Explore Interventional Cardiology Review (ICR) May 28 2021 Cardiology
  
  Heavily calcified coronary artery lesions hinder the delivery of devices and limit stent expansion, resulting in low procedural success and poor clinical outcomes driven by an increase in restenosis and stent thrombosis. Intracoronary imaging provides a more precise assessment of lesions and is a critical step when deciding whether the lesion needs to be prepared with atherectomy devices. Physiological assessment of lesion significance is an important consideration to avoid unnecessary ...
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  Mentions: University of Bern
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