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2. Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis
  
  Explore Wiley Online Library Feb 13 2019 Ophthalmology
  
  Purpose To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept‐source optical coherence tomography angiography (OCTA). Methods In this study consecutive patients with intermediate uveitis vasculitis and healthy age‐matched controls were evaluated using central 3 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
3. Comparison of Optical Coherence Tomography-derived Minimal Lumen Area, Invasive Fractional Flow Reserve and FFRCT
  
  Explore Home - ClinicalTrials.gov Jan 29 2019 Clinical Trials
  
  Significant left main (LM) stenosis is associated with a poor prognosis, therefore, adequate judgement of the prognostic significance of LM stenosis is essential to improve patients' prognosis. Recently, fractional flow reserve (FFR) has become widespread practice and carries a Class Ia recommendation to assess functional significance of intermediate coronary stenosis in patients with stable angina. Intravascular ultrasound (IVUS)-derived minimum lumen area (MLA) represents an accurate measure to determine LM ...
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  Mentions: Bern University Hospital
4. Vascular Abnormalities In Diabetic Retinopathy Assessed With SWEPT-SOURCE Optical Coherence Tomography Angiography Widefield Imaging
  
  Explore LWW Online Dec 22 2018 Ophthalmology
  
  Purpose: To detect vascular abnormalities in diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) widefield images, and to compare the findings with color fundus photographs (CFPs) using Early Treatment Diabetic Retinopathy Study severity grading. Methods: 3 mm 3 mm and 12 mm 12 mm scans were acquired to cover 70 to 80 of the posterior pole using a 100-kHz SS-OCTA instrument. Two masked graders assessed the presence of vascular ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
5. Changes in Coronary Plaque Composition in Patients With Acute Myocardial Infarction Treated With High-Intensity Statin Therapy (IBIS-4): A Serial Optical Coherence Tomography Study
  
  Explore ScienceDirect Dec 19 2018 Cardiology
  
  Objectives This study assessed changes in optical coherence tomography (OCT)-defined plaque composition in patients with ST-elevation myocardial infarction (STEMI) receiving high-intensity statin treatment. Background OCT is a high-resolution modality capable of measuring plaque characteristics including fibrous cap thickness (FCT) and macrophage infiltration. There is limited in vivo evidence regarding the effects of statins on OCT-defined coronary atheroma composition and no evidence in the context of STEMI. Methods In the ...
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  Mentions: Imperial College London Leiden University University of Copenhagen
6. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography
  
  Explore BJO Online Dec 15 2018 Ophthalmology
  
  Purpose To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). Methods This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively ...
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  Mentions: University of Bern Bern University Hospital
7. Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging
  
  Explore Journals | PLOS Oct 9 2018 Ophthalmology
  
  Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
8. Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography
  
  Explore BJO Online Jun 2 2018 Ophthalmology
  
  Aim To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). Methods This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 66mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP ...
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  Mentions: Heidelberg Engineering Carl Zeiss Meditec San Raffaele Scientfic Institute
9. Quality difference of neointima following the implantation of bioresorbable scaffold and metallic stent in patients with ST elevation myocardial infarction: quantitative assessments by light intensity, light attenuation, and backscatter on optical coheren
  
  Explore eurointervention.org Mar 8 2018 Cardiology
  
  Aims: We aimed to assess possible difference of the neointimal quality after everolimus-eluting bioresorbable scaffold (BVS) implantation in comparison with cobalt chromium everolimus-eluting scaffold (CoCr-EES) by optical frequency domain imaging (OFDI). Methods and results: This study is a post-hoc analysis of TROFI II trial assessing neointimal quality 6-month after the implantation of BVS(N=82) and CoCr-EES(N=87) in STEMI patients. Neointimal light property analysis by OFDI full-automatically computed ...
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  Mentions: Imperial College London Leiden University Academic Medical Center at the University of Amsterdam
10. Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration
  
  Explore SAGE Journals Feb 6 2018 Ophthalmology
  
  Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes) from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert (control eyes). Parameters related to ...
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  Mentions: Sebastian Wolf University of Bern Bern University Hospital
11. Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age) (OCTAC)
  
  Explore Home - ClinicalTrials.gov Jan 17 2018 Ophthalmology , Clinical Trials
  
  Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality ...
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  Mentions: Bern University Hospital
12. Müller Glia Cell Activation in a Laser-induced Retinal Degeneration and Regeneration Model in Zebrafish
  
  Explore jove.com Nov 28 2017 Developmental Biology , Ophthalmology
  
  A fascinating difference between teleost and mammals is the lifelong potential of the teleost retina for retinal neurogenesis and regeneration after severe damage. Investigating the regeneration pathways in zebrafish might bring new insights to develop innovative strategies for the treatment of retinal degenerative diseases in mammals. Herein, we focused on the induction of a focal lesion to the outer retina in adult zebrafish by means of a 532 nm diode ...
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  Mentions: University of Bern Volker Enzmann Bern University Hospital
13. In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
  
  Explore jove.com Nov 28 2017 Ophthalmology
  
  Spectral domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO) are extensively used in experimental ophthalmology. In the present protocol, mice expressing green fluorescent protein (gfp) under the promoter of Cx3cr1 (BALB/c-Cx3cr1 gfp/gfp ) were used to image microglia cells in vivo in the retina. Microglia are resident macrophages of the retina and have been implicated in several retinal diseases 1 , 2 , 3 , 4 , 5 , 6 . This protocol ...
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  Mentions: Bern University Hospital Martin S. Zinkernagel
14. In Vivo Imaging of Cx3cr1 Reporter Mice with Spectral-domain Optical Coherence Tomography ...
  
  Explore jove.com Nov 11 2017 Ophthalmology
  
  ...igid gas permeable contact Quantum I, Bausch + Lomb Inc., lens Rochester, NY N/A balanced salt solution (BSS) Inselspital, Bern, Switzerland N/A silicon forceps N/A N/A atipamezole 5 mg/mL (Antisedan) Provet AG, Lyssach,...
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  Mentions: Heidelberg Engineering University of Bern Bern University Hospital
15. Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT
  
  Explore ScienceDirect Oct 3 2017 Cardiology
  
  Objectives The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUSvirtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. Background IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. Methods Anatomic landmarks and endoluminal radiopaque markers ...
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  Mentions: Imperial College London Leiden University Capital Medical University
16. Effect of Post-Dilatation Following Primary PCI With Everolimus-Eluting Bioresorbable Scaffold Versus Everolimus-Eluting Metallic Stent Implantation: An Angiographic and Optical Coherence Tomography TROFI II Substudy
  
  Explore ScienceDirect Sep 24 2017 Cardiology
  
  Objectives This study sought to investigate the effect of post-dilatation on angiographic and intracoronary imaging parameters in the setting of primary percutaneous coronary intervention comparing the everolimus-eluting bioresorbable scaffold (BRS) with the everolimus-eluting metallic stent (EES). Background Routine post-dilatation of BRS has been suggested to improve post-procedural angiographic and subsequent device-related clinical outcomes. Methods In the ABSORB STEMI TROFI II trial, 191 patients with ST-segment elevation myocardial infarction were randomly ...
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  Mentions: Academic Medical Center at the University of Amsterdam Patrick W. Serruys Stephan Windecker
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