1. Benjamin J. Vakoc

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    1. Mentioned In 84 Articles

    2. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography

      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography
      Purpose : To compare the rates of clinically significant artifacts for two-dimensional peripapillary retinal nerve fiber layer (RNFL) thickness versus three-dimensional (3D) neuroretinal rim thickness using spectral-domain optical coherence tomography (SD-OCT). Methods : Only one eye per patient was used for analysis of 120 glaucoma patients and 114 normal patients. For RNFL scans and optic nerve scans, 15 artifact types were calculated per B-scan and per eye. Neuroretinal rim tissue was quantified ...
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    3. A Neural Network Approach to Quantify Blood Flow from Retinal OCT Intensity Time-Series Measurements

      A Neural Network Approach to Quantify Blood Flow from Retinal OCT Intensity Time-Series Measurements
      Many diseases of the eye are associated with alterations in the retinal vasculature that are possibly preceded by undetected changes in blood flow. In this work, a robust blood flow quantification framework is presented based on optical coherence tomography (OCT) angiography imaging and deep learning. The analysis used a forward signal model to simulate OCT blood flow data for training of a neural network (NN). The NN was combined with ...
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    4. Stepped frequency comb generation based on electro-optic phase-code mode-locking for moderate-speed circular-ranging OCT

      Stepped frequency comb generation based on electro-optic phase-code mode-locking for moderate-speed circular-ranging OCT
      Circular-ranging (CR) optical coherence tomography (OCT) uses frequency comb sources to improve long-range imaging. While the initial development of CR-OCT focused on extremely high-speed imaging (i.e., operation at A-line rates of several to tens of MHz), there are many applications and imaging strategies for which more moderate speeds are preferred. However, we lack suitable frequency comb sources to enable moderate speed CR-OCT imaging. Here, we describe a novel phase-code ...
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    5. 9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking

      9.4 MHz A-line rate optical coherence tomography at 1300 nm using a wavelength-swept laser based on stretched-pulse active mode-locking
      In optical coherence tomography (OCT), high-speed systems based at 1300nm are among the most broadly used. Here, we present 9.4 MHz A-line rate OCT system at 1300nm. A wavelength-swept laser based on stretched-pulse active mode locking (SPML) provides a continuous and linear-in-wavenumber sweep from 1240nm to 1340nm, and the OCT system using this light source provides a sensitivity of 98dB and a single-sided 6-dB roll-off depth of 2.5mm ...
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    6. Characterization of New Optical Imaging Biomarkers of Peripheral Nerve Overstimulation

      Characterization of New Optical Imaging Biomarkers of Peripheral Nerve Overstimulation
      An animal study was designed to explore the potentially damaging effects of electrical overstimulation on peripheral nerves using a polarization‐sensitive optical coherence tomography (PS‐OCT) imaging and stimulation platform. Lewis rats (n = 15) were divided into 3 groups with 2 different levels of stimulation applied to the exposed sciatic nerve: Group 1 (sham control): 0.0 mA/0 Hz, Group 2: 3.4 mA/50 Hz, and Group 3 ...
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    7. Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume

      Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Retinal Nerve Fiber Layer Volume
      Purpose : To compare artifact rates in two-dimensional (2D) versus three-dimensional (3D) retinal nerve fiber layer (RNFL) scans using Spectralis optical coherence tomography (OCT) Methods : Thirteen artifact types in 2D and 3D RNFL scans were identified in 106 glaucomatous eyes and 95 normal eyes. Artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were counted only for the 97 B-scans used to calculate RNFL parameters for ...
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    8. Resolving absolute depth in circular-ranging optical coherence tomography by using a degenerate frequency comb

      Resolving absolute depth in circular-ranging optical coherence tomography by using a degenerate frequency comb
      In Fourier-domain optical coherence tomography, an interference signal is generated that spans an RF bandwidth proportional to the product of three parameters: the imaging range, the imaging speed, and the inverse of the axial resolution. Circular-ranging optical coherence tomography (CR-OCT) architectures were introduced to ease long-range imaging by decoupling the imaging range from the signal RF bandwidth. As a consequence, present CR-OCT systems resolve the relative, but not the absolute ...
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    9. Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm

      Stable multi-megahertz circular-ranging optical coherence tomography at 1.3 µm
      In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 m wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these ...
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    10. Highly-stable, multi-megahertz circular-ranging optical coherence tomography at 1.3 µm based on a chirped fiber Bragg grating

      Highly-stable, multi-megahertz circular-ranging optical coherence tomography at 1.3 µm based on a chirped fiber Bragg grating
      In Fourier-domain optical coherence tomography (OCT), the finite bandwidth of the acquisition electronics constrains the depth range and speed of the system. Circular-ranging (CR) OCT methods use optical-domain compression to surpass this limit. However, the CR-OCT system architectures of prior reports were limited by poor stability and were confined to the 1.55 m wavelength range. In this work, we describe a novel CR-OCT architecture that is free from these ...
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    11. Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II

      Three-Dimensional Optical Coherence Tomography Imaging for Glaucoma Associated with Boston Keratoprosthesis Type I and II
      Precis: 3D spectral domain OCT volume scans of the optic nerve head and the peripapillary area are useful in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Purpose: To report the use of spectral domain optical coherence tomography (OCT) in the management of glaucoma in patients with a type I or II Boston Keratoprosthesis (KPro). Methods: Observational case series. Four consecutive patients with ...
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    12. Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software

      Diagnostic Capability of 3D Peripapillary Retinal Volume for Glaucoma Using Optical Coherence Tomography Customized Software
      Prcis: The diagnostic capability of peripapillary retinal volume is similar to peripapillary retinal nerve fiber layer thickness for diagnosing glaucoma, but with fewer artifacts. Purpose: To compare the diagnostic capability of three-dimensional (3D) peripapillary retinal volume (RV) versus two-dimensional (2D) peripapillary retinal nerve fiber layer (RNFL) thickness for open-angle glaucoma . Patients and Methods: A retrospective cross-sectional analysis was conducted. A total of 180 subjects [113 open-angle glaucomas (OAG), 67 normal ...
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    13. Massachusetts General Hospital Receives NIH Grant for Novel Optical Coherence Tomography Tool Development for Quantitative Peripheral Nerve Imaging

      Massachusetts General Hospital Receives NIH Grant for Novel Optical Coherence Tomography Tool Development for Quantitative Peripheral Nerve Imaging
      ...oherence Tomography Tool Development for Quantitative Peripheral Nerve Imaging. The principal investigator is Benjamin Vakoc. The program began in 2019 and ends in 2020.

      Below is a sum...

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    14. Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling

      Retinal Blood Vessel Caliber Estimation for Optical Coherence Tomography Angiography Images Based on 3D Superellipsoid Modeling
      Changes of retinal blood vessel calibers may reflect various retinal diseases and even several non-retinal diseases. We propose a new method to estimate retinal vessel calibers from 3D optical coherence tomography angiography (OCTA) images based on 3D modeling using superellipsoids. Taking advantage of 3D visualization of the retinal tissue microstructures in vivo provided by OCTA, our method can detect retinal blood vessels precisely, estimate their calibers reliably, and show the ...
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    15. 1-15 of 84 1 2 3 4 5 6 »
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  2. About Benjamin J. Vakoc

    Benjamin J. Vakoc

    Benjamin J. Vakoc is an Instructor at the Wellman Center for Photomedicine at the Massachusetts General Hosptial .