1. Baylor College of Medicine

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    1. Mentioned In 125 Articles

    2. Live dynamic analysis of mouse embryonic cardiogenesis with functional optical coherence tomography

      Live dynamic analysis of mouse embryonic cardiogenesis with functional optical coherence tomography
      Hemodynamic load, contractile forces, and tissue elasticity are regulators of cardiac development and contribute to the mechanical homeostasis of the developing vertebrate heart. Congenital heart disease (CHD) is a prevalent condition in the United States that affects 8 in 1000 live births[1], and has been linked to disrupted cardiac biomechanics[2-4]. Therefore, it is important to understand how these forces integrate and regulate vertebrate cardiac development to inform clinical ...
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    3. Biomechanical assessment of myocardial infarction using optical coherence elastography

      Biomechanical assessment of myocardial infarction using optical coherence elastography
      Myocardial infarction (MI) leads to cardiomyocyte loss, impaired cardiac function, and heart failure. Molecular genetic analyses of myocardium in mouse models of ischemic heart disease have provided great insight into the mechanisms of heart regeneration, which is promising for novel therapies after MI. Although biomechanical factors are considered an important aspect in cardiomyocyte proliferation, there are limited methods for mechanical assessment of the heart in the mouse MI model. This ...
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    4. Prolonged in vivo functional assessment of the mouse oviduct using optical coherence tomography through a dorsal imaging window

      Prolonged in vivo functional assessment of the mouse oviduct using optical coherence tomography through a dorsal imaging window
      The oviduct (or fallopian tube) serves as an environment for gamete transport, fertilization, and preimplantation embryo development in mammals. Although there has been increasing evidence linking infertility with disrupted oviduct function, the specific roles that the oviduct plays in both normal and impaired reproductive processes remain unclear. The mouse is an important mammalian model to study human reproduction. However, most of the current analyses of the mouse oviduct rely on ...
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    5. Evaluation of Femtosecond Laser Versus Manual Clear Corneal Incisions in Cataract Surgery Using Spectral-Domain Optical Coherence Tomography

      Evaluation of Femtosecond Laser Versus Manual Clear Corneal Incisions in Cataract Surgery Using Spectral-Domain Optical Coherence Tomography
      PURPOSE: To investigate the wound healing changes of clear corneal incisions performed with a femtosecond laser or a steel bevel knife in cataract surgery using spectral-domain optical coherence tomography. METHODS: Prospectively, consecutive patients undergoing either femtosecond laserassisted cataract surgery (femtosecond laser group) using the LenSx laser (Alcon Laboratories, Inc., Fort Worth, TX) or traditional cataract surgery using steel blades (control group) were enrolled. The incidence of posterior wound gape, Descemet ...
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    6. Optical Coherence Tomography Transecting an Omega Retinal Venous Loop en Face in a Patient With Diabetic Retinopathy

      Optical Coherence Tomography Transecting an Omega Retinal Venous Loop en Face in a Patient With Diabetic Retinopathy
      The image depicts a woman in her mid-40s with poorly controlled insulin-dependent diabetes and bilateral proliferative diabetic retinopathy. Fundus photography of the left eye with corresponding spectral-domain optical coherence tomography captured an omega retinal venous loop en face ( Figure , A). This image demonstrates that the venous loop is located in the preretinal plane and is in direct contact with the posterior hyaloid face ( Figure , B).
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    7. Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison and combination of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      Several optical imaging techniques have been applied for high-resolution embryonic imaging using different contrast mechanisms, each with their own benefits and limitations. In this study, we imaged the same E9.5 mouse embryo with rotational imaging optical coherence tomography (RI-OCT) and selective plane illumination microscopy (SPIM). RI-OCT overcomes optical penetration limits of traditional OCT imaging that prohibit full-body imaging of mouse embryos at later stages by imaging the samples from ...
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    8. Space Flight–Associated Neuro-ocular Syndrome

      Space Flight–Associated Neuro-ocular Syndrome
      New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flightassociated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the ...
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    9. Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart

      Speckle variance optical coherence tomography of blood flow in the beating mouse embryonic heart
      Efficient separation of blood and cardiac wall in the beating embryonic heart is essential and critical for experiment-based computational modelling and analysis of early-stage cardiac biomechanics. Although speckle variance optical coherence tomography (SV-OCT) relying on calculation of intensity variance over consecutively acquired frames is a powerful approach for segmentation of fluid flow from static tissue, application of this method in the beating embryonic heart remains challenging because moving structures generate ...
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    10. Quantifying the effects of UV-A/riboflavin crosslinking on the elastic anisotropy and hysteresis of the porcine cornea by noncontact optical coherence elastography

      Quantifying the effects of UV-A/riboflavin crosslinking on the elastic anisotropy and hysteresis of the porcine cornea by noncontact optical coherence elastography
      The collagen fibril orientation of the cornea can provide critical information about cornea tissue health because diseases such as keratoconus and therapeutic interventions such as UV-A/riboflavin corneal collagen crosslinking (CXL) can alter the ultrastructural arrangement of collagen fibrils. Here, we quantify the elastic anisotropy and hysteresis of in situ porcine corneas as a function of intraocular pressure (IOP) with noncontact optical coherence elastography. Moreover, the effects of UV-A riboflavin ...
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    11. Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument

      Applanation optical coherence elastography: noncontact measurement of intraocular pressure, corneal biomechanical properties, and corneal geometry with a single instrument
      Current clinical tools provide critical information about ocular health such as intraocular pressure (IOP). However, they lack the ability to quantify tissue material properties, which are potent markers for ocular tissue health and integrity. We describe a single instrument to measure the eye-globe IOP, quantify corneal biomechanical properties, and measure corneal geometry with a technique termed applanation optical coherence elastography (Appl-OCE). An ultrafast OCT system enabled visualization of corneal dynamics ...
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    12. Evaluation of dermal fillers with noncontact optical coherence elastography

      Evaluation of dermal fillers with noncontact optical coherence elastography
      Over 2 million dermal filler procedures are performed each year in the USA alone, and this figure is only expected to increase as the aging population continues to grow. Dermal filler treatments can last from a few months to years depending on the type of filler and its placement. Although adverse reactions are rare, they can be quite severe due to ischemic events and filler migration. Previously, techniques such as ...
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    13. A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging

      A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
      Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. However, each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse ...
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    14. Live dynamic analysis of the developing cardiovascular system in mice

      Live dynamic analysis of the developing cardiovascular system in mice
      The study of the developing cardiovascular system in mice is important for understanding human cardiogenesis and congenital heart defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development under the regulation of dynamic factors like contractile force and blood flow using optical coherence tomography (OCT). We have previously developed an OCT based approach that combines static embryo culture and advanced image processing with ...
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    15. Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

      Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation
      Dermal fillers are a very popular anti-aging treatment with estimated sales in the billions of dollars and millions of procedures performed. As the aging population continues to grow, these figures are only expected to increase. Dermal fillers have various compositions depending on their intended application. Reactions to dermal fillers can be severe, such as ischemic events and filler migration to the eyes. However, these adverse reactions are rare. Nevertheless, the ...
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  2. About Baylor College of Medicine

    Baylor College of Medicine

    Baylor College of Medicine, located in Houston, Texas, USA, is one of the world's leading centers for biomedical research and clinical care. Situated within the Texas Medical Center, a 1,000-acre complex that is home to 46 member institutions and is the largest medical center in the world, Baylor College of Medicine has affiliations with eight teaching hospitals, including the world-renowned Texas Children's Hospital, MD Anderson Cancer Center, Menninger Clinic and Texas Heart Institute. It has been consistently rated the top medical school in Texas and among the top 10 medical schools in the United States. Its Graduate School of Biomedical Sciences is also highly rated. BCM, despite being solely focused on medical and graduate education, has become one of 63 American colleges with an endowment greater than $1 billion.