1. Baylor College of Medicine

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    1. Mentioned In 111 Articles

    2. A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging

      A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging
      Both optical coherence tomography (OCT) and selective plane illumination microscopy (SPIM) are frequently used in mouse embryonic research for high-resolution three-dimensional imaging. However, each of these imaging methods provide a unique and independent advantage: SPIM provides morpho-functional information through immunofluorescence and OCT provides a method for whole-embryo 3D imaging. In this study, we have combined rotational imaging OCT and SPIM into a single, dual-modality device to image E9.5 mouse ...
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    3. Live dynamic analysis of the developing cardiovascular system in mice

      Live dynamic analysis of the developing cardiovascular system in mice
      The study of the developing cardiovascular system in mice is important for understanding human cardiogenesis and congenital heart defects. Our research focuses on imaging early development in the mouse embryo to specifically understand cardiovascular development under the regulation of dynamic factors like contractile force and blood flow using optical coherence tomography (OCT). We have previously developed an OCT based approach that combines static embryo culture and advanced image processing with ...
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    4. Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation

      Optical coherence tomography for image-guided dermal filler injection and biomechanical evaluation
      Dermal fillers are a very popular anti-aging treatment with estimated sales in the billions of dollars and millions of procedures performed. As the aging population continues to grow, these figures are only expected to increase. Dermal fillers have various compositions depending on their intended application. Reactions to dermal fillers can be severe, such as ischemic events and filler migration to the eyes. However, these adverse reactions are rare. Nevertheless, the ...
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    5. Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography

      Dynamic imaging and quantitative analysis of cranial neural tube closure in the mouse embryo using optical coherence tomography
      Neural tube closure is a critical feature of central nervous system morphogenesis during embryonic development. Failure of this process leads to neural tube defects, one of the most common forms of human congenital defects. Although molecular and genetic studies in model organisms have provided insights into the genes and proteins that are required for normal neural tube development, complications associated with live imaging of neural tube closure in mammals limit ...
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    6. Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography

      Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography
      In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Youngs modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the ...
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    7. Optical Modalities for Embryonic Imaging

      Optical Modalities for Embryonic Imaging
      tudies of disease etiology often rely on the murine (mouse) model, which provides valuable genotypic information. Yet associated phenotypic information from murine embryos is often lacking. Of the various techniques that have been proposed for imaging such embryos, optical modalities may provide the best compromise among speed, penetration depth and resolution. This year, we developed approaches to improve embryonic imaging with optical coherence tomography (OCT), 1 and also provided a ...
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    8. Comparison of Newer IOL Power Calculation Methods for Eyes With Previous Radial Keratotomy

      Comparison of Newer IOL Power Calculation Methods for Eyes With Previous Radial Keratotomy
      Purpose : To evaluate the accuracy of the optical coherence tomographybased (OCT formula) and Barrett True K (True K) intraocular lens (IOL) calculation formulas in eyes with previous radial keratotomy (RK). Methods : In 95 eyes of 65 patients, using the actual refraction following cataract surgery as target refraction, the predicted IOL power for each method was calculated. The IOL prediction error (PE) was obtained by subtracting the predicted IOL power from ...
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    9. Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant

      Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant
      Efficient phenotyping of developmental defects in model organisms is critical for understanding the genetic specification of normal development and congenital abnormalities in humans. We previously reported that optical coherence tomography (OCT) combined with live embryo culture is a valuable tool for mouse embryo imaging and four-dimensional (4-D) cardiodynamic analysis; however, its capability for analysis of mouse mutants with cardiac phenotypes has not been previously explored. Here, we report 4-D (three-dimensional ...
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    10. Optical coherence tomography for embryonic imaging: a review

      Optical coherence tomography for embryonic imaging: a review
      Embryogenesis is a highly complex and dynamic process, and its visualization is crucial for understanding basic physiological processes during development and for identifying and assessing possible defects, malformations, and diseases. While traditional imaging modalities, such as ultrasound biomicroscopy, micro-magnetic resonance imaging, and micro-computed tomography, have long been adapted for embryonic imaging, these techniques generally have limitations in their speed, spatial resolution, and contrast to capture processes such as cardiodynamics during ...
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    11. Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography

      Applicability, usability, and limitations of murine embryonic imaging with optical coherence tomography and optical projection tomography
      We present an analysis of imaging murine embryos at various embryonic developmental stages (embryonic day 9.5, 11.5, and 13.5) by optical coherence tomography (OCT) and optical projection tomography (OPT). We demonstrate that while OCT was capable of rapid high-resolution live 3D imaging, its limited penetration depth prevented visualization of deeper structures, particularly in later stage embryos. In contrast, OPT was able to image the whole embryos, but ...
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    12. BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)

      BIOPHOTONICS AND IMAGING SUMMER SCHOOL (BIGSS 2016)
      The Bi-annual Biophotonics and Imaging Summer School (BIGSS16) will be held 5-9 September 2016 in Galway, Ireland. It is a five ECTS accredited course with leading professors teaching. Sessions are approx. four hours each to give a substantial grounding in the main topics of Biophotonics. The location is in the picturesque village of Ballyvaughanin the Burren . This will be augmented with hands on training at NUI Galway. Fee: 800 including ...
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    13. Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography

      Four-dimensional live imaging of hemodynamics in mammalian embryonic heart with Doppler optical coherence tomography
      Four-dimensional live hemodynamic imaging of the mouse embryonic heart at embryonic day 9.0 using Doppler optical coherence tomography, showing directional blood flows in the sinus venosus, primitive atrium, atrioventricular region and vitelline vein. Hemodynamic analysis of the mouse embryonic heart is essential for understanding the functional aspects of early cardiogenesis and advancing the research in congenital heart defects. However, high-resolution imaging of cardiac hemodynamics in mammalian models remains challenging ...
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    14. Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

      Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study
      The mouse is a common model for studying developmental diseases. Different optical techniques have been developed to investigate mouse embryos, but each has its own set of limitations and restrictions. In this study, we imaged the same E9.5 mouse embryo with rotational imaging Optical Coherence Tomography (RI-OCT) and Selective Plane Illumination Microscopy (SPIM), and compared the two techniques. Results demonstrate that both methods can provide images with micrometer-scale spatial ...
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    15. 1-15 of 111 1 2 3 4 5 6 7 8 »
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  2. About Baylor College of Medicine

    Baylor College of Medicine

    Baylor College of Medicine, located in Houston, Texas, USA, is one of the world's leading centers for biomedical research and clinical care. Situated within the Texas Medical Center, a 1,000-acre complex that is home to 46 member institutions and is the largest medical center in the world, Baylor College of Medicine has affiliations with eight teaching hospitals, including the world-renowned Texas Children's Hospital, MD Anderson Cancer Center, Menninger Clinic and Texas Heart Institute. It has been consistently rated the top medical school in Texas and among the top 10 medical schools in the United States. Its Graduate School of Biomedical Sciences is also highly rated. BCM, despite being solely focused on medical and graduate education, has become one of 63 American colleges with an endowment greater than $1 billion.