1. Barry Cense

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    1. Mentioned In 31 Articles

    2. Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature

      Short-time series optical coherence tomography angiography and its application to cutaneous microvasculature
      We present a new optical coherence tomography (OCT) angiography method for imaging tissue microvasculature in vivo based on the characteristic frequency-domain flow signature in a short time series of a single voxel. The angiography signal is generated by Fourier transforming the OCT signal time series from a given voxel in multiple acquisitions and computing the average magnitude of non-zero (high-pass) frequency components. Larger temporal variations of the OCT signal caused ...
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    3. Retinal imaging with optical coherence tomography and low‐loss adaptive optics using a 2.8‐mm beam size

      Retinal imaging with optical coherence tomography and low‐loss adaptive optics using a 2.8‐mm beam size
      As data acquisition for retinal imaging with optical coherence tomography (OCT) becomes faster, efficient collection of photons becomes more important to maintain image quality. One approach is to use a larger aperture at the eyes pupil to collect more photons that have been reflected from the retina. A 2.8‐mm beam diameter system with only 7 reflecting surfaces was developed for low‐loss retinal imaging. The larger beam size ...
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    4. Measuring polarization changes in the human outer retina with polarization‐sensitive optical coherence tomography

      Measuring polarization changes in the human outer retina with polarization‐sensitive optical coherence tomography
      Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age‐related macular degeneration. However, earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization‐altering properties. To test this hypothesis, we developed a method based on polarization‐sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (25years) and 10 ...
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    5. Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography

      Measuring polarization changes in the human outer retina with polarization-sensitive optical coherence tomography
      Morphological changes in the outer retina such as drusen are established biomarkers to diagnose age-related macular degeneration. However earlier diagnosis might be possible by taking advantage of more subtle changes that accompany tissues that bear polarization-altering properties. To test this hypothesis, we developed a method based on polarization-sensitive optical coherence tomography with which volumetric data sets of the macula were obtained from 10 young (25 yr) and 10 older (54 ...
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    6. A 3.4-mm beam diameter system for retinal imaging with OCT and adaptive optics

      A 3.4-mm beam diameter system for retinal imaging with OCT and adaptive optics
      We present an adaptive-optics optical coherence tomography (AO-OCT) system with 3.4-mm beam diameter. A deformable mirror is used for the correction of two radial Zernike orders (defocus, vertical and oblique astigmatism). The aberrations are corrected sequentially with a Shack-Hartmann wave-front sensor and the deformable mirror. This system fills a gap between a standard clinical 1.2-mm beam diameter OCT system and a 6-mm beam diameter AO-OCT system. We also ...
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      Mentions: Barry Cense
    7. Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer

      Ultra-high resolution polarization-sensitive optical coherence tomography for imaging of the retinal nerve fiber layer
      A spectrometer design with a multiple line line-scan camera and beam displacer is presented for ultra-high resolution optical coherence tomography measurements of the human retina at 840 nm. The beam displacer offsets the two orthogonal polarization states on the same line-scan camera, which reduces k-space mapping complexity, as data in both polarization channels can be mapped with the same procedure. Its coherence length is 2.8 m in tissue (n ...
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      Mentions: Barry Cense
    8. Optical coherence tomography with a 2.8-mm beam diameter and sensorless defocus and astigmatism correction

      Optical coherence tomography with a 2.8-mm beam diameter and sensorless defocus and astigmatism correction
      An optical coherence tomography (OCT) system with a 2.8-mm beam diameter is presented. Sensorless defocus correction can be performed with a Badal optometer and astigmatism correction with a liquid crystal device. OCT B-scans were used in an image-based optimization algorithm for aberration correction. Defocus can be corrected from 4.3 D 4.3D to + 4.3 D +4.3D and vertical and oblique astigmatism from 2.5 D 2 ...
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      Mentions: Barry Cense
    9. Influence of coherence length, signal-to-noise ratio, log transform, and low-pass filtering on layer thickness assessment with OCT in the retina

      Influence of coherence length, signal-to-noise ratio, log transform, and low-pass filtering on layer thickness assessment with OCT in the retina
      Optical coherence tomography (OCT) images of the retina are inevitably affected by the finite width of the coherence function and noise. To make low-reflective layers visible, the raw OCT signal is log transformed; to reduce the effect of noise the images can be low-pass filtered. We determined the effects of these operations on layer thickness assessment, as a function of signal-to-noise ratio (SNR), by performing measurements in a phantom eye ...
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    10. Impact of motion-associated noise on intrinsic optical signal imaging in humans with optical coherence tomography

      Impact of motion-associated noise on intrinsic optical signal imaging in humans with optical coherence tomography
      A growing body of evidence suggests that phototransduction can be studied in the human eye in vivo by imaging of fast intrinsic optical signals (IOS). There is consensus concerning the limiting influence of motion-associated imaging noise on the reproducibility of IOS-measurements, especially in those employing spectral-domain optical coherence tomography (SD-OCT). However, no study to date has conducted a comprehensive analysis of this noise in the context of IOS-imaging. In this ...
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      Mentions: Barry Cense
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  2. About Barry Cense

    Barry Cense

    Barry Cense is at the University of Western Australia.