1. B. Hyle Park

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    1. Mentioned In 26 Articles

    2. OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in the Drosophila CNS [Invited]

      OCT intensity and phase fluctuations correlated with activity-dependent neuronal calcium dynamics in the Drosophila CNS [Invited]
      Phase-resolved OCT and fluorescence microscopy were used simultaneously to examine stereotypic patterns of neural activity in the isolated Drosophila central nervous system. Both imaging modalities were focused on individually identified bursicon neurons known to be involved in a fixed action pattern initiated by ecdysis-triggering hormone. We observed clear correspondence of OCT intensity, phase fluctuations, and activity-dependent calcium-induced fluorescence.
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    3. Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography

      Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
      A system, process and software arrangement are provided to determine at least one position of at least one portion of a sample. In particular, information associated with the portion of the sample is obtained. Such portion may be associated with an interference signal that includes a first electro-magnetic radiation received from the sample and a second electro-magnetic radiation received from a reference. In addition, depth information and/or lateral information ...
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    4. Visualizing Cortical Tissue Optical Changes During Seizure Activity with Optical Coherence Tomography

      Visualizing Cortical Tissue Optical Changes During Seizure Activity with Optical Coherence Tomography
      Optical coherence tomography (OCT) is a label-free, high resolution, minimally invasive imaging tool, which can produce millimeter depth-resolved cross-sectional images. We identified changes in the backscattered intensity of infrared light, which occurred during the development of induced seizures in vivo in mice. In a large region of interest, we observed significant decreases in the OCT intensity from cerebral cortex tissue preceding and during generalized tonic-clonic seizures induced with pentylenetetrazol (PTZ ...
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    5. In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography

      In vivo optical microscopy of peripheral nerve myelination with polarization sensitive-optical coherence tomography
      Assessing nerve integrity and myelination after injury is necessary to provide insight for treatment strategies aimed at restoring neuromuscular function. Currently, this is largely done with electrical analysis, which lacks direct quantitative information. In vivo optical imaging with sufficient imaging depth and resolution could be used to assess the nerve microarchitecture. In this study, we examine the use of polarization sensitive-optical coherence tomography (PS-OCT) to quantitatively assess the sciatic nerve ...
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    6. Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography

      Decreased light attenuation in cerebral cortex during cerebral edema detected using optical coherence tomography
      Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, and contributes to the poor prognosis associated with these injuries. This study examines the use of optical coherence tomography (OCT) for detecting cerebral edema in vivo . Three-dimensional imaging of an in vivo water intoxication model in mice was performed using a spectral-domain OCT system centered at 1300 nm. The change in attenuation coefficient was ...
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    7. Investigation of Biodegradable Composite Coated Magnesium Alloy Using Optical Coherence Tomography

      Investigation of Biodegradable Composite Coated Magnesium Alloy Using Optical Coherence Tomography
      Optical coherence tomography (OCT) was used to characterize poly (lactic-co-glycolic acid) (PLGA) and nanophase hydroxyapatite (nHA) / PLGA coatings on magnesium (Mg) substrates before and after immersion in revised simulated body fluid (rSBF) under standard cell culture conditions. The OCT images clearly showed: the surface of the coatings, the metallic surface underneath the coatings, the presence of a dispersed phase within the polymer matrix, and defects and structural changes to the ...
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    8. OCT News 2013 Student Paper Awarded to Carissa Reynolds from University of California Riverside

      OCT News 2013 Student Paper Awarded to Carissa Reynolds from University of California Riverside
      Carissa Reynolds from University of California Riverside was a winner of the 2013 OCT News Student paper award for her submission Using Optical Coherence Tomography to Detect Cerebral Edema. Below is a summary of her work: Cerebral edema, an increase in brain water content, is responsible for significant morbidity and mortality among patients suffering from neurological disorders such as traumatic brain injury, stroke, brain tumor and infection. Cerebral edema develops ...
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    9. In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography

      In vivo detection of cortical optical changes associated with seizure activity with optical coherence tomography
      The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG technology and previous research has suggested that optical changes, specifically changes in near-infrared optical scattering, may precede EEG seizure onset in in vivo models. Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which ...
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    10. GPU accelerated real-time multi-functional spectral-domain optical coherence tomography system at 1300nm

      GPU accelerated real-time multi-functional spectral-domain optical coherence tomography system at 1300nm
      We present a GPU accelerated multi-functional spectral domain optical coherence tomography system at 1300nm. The system is capable of real-time processing and display of every intensity image, comprised of 512 pixels by 2048 A-lines acquired at 20 frames per second. The update rate for all four images with size of 512 pixels by 2048 A-lines simultaneously (intensity, phase retardation, flow and en face view) is approximately 10 frames per second ...
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    11. In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography

      In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography
      The accurate determination of burn depth is critical in the clinical management of burn wounds. Polarization-sensitive optical coherence tomography (PS-OCT) has been proposed as a potentially non-invasive method for determining burn depth by measuring thermally induced changes in the structure and birefringence of skin, and has been investigated in pre-clinical burn studies with animal models and ex vivo human skin. In this study, we applied PS-OCT to the in-vivo imaging ...
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    12. Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography

      Extracting structural features of rat sciatic nerve using polarization-sensitive spectral domain optical coherence tomography
      We present spectral domain polarization-sensitive optical coherence tomography (SD PS-OCT) imaging of peripheral nerves. Structural and polarization-sensitive OCT imaging of uninjured rat sciatic nerves was evaluated both qualitatively and quantitatively. OCT and its functional extension, PS-OCT, were used to image sciatic nerve structure with clear delineation of the nerve boundaries to muscle and adipose tissues. A long-known optical effect, bands of Fontana, was also observed. Postprocessing analysis of these images ...
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    13. 1-15 of 26 1 2 »
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  2. About B. Hyle Park

    B. Hyle Park

    Boris Hyle Park is an assistant professor in the Bioengineering Department at the University of California Riverside.  The Park Research Group, led by B. Hyle Park, is based in Bioengineering department at University of California, Riverside. Dr Park obtained his PhD in Physics from University of California, Irvine and performed the bulk of his research on PS-OCT at the Wellman Center for Photomedicine under Johannes F. de Boer. The research focus of this group is the development and application of optical imaging techniques to neuroscience.  Current projects aim to study the structure, viability, and activity in nerves and neural networks in order to complement current methodologies and knowledge in neuroscience, and find ways to apply these discoveries clinically. The presented project presented is one of two larger ongoing efforts, and the lab is partially sponsored by NIH funding.