1. Axel Petzold

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    1. Mentioned In 34 Articles

    2. Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

      Explore Frontiers Neurology , Ophthalmology
      Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
      Vascular changes are increasingly recognized as important factors in the pathophysiology of neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel technology of optical coherence tomography angiography (OCTA) images the retinal and choroidal vasculature non-invasively and in a depth-resolved manner. OCTA provides an alternative quantitative measure of retinal damage, by measuring vascular density instead of structural atrophy. Preliminary results suggest OCTA is sensitive to retinal damage in early disease ...
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      Mentions: University College London Axel Petzold

    3. Optical coherence tomography (OCT) in neuro-ophthalmology

      Explore Nature Publishing Group Ophthalmology
      Optical coherence tomography (OCT) in neuro-ophthalmology
      Optical coherence tomography (OCT) is a non-invasive medical imaging technology that is playing an increasing role in the routine assessment and management of patients with neuro-ophthalmic conditions. Its ability to characterise the optic nerve head, peripapillary retinal nerve fibre layer and cellular layers of the macula including the ganglion cell layer enables qualitative and quantitative assessment of optic nerve disease. In this review, we discuss technical features of OCT and ...
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      Mentions: University College London Academic Medical Center at the University of Amsterdam Axel Petzold

    4. Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System

      Explore American Journal of Ophthalmology Ophthalmology
      Automated Pupillometry using a Prototype Binocular Optical Coherence Tomography System
      Purpose To determine the test-retest reliability and diagnostic accuracy of a binocular optical coherence tomography (OCT) prototype (Envision Diagnostics, USA) for pupillometry. Design Assessment of diagnostic reliability and accuracy. Methods Fifty participants with RAPD confirmed using the swinging flashlight method (mean age 49.6 years) and 50 healthy controls (mean age 31.3 years) were examined. Participants twice underwent an automated pupillometry exam using a binocular OCT system that presents ...
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      Mentions: University College London Axel Petzold Pearse A. Keane

    5. Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study

      Explore Wiley Online Library Neurology , Ophthalmology
      Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: An international study
      Objective To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multicenter international study at 11 sites, optical ...
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      Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer

    6. Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study

      Explore Wiley Online Library Neurology , Ophthalmology
      Optimal Inter‐Eye Difference Thresholds by OCT in MS: An International Study
      Objective To determine the optimal thresholds for inter‐eye differences in retinal nerve fiber and ganglion cell+inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Background Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods In this multi‐center international study at ...
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      Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer

    7. The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis

      Explore LWW Online Neurology , Ophthalmology
      The International Multiple Sclerosis Visual System Consortium: Advancing Visual System Research in Multiple Sclerosis
      Background: The International Multiple Sclerosis Visual System Consortium (IMSVISUAL) was formed in November 2014 with the primary goal of improving research, care, and education regarding the role of the visual system in multiple sclerosis (MS) and related disorders. Methods: In this review, we describe the formation, goals, activities, and structure of IMSVISUAL, as well as the relationship of IMSVISUAL with the Americas Committee for Treatment and Research in MS (ACTRIMS ...
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      Mentions: Peter A. Calabresi Johns Hopkins University University College London

    8. The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis

      Explore futuremedicine.com Ophthalmology
      The role of optical coherence tomography and infrared oculography in assessing the visual pathway and CNS in multiple sclerosis
      In this review, a current overview is provided of how optical coherence tomography and infrared oculography can aid in assessing the visual system and CNS in multiple sclerosis (MS). Both afferent and efferent visual disorders are common in MS and visual complaints can have a tremendous impact on daily functioning. Optical coherence tomography and infrared oculography can detect and quantify visual disorders with high accuracy, but could also serve as ...
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      Mentions: Academic Medical Center at the University of Amsterdam Axel Petzold

    9. Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank

      Explore Optical Coherence Tomography News Neurology , Ophthalmology
      Feature Of The Week 07/08/2018: Retinal Nerve Fibre Layer Thickness & Cognition - Results from UK Biobank
      Importance: Identifing potential screening tests for future cognitive decline is a priority for developing treatments for and the prevention of dementia. Objective: To examine the potential of retinal nerve fiber layer (RNFL) thickness measurement in identifying those at greater risk of cognitive decline in a large community cohort of healthy people. Design, Setting, and Participants: UK Biobank is a prospective, multicenter, community-based study of UK residents aged 40 to 69 ...
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      Mentions: University College London Topcon Medical Systems Oxford University

    10. Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography

      Explore The JAMA Network Neurology , Ophthalmology
      Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline A Study Using Optical Coherence Tomography
      ... Research Centre, Euan Paterson, BSc, Queens University Belfast, Tunde Peto, PhD, Queen's University Belfast, Axel Petzold, PhD, UCL, Jugnoo S. Rahi, PhD, UCL Great Ormond Street Institute of Child Health, Alicja R. Rudn...
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      Mentions: University College London Praveen J. Patel Axel Petzold

    11. Multicenter reliability of semiautomatic retinal layer segmentation using OCT

      Explore Neurology Neurology , Ophthalmology
      Multicenter reliability of semiautomatic retinal layer segmentation using OCT
      Objective To evaluate the inter-rater reliability of semiautomated segmentation of spectral domain optical coherence tomography (OCT) macular volume scans. Methods Macular OCT volume scans of left eyes from 17 subjects (8 patients with MS and 9 healthy controls) were automatically segmented by Heidelberg Eye Explorer (v1.9.3.0) beta-software (Spectralis Viewing Module v6.0.0.7), followed by manual correction by 5 experienced operators from 5 different academic centers ...
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      Mentions: University College London UCSF Friedemann Paul

    12. Software updates of OCT segmentation algorithms influence longitudinal assessment of retinal atrophy

      Explore Journal of the Neurological Sciences Ophthalmology
      Software updates of OCT segmentation algorithms influence longitudinal assessment of retinal atrophy
      Objective To investigate whether there is a systematic difference in peripapillary retinal nerve fiber layer (pRNFL) thickness measurements between subsequent updates of pRNFL segmentation software provided by Heidelberg Spectralis optical coherence tomography (OCT). Methods In total, 838 pRNFL scans from 213 multiple sclerosis (MS) patients and 61 healthy controls were analyzed. All scans were performed on the same OCT device followed by automated segmentation (HRA 5.6.4.0) and ...
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      Mentions: Heidelberg Engineering Axel Petzold

    14. Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

      Explore TheLancet.com Neurology , Ophthalmology
      Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study
      Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study ...
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      Mentions: Peter A. Calabresi Johns Hopkins University Laura J. Balcer

    15. The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography

      Explore LWW Online Neurology , Ophthalmology
      The Optic Disc Drusen Studies Consortium Recommendations for Diagnosis of Optic Disc Drusen Using Optical Coherence Tomography
      Background: Making an accurate diagnosis of optic disc drusen (ODD) is important as part of the work-up for possible life-threatening optic disc edema. It also is important to follow the slowly progressive visual field defects many patients with ODD experience. The introduction of enhanced depth imaging optical coherence tomography (EDI-OCT) has improved the visualization of more deeply buried ODD. There is, however, no consensus regarding the diagnosis of ODD using ...
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      Mentions: University College London University of Calgary Fiona E. Costello

    16. Diagnostic accuracy of optical coherence tomography Inter-Eye Percentage Difference (IEPD) for optic neuritis in multiple sclerosis - Coric - 2017 - European Journal of Neurology - Wiley Online Library

      Explore Wiley Online Library Neurology , Ophthalmology
      Diagnostic accuracy of optical coherence tomography Inter-Eye Percentage Difference (IEPD) for optic neuritis in multiple sclerosis - Coric - 2017 - European Journal of Neurology - Wiley Online Library
      Background Multiple sclerosis (MS) associated optic neuritis (MSON) causes atrophy of the inner retinal layers, which can be quantified by optical coherence tomography (OCT). It has been suggested that the Inter-Eye Percentage Difference (IEPD) of atrophy may be of diagnostic value in MSON. Methods Prospective, cross-sectional study in MS patients and healthy controls (HC). Spectral-domain OCT of both eyes was performed, followed by automated retinal layer segmentation of the peripapillary ...
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      Mentions: University College London Axel Petzold
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  4. About Axel Petzold

    Axel Petzold

    Axel Petzold is a Consultant Neurologist at Departments of Neurology and Ophthalmology at the VUmc and Honorary Senior Lecturer at UCL, Institute of Neurology, Queen Square, London, UK. He did his MD on colour vision with Lindsey Ted Sharpe, his PhD in neuroimmunology with Ed Thompson and was trained in neuro-ophthalmology by Gordon T. Plant. He has contributed to developing and validating body fluid and imaging biomarkers for inflammation and neurodegeneration in multiple sclerosis and optic neuropathies. He has been involved in setting up a joint neuro-ophthalmology service at the VUmc which integrates with existing research lines at the MS Centre Amsterdam. 

  5. Related Topics

    1. The Physiological Variation of the Retinal Nerve Fiber Layer Thickness and Macular Volume in Humans as Assessed by Spectral Domain–Optical Coherence Tomography
      17 articles also mentioned University College London
    2. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis
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    3. A Simple Sign for Recognizing Off–Axis OCT Measurement Beam Placement in the Context of Multicentre Studies
      12 articles also mentioned Friedemann Paul
    4. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria
      8 articles also mentioned Laura J. Balcer
    5. The OSCAR-IB Consensus Criteria for Retinal OCT Quality Assessment
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