1. Audrey K. Bowden

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    1. Mentioned In 47 Articles

    2. Review of methods and applications of attenuation coefficient measurements with optical coherence tomography

      Review of methods and applications of attenuation coefficient measurements with optical coherence tomography
      The optical attenuation coefficient (AC), an important tissue parameter that measures how quickly incident light is attenuated when passing through a medium, has been shown to enable quantitative analysis of tissue properties from optical coherence tomography (OCT) signals. Successful extraction of this parameter would facilitate tissue differentiation and enhance the diagnostic value of OCT. In this review, we discuss the physical and mathematical basis of AC extraction from OCT data ...
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    3. Postdoc Position at Vanderbilt University

      Postdoc Position at Vanderbilt University
      Description: The Bowden Laboratory for Biomedical Optics (https://lab.vanderbilt.edu/bowdenlab), as part of the Department of Biomedical Engineering and the Vanderbilt Biophotonics Center, develops optical imaging and sensing technologies for clinical and basic science applications, with additional interest in the development of low-cost and portable technologies for low-resource environments. We seek a new postdoc with expertise in programming and computer vision and an interest in biomedical applications to ...
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    4. Automatically Determining the Confocal Parameters from OCT B-Scans for Quantification of the Attenuation Coefficients

      Automatically Determining the Confocal Parameters from OCT B-Scans for Quantification of the Attenuation Coefficients
      The attenuation coefficient is a relevant biomarker for many diagnostic medical applications. Recently, the Depth- Resolved Confocal (DRC) technique was developed to automatically estimate the attenuation coefficients from Optical Coherence Tomography (OCT) data with pixel-level resolution. However, DRC requires that the confocal function parameters (i.e., focal plane location and apparent Rayleigh range) be known a priori. In this paper we present the autoConfocal algorithm: a simple, automatic method for ...
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    5. Registration of free-hand OCT daughter endoscopy to 3D organ reconstruction

      Registration of free-hand OCT daughter endoscopy to 3D organ reconstruction
      Despite the trend to pair white light endoscopy with secondary image modalities for in vivo characterization of suspicious lesions, challenges remain to co-register such data. We present an algorithm to co-register two different optical imaging modalities as a mother-daughter endoscopy pair. Using white light cystoscopy (mother) and optical coherence tomography (OCT) (daughter) as an example, we developed the first forward-viewing OCT endoscope that fits in the working channel of flexible ...
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    6. Combined optical coherence tomography and hyperspectral imaging using a double-clad fiber coupler

      Combined optical coherence tomography and hyperspectral imaging using a double-clad fiber coupler
      This work demonstrates the combination of optical coherence tomography (OCT) and hyperspectral imaging (HSI) using a double-clad optical fiber coupler. The single-mode core of the fiber is used for OCT imaging, while the inner cladding of the double-clad fiber provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of the sample morphology with OCT, enhanced with complementary molecular information ...
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    7. Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography

      Classification of basal cell carcinoma in human skin using machine learning and quantitative features captured by polarization sensitive optical coherence tomography
      We report the first fully automated detection of basal cell carcinoma (BCC), the most commonly occurring type of skin cancer, in human skin using polarization-sensitive optical coherence tomography (PS-OCT). Our proposed automated procedure entails building a machine-learning based classifier by extracting image features from the two complementary image contrasts offered by PS-OCT, intensity and phase retardation (PR), and selecting a subset of features that yields a classifier with the highest ...
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    8. Multimodal 3D cancer-mimicking optical phantom

      Multimodal 3D cancer-mimicking optical phantom
      Three-dimensional (3D) organ-mimicking phantoms provide realistic imaging environments for testing various aspects of optical systems, including for evaluating new probe designs, characterizing the diagnostic potential of new technologies, and assessing novel image processing algorithms prior to validation in real tissue. We introduce and characterize the use of a new material, Dragon Skin (Smooth-On Inc.), and fabrication technique, air-brushing, for fabrication of a 3D phantom that mimics the appearance of a ...
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    9. Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler

      Combined optical coherence tomography and hyper-spectral imaging using a double clad fiber coupler
      This proceedings shows the combination of Optical Coherence Tomography (OCT) and Hyper-Spectral Imaging (HSI) using a double-clad optical fiber. The single mode core of the fiber is used to transmit OCT signals, while the cladding, with its large collection area, provides an efficient way to capture the reflectance spectrum of the sample. The combination of both methods enables three-dimensional acquisition of sample morphology with OCT, enhanced by the molecular information ...
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    10. Iterative re-weighted approach to high-resolution optical coherence tomography with narrow-band sources

      Iterative re-weighted approach to high-resolution optical coherence tomography with narrow-band sources
      Optical coherence tomography (OCT) is a non-invasive optical imaging modality capable of high resolution imaging of internal tissue structures. It is widely believed that the high axial resolution in OCT systems requires a wide-bandwidth light source. As a result, often the potential advantages of narrow-bandwidth sources (in terms of cost and/or imaging speed) are understood to come at the cost of significant reduction in imaging resolution. In this paper ...
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    11. Automated, Depth-Resolved Estimation of the Attenuation Coefficient From Optical Coherence Tomography Data

      Automated, Depth-Resolved Estimation of the Attenuation Coefficient From Optical Coherence Tomography Data
      We present a method for automated, depth-resolved extraction of the attenuation coefficient from Optical Coherence Tomography (OCT) data. In contrast to previous automated, depth-resolved methods, the Depth-Resolved Confocal (DRC) technique derives an invertible mapping between the measured OCT intensity data and the attenuation coefficient while considering the confocal function and sensitivity fall-off, which are critical to ensure accurate measurements of the attenuation coefficient in practical settings (e.g., clinical endoscopy ...
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  2. About Audrey K. Bowden

    Audrey K. Bowden

    Audrey (Ellerbee) Bowden holds a BSE in Electrical Engineering from Princeton University and a PhD in Biomedical Engineering from Duke University; she completed her postdoctoral training at Harvard University. She is currently Associate Professor of Biomedical Engineering at Vanderbilt University, having previously been Assistant and later Associate Professor of Electrical Engineering and Bioengineering at Stanford University. Dr. Bowden’s research interests include development of new optical technologies for clinical applications and resource-constrained environments, with a larger goal to improve and democratize healthcare. She is a member of the Optical Society of America and the SPIE.

  3. Quotes

    1. Being named a Fellow is a great honor, and I am in very illustrious company.
      In Biomedical engineering professor named a Fellow of optics society