1. Antonia Lichtenegger

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    1. Mentioned In 11 Articles

    2. Three-dimensional visualization of opacifications in the murine crystalline lens by in vivo optical coherence tomography

      Three-dimensional visualization of opacifications in the murine crystalline lens by in vivo optical coherence tomography
      Diagnostic classification techniques used to diagnose cataracts, the worlds leading cause of blindness, are currently based on subjective methods. Here, we present optical coherence tomography as a noninvasive tool for volumetric visualization of lesions formed in the crystalline lens. A custom-made swept-source optical coherence tomography (SS-OCT) system was utilized to investigate the murine crystalline lens. In addition to imaging cataractous lesions in aged wildtype mice, we studied the structure and ...
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    3. Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography

      Polarization-sensitive imaging with simultaneous bright- and dark-field optical coherence tomography
      We present a polarization-sensitive (PS) extension for bright- and dark-field (BRAD) optical coherence tomography imaging. Using a few-mode fiber detection scheme, the light backscattered at different angles is separated, and the BRAD images of tissue scattering are generated. A calibration method to correct for the fiber birefringence is proposed. Since particle scattering profiles are polarization dependent, a PS detection extends the capabilities for investigating the scattering properties of biological tissues ...
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    4. Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography

      Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography
      One key hallmark of Alzheimers disease (AD) is the accumulation of extracellular amyloid-beta protein in cortical regions of the brain. For a definitive diagnosis of AD, post-mortem histological analysis, including sectioning and staining of different brain regions, is required. Here, we present optical coherence tomography (OCT) as a tissue-preserving imaging modality for the visualization of amyloid-beta plaques and compare their contrast in intensity- and polarization-sensitive (PS) OCT. Human brain samples ...
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    5. Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope

      Assessment of pathological features in Alzheimer’s disease brain tissue with a large field-of-view visible-light optical coherence microscope
      We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for investigating ex-vivo brain tissue of patients diagnosed with Alzheimers disease (AD) and of a mouse model of AD. A submicrometer axial resolution in tissue was achieved using a broad visible light spectrum. The use of various objective lenses enabled reaching micrometer transversal resolution and the acquisition of images of microscopic brain features, such as cell structures, vessels, and white ...
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    6. Beyond backscattering: optical neuroimaging by BRAD

      Beyond backscattering: optical neuroimaging by BRAD
      Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked ...
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    7. White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina

      White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina
      A white light polarization sensitive optical coherence tomography system has been developed, using a supercontinuum laser as the light source. By detecting backscattered light from 400700 nm, an axial resolution of 1.0 m in air was achieved. The system consists of a free-space interferometer and two homemade spectrometers that detect orthogonal polarization states. Following system specifications, images of a healthy murine retina as acquired by this non-contact system are ...
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    8. Polarization-sensitive optical coherence tomography in the anterior mouse eye

      Polarization-sensitive optical coherence tomography in the anterior mouse eye
      Polarization-sensitive optical coherence tomography (PS-OCT) provides intrinsic contrast related to tissue microstructure. In the past, PS-OCT has been successfully used for imaging the anterior eye of humans in a variety of pathologic conditions. Here, we present PS-OCT imaging of the anterior eye in mice. Spectral domain PS-OCT centered at a wavelength of 840 nm was performed in anaesthetized laboratory mice. Three dimensional data sets were acquired at a 70 kHz ...
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    9. Beyond backscattering: Optical neuroimaging by BRAD

      Beyond backscattering: Optical neuroimaging by BRAD
      Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby waiving the wealth of information contained in the angular scattering distribution. Here we demonstrate that the unique features of few-mode fibers (FMF) enable simultaneous bright and dark field (BRAD) imaging for OCT. As backscattered light is picked ...
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    10. Feature Of The Week 09/03/2017: Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      Feature Of The Week 09/03/2017: Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples
      ...alize hyperscattering structures in deeper cortical regions.For more information see recent Article. Courtesy Antonia Lichtenegger from Medical University of Vienna. To find out more about the Baumann Lab and the OPTIMAL...
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    11. Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples

      Spectroscopic imaging with spectral domain visible light optical coherence microscopy in Alzheimer’s disease brain samples
      A visible light spectral domain optical coherence microscopy system was developed. A high axial resolution of 0.88 m in tissue was achieved using a broad visible light spectrum (425 685 nm). Healthy human brain tissue was imaged to quantify the difference between white (WM) and grey matter (GM) in intensity and attenuation. The high axial resolution enables the investigation of amyloid-beta plaques of various sizes in human brain tissue ...
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    12. Visible light spectral domain optical coherence microscopy system for ex vivo imaging

      Visible light spectral domain optical coherence microscopy system for ex vivo imaging
      A visible light spectral domain optical coherence microscopy system operating in the wavelength range of 450-680 nm was developed. The resulting large wavelength range of 230 nm enabled an ultrahigh axial resolution of 0.88m in tissue. The setup consisted of a Michelson interferometer combined with a homemade spectrometer with a spectral resolution of 0.03 nm. Scanning of 1 x 1 mm 2 and 0.5 x 0.5 ...
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    13. 1-11 of 11
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  2. About Antonia Lichtenegger

    Antonia Lichtenegger

    Antonia Lichtenegger is at the Center for Medical Physics and Biomedical Engineering at the Medical Univesity of Vienna.