1. Angelika Unterhuber

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    1. Mentioned In 32 Articles

    2. Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography

      Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography
      Many different parameters exist for the investigation of tear film dynamics. We present a new tear meniscus segmentation algorithm which automatically extracts tear meniscus area (TMA), height (TMH), depth (TMD) and radius (TMR) from UHR-OCT measurements and apply it to a data set including repeated measurements from ten healthy subjects. Mean values and standard deviations are 0.0174 0.007 mm 2 , 0.272 0.069 mm, 0.191 0 ...
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    3. Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Feature Of The Week 03/31/2019: Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue
      ...alth of intrinsic molecular and morphological information. For more information see recent Article . Courtesy Angelika Unterhuber from Medical University of Vienna . We have developed a multimodal laser scanning microsco...
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    4. Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue

      Depth resolved label-free multimodal optical imaging platform to study morpho-molecular composition of tissue
      Multimodal imaging platforms offer a vast array of tissue information in a single image acquisition by combining complementary imaging techniques. By merging different systems, better tissue characterization can be achieved than is possible by the constituent imaging modalities alone. The combination of optical coherence tomography (OCT) with non-linear optical imaging (NLOI) techniques such as two-photon excited fluorescence (TPEF), second harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) provides access ...
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    5. Ultrahigh‐resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing

      Ultrahigh‐resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing
      Purpose To employ ultrahigh‐resolution (UHR) optical coherence tomography (OCT) for investigation of the early wound healing process in corneal epithelium. Methods A custom‐built UHR‐OCT system assessed epithelial healing in human keratoconic cornea after epi‐off crosslinking (CXL) procedure and a wound healing model in rabbits with iatrogenic corneal injury. 3D OCT data sets enhanced obtaining epithelial thickness maps and evaluation of reepithelization stage. Accompanying changes in deeper ...
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    6. Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer

      Combination of High-Resolution Optical Coherence Tomography and Raman Spectroscopy for Improved Staging and Grading in Bladder Cancer
      We present a combination of optical coherence tomography (OCT) and Raman spectroscopy (RS) for improved diagnosis and discrimination of different stages and grades of bladder cancer ex vivo by linking the complementary information provided by these two techniques. Bladder samples were obtained from biopsies dissected via transurethral resection of the bladder tumor (TURBT). As OCT provides structural information rapidly, it was used as a red-flag technology to scan the bladder ...
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    7. In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography

      In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography
      Dry eye syndrome is a highly prevalent disease of the ocular surface characterized by an instability of the tear film. Traditional methods used for the evaluation of tear film stability are invasive or show limited repeatability. Here we propose a new non-invasive fully automated approach to measure tear film thickness based on spectral domain optical coherence tomography and on an efficient delay estimator. Silicon wafer phantom were used to validate ...
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    8. Single-pulse CARS based multimodal nonlinear optical microscope for bioimaging

      Single-pulse CARS based multimodal nonlinear optical microscope for bioimaging
      Noninvasive label-free imaging of biological systems raises demand not only for high-speed three-dimensional prescreening of morphology over a wide-field of view but also it seeks to extract the microscopic functional and molecular details within. Capitalizing on the unique advantages brought out by different nonlinear optical effects, a multimodal nonlinear optical microscope can be a powerful tool for bioimaging. Bringing together the intensity-dependent contrast mechanismsviasecond harmonic generation, third harmonic generation and ...
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    9. Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages

      Dual modality optical coherence and whole-body photoacoustic tomography imaging of chick embryos in multiple development stages
      ...r Affiliations Mengyang Liu,^1 Barbara Maurer,^2 Boris Hermann,^1 Behrooz Zabihian,^1 Michelle G. Sandrian,^3 Angelika Unterhuber,^1 Bernhard Baumann,^1 Edward Z. Zhang,^4 Paul C. Beard,^4 Wolfgang J. Weninger,^2 and Wol...
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    10. Optical coherence tomography today: speed, contrast, and multimodality

      Optical coherence tomography today: speed, contrast, and multimodality
      In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans ...
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  2. About Angelika Unterhuber

    Angelika Unterhuber

    Angelika Unterhuber received her M.Sc. in Physics from the Vienna University of Technology in 1998. From 1998 to 2002 she was product manager for ultrafast lasers at Femtolasers Produktions GmbH. In 2006 she received the Ph.D. degree in Electrical Engineering and joined the School of Optometry and Vision Sciences, Cardiff. She returned to Vienna with a Marie Curie Fellowship in 2009. Now she works at the Center for Medical Physic and Biomedical Engineering at the Medical University of Vienna as Associate Professor. Her current research interests are focused on development of novel light sources and integration in multimodal imaging platforms and their biomedical applications especially in the field of OCT, Raman spectroscopy and nonlinear imaging.