1. Andrew M. Rollins

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    1. Mentioned In 123 Articles

    2. Complex decorrelation averaging in optical coherence tomography: a way to reduce the effect of multiple scattering and improve image contrast in a dynamic scattering medium

      Complex decorrelation averaging in optical coherence tomography: a way to reduce the effect of multiple scattering and improve image contrast in a dynamic scattering medium
      We demonstrate that complex decorrelation averaging can reduce the effect of multiple scattering and improve optical coherence tomography (OCT) imaging contrast. Complex decorrelation averaging calculates the product of an A-scan and the complex conjugate of a subsequent A-scan. The resultant signal is the product of the amplitudes and the phase difference. All these resulting complex signals at a particular location are then averaged. We take advantage of the fact that ...
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    3. Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography
      An estimated 17.5 million people died from a cardiovascular disease in 2012, representing 31 percent of all global deaths. Most acute coronary events result from rupture of the protective fibrous cap overlying an atherosclerotic plaque. The task of early identification of plaque types that can potentially rupture is, therefore, of great importance. The state-of-the-art approach to imaging blood vessels is intravascular optical coherence tomography (IVOCT). However, currently, this is ...
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    4. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Simultaneous multimodal ophthalmic imaging using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) benefits diagnostic imaging and therapeutic guidance by allowing for high-speeden faceimaging of retinal structures. When combined with optical coherence tomography (OCT), SLO enables real-time aiming and retinal tracking and provides complementary information for post-acquisition volumetric co-registration, bulk motion compensation, and averaging. However, multimodality SLO-OCT systems generally require dedicated light sources, scanners, relay optics, detectors, and additional digitization and synchronization electronics, which increase system complexity. Here, we ...
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    5. Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western Reserve University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart
      Case Western Reserve University Receives a 2016 NIH Grant for $356,784 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in ...
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    6. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks

      Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
      Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame ...
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    7. Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

      Multimodal ophthalmic imaging using swept source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
      Scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) benefit clinical diagnostic imaging in ophthalmology by enabling in vivo noninvasive en face and volumetric visualization of retinal structures, respectively. Spectrally encoding methods enable confocal imaging through fiber optics and reduces system complexity. Previous applications in ophthalmic imaging include spectrally encoded confocal scanning laser ophthalmoscopy (SECSLO) and a combined SECSLO-OCT system for image guidance, tracking, and registration. However, spectrally encoded imaging ...
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    8. Measurement Of Biomechanical Properties In An OCT Image

      Measurement Of Biomechanical Properties In An OCT Image
      Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator is configured to induce a shear wave in the tissue. An optical coherence tomography (OCT) imager is configured to capture a B-scan frame of the tissue. An image processing component is configured to determine a frequency of the shear wave in the tissue from the B-scan frame of the tissue at each of a ...
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    9. Characterizing Ablation Lesions Using Optical Coherence Tomography (OCT)

      Characterizing Ablation Lesions Using Optical Coherence Tomography (OCT)
      Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.
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    10. Case Western Reserve University Receives NIH Grant for Cardiac Radiofrequency Ablation Catheter with Integrated OCT Imaging

      Case Western Reserve University Receives NIH Grant for Cardiac Radiofrequency Ablation Catheter with Integrated OCT Imaging
      Case Western Reserve University Receives a 2015 NIH grant for $198,125 for Cardiac Radiofrequency Ablation Catheter with Integrated OCT Imaging. The principal investigator is Andrew Rollins. The program began in 2015 and ends in 2017. Below is a summary of the proposed work. The long-term goal of this research program is to develop catheter-based optical coherence tomography (OCT) imaging tools that will improve the care of patients suffering from ...
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    11. Mapping conduction velocity of early embryonic hearts with a robust fitting algorithm

      Mapping conduction velocity of early embryonic hearts with a robust fitting algorithm
      Cardiac conduction maturation is an important and integral component of heart development. Optical mapping with voltage-sensitive dyes allows sensitive measurements of electrophysiological signals over the entire heart. However, accurate measurements of conduction velocity during early cardiac development is typically hindered by low signal-to-noise ratio (SNR) measurements of action potentials. Here, we present a novel image processing approach based on least squares optimizations, which enables high-resolution, low-noise conduction velocity mapping of ...
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    12. Case Western University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart

      Case Western University Receives NIH Grant for Integrated Imaging of the Form and Function of the Beating Embryonic Heart
      Case Western University Receives a 2015 NIH Grant for $359,023 for Integrated Imaging of the Form and Function of the Beating Embryonic Heart. The principal investigator is Andrew Rollins. The program began in 2006 and ends in 2017. Below is a summary of the proposed work. Congenital heart defects (CHDs) afflict 36,000 babies born in the US each year and survivors often require several surgical interventions in their ...
      Read Full Article
    13. 3-D Stent Detection in Intravascular OCT Using a Bayesian Network and Graph Search

      3-D Stent Detection in Intravascular OCT Using a Bayesian Network and Graph Search
      Worldwide, many hundreds of thousands of stents are implanted each year to revascularize occlusions in coronary arteries. Intravascular optical coherence tomography (OCT) is an important emerging imaging technique, which has the resolution and contrast necessary to quantitatively analyze stent deployment and tissue coverage following stent implantation. Automation is needed, as current, it takes up to 16 hours to manually analyze hundreds of images and thousands of stent struts from a ...
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    14. Intraoperative optical coherence tomography using an optimized reflective optical relay, real-time heads-up display, and semitransparent surgical instrumentation

      Intraoperative optical coherence tomography using an optimized reflective optical relay, real-time heads-up display, and semitransparent surgical instrumentation
      ...rumentation Yuankai K. Tao ; Mohamed T. El-Haddad ; Sunil K. Srivastava ; Daniel Feiler ; Amanda I. Noonan ; Andrew M. Rollins ; Justis P. Ehlers; Intraoperative optical coherence tomography using an optimized reflectiv...
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    15. Feature Of The Week 02/22/15: Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure

      Feature Of The Week 02/22/15:  Case Western Reserve University Demostrates Using OCT to Rapidly Phenotype and Quantify Congenital Heart Defects Associated with Prenatal Alcohol Exposure
      The most commonly used method to analyze congenital heart defects involves serial sectioning and histology. However, this is often a time-consuming process where the quantification of cardiac defects can be difficult due to problems with accurate section registration. Here we demonstrate the advantages of using optical coherence tomography, a comparatively new and rising technology, to phenotype avian embryo hearts in a model of Fetal Alcohol Syndrome where a binge-like quantity ...
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    16. Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography

      Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography
      We developed robust, three-dimensional methods, as opposed to traditional A-line analysis, for estimating the optical properties of calcified, fibrotic, and lipid atherosclerotic plaques from in vivo coronary artery intravascular optical coherence tomography clinical pullbacks. We estimated attenuation t and backscattered intensity I 0 from small volumes of interest annotated by experts in 35 pullbacks. Some results were as follows: noise reduction filtering was desirable, parallel line (PL) methods outperformed individual ...
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    17. 1-15 of 123 1 2 3 4 5 6 7 8 9 »
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  2. About Andrew M. Rollins

    Andrew M. Rollins

    Andrew M. Rollins, Ph.D., is an Assistant Professor of Medicine and Biomedical Engineering, Case Western Reserve University (CWRU). Lab Director of the Biophotonics Imaging Laboratory, Director of the Endoscopy Research Laboratory in the Division of Gastroenterology at University Hospitals of Cleveland (UHC), co-chair of the Optical Diagnostic Imaging group of the Comprehensive Cancer Center of CWRU and UHC, and a member of the Research Committee of the CWRU Biophotonics Initiative.
    Dr. Rollins' research interests are in the application of advanced optics and photonics technologies for imaging and characterization of biological samples, with particular emphasis on detection of early disease and monitoring of therapy in human tissues. His research program focuses on advancing the state of the art in imaging of tissue microstructure and function using coherent optical interactions with biological samples. The technique of optical coherence tomography (OCT) is the primary basis of his research. Current clinical studies include detection of dysplasia in gastrointestinal mucosa using endoscopic OCT, biometry and diagnostic imaging in the anterior segment of the eye, in situ imaging of basal cell carcinoma in skin for application to Mohs Micrographic Surgery, and imaging of the atrio-ventricular node for elucidation of the anatomical substrate for re-entrant conduction circuits. Current development projects include imaging blood flow in living patients and animals using Doppler OCT, and developing novel functional imaging methods of spectroscopic OCT. Dr. Rollins has active collaborations with clinical and scientific investigators at CWRU (Division of Gastroenterology, Department of Ophthalmology, Department of Dermatology Department of Biomedical Engineering), the Cleveland Clinic Foundation (Cole Eye Institute), and Duke University (Department of Biomedical Engineering). Andrew Rollins received his B.S. degree in electrical and computer engineering from Brigham Young University in 1992, his M.S. degree in biomedical engineering from CWRU in 1997, and his Ph.D. degree in biomedical engineering from CWRU in January of 2000. From 1987 to 1989, Andrew served as a missionary in the Philippines. From 1992 to 1994, he served as a Peace Corps volunteer in Malawi, Africa. He is married to Lynn and they have a daughter, Dominica, and two sons, Alexander and Maxwell.

  3. Quotes

    1. All previous attempts at shear-stress mapping have been two dimensional, but the 3-D geometry of the embryonic heart is changing hour by hour at these early stages, and the shape of the heart twists and turns as it develops...so a 2-D projection doesn’t really provide a good approximation...It is just like RADAR or ultrasound,” Rollins explains, “except we use infrared light and we image tiny things at really high resolution...We can use this technique to figure out just how function or dysfunction fits into normal heart development and the development of heart defects...An understanding of normal and abnormal development is critical for preventing and treating these defect
      In First-ever 3-D Stress Map of Developing Embryonic Heart Sheds Light on Why Defects Form
    2. OCT fills a role that’s not being filled by any other diagnostic technology right now...With cancers of the epithelium, many of the tissues are accessible endoscopically. Using OCT, we can image these epithelial tissues through their whole thickness, and we can see the transformations as they start to become dysplastic, which aren’t always easy to see using conventional tools.
      In Optical Tomography May Aid 3D Cancer Diagnostics
    3. Avo's attention to detail and resourcefulness allowed us to move quite rapidly from concept to design to prototyping. We are looking forward to continuing with the development efforts and providing the medical community with this and other enhanced tools
      In Avo Photonics and Case Western Reserve University Are Pleased to Announce the Completion of a Design and Development Contract for an Optical Coherence Tomography (OCT) Forward Imaging Catheter