1. Andrea Giani

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    1. Mentioned In 16 Articles

    2. COMPARISON BETWEEN SEVERAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES AND INDOCYANINE GREEN ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION

      COMPARISON BETWEEN SEVERAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY DEVICES AND INDOCYANINE GREEN ANGIOGRAPHY OF CHOROIDAL NEOVASCULARIZATION
      Purpose: To compare indocyanine green angiography and four different optical coherence tomography angiography (OCTA) devices and to test their reproducibility in the evaluation of choroidal neovascularization (CNV). Methods: This study was an observational case series of Type 1 and Type 2 CNV presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan, imaged with indocyanine green angiography and four different OCTA devices: prototype ...
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    3. Looking Outside The Maculaa Wide-Field Optical Coherence Tomography Study

      Looking Outside The Maculaa Wide-Field Optical Coherence Tomography Study
      Purpose: To evaluate baseline features and morphologic changes of vitreoretinal adhesion and outer retinal layers outside the macula after intravitreal ocriplasmin injection. To study the relation between vitreous detachment and attenuation of retinal outer segments signal. Methods: Retrospective cases series of 15 eyes. Each eye was scanned with the 55 wide-field optical coherence tomography lens in 6 different locations, three horizontal B-scan (central, temporal, and nasal) and three vertical B-scan ...
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    4. Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices

      Reproducibility of vessel density, fractal dimension and foveal avascular zone using 7 different optical coherence tomography angiography devices
      Purpose To evaluate the reproducibility of parafoveal microvascular anatomy of 7 different optical coherence tomography angiography (OCT-A) devices by comparing vessels density (VD), fractal dimension (FD) and foveal avascular zone (FAZ) of superficial and deep capillary plexus in healthy volunteers. Design Reliability analysis. Methods Consecutive healthy volunteers presenting at the Eye Clinic, Department of Biomedical and Clinical Sciences, Luigi Sacco Hospital, University of Milan in the same clinic visit were ...
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    5. OCRIPLASMIN FOR VITREOMACULAR TRACTION: LOOKING OUTSIDE THE MACULA: A Wide-Field Optical Coherence Tomography Study

      OCRIPLASMIN FOR VITREOMACULAR TRACTION: LOOKING OUTSIDE THE MACULA: A Wide-Field Optical Coherence Tomography Study
      Purpose: To evaluate baseline features and morphologic changes of vitreoretinal adhesion and outer retinal layers outside the macula after intravitreal ocriplasmin injection. To study the relation between vitreous detachment and attenuation of retinal outer segments signal. Methods: Retrospective cases series of 15 eyes. Each eye was scanned with the 55[degrees] wide-field optical coherence tomography lens in 6 different locations, three horizontal B-scan (central, temporal, and nasal) and three vertical ...
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    6. Dark Atrophy: An Optical Coherence Tomography Angiography Study

      Dark Atrophy: An Optical Coherence Tomography Angiography Study
      Purpose To assess the status of choriocapillaris in eyes with macular atrophy secondary to age-related macular degeneration (AMD) (geographic atrophy [GA]) and Stargardt disease (STGD) using optical coherence tomography angiography (OCTA). Design Prospective, observational case series. Participants A total of 14 patients (20 eyes) affected by GA and 10 patients (20 eyes) affected by STGD. Methods Each patient underwent a complete ophthalmological examination including fundus autofluorescence (FAF), dynamic simultaneous fluorescein ...
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    7. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography

      Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography
      Purpose: To evaluate differences between the retinal nerve fiber layer (RNFL) thickness and RNFL + ganglion cell layer (GCL) thickness in patients affected by Alzheimer's disease (AD) and healthy patients using spectral-domain optical coherence tomography (SD-OCT). Methods: This was a case-control prospective study. Twenty-one AD patients and 21 healthy subjects underwent neurological examination, clock drawing test (CDT), mini mental state examination (MMSE) and comprehensive ophthalmic evaluation with visual acuity. SD-OCT ...
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    8. Retrobulbar Structure Visualization with Enhanced Depth Imaging Optical Coherence Tomography

      Retrobulbar Structure Visualization with Enhanced Depth Imaging Optical Coherence Tomography
      Purpose: To assess enhanced depth imaging optical coherence tomography (EDI-OCT) visualization of deep posterior pole structures and retrobulbar tissues in myopic eyes and evaluate ocular structural elements that influenced this capability. Methods: Thirty consecutive myopic eyes (-6 diopters) from 21 patients were enrolled. Exclusion criteria included any pathological condition affecting the posterior pole. Patients underwent biometry to assess axial length, and irises were classified as darkly or lightly pigmented. EDI-OCT ...
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    9. Repeatability and Reproducibility of Retinal Thickness Measurements With Spectral-Domain Optical Coherence Tomography Using Different Scan Parameters

      Repeatability and Reproducibility of Retinal Thickness Measurements With Spectral-Domain Optical Coherence Tomography Using Different Scan Parameters
      Purpose: To evaluate repeatability (test-retest) and reproducibility of retinal thickness measurements using spectral-domain optical coherence tomography with different densities of A-scans per B-scan and different frames per B-scan for real-time averaging. Methods: Twelve healthy subjects were analyzed by spectral-domain optical coherence tomography. Raster lines analysis with 19 B-scans over the examined area centered on the macula was performed. Images were acquired both in standard-density (768 A-scans/B-scan) and high-density (1 ...
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      Mentions: Andrea Giani
    10. Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization

      Utilizing Targeted Gene Therapy with Nanoparticles Binding Alpha v Beta 3 for Imaging and Treating Choroidal Neovascularization
      Purpose The integrin αvβ3 is differentially expressed on neovascular endothelial cells. We investigated whether a novel intravenously injectable αvβ3 integrin-ligand coupled nanoparticle (NP) can target choroidal neovascular membranes (CNV) for imaging and targeted gene therapy. Methods CNV lesions were induced in rats using laser photocoagulation. The utility of NP for in vivo imaging and gene delivery was evaluated by coupling the NP with a green fluorescing protein plasmid (NP-GFPg). Rhodamine ...
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    11. Displayed Reflectivity Of Choroidal Neovascular Membranes By Optical Coherence Tomography Correlates With Presence of Leakage By Fluorescein Angiography

      Displayed Reflectivity Of Choroidal Neovascular Membranes By Optical Coherence Tomography Correlates With Presence of Leakage By Fluorescein Angiography
      Purpose: To evaluate and correlate the displayed optical reflectivity of choroidal neovascularization (CNV) subretinal material on spectral-domain optical coherence tomography with the presence of dye leakage on fluorescein angiography (FA).Methods: Thirty-nine eyes of 39 patients with a diagnosis of predominantly classic CNV from age-related macular degeneration underwent simultaneous spectral-domain optical coherence tomography and FA imaging. Eight patients had a newly diagnosed untreated CNV. Thirty-one patients had already been treated ...
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    12. Reproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments

      Reproducibility of Retinal Thickness Measurements on Normal and Pathologic Eyes by Different Optical Coherence Tomography Instruments
      Purpose:To compare retinal thickness measurements produced by different time-domain and spectral-domain optical coherence tomography (TD-OCT and SD-OCT) devices when imaging normal and pathologic eyes.Design:Prospective, observational study in an academic institutional setting.Methods:A total of 110 eyes were imaged by 6 different OCT devices: Stratus and Cirrus (Carl Zeiss Meditec Inc), Spectralis HRA+OCT (Heidelberg Engineering), RTVue-100 (Optovue Inc), SDOCT Copernicus HR (Optopol Technology S.A.), and ...
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    13. Artifacts In Automatic Retinal Segmentation Using Different Optical Coherence Tomography Instruments

      Purpose: The purpose of this study was to compare and evaluate artifact errors in automatic inner and outer retinal boundary detection produced by different time-domain and spectral-domain optical coherence tomography (OCT) instruments.Methods: Normal and pathologic eyes were imaged by six different OCT devices. For each instrument, standard analysis protocols were used for macular thickness evaluation. Error frequencies, defined as the percentage of examinations affected by at least one error ...
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  2. About Andrea Giani

    Andrea Giani is with the Retina Service, Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA and with the Eye Clinic - Department of Clinical Science “Luigi Sacco”-- Sacco Hospital - University of Milan -- Italy.