1. Andrea Curatolo

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    1. Mentioned In 25 Articles

    2. Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

      Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation
      Realistic simulation of image formation in optical coherence tomography, based on Maxwells equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known ...
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    3. Wide-field quantitative micro-elastography of human breast tissue

      Wide-field quantitative micro-elastography of human breast tissue
      Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical ...
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    4. Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta

      Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta
      Cellular-scale imaging of the mechanical properties of tissue has helped to reveal the origins of disease; however, cellular-scale resolution is not readily achievable in intact tissue volumes. Here, we demonstrate volumetric imaging of Youngs modulus using ultrahigh-resolution optical coherence elastography, and apply it to characterizing the stiffness of mouse aortas. We achieve isotropic resolution of better than 15 m over a 1-mm lateral field of view through the entire depth ...
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    5. Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

      Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
      Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the ...
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    6. Quantifying the influence of Bessel beams on image quality in optical coherence tomography

      Quantifying the influence of Bessel beams on image quality in optical coherence tomography
      Light scattered by turbid tissue is known to degrade optical coherence tomography (OCT) image contrast progressively with depth. Bessel beams have been proposed as an alternative to Gaussian beams to image deeper into turbid tissue. However, studies of turbid tissue comparing the image quality for different beam types are lacking. We present such a study, using numerically simulated beams and experimental OCT images formed by Bessel or Gaussian beams illuminating ...
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    7. Ultrahigh-resolution optical coherence elastography

      Ultrahigh-resolution optical coherence elastography
      Visualizing stiffness within the local tissue environment at the cellular and subcellular level promises to provide insight into the genesis and progression of disease. In this Letter, we propose ultrahigh-resolution optical coherence elastography (UHROCE), and demonstrate 3D imaging of local axial strain of tissues undergoing compressive loading. We combine optical coherence microscopy (OCM) and phase-sensitive detection of local tissue displacement to produce strain elastograms with resolution (
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    8. Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue
      Accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high re-excision rates without resorting to the removal of excess healthy tissue. Optical coherence micro-elastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to micro-scale variations of the mechanical properties ...
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    9. Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

      Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure
      We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of ...
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    10. Ultrasound-Guided Optical Coherence Tomography Needle Probe for the Assessment of Breast Cancer Tumor Margins

      Ultrasound-Guided Optical Coherence Tomography Needle Probe for the Assessment of Breast Cancer Tumor Margins
      OBJECTIVE.The purpose of this study was to evaluate a new imaging technique for the assessment of breast cancer tumor margins. The technique entails deployment of a high-resolution optical imaging needle under ultrasound guidance. Assessment was performed on fresh ex vivo tissue samples. CONCLUSION. Use of the ultrasound-guided optical needle probe allowed in situ assessment of fresh tissue margins. The imaging findings corresponded to the histologic findings.
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    11. Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography

      Review of tissue simulating phantoms with controllable optical, mechanical and structural properties for use in optical coherence tomography
      We review the development of phantoms for optical coherence tomography (OCT) designed to replicate the optical, mechanical and structural properties of a range of tissues. Such phantoms are a key requirement for the continued development of OCT techniques and applications. We focus on phantoms based on silicone, fibrin and poly(vinyl alcohol) cryogels (PVA-C), as we believe these materials hold the most promise for durable and accurate replication of tissue ...
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    12. Imaging of Breast Cancer with Optical Coherence Tomography Needle Probes: Feasibility and Initial Results

      Imaging of Breast Cancer with Optical Coherence Tomography Needle Probes: Feasibility and Initial Results
      Optical coherence tomography (OCT) is a high-resolution imaging modality with the potential to provide in situ assessment to distinguish normal from cancerous tissue. However, limited image penetration depth has restricted its utility. This paper demonstrates the feasibility of an OCT needle probe to perform interstitial imaging deep below the tissue surface. The side-facing needle probe comprises miniaturized focusing optics consisting of no-core and GRIN fiber encased within either a 22- ...
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    13. 1-15 of 25 1 2 »
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  2. About Andrea Curatolo

    Andrea Curatolo

    Andrea Curatolo is a Research Associate in the Optical+Biomedical Engineering Laboratory (OBEL), at The University of Western Australia. He is currently working on optical coherence tomography (OCT). His work includes diagnostic imaging systems engineering design, technology development and supervision of endoscopic and interstitial OCT imaging system prototypes deployed in clinical settings, for pulmonary and oncology applications. He is also active in the study of image formation in the context of coherent imaging modalities and intrinsic noise - speckle. In this area he has worked on developing processing methods to increase the information content extracted from an image (multiple scattering detection), techniques to reduce intrinsic noise and imaging artefacts (i.e. image quality improvement), and tools (structured phantoms) to verify and validate those methods and techniques.

    Prior to joining OBEL in 2008, he worked for a year in industry as a Systems Engineer. His background is in photonics, having completed his MSc in 2006 in physics engineering at Politecnico di Milano, Italy, with a thesis on the development of a portable multispectral imaging system. He attended the first year of his master's degree at the Institute of Technology (LTH) in Lund, Sweden.