1. Andrea Curatolo

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    1. Mentioned In 27 Articles

    2. Finger-mounted quantitative micro-elastography

      Finger-mounted quantitative micro-elastography
      We present a finger-mounted quantitative micro-elastography (QME) probe, capable of measuring the elasticity of biological tissue in a format that avails of the dexterity of the human finger. Finger-mounted QME represents the first demonstration of a wearable elastography probe. The approach realizes optical coherence tomography-based elastography by focusing the optical beam into the sample via a single-mode fiber that is fused to a length of graded-index fiber. The fiber is ...
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    3. Handheld optical palpation of turbid tissue with motion-artifact correction

      Handheld optical palpation of turbid tissue with motion-artifact correction
      Handheld imaging probes are needed to extend the clinical translation of optical elastography to in vivo applications, yet such probes have received little attention. In this paper, we present the first demonstration of optical palpation using a handheld probe. Optical palpation is a variant of optical elastography that uses three-dimensional optical coherence tomography (3D-OCT) to provide maps of stress at the tissue surface under static compression. Using this technique, stiff ...
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    4. Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation

      Realistic simulation and experiment reveals the importance of scatterer microstructure in optical coherence tomography image formation
      Realistic simulation of image formation in optical coherence tomography, based on Maxwells equations, has recently been demonstrated for sample volumes of practical significance. Yet, there remains a limitation whereby reducing the size of cells used to construct a computational grid, thus allowing for a more realistic representation of scatterer microstructure, necessarily reduces the overall sample size that can be modelled. This is a significant problem since, as is well known ...
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    5. Wide-field quantitative micro-elastography of human breast tissue

      Wide-field quantitative micro-elastography of human breast tissue
      Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical ...
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    6. Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta

      Ultrahigh-Resolution Optical Coherence Elastography Images Cellular-Scale Stiffness of Mouse Aorta
      Cellular-scale imaging of the mechanical properties of tissue has helped to reveal the origins of disease; however, cellular-scale resolution is not readily achievable in intact tissue volumes. Here, we demonstrate volumetric imaging of Youngs modulus using ultrahigh-resolution optical coherence elastography, and apply it to characterizing the stiffness of mouse aortas. We achieve isotropic resolution of better than 15 m over a 1-mm lateral field of view through the entire depth ...
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    7. Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

      Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces
      Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the ...
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    8. Quantifying the influence of Bessel beams on image quality in optical coherence tomography

      Quantifying the influence of Bessel beams on image quality in optical coherence tomography
      Light scattered by turbid tissue is known to degrade optical coherence tomography (OCT) image contrast progressively with depth. Bessel beams have been proposed as an alternative to Gaussian beams to image deeper into turbid tissue. However, studies of turbid tissue comparing the image quality for different beam types are lacking. We present such a study, using numerically simulated beams and experimental OCT images formed by Bessel or Gaussian beams illuminating ...
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    9. Ultrahigh-resolution optical coherence elastography

      Ultrahigh-resolution optical coherence elastography
      Visualizing stiffness within the local tissue environment at the cellular and subcellular level promises to provide insight into the genesis and progression of disease. In this Letter, we propose ultrahigh-resolution optical coherence elastography (UHROCE), and demonstrate 3D imaging of local axial strain of tissues undergoing compressive loading. We combine optical coherence microscopy (OCM) and phase-sensitive detection of local tissue displacement to produce strain elastograms with resolution (
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    10. Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue
      Accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high re-excision rates without resorting to the removal of excess healthy tissue. Optical coherence micro-elastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to micro-scale variations of the mechanical properties ...
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    11. Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

      Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure
      We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of ...
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    12. Ultrasound-Guided Optical Coherence Tomography Needle Probe for the Assessment of Breast Cancer Tumor Margins

      Ultrasound-Guided Optical Coherence Tomography Needle Probe for the Assessment of Breast Cancer Tumor Margins
      OBJECTIVE.The purpose of this study was to evaluate a new imaging technique for the assessment of breast cancer tumor margins. The technique entails deployment of a high-resolution optical imaging needle under ultrasound guidance. Assessment was performed on fresh ex vivo tissue samples. CONCLUSION. Use of the ultrasound-guided optical needle probe allowed in situ assessment of fresh tissue margins. The imaging findings corresponded to the histologic findings.
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    13. 1-15 of 27 1 2 »
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  2. About Andrea Curatolo

    Andrea Curatolo

    Andrea Curatolo is a Research Associate in the Optical+Biomedical Engineering Laboratory (OBEL), at The University of Western Australia. He is currently working on optical coherence tomography (OCT). His work includes diagnostic imaging systems engineering design, technology development and supervision of endoscopic and interstitial OCT imaging system prototypes deployed in clinical settings, for pulmonary and oncology applications. He is also active in the study of image formation in the context of coherent imaging modalities and intrinsic noise - speckle. In this area he has worked on developing processing methods to increase the information content extracted from an image (multiple scattering detection), techniques to reduce intrinsic noise and imaging artefacts (i.e. image quality improvement), and tools (structured phantoms) to verify and validate those methods and techniques.

    Prior to joining OBEL in 2008, he worked for a year in industry as a Systems Engineer. His background is in photonics, having completed his MSc in 2006 in physics engineering at Politecnico di Milano, Italy, with a thesis on the development of a portable multispectral imaging system. He attended the first year of his master's degree at the Institute of Technology (LTH) in Lund, Sweden.