1. Anant Agrawal

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    1. Mentioned In 22 Articles

    2. Label-free adaptive optics imaging of human retinal macrophage distribution and dynamics

      Explore pnas.org Ophthalmology
      Label-free adaptive optics imaging of human retinal macrophage distribution and dynamics
      Microglia are resident central nervous system macrophages and the first responders to neural injury. Until recently, microglia have been studied only in animal models with exogenous or transgenic labeling. While these studies provided a wealth of information on the delicate balance between neuroprotection and neurotoxicity within which these cells operate, extrapolation to human immune function has remained an open question. Here we examine key characteristics of retinal macrophage cells in ...
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      Mentions: Daniel X. Hammer FDA Anant Agrawal

    3. Application of optical coherence tomography and optical path length method for monitoring corneal thickness and refractive index change during corneal cross-linking

      Explore OSA | OSA Publishing Ophthalmology
      Application of optical coherence tomography and optical path length method for monitoring corneal thickness and refractive index change during corneal cross-linking
      Corneal cross-linking (CXL) using UVA irradiation with a riboflavin photosensitizer has emerged as a new treatment paradigm for corneal ectatic disorders. The thickness threshold for protection of intraocular structures has often been challenged with ongoing developments, and corneal thinning becomes an important safety concern, especially for patients with thin corneas. In this study with an ex vivo bovine eye model, we monitored corneal thinning and corneal refractive index changes using ...
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      Mentions: Daniel X. Hammer FDA Anant Agrawal

    4. 3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems

      Explore OSA | OSA Publishing
      3-D printed photoreceptor phantoms for evaluating lateral resolution of adaptive optics imaging systems
      With adaptive optics (AO), optical coherence tomography and scanning laser ophthalmoscopy imaging systems can resolve individual photoreceptor cells in living eyes, due to enhanced lateral spatial resolution. However, no standard test method exists for experimentally quantifying this parameter in ophthalmic AO imagers. Here, we present three-dimensional (3-D) printed phantoms, which enable the measurement of lateral resolution in an anatomically relevant manner. We used two-photon polymerization to fabricate two phantoms, which ...
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      Mentions: University of Maryland National Institutes of Health Daniel X. Hammer

    5. Methods to assess sensitivity of optical coherence tomography systems

      Explore OSA | OSA Publishing
      Methods to assess sensitivity of optical coherence tomography systems
      Measuring the sensitivity of an optical coherence tomography (OCT) system determines the minimum sample reflectivity it can detect and provides a figure of merit for system optimization and comparison. The published literature lacks a detailed description of OCT sensitivity measurement procedures. Here we describe a commonly-used measurement method and introduce two new phantom-based methods, which also offer a means to directly visualize low reflectivity conditions relevant to biological tissue. We ...
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      Mentions: Pete H. Tomlins UK National Physical Laboratory FDA

    6. Optic Nerve Head Measurements With Optical Coherence Tomography: A Phantom-Based Study Reveals Differences Among Clinical Devices

      Explore IOVS Journal Ophthalmology
      Optic Nerve Head Measurements With Optical Coherence Tomography: A Phantom-Based Study Reveals Differences Among Clinical Devices
      Purpose : Optical coherence tomography (OCT) can monitor for glaucoma by measuring dimensions of the optic nerve head (ONH) cup and disc. Multiple clinical studies have shown that different OCT devices yield different estimates of retinal dimensions. We developed phantoms mimicking ONH morphology as a new way to compare ONH measurements from different clinical OCT devices. Methods : Three phantoms were fabricated to model the ONH: One normal and two with glaucomatous ...
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      Mentions: University of Pittsburgh Joel S. Schuman Daniel X. Hammer

    7. Image quality metrics for optical coherence angiography

      Explore OSA | OSA Publishing Ophthalmology
      Image quality metrics for optical coherence angiography
      We characterized image quality in optical coherence angiography (OCA)en faceplanes of mouse cortical capillary network in terms of signal-to-noise ratio (SNR) and Weber contrast (Wc) through a novel mask-based segmentation method. The method was used to compare two adjacent B-scan processing algorithms, (1) average absolute difference (AAD) and (2) standard deviation (SD), while varying the number of lateral cross-sections acquired (also known as the gate length, N). AAD and ...
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      Mentions: Daniel X. Hammer FDA Anant Agrawal

    8. The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina

      Explore iovs.org Ophthalmology
      The use of time-lapse optical coherence tomography to image the effects of microapplied toxins on the retina
      Purpose: We developed a novel technique using a drug microperfusion device and time-lapse optical coherence tomography (OCT) for accelerated drug screening and retinotoxin characterization. Methods: Using an ex vivo rabbit eyecup preparation, we studied retinotoxin effects in real-time by microperfusing small retinal areas under a transparent fluoropolymer tube. Known retinotoxic agents were applied to the retina for 5 minute periods while changes in retinal structure, thickness, and reflectance were monitored ...
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      Mentions: Daniel X. Hammer FDA Rice University

    9. Feature Of The Week 11/2/14: Longitudinal Vascular Dynamics Following Cranial Window and Electrode Implantation Measured with Speckle Variance Optical Coherence Angiography

      Explore Optical Coherence Tomography News
      Feature Of The Week 11/2/14: Longitudinal Vascular Dynamics Following Cranial Window and Electrode Implantation Measured with Speckle Variance Optical Coherence Angiography
      ...rtesy Daniel Hammer from FDA . FDA researchers Daniel X. Hammer, Andrea Lozzi, Erkinay Abliz, Noah Greenbaum, Anant Agrawal, Victor Krauthamer, and Cristin G. Welle published a paper in Biomedical Optics Express titled, ...
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      Mentions: Daniel X. Hammer FDA Anant Agrawal

    13. International Workshop on Tissue Phantoms and Standardization in Biophotonics at University of Maryland, May 21, 2014

      Explore Optical Coherence Tomography News
      International Workshop on Tissue Phantoms and Standardization in Biophotonics at University of Maryland, May 21, 2014
      ...nistration Maritoni Litorja, National Institute of Standards and Technology Organizing Committee Members: Anant Agrawal, Food and Drug Administration Albert Cerussi, University of California, Irvine Robert Nordstrom,...
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      Mentions: University of Maryland University of Pittsburgh National Institutes of Health

    14. Retina-simulating phantom for optical coherence tomography

      Explore SPIE | Journal Ophthalmology
      Retina-simulating phantom for optical coherence tomography
      Optical coherence tomography (OCT) is a rapidly growing imaging modality, particularly in the field of ophthalmology. Accurate early diagnosis of diseases requires consistent and validated imaging performance. In contrast to more well-established medical imaging modalities, no standardized test methods currently exist for OCT quality assurance. We developed a retinal phantom which mimics the thickness and near-infrared optical properties of each anatomical retinal layer as well as the surface topography of ...
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      Mentions: Johns Hopkins University Daniel X. Hammer FDA
    17. 1-15 of 22 1 2 »
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  4. About Anant Agrawal

    Anant Agrawal received the B.S. degree from the University of Virginia in 1995 and the M.S. degree from the University of Texas at Austin in 1998, both in Electrical Engineering. He is currently a Ph.D. candidate in Electrical Engineering at the Catholic University of America. He has close to 20 years R&D experience in optical imaging and spectroscopy for clinical and other biomedical applications through academic, industry, and government positions, with the past 10 years focused on the regulatory science of optical diagnostic devices at CDRH/OSEL/DBP. He is a co-inventor on two patents, has 20 peer-reviewed publications, and has served on SPIE conference committees and international working groups in this field.

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