1. Amy L. Oldenburg

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    1. Mentioned In 54 Articles

    2. Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography

      Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography
      Optical coherence tomography (OCT) has gained widespread application for many biomedical applications, yet the traditional array of contrast agents used in incoherent imaging modalities do not provide contrast in OCT. Owing to the high biocompatibility of iron oxides and noble metals, magnetic and plasmonic nanoparticles, respectively, have been developed as OCT contrast agents to enable a range of biological and pre-clinical studies. Here, we provide a review of these developments ...
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    3. Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography

      Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography
      The mammary gland extracellular matrix (ECM) is comprised of biopolymers, primarily collagen I, that are created and maintained by stromal fibroblasts. ECM remodeling by fibroblasts results in changes in ECM fiber spacing (pores) that have been shown to play a critical role in the aggressiveness of breast cancer. However, minimally invasive methods to measure the spatial distribution of ECM pore areas within tissues and in vitro 3D culture models are ...
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    4. Swept-source anatomic optical coherence elastography of porcine trachea

      Swept-source anatomic optical coherence elastography of porcine trachea
      Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dimensions. By coupling aOCT with measurements of pressure, optical coherence elastography (OCE) can be performed to characterize airway wall stiffness. This can aid in identifying regions of dynamic collapse as well as informing ...
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    5. Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments

      Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments
      Mucus hydration (wt%) has become an increasingly useful metric in real-time assessment of respiratory health in diseases like cystic fibrosis and COPD, with higher wt% indicative of diseased states. However, available in vivo rheological techniques are lacking. Gold nanorods (GNRs) are attractive biological probes whose diffusion through tissue is sensitive to the correlation length of comprising biopolymers. Through employment of dynamic light scattering theory on OCT signals from GNRs, we ...
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    6. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.

      University of North Carolina Receives NIH Grant for  Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.
      ...ntitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment. The principal investigator is Amy Oldenburg. The program began in 2014 and ends in 2015. Below is as summary of the proposed work. With no ...
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    7. Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill

      Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill
      ...o be competitive for the position. To apply for the position, please email your Resume in PDF format to Prof. Amy Oldenburg at aold@physics.unc.edu. Applications will be reviewed immediately until the position is filled....
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    8. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment

      University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment
      The University of North Carolina Received a 2014 NIH grant for $185,155 for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D microenvironment. The principal investigator is Amy Oldenberug The program began in 2014 and ends ind 2015. Below is a summary of the proposed work. With no available targeted therapies, basal-like breast cancers are particularly aggressive cancers with a poor prognosis. Basal-like breast cancers have unique stromal-epithelial ...
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    9. Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures

      Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures
      ...nd functional (cellular activity) imaging using standard PS-OCT hardware. © 2013 Optical Society of America Amy L. Oldenburg, Raghav K. Chhetri, Jason M. Cooper, Wei-Chen Wu, Melissa A. Troester, and Joseph B. Tracy, "...
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    10. University of North Carolina Receives NIH Grant for Development Of A Method For In Situ Nanorheology Of Human Airway Mucus

      University of North Carolina Receives NIH Grant for Development Of A Method For In Situ Nanorheology Of Human Airway Mucus
      ...3 NIH Grant for $168,096 for a quantitative Imaging of cilia-driven fluid flow. The principal investigator is Amy Oldenburg. The program started in 2012 and lends in 2014. A summary of the program is given below. We pro...
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    11. Feature Of The Week 2/24/13: University of North Carolina uses OCT To Study Breast Cancer Morphology

      Feature Of The Week 2/24/13: University of North Carolina uses OCT To Study Breast Cancer Morphology
      The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate morphology and size of organoids in 3D co-cultures of normal (MCF10A) or pre-malignant (MCF10DCIS.com) MEC and hTERT-immortalized fibroblasts from reduction mammoplasty (RMF). This co-culture model, based on an isogenic panel of cell lines, can yield ...
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    12. Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy

      Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy
      The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate morphology and size of organoids in 3D co-cultures of normal (MCF10A) or pre-malignant (MCF10DCIS.com) MEC and hTERT-immortalized fibroblasts from reduction mammoplasty (RMF). This co-culture model, based on an isogenic panel of cell lines, can yield ...
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    13. University of North Carolina at Chapel Hill Receives a 2012 NIH Grant for Development of a Method for In Situ Nanorehology of Human Airway Mucus

      University of North Carolina at Chapel Hill Receives a 2012 NIH Grant for Development of a Method for In Situ Nanorehology of Human Airway Mucus
      ...ucus. The program is a multi-year program and started in 2012 and ends in 2014. The principle investigator is Amy Oldenburg. A brief description of the project is given below. We propose to develop a novel nanorheology ...
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    14. 16-30 of 54 « 1 2 3 4 »
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  2. About Amy L. Oldenburg

    Amy L. Oldenburg

    Amy Oldenburg received her B.S. in Applied Physics at the California Institute of Technology in 1995, M.S. and Ph.D. in Physics at the University of Illinois at Urbana-Champaign in 1997 and 2001, respectively. Dr. Oldenburg was postdoctoral researcher and subsequently senior research scientist at the Beckman Institute at the University of Illinois from 2001-2008. Since 2008, Dr. Oldenburg has been Assistant Professor of Physics & Astronomy and part of the Biomedical Research Imaging Center at the University of North Carolina at Chapel Hill, where she directs the coherence imaging laboratory.

  3. Quotes

    1. The ability to monitor how well mucus-thinning treatments are working in real-time may allow us to determine better treatments and tailor them for the individual.
      In Cystic Fibrosis, COPD Patients Could Benefit From Nanoparticle-based Mucus