1. Amy L. Oldenburg

    0 Comments Leave a Comment

    16-30 of 52 « 1 2 3 4 »
    1. Mentioned In 52 Articles

    2. Swept-source anatomic optical coherence elastography of porcine trachea

      Swept-source anatomic optical coherence elastography of porcine trachea
      Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dimensions. By coupling aOCT with measurements of pressure, optical coherence elastography (OCE) can be performed to characterize airway wall stiffness. This can aid in identifying regions of dynamic collapse as well as informing ...
      Read Full Article
    3. Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments

      Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments
      Mucus hydration (wt%) has become an increasingly useful metric in real-time assessment of respiratory health in diseases like cystic fibrosis and COPD, with higher wt% indicative of diseased states. However, available in vivo rheological techniques are lacking. Gold nanorods (GNRs) are attractive biological probes whose diffusion through tissue is sensitive to the correlation length of comprising biopolymers. Through employment of dynamic light scattering theory on OCT signals from GNRs, we ...
      Read Full Article
    4. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.

      University of North Carolina Receives NIH Grant for  Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.
      ...ntitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment. The principal investigator is Amy Oldenburg. The program began in 2014 and ends in 2015. Below is as summary of the proposed work. With no ...
      Read Full Article
    5. Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill

      Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill
      ...o be competitive for the position. To apply for the position, please email your Resume in PDF format to Prof. Amy Oldenburg at aold@physics.unc.edu. Applications will be reviewed immediately until the position is filled....
      Read Full Article
    6. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment

      University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment
      The University of North Carolina Received a 2014 NIH grant for $185,155 for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D microenvironment. The principal investigator is Amy Oldenberug The program began in 2014 and ends ind 2015. Below is a summary of the proposed work. With no available targeted therapies, basal-like breast cancers are particularly aggressive cancers with a poor prognosis. Basal-like breast cancers have unique stromal-epithelial ...
      Read Full Article
    7. Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures

      Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures
      ...nd functional (cellular activity) imaging using standard PS-OCT hardware. © 2013 Optical Society of America Amy L. Oldenburg, Raghav K. Chhetri, Jason M. Cooper, Wei-Chen Wu, Melissa A. Troester, and Joseph B. Tracy, "...
      Read Full Article
    8. University of North Carolina Receives NIH Grant for Development Of A Method For In Situ Nanorheology Of Human Airway Mucus

      University of North Carolina Receives NIH Grant for Development Of A Method For In Situ Nanorheology Of Human Airway Mucus
      ...3 NIH Grant for $168,096 for a quantitative Imaging of cilia-driven fluid flow. The principal investigator is Amy Oldenburg. The program started in 2012 and lends in 2014. A summary of the program is given below. We pro...
      Read Full Article
    9. Feature Of The Week 2/24/13: University of North Carolina uses OCT To Study Breast Cancer Morphology

      Feature Of The Week 2/24/13: University of North Carolina uses OCT To Study Breast Cancer Morphology
      The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate morphology and size of organoids in 3D co-cultures of normal (MCF10A) or pre-malignant (MCF10DCIS.com) MEC and hTERT-immortalized fibroblasts from reduction mammoplasty (RMF). This co-culture model, based on an isogenic panel of cell lines, can yield ...
      Read Full Article
    10. Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy

      Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy
      The human mammary gland is a complex and heterogeneous organ, where the interactions between mammary epithelial cells (MEC) and stromal fibroblasts are known to regulate normal biology and tumorigenesis. We aimed to longitudinally evaluate morphology and size of organoids in 3D co-cultures of normal (MCF10A) or pre-malignant (MCF10DCIS.com) MEC and hTERT-immortalized fibroblasts from reduction mammoplasty (RMF). This co-culture model, based on an isogenic panel of cell lines, can yield ...
      Read Full Article
    11. University of North Carolina at Chapel Hill Receives a 2012 NIH Grant for Development of a Method for In Situ Nanorehology of Human Airway Mucus

      University of North Carolina at Chapel Hill Receives a 2012 NIH Grant for Development of a Method for In Situ Nanorehology of Human Airway Mucus
      ...ucus. The program is a multi-year program and started in 2012 and ends in 2014. The principle investigator is Amy Oldenburg. A brief description of the project is given below. We propose to develop a novel nanorheology ...
      Read Full Article
    12. Monitoring airway mucus flow and ciliary activity with optical coherence tomography

      Monitoring airway mucus flow and ciliary activity with optical coherence tomography
      Muco-ciliary transport in the human airway is a crucial defense mechanism for removing inhaled pathogens. Optical coherence tomography (OCT) is well-suited to monitor functional dynamics of cilia and mucus on the airway epithelium. Here we demonstrate several OCT-based methods upon an actively transporting in vitro bronchial epithelial model and ex vivo mouse trachea. We show quantitative flow imaging of optically turbid mucus, semi-quantitative analysis of the ciliary beat frequency, and ...
      Read Full Article
    13. Optimizing magnetomotive contrast of SPIO-labeled platelets for thrombosis imaging in optical coherence tomography

      Optimizing magnetomotive contrast of SPIO-labeled platelets for thrombosis imaging in optical coherence tomography
      External link. Please review our privacy policy . Rehydratable, lyophilized platelets loaded with superparamagnetic iron oxides (SPIOs) has the potential to provide magnetomotive imaging contrast to sites of vascular damage, including thrombosis complicating atherosclerosis and hemorrhage. Magnetomotive optical coherence tomography (MMOCT) contrasts SPIO-platelets based on their nanoscale, magnetically-induced motion. We report improvements in MMOCT imaging contrast and sensitivity by optimizing the magnetic properties and SPIO loading of the platelets. SPIO-platelets have ...
      Read Full Article
    14. 16-30 of 52 « 1 2 3 4 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Amy L. Oldenburg

    Amy L. Oldenburg

    Amy Oldenburg received her B.S. in Applied Physics at the California Institute of Technology in 1995, M.S. and Ph.D. in Physics at the University of Illinois at Urbana-Champaign in 1997 and 2001, respectively.  Dr. Oldenburg was postdoctoral researcher and subsequently senior research scientist at the Beckman Institute at the University of Illinois from 2001-2008.  Since 2008, Dr. Oldenburg has been Assistant Professor of Physics & Astronomy and part of the Biomedical Research Imaging Center at the University of North Carolina at Chapel Hill, where she directs the coherence imaging laboratory.

  3. Quotes

    1. The ability to monitor how well mucus-thinning treatments are working in real-time may allow us to determine better treatments and tailor them for the individual.
      In Cystic Fibrosis, COPD Patients Could Benefit From Nanoparticle-based Mucus