1. Amy L. Oldenburg

    0 Comments Leave a Comment

    1-15 of 42 1 2 3 »
    1. Mentioned In 42 Articles

    2. Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging

      Multi-modal anatomical optical coherence tomography and CT for in vivo dynamic upper airway imaging
      We describe a novel, multi-modal imaging protocol for validating quantitative dynamic airway imaging performed using anatomical Optical Coherence Tomography (aOCT). The aOCT system consists of a catheter-based aOCT probe that is deployed via a bronchoscope, while a programmable ventilator is used to control airway pressure. This setup is employed on the bed of a Siemens Biograph CT system capable of performing respiratory-gated acquisitions. In this arrangement the position of the ...
      Read Full Article
    3. High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source

      High-speed and high-sensitivity parallel spectral-domain optical coherence tomography using a supercontinuum light source
      The three most important metrics in optical coherence tomography (OCT) are resolution, speed, and sensitivity. Because there is a complex interplay between these metrics, no previous work has obtained the best performance in all three metrics simultaneously. We demonstrate that a high-power supercontinuum source, in combination with parallel spectral-domain OCT, achieves an unparalleled combination of resolution, speed, and sensitivity. This system captures cross-sectional images spanning 4 mm 0.5 mm ...
      Read Full Article
    4. University of North Carolina Receives NIH Grant for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus

      University of North Carolina Receives NIH Grant for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus
      ...4 for Imaging Nanophysical Properties of Actively Transporting Bronchial Mucus. The principal investigator is Amy Oldenburg. The program began in 2016 and ends in 2018. Below is a summary of the proposed work. Mucus coa...
      Read Full Article
    5. Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography

      Magnetic and Plasmonic Contrast Agents in Optical Coherence Tomography
      Optical coherence tomography (OCT) has gained widespread application for many biomedical applications, yet the traditional array of contrast agents used in incoherent imaging modalities do not provide contrast in OCT. Owing to the high biocompatibility of iron oxides and noble metals, magnetic and plasmonic nanoparticles, respectively, have been developed as OCT contrast agents to enable a range of biological and pre-clinical studies. Here, we provide a review of these developments ...
      Read Full Article
    6. Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography

      Imaging Extracellular Matrix Remodeling In Vitro by Diffusion-Sensitive Optical Coherence Tomography
      The mammary gland extracellular matrix (ECM) is comprised of biopolymers, primarily collagen I, that are created and maintained by stromal fibroblasts. ECM remodeling by fibroblasts results in changes in ECM fiber spacing (pores) that have been shown to play a critical role in the aggressiveness of breast cancer. However, minimally invasive methods to measure the spatial distribution of ECM pore areas within tissues and in vitro 3D culture models are ...
      Read Full Article
    7. Swept-source anatomic optical coherence elastography of porcine trachea

      Swept-source anatomic optical coherence elastography of porcine trachea
      Quantitative endoscopic imaging is at the vanguard of novel techniques in the assessment upper airway obstruction. Anatomic optical coherence tomography (aOCT) has the potential to provide the geometry of the airway lumen with high-resolution and in 4 dimensions. By coupling aOCT with measurements of pressure, optical coherence elastography (OCE) can be performed to characterize airway wall stiffness. This can aid in identifying regions of dynamic collapse as well as informing ...
      Read Full Article
    8. Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments

      Diffusion-sensitive optical coherence tomography for real-time monitoring of mucus thinning treatments
      Mucus hydration (wt%) has become an increasingly useful metric in real-time assessment of respiratory health in diseases like cystic fibrosis and COPD, with higher wt% indicative of diseased states. However, available in vivo rheological techniques are lacking. Gold nanorods (GNRs) are attractive biological probes whose diffusion through tissue is sensitive to the correlation length of comprising biopolymers. Through employment of dynamic light scattering theory on OCT signals from GNRs, we ...
      Read Full Article
    9. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.

      University of North Carolina Receives NIH Grant for  Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment.
      ...ntitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment. The principal investigator is Amy Oldenburg. The program began in 2014 and ends in 2015. Below is as summary of the proposed work. With no ...
      Read Full Article
    10. Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill

      Post Doctoral Position Opening at The Coherence Imaging Laboratory at the University of North Carolina at Chapel Hill
      ...o be competitive for the position. To apply for the position, please email your Resume in PDF format to Prof. Amy Oldenburg at aold@physics.unc.edu. Applications will be reviewed immediately until the position is filled....
      Read Full Article
    11. University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment

      University of North Carolina Receives NIH Grant for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D Microenvironment
      The University of North Carolina Received a 2014 NIH grant for $185,155 for Quantitative Motility Phenotyping of Basal Breast Cancer in a 3D microenvironment. The principal investigator is Amy Oldenberug The program began in 2014 and ends ind 2015. Below is a summary of the proposed work. With no available targeted therapies, basal-like breast cancers are particularly aggressive cancers with a poor prognosis. Basal-like breast cancers have unique stromal-epithelial ...
      Read Full Article
    12. Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures

      Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures
      ...nd functional (cellular activity) imaging using standard PS-OCT hardware. © 2013 Optical Society of America Amy L. Oldenburg, Raghav K. Chhetri, Jason M. Cooper, Wei-Chen Wu, Melissa A. Troester, and Joseph B. Tracy, "...
      Read Full Article
    13. University of North Carolina Receives NIH Grant for Development Of A Method For In Situ Nanorheology Of Human Airway Mucus

      University of North Carolina Receives NIH Grant for Development Of A Method For In Situ Nanorheology Of Human Airway Mucus
      ...3 NIH Grant for $168,096 for a quantitative Imaging of cilia-driven fluid flow. The principal investigator is Amy Oldenburg. The program started in 2012 and lends in 2014. A summary of the program is given below. We pro...
      Read Full Article
    14. 1-15 of 42 1 2 3 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Amy L. Oldenburg

    Amy L. Oldenburg

    Amy Oldenburg received her B.S. in Applied Physics at the California Institute of Technology in 1995, M.S. and Ph.D. in Physics at the University of Illinois at Urbana-Champaign in 1997 and 2001, respectively.  Dr. Oldenburg was postdoctoral researcher and subsequently senior research scientist at the Beckman Institute at the University of Illinois from 2001-2008.  Since 2008, Dr. Oldenburg has been Assistant Professor of Physics & Astronomy and part of the Biomedical Research Imaging Center at the University of North Carolina at Chapel Hill, where she directs the coherence imaging laboratory.

  3. Quotes

    1. The ability to monitor how well mucus-thinning treatments are working in real-time may allow us to determine better treatments and tailor them for the individual.
      In Cystic Fibrosis, COPD Patients Could Benefit From Nanoparticle-based Mucus