1. Alfred L. Nuttall

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    1. Mentioned In 29 Articles

    2. Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography

      Measurement and visualization of stimulus-evoked tissue dynamics in mouse barrel cortex using phase-sensitive optical coherence tomography
      ...hanges in Squid Giant Axons During Activity,” J. Membr. Biol. 231(1), 35–46 (2009). [Crossref] R. K. Wang and A. L. Nuttall, “Phase-sensitive optical coherence tomography imaging of the tissue motion within the organ of ...
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    3. Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography

      Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography
      Optical coherence tomography (OCT) has revolutionized physiological studies of the hearing organ, the vibration and morphology of which can now be measured without opening the surrounding bone. In this review, we provide an overview of OCT as used in the otological research, describing advances and different techniques in vibrometry, angiography, and structural imaging.
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    4. Minimal basilar membrane motion in low-frequency hearing

      Minimal basilar membrane motion in low-frequency hearing
      To perceive speech, the brain relies on inputs from sensory cells located near the top of the spiral-shaped cochlea. This low-frequency region of the inner ear is anatomically difficult to access, and it has not previously been possible to study its mechanical response to sound in intact preparations. Here, we used optical coherence tomography to image sound-evoked vibration inside the intact cochlea. We show that low-frequency sound moves a small ...
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    5. Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography

      Minimally invasive surgical method to detect sound processing in the cochlear apex by optical coherence tomography
      Sound processing in the inner ear involves separation of the constituent frequencies along the length of the cochlea. Frequencies relevant to human speech (100 to 500 Hz) are processed in the apex region. Among mammals, the guinea pig cochlear apex processes similar frequencies and is thus relevant for the study of speech processing in the cochlea. However, the requirement for extensive surgery has challenged the optical accessibility of this area ...
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    6. Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns

      Development of a phase-sensitive Fourier domain optical coherence tomography system to measure mouse organ of Corti vibrations in two cochlear turns
      In this study, we have developed a phase-sensitive Fourier-domain optical coherence tomography system to simultaneously measure the in vivo inner ear vibrations in the hook area and second turn of the mouse cochlea. This technical development will enable measurement of intra-cochlear distortion products at ideal locations such as the distortion product generation site and reflection site. This information is necessary to un-mix the complex mixture of intra-cochlear waves comprising the ...
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    7. Oregon Health and Science University Receives NIH Grant for Studying In Vivo Organ of Corti Mechanoelectric Physiology

      Oregon Health and Science University Receives  NIH Grant for Studying In Vivo Organ of Corti Mechanoelectric Physiology
      Oregon Health and Science University Receives a 2015 NIH Grant for $370,365 for Studying In Vivo Organ of Corti Mechanoelectric Physiology. The principal investigator is Alfred Nuttall. THe program began in 1979 and ends in 2016. Below is a summary of the proposed work. A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti enhance the sound induced vibration of the ...
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    8. Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography

      Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using phase sensitive Fourier domain optical coherence tomography
      ...mamoorthy ; Yuan Zhang ; Tracy Petrie ; Anders Fridberger ; Tianying Ren ; Ruikang Wang ; Steven L. Jacques ; Alfred L. Nuttall; Two dimensional vibrations of the guinea pig apex organ of Corti measured in vivo using pha...
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    9. Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry

      Changes in cochlear blood flow in mice due to loud sound exposure measured with Doppler optical microangiography and laser Doppler flowmetry
      ...r optical microangiography and laser Doppler flowmetry Authors: Roberto Reif, Zhongwei Zhi, Suzan Dziennis, Alfred L. Nuttall, Ruikang K. Wang Abstract In this work we determined the contributions of loud sound ex...
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    10. OHSU Receives NIH Grant for In Vivo Organ of Corti Mechanoelectric Physiology

      OHSU Receives NIH Grant for In Vivo Organ of Corti Mechanoelectric Physiology
      Oregon Health and Science University Received a 2013 NIH Grant for $355,401 for In Vivo Organ of Corti Mechanoelectric Physiology. The principal investigator is Alfred Nuttall. The program began in 1979 and ends in 2016. Below is a summary of the work. A goal of the cochlear physiology laboratory is to understand how the components of the organ of Corti enhance the sound induced vibration of the basilar membrane ...
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    11. Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea

      Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea
      ...res through intact bone of an excised guinea pig cochlea Hrebesh M. Subhash ; Ruikang K. Wang ; Fangyi Chen ; Alfred L. Nuttall; Reflective type objective based spectral-domain phase-sensitive optical coherence tomograph...
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    12. Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing

      Feature Of The Week 3/17/13: Using Optical Coherence Tomography to Study Mechanisms of Hearing
      ...iomed. Opt. 15, 056005 (2010).5. Hrebesh M. Subhash, Anh Nguyen-Huynh, Ruikang K. Wang, Steven L. Jacques and Alfred L. Nuttall, "Feasibility of spectral-domain phase-sensitive optical coherence tomography for middle ear...
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    13. Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography

      Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fourier domain optical coherence tomography
      ...hang ; Tracy Petrie ; Fangyi Chen ; Hrebesh M. Subhash ; Niloy Choudhury ; Ruikang Wang ; Steven L. Jacques ; Alfred L. Nuttall; Measurement of in vivo basal-turn vibrations of the organ of Corti using phase-sensitive Fo...
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    14. Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry

      Depth-resolved dual-beamlet vibrometry based on Fourier domain low coherence interferometry
      We present an optical vibrometer based on delay-encoded, dual-beamlet phase-sensitive Fourier domain interferometric system to provide depth-resolved subnanometer scale vibration information from scattering biological specimens. System characterization, calibration, and preliminary vibrometry with biological specimens were performed. The proposed system has the potential to provide both amplitude and direction of vibration of tissue microstructures on a single two-dimensional plane.
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    15. Oregon Health and Science University Receiveds NIH Grant f for 3-D Optical Imaging of The In Vivo Organ of Corti Motion at a Sub-Nanometer Scale

      Oregon Health and Science University Receiveds NIH Grant f for 3-D Optical Imaging of The In Vivo Organ of Corti Motion at a Sub-Nanometer Scale
      The Oregon Health and Science University Received a 2012 a NIH Grant for $310,929 for 3-D Optical Imaging of The In Vivo Organ of Corti Motion at a Sub-Nanometer Scale. The principal investigator is Alfred Nuttall. The program began in 2009 and ends in 2013. Below is a summary of the work. Low optical coherence tomography (OCT) has been used to image biological tissue and is the theoretical basis ...
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    16. 1-15 of 29 1 2 »
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  2. About Alfred L. Nuttall

    Alfred L. Nuttall

    Alfred L. Nuttall (S’63–M’71–SM’93) received the First degree in electrical engineering from Lowell Technological Institute, Lowell, MA, in 1965, two M.S. degrees in bioengineering and electrical engineering and the Ph.D. degree in bioengineering from the University of Michigan, Ann Arbor, in 1968, 1969, and 1972, respectively. He was a Research Associate at Kresge Hearing Research Institute, Department of Otolaryngology, University of Michigan, where he became an Assistant Professor in 1976, a Professor in 1987, and a Professor-Emeritus in 1996. Thereafter, he joined Oregon Health & Science University, Portland, where he is currently a Professor of otolaryngology and Director, Oregon Hearing Research Center. He is the author or coauthor of many peer-reviewed articles on cochlear mechanics and cochlear blood flow. His current research interests include cochlear mechanics and cochlear blood flow.