1. Alexandre R. Tumlinson

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    1. Mentioned In 18 Articles

    2. Ultrahigh-Resolution Endoscopic Optical Coherence Tomography for In Vivo Mouse Colonoscopy (Thesis)

      Ultrahigh-Resolution Endoscopic Optical Coherence Tomography for In Vivo Mouse Colonoscopy (Thesis)
      In vivo monitoring of mouse models of colon cancer promises to reduce the cost of research by improving sacrifice timing and allowing serial studies that observe the progression of disease and drug efficacy in a relatively small set of animals. Optical coherence tomography (OCT) is an optical analog of ultrasound imaging, capable of minimally-invasive mapping of light scatter intensity up to 2 mm deep in tissue. In this work, factors ...
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    3. Endoscopic optical coherence tomography and laser-induced fluorescence spectroscopy in a murine colon cancer model

      Background and Objectives The diagnostic feasibility of optical coherence tomography (OCT) and laser-induced fluorescence (LIF) have been evaluated for human colorectal cancer. This study applies these technologies to a murine model of colorectal adenoma. Study Design/Materials and Methods The lower colon of 10 ApcMin and two C57BL/6J mice was surveyed over five 4-week intervals using a prototype 2.0 mm diameter OCT-LIF endoscope-based system. Four categories were histologically ...
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    4. Miniature Endoscope for Simultaneous Optical Coherence Tomography and Laser-Induced Fluorescence Measurement

      We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides ~18-μm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by ...
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  2. About Alexandre R. Tumlinson

    Alexandre R. Tumlinson

    Alex Tumlinson is a former Graduate Research Assistant at The Tissue Optics Laboratory, Biomedical Engineering, University of Arizona.