1. Alexander V. Bykov

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    1. Mentioned In 20 Articles

    2. Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry

      Monitoring of temperature-mediated phase transitions of adipose tissue by combined optical coherence tomography and Abbe refractometry
      Observation of temperature-mediated phase transitions between lipid components of the adipose tissues has been performed by combined use of the Abbe refractometry and optical coherence tomography. The phase transitions of the lipid components were clearly observed in the range of temperatures from 24C to 60C, and assessed by quantitatively monitoring the changes of the refractive index of 1- to 2-mm-thick porcine fat tissue slices. The developed approach has a great ...
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    3. Noninvasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles

      Noninvasive control of influence of polyethylene glycol on transport function of fluorescent colored liposomal nanoparticles
      The studies were carried out on groups of clinically healthy mice line of outbred CD-1 stock. The model animals were divided into 2 groups and received experimental liposomal formulations. Using the method of fluorescence spectroscopy, we investigated the effectiveness of penetration into the circulatory system of fluorescently stained liposomes with polyethylene glycol (PEG) and without PEG when administered orally. Fluorescence channel with a fiber probe series of multifunctional laser non-invasive ...
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    4. Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography

      Quantification of cell-free layer thickness and cell distribution of blood by optical coherence tomography
      A high-speed optical coherence tomography (OCT) with 1 - m axial resolution was applied to assess the thickness of a cell-free layer (CFL) and a spatial distribution of red blood cells (RBC) next to the microchannel wall. The experiments were performed in vitro in a plain glass microchannel with a width of 2 mm and height of 0.2 mm. RBCs were suspended in phosphate buffered saline solution at the hematocrit ...
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    5. Optical clearing of articular cartilage: a comparison of clearing agents

      Optical clearing of articular cartilage: a comparison of clearing agents
      Optical clearing technique was applied to the problem of OCT imaging of articular cartilage and subchondral bone. We show that optical clearing significantly enhances visualization of articular cartilage and cartilage-bone interface. The effect of different clearing agents was analyzed. For the clearing, iohexol solution and propylene glycol (PG) were used. Clearing was performed in vitro at room temperature by immersion method. Cylindrical osteochondral samples (d=4.8mm) were drilled from ...
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    6. Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage

      Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage
      Optical clearing is an effective method to reduce light scattering of biological tissues that provides significant enhancement of light penetration into the biological tissues making non-invasive diagnosis more feasible. In current report Optical Coherence Tomography (OCT) in conjunction with optical clearing is applied for assessment of deep cartilage layers and cartilage-bone interface. The solution of Iohexol in water has been used as an optical clearing agent. The cartilage-bone boundary becomes ...
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    7. Evaluation of Freshness of Soft Tissue Samples with Optical Coherence Tomography Assisted by Low Frequency Electric Field

      Evaluation of Freshness of Soft Tissue Samples with Optical Coherence Tomography Assisted by Low Frequency Electric Field
      We present an optical coherence tomography based methodology to determine freshness of soft tissue samples by evaluation of their interaction with low frequency electric field. Various biological tissues samples of different stages of freshness were exposed by low frequency electric current. The influence of the low frequency electric field on tissues was observed and quantified by the double correlation optical coherence tomography (dcOCT) approach developed in house. The quantitative evaluation ...
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    8. Multiple scattering effects in Doppler optical coherence tomography of flowing blood

      Multiple scattering effects in Doppler optical coherence tomography of flowing blood
      We investigate the effect of multiple scattering on the optical coherence tomography (OCT) signal and the Doppler OCT signal of flowing blood. Doppler OCT measurements at 1300 nm are performed on flowing diluted porcine blood with hematocrit ranging between 0% and 15%. Measured blood hematocrit and mean red blood cell volume are used to calculate, using the discrete dipole approximation model, the (single) scattering coefficient and scattering anisotropy of blood ...
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    9. Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques

      Glucose sensing in flowing blood and Intralipid by laser pulse time-of-flight and optical coherence tomography techniques
      In this paper, we compare the sensitivities of the two optical modalities, laser pulse time-of-flight (TOF) and optical coherence tomography (OCT), in regard to glucose sensing within the range of 0-1000 mg/dl in flowing blood and tissue-mimicking liquid (Intralipid). We show that TOF technique is about twice more sensitive than OCT, as well for blood as for Intralipid measurements. In case of TOF technique, glucose sensitivity in Intralipid is ...
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    10. Determination of suspension viscosity from the flow velocity profile measured by Doppler Optical Coherence Tomography

      Determination of suspension viscosity from the flow velocity profile measured by Doppler Optical Coherence Tomography
      In this paper we present, for the first time to our knowledge, the experimental results for determining suspension viscosity in a capillary type viscometer from flow velocity profiles measured by Doppler Optical Coherence Tomography. The suspension of 0.3?m polystyrene microspheres in a glycerol-water solution was used as a model fluid. The viscosity of the suspension was controlled by glycerol concentration. The shear rate and the shear stress at ...
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    11. Experimental study of the multiple scattering effect on the flow velocity profiles measured in intralipid phantoms by DOCT

      Experimental study of the multiple scattering effect on the flow velocity profiles measured in intralipid phantoms by DOCT
      Abstract  Time domain Doppler Optical Coherence Tomography (DOCT) technique was applied to measure flow velocity profiles in highly scattering media. We analyzed the distortions of the measured velocity profiles of the 1% Intralipid solution flow embedded into the scattering medium at different embedding depths. For this purpose a tissue phantom consisting of a plain glass capillary (inner diameter 0.3 mm) embedded into a slab of Intralipid solution mimicking human ...
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    12. Multiple and dependent scattering effects in Doppler optical coherence tomography

      Multiple and dependent scattering effects in Doppler optical coherence tomography
      Doppler optical coherence tomography (OCT) is a technique to image tissue morphology and to measure flow in turbid media. In its most basic form, it is based on single (Mie) scattering. However, for highly scattering and dense media multiple and concentration dependent scattering can occur. For Intralipid solutions with varying scattering strength, the effect of multiple and dependent scattering on the OCT signal attenuation and Doppler flow is investigated. We ...
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    13. 1-15 of 20 1 2 »
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  2. About Alexander V. Bykov

    Alexander V. Bykov

    Alexander V. Bykov is PhD student in technology in the Optoelectronics and Measurement Techniques Laboratory of University of Oulu, Finland. He graduated with honors in 2005 from Physics Department of Moscow State University and received his Ph.D degree in physics in 2008 from the same university. His scientific interests are in the area of biophotonics, non-invasive optical diagnostics, theory of light propagation in scattering media including biotissues and numerical simulation of light transport.