1. Alexander Krüger

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    1. Mentioned In 14 Articles

    2. Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye

      Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye
      While fs-lasers are clinically established for surgery in the anterior eye, their use in the posterior eye is impeded by aberrations and focus position errors. We implemented a laboratory system to investigate whether fs-laser surgery in the posterior eye is made more feasible by aberration correction and tomographic image guidance. Aberration correction is obtained by adaptive optics (AO) and the image guidance is accomplished by optical coherence tomography (OCT). System ...
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    3. Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

      Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography
      Objectives/Hypothesis Examination of tissue structures by optical coherence tomography (OCT) has been shown to be useful on mucous membranes of the vocal folds, but so far its application to the human larynx has been limited because it is technically cumbersome and usually needs to be performed with sedation. Here a newly developed, noninvasive combined laryngoscopy and OCT procedure is described and its suitability for ambulatory OCT studies evaluated. Because ...
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    4. Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients

      Automated working distance adjustment enables optical coherence tomography of the human larynx in awake patients
      Optical coherence tomography (OCT) provides structural information of laryngeal tissue which is comparable to histopathological analysis of biopsies taken under general anesthesia. In awake patients, movements impede clinically useful OCT acquisition. Therefore, an automatic compensation of movements was implemented into a swept source OCT-laryngoscope. Video and OCT beam path were combined in one tube of 10-mm diameter. Segmented OCT images served as distance sensor and a feedback control adjusted the ...
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    5. Towards femtosecond laser surgery guidance in the posterior eye: utilization of optical coherence tomography and adaptive optics for focus positioning and shaping

      Towards femtosecond laser surgery guidance in the posterior eye: utilization of optical coherence tomography and adaptive optics for focus positioning and shaping
      ...rior eye: utilization of optical coherence tomography and adaptive optics for focus positioning and shaping. Alexander Krüger ; Anja Hansen ; Ben Matthias ; Tammo Ripken; Towards femtosecond laser surgery guidance in th...
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    6. In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model

      In situ optical coherence tomography of percutaneous implant-tissue interfaces in a murine model
      Novel surface coatings of percutaneous implants need to be tested in biocompatibility studies. The use of animal models for testing usually involves numerous lethal biopsies for the analysis of the implant-tissue interface. In this study, optical coherence tomography (OCT) was used to monitor the reaction of the skin to a percutaneous implant in an animal model of hairless but immunocompetent mice. In vivo optical biopsies with OCT were taken at ...
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    7. Compensating Motion Artifacts of 3D in vivo SD-OCT Scans

      Compensating Motion Artifacts of 3D in vivo SD-OCT Scans
      We propose a probabilistic approach for compensating motion artifacts in 3D in vivo SD-OCT (spectral-domain optical coherence tomography) tomographs. Subject movement causing axial image shifting is a major problem for in vivo imaging. Our technique is applied to analyze the tissue at percutaneous implants recorded with SD-OCT in 3D. The key challenge is to distinguish between motion and the natural 3D spatial structure of the scanned subject. To achieve this ...
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    8. Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants

      Feature Of The Week 12/4/11: Researchers in Hannover Germany Utilize OCT to Measure Skin Swelling Along Percutaneous Implants
      Researchers from the Leibniz University of Hannover (LUH), Laser Zentrum Hannover (LZH), and the Hannover Medical School (MHH) used OCT to measure skin swelling along percutaneous implants. An undistortion technique is proposed to compensate for the refractive distortions [1].Optical Coherence Tomography is a non invasive imaging modality recently used for taking high resolution optical biopsies of layered tissue structures such as the epidermis and the retina.As the OCT ...
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    9. In vivo optical coherence tomography of percutaneous implants in hairless mice

      In vivo optical coherence tomography of percutaneous implants in hairless mice
      Biocompatibility studies of percutanous implants in animal models usually involve numerous lethal biopsies for subsequent morphometric analysis of the implant-tissue interface. A common drawback of the study protocol is the restriction of the analysis to one final time point. In this study optical coherence tomography (OCT) was used to visualize and enable quantification of the local skin anatomy in the vicinity of a percutaneous implant in an animal model using ...
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    10. Simultaneous three-dimensional optical coherence tomography and intravital microscopy for imaging subpleural pulmonary alveoli in isolated rabbit lungs

      ...siology and Intensive Care, Faculty of Medicine Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany Alexander Krueger University of Technology, Dresden, Clinical Sensoring and Monitoring, Faculty of Medicine C...
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    11. A laryngoscope for office-based imaging of human vocal folds using OCT

      We developed a laryngoscope with an integrated OCT beam path for office-based non-contact imaging of human vocal folds. In combination with conventional videolaryngoscopy superficial and subsurface lesions can be detected. For error-free interpretation of OCT images obtained in office-based examination motion artifacts have to be considered. To demonstrate the implications on OCT images we simulated probe and patient movements for different commercial systems representing the three OCT modalities and analyzed ...
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    12. Alveolar dynamics in acute lung injury: Heterogeneous distension rather than cyclic opening and collapse *

      Objectives: To analyze alveolar dynamics in healthy and acid-injured lungs of ventilated mice. Protective ventilation is potentially lifesaving in patients with acute lung injury. However, optimization of ventilation strategies is hampered by an incomplete understanding of the effects of mechanical ventilation at the alveolar level. Design: In anesthetized and ventilated Balb/c mice, subpleural alveoli were visualized by darkfield intravital microscopy and optical coherence tomography. Setting: Animal research laboratory. Subjects ...
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  2. About Alexander Krüger

    Alexander Krüger

    Alexander Krueger is in the Laser Medicine and Biophotonics Group at the Laser Zentrum Hannover. Alexander Krüger (geb. Popp) studied physics at the University of Bonn and finished his PHD (Dr.rer.nat.) in 2003. After working at the department "Clinical Sensoring und Monitoring" of the Medical Faculty at the Dresden University of Technology he started in the biophotonics group of the LZH in 2008.