1. Alexander C. Walsh

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    1. Mentioned In 44 Articles

    2. Error Correction and Quantitative Subanalysis of Optical Coherence Tomography Data Using Computer-Assisted Grading

      Error Correction and Quantitative Subanalysis of Optical Coherence Tomography Data Using Computer-Assisted Grading
      purpose. To demonstrate feature subanalysis and error correction of optical coherence tomography (OCT) data by using computer-assisted grading. methods. The raw exported StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) scan data from 20 eyes of 20 patients were analyzed using custom software (termed OCTOR) designed to allow the user to define manually the retinal borders on each radial line scan. Measurements calculated by the software, including thickness of the nine ...
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    3. Errors in Retinal Thickness Measurements Obtained by Optical Coherence Tomography

      Errors in Retinal Thickness Measurements Obtained by Optical Coherence Tomography
      Objective To report the frequency and severity of optical coherence tomography (OCT) retinal thickness measurement errors and to describe parameters that predict these errors. Design Observational case series. Participants Two hundred consecutive patients undergoing OCT imaging. Methods One eye (primary) from each of 200 consecutive patients undergoing Stratus OCT imaging (Carl Zeiss Meditec, Dublin, CA) with radial lines or fast macular thickness-based acquisition protocols was selected for review by 2 ...
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    4. Optical coherence tomography-based ophthalmic testing methods, devices and systems

      Optical coherence tomography-based ophthalmic testing methods, devices and systems
      In accordance with one aspect of the present invention, an optical coherence tomography-based ophthalmic testing center system includes an optical coherence tomography instrument comprising an eyepiece for receiving at least one eye of a user or subject; a light source that outputs light that is directed through the eyepiece into the user's or subject's eye, an interferometer configured to produce optical interference using light reflected from the user ...
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    5. Inflatable medical interfaces and other medical devices, systems, and methods

      Inflatable medical interfaces and other medical devices, systems, and methods
      An inflatable mask with two ocular cavities can seal against a user's face by forming an air-tight seal around the periphery of the user's eye socket. The sealed air-tight ocular cavity can be pressurized to take ocular measurements. The mask can conform to the contours of a user's face by inflating or deflating the mask. In addition, the distance between the user and a medical device (e ...
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    6. Inflatable Medical Interfaces And Other Medical Devices, Systems, And Methods

      Inflatable Medical Interfaces And Other Medical Devices, Systems, And Methods
      An inflatable mask with two ocular cavities can seal against a user's face by forming an air-tight seal around the periphery of the user's eye socket. The sealed air-tight ocular cavity can be pressurized to take ocular measurements. The mask can conform to the contours of a user's face by inflating or deflating the mask. In addition, the distance between the user and a medical device (e ...
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    7. Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding

      Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding
      BACKGROUND AND OBJECTIVE: To report a novel optical coherence tomography (OCT) finding in choroidal neovascularization (CNV). PATIENTS AND METHODS: The authors identified seven eyes with CNV demonstrating the atypical pattern of fluid accumulation within the outer retina on OCT. Patient demographics, best corrected visual acuity and spectral-domain OCT (SD-OCT) images were collected for all available follow-up visits. Volume and area of the fluid were measured on SD-OCT. Microperimetry was performed ...
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    8. Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration

      Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration
      Purpose: Relationship between spectral domain optical coherence tomography (SD-OCT) and visual acuity (VA) in neovascular age-related macular degeneration (NVAMD). Procedures: VA and SD-OCTs of 64 treatment-naive eyes with NVAMD were retrospectively collected at baseline and 1 year (n = 30). Retinal and subretinal spaces were manually analyzed. Volume and thickness measurements were correlated with VA. Results: At baseline, lower VA correlated with increased volume of subretinal hyperreflective material (R = 0.4 ...
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    9. The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities
      ...ies 1. Yanling Ouyang^1,^2, 2. Florian M. Heussen^1,^2, 3. Pearse A. Keane^3, 4. Srinivas R. Sadda^1 and 5. Alexander C. Walsh^1 1. ^1Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine ...
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    10. Optical Coherence Tomography Device, Method, And System

      Optical Coherence Tomography Device, Method, And System
      In accordance with one aspect of the present invention, an optical coherence tomography instrument comprises an eyepiece for receiving at least one eye of a user is provided; a light source that outputs light that is directed through the eyepiece into the user's eye; an interferometer configured to produce optical interference using light reflected from the user's eye; an optical detector disposed so as to detect said optical ...
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    11. Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities
      Purpose:To determine the sensitivity of detection for retinal abnormalities using 3D-OCT versus single field fundus imaging. Methods:Images from consecutive patients in a retina clinic undergoing simultaneous 3D-OCT (512x128) and single, foveal non-mydriatic 45 degree color fundus imaging with 3D-OCT-1000 (Topcon Corp, Tokyo, Japan) in a 4 months period were retrospectively collected. Findings for each modality were graded independently by two graders as present, questionable or absent. Findings were ...
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    12. Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography
      Purpose To present a selected case series of different phenotypes of the normal outer plexiform layer (OPL) visualized by optical coherence tomography (OCT). Methods Five cases were selected to represent the spectrum of appearances of the OPL in this case series. Categorical descriptions of each manifestation were then developed. Additional SD-OCT scans were obtained from a normal volunteer to further support the hypothesis. Results The inner one-third of the OPL ...
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    13. Evaluation of the Axial Location of Cystoid Spaces in Retinal Vein Occlusion Using Optical Coherence Tomography

      Evaluation of the Axial Location of Cystoid Spaces in Retinal Vein Occlusion Using Optical Coherence Tomography
      Purpose: To analyze the axial distribution of intraretinal cystoid changes in patients with retinal vein occlusion (RVO), incorporating a new hypothesis about the optical coherence tomographic boundary between the outer nuclear layer and the outer plexiform layer. Methods: Data were collected from patients with RVO who underwent spectral domain coherence tomography imaging. For each image set, certified graders evaluated each retinal layer for cystoid macular edema, defined as hyporeflective intraretinal ...
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    14. The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities
      ...1. Yanling Ouyang^1,^2,^4, 2. Florian M. Heussen^1,^2,^4, 3. Pearse A. Keane^3, 4. SriniVas R. Sadda^1 and 5. Alexander C. Walsh^1 1. From the ^1Doheny Eye Institute and Department of Ophthalmology, Keck School of Medici...
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    15. The Retinal Disease Screening Study: Prospective Comparison of Non-Mydriatic FP and Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Prospective Comparison of Non-Mydriatic FP and Optical Coherence Tomography for Detection of Retinal Irregularities
      Purpose:To compare the sensitivity of volume scanning with optical coherence tomography (OCT), to non-mydriatic fundus photography, for the detection of retinal abnormalities in asymptomatic populations. Methods:Asymptomatic subjects without known ocular disease recruited over a six-month period .For each eye, two undilated 45 fundus images, and four undilated volume OCT image sets covering the macula and optic nerve, were obtained. Fundus photographs were evaluated for abnormalities both inside and ...
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  2. About Alexander C. Walsh

    Alexander C. Walsh

    Dr. Alexander Walsh received his M.D. from Columbia University College of Physicians and Surgeons and completed his internship as an Osler Intern in the Department of Medicine at Johns Hopkins Hospital. Dr. Walsh also completed his Ophthalmology residency at the Wilmer Eye Institute, Johns Hopkins Hospital, followed by a clinical and research fellowship in vitreoretinal surgery at the Doheny Eye Institute. His clinical interests are the diagnosis and treatment of disorders of the retina. He is also very active in the research and development of ophthalmic imaging devices and instrumentation.

  3. Quotes

    1. I think that intraoperative OCT will be incredibly useful in the future...I have high hopes for functional OCT (measuring tissue function directly with OCT instead of using surrogate tests like we’re doing with our ‘apps-driven’ platform)...We want to begin moving health care into the home...It would be tremendously useful if my patients could capture OCTs of their own eyes and send them to me to determine if they need to come in. That could both improve care and reduce costs if we can do it safely and effectively. To do this, OCT systems will need to get smaller, cheaper and better. And they are.
      In OCT Moves from Clinic to OR to . . . Home?
    2. The major advantage of OCT to me is that it is really, truly non-mydriatic and can potentially be operated by an individual without ancillary personnel being involved. With that, you can begin to touch hundreds of millions of people around the world.
      In OCT devices increasingly finding use outside retinal practice
    3. I'd like to get rid of slit-lamp biomicroscopes. I think they have served us well for 100 years, but it's an archaic technology that doesn't do a whole lot of the things we need to do in modern medicine.
      In OCT devices increasingly finding use outside retinal practice
    4. I have patients with OCTs over the course of 5 or 6 years, and I can go back and see the status of the retina over 5 and 6 years in a way that I can’t do with my exams...I think the longitudinal capabilities of OCT in terms of quantitative analysis are just now becoming evident to a lot of people and will hopefully dominate the future of the clinical exam.
      In OCT devices increasingly finding use outside retinal practice