1. Adam Wax

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    1. Mentioned In 75 Articles

    2. Dual-axis optical coherence tomography for deep tissue imaging

      Dual-axis optical coherence tomography for deep tissue imaging
      We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a ...
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    3. Systems and methods of angle-resolved low coherence interferometry based optical correlation

      Systems and methods of angle-resolved low coherence interferometry based optical correlation
      Systems and methods of angle-resolved low coherence interferometry based optical correlation are disclosed. According to an aspect, a method includes directing a sample beam towards a sample for producing a scattered sample beam from the sample. The method also includes receiving the scattered sample beam at a multitude of scattering angles in at least two directions. Further, the method includes cross-correlating the scattered sample beam with a reference beam to ...
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    4. Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography

      Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography
      Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ . However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which ...
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    5. Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry

      Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution may relate to scattering information about a sample, and temporal ...
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    6. Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography

      Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography
      Clinical management of burn injuries depends upon an accurate assessment of the depth of the wound. Current diagnostic methods rely primarily on subjective visual inspection, which can produce variable results. In this study, spectroscopic optical coherence tomography was used to objectively evaluate burn injuries in vivo in a mouse model. Significant spectral differences were observed and correlated with the depth of the injury as determined by histopathology. The relevance of ...
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    7. Functional optical coherence tomography: principles and progress

      Functional optical coherence tomography: principles and progress
      In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo ...
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    8. UV-VIS Spectroscopy in the Clinic – What’s Stopping It?

      UV-VIS Spectroscopy in the Clinic – What’s Stopping It?
      Bigios team isnt the only one to encounter this difficulty in attracting funding. Dr. Adam Waxs group at Duke University has been developing a technique angle-resolved low-coherence interferometry, or a/LCI enabling early detection of cancer and other biomedical applications by measuring the average size of cell nuclei using scattered light. The focus of the a/LCI instrument has been Barretts esophagus, a precursor to esophageal cancer. But Wax is ...
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  2. About Adam Wax

    Adam Wax

    Adam Wax joined the faculty of the Biomedical Engineering department at Duke University as an assistant professor in 2002 and was promoted to associate professor in 2008. Dr. Wax received his Ph.D. in physics from Duke in 1999 and completed his postdoctoral training at MIT. His research interests include optical spectroscopy for early cancer detection, novel microscopy and interferometry techniques.

  3. Quotes

    1. We expect that this new technique will have several important applications, such as visualizing tumor-development processes, like angiogenesis and oxygen deprivation...It also could help in detecting diseases of the eye, especially those that impact the tiny vessels of the eye. It may have effectiveness in monitoring the delivery and effectiveness of drugs.
      In Biomolecules Show Their True Colors
    2. When light is directed at these tissues, it scatters...We can collect and analyze that scattered light looking for the tell-tale signs of dysplasia. Significantly, the technique is noninvasive so no tissue is taken and no dyes or contrast agents are needed...The important thing for clinicians is being able to detect these changes in the nuclei in cells just below the surface, which might not be detected by just looking at the lining of the colon through an endoscope alone.
      In Light Can Detect Pre-Cancerous Colon Cells
    3. This optical approach of sampling allows us to cover more tissue sites in less time and has the potential to significantly improve our ability to spot and monitor these pre-cancerous cells....This type of approach could be used to improve and, perhaps one day, supplant the physical biopsies currently being used.
      In Let There be Light
    4. This optical approach of sampling allows us to cover more tissue sites in less time and has the potential to significantly improve our ability to spot and monitor these pre-cancerous cells...This type of approach could be used to improve and perhaps one day supplant the physical biopsies currently being used.
      In Detecting Esophageal Cancer with Light