1. Adam Wax

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    1. Mentioned In 84 Articles

    2. OCT Promising as Clear Point-of-Care Solution

      OCT Promising as Clear Point-of-Care Solution
      Medical devices at the point of care allow clinicians to do what they do best: determine a patients exact condition and a course of treatment. These technologies work best when they fit seamlessly into the provider-patient workflow without a steep learning curve or worry about the underlying scientific principles, and without the high cost seen for so many medical technologies. Optical coherence tomography (OCT) is an imaging technology that has ...
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    3. Design and implementation of a low-cost, portable OCT system

      Design and implementation of a low-cost, portable OCT system
      Optical coherence tomography (OCT) is a widely used biomedical imaging tool, primarily in ophthalmology to diagnose and stage retinal diseases. In order to increase access for a wider range of applications and in low resource settings, we developed a portable, low-cost OCT system that has comparable imaging performance to commercially available systems. Here, we present the system design and characterization and compare the system performance to other commercially available OCT ...
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    4. Real-time speckle reduction in optical coherence tomography using the dual window method

      Real-time speckle reduction in optical coherence tomography using the dual window method
      Speckle is an intrinsic noise of interferometric signals which reduces contrast and degrades the quality of optical coherence tomography (OCT) images. Here, we present a frequency compounding speckle reduction technique using the dual window (DW) method. Using the DW method, speckle noise is reduced without the need to acquire multiple frames. A ~25% improvement in the contrast-to-noise ratio (CNR) was achieved using the DW speckle reduction method with only minimal ...
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    5. Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer

      Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer
      Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an illumination beam, an interferometer, and a spectrometer. The interferometer includes a first beam splitter configured to split the illumination beam into an incident beam and a reference beam; an optical lens directs the incident beam onto a biological sample at a ...
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    6. Label-free analysis of tenofovir delivery to vaginal tissue using co-registered confocal Raman spectroscopy and optical coherence tomography

      Label-free analysis of tenofovir delivery to vaginal tissue using co-registered confocal Raman spectroscopy and optical coherence tomography
      Vaginally applied microbicide products offer a female-controlled strategy for preventing sexual transmission of HIV. Microbicide transport processes are central to their functioning, and there is a clear need for a better understanding of them. To contribute to that end, we developed an assay to analyze mass transport rates of microbicide molecules within the epithelial and stromal layers of polarized vaginal mucosal tissue during contact with a gel vehicle. The assay ...
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    7. Multiple window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry

      Multiple window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry
      Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength) resolution. In one non-limiting embodiment, multiple or dual window (DW) apparatuses and methods for reconstructing time-frequency distributions (TFDs) that applies two windows that independently determine the optical and temporal resolution is provided. For example, optical resolution is provided. For example, optical resolution may relate to scattering ...
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    8. Dual-axis optical coherence tomography for deep tissue imaging

      Dual-axis optical coherence tomography for deep tissue imaging
      We have developed dual-axis optical coherence tomography (DA-OCT) which enables deep tissue imaging by using a novel off-axis illumination/detection configuration. DA-OCT offers a 100-fold speed increase compared with its predecessor, multispectral multiple-scattering low coherence interferometry (ms2/LCI), by using a new beam scanning mechanism based on a microelectro-mechanical system (MEMS) mirror. The data acquisition scheme was altered to take advantage of this scanning speed, producing tomographic images at a ...
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    9. Systems and methods of angle-resolved low coherence interferometry based optical correlation

      Systems and methods of angle-resolved low coherence interferometry based optical correlation
      Systems and methods of angle-resolved low coherence interferometry based optical correlation are disclosed. According to an aspect, a method includes directing a sample beam towards a sample for producing a scattered sample beam from the sample. The method also includes receiving the scattered sample beam at a multitude of scattering angles in at least two directions. Further, the method includes cross-correlating the scattered sample beam with a reference beam to ...
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    10. 1-15 of 84 1 2 3 4 5 6 »
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  2. About Adam Wax

    Adam Wax

    Adam Wax joined the faculty of the Biomedical Engineering department at Duke University as an assistant professor in 2002 and was promoted to associate professor in 2008. Dr. Wax received his Ph.D. in physics from Duke in 1999 and completed his postdoctoral training at MIT. His research interests include optical spectroscopy for early cancer detection, novel microscopy and interferometry techniques.

  3. Quotes

    1. We expect that this new technique will have several important applications, such as visualizing tumor-development processes, like angiogenesis and oxygen deprivation...It also could help in detecting diseases of the eye, especially those that impact the tiny vessels of the eye. It may have effectiveness in monitoring the delivery and effectiveness of drugs.
      In Biomolecules Show Their True Colors
    2. When light is directed at these tissues, it scatters...We can collect and analyze that scattered light looking for the tell-tale signs of dysplasia. Significantly, the technique is noninvasive so no tissue is taken and no dyes or contrast agents are needed...The important thing for clinicians is being able to detect these changes in the nuclei in cells just below the surface, which might not be detected by just looking at the lining of the colon through an endoscope alone.
      In Light Can Detect Pre-Cancerous Colon Cells
    3. This optical approach of sampling allows us to cover more tissue sites in less time and has the potential to significantly improve our ability to spot and monitor these pre-cancerous cells....This type of approach could be used to improve and, perhaps one day, supplant the physical biopsies currently being used.
      In Let There be Light
    4. This optical approach of sampling allows us to cover more tissue sites in less time and has the potential to significantly improve our ability to spot and monitor these pre-cancerous cells...This type of approach could be used to improve and perhaps one day supplant the physical biopsies currently being used.
      In Detecting Esophageal Cancer with Light