1. Adam de la Zerda

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    1. Mentioned In 11 Articles

    2. High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging

      High sensitivity contrast enhanced optical coherence tomography for functional in vivo imaging
      In this study, we developed and applied highly-scattering large gold nanorods (LGNRs) and custom spectral detection algorithms for high sensitivity contrast-enhanced optical coherence tomography (OCT). We were able to detect LGNRs at a concentration as low as 50 pM in blood. We used this approach for noninvasive 3D imaging of blood vessels deep in solid tumors in living mice. Additionally, we demonstrated multiplexed imaging of spectrally-distinct LGNRs that enabled observations ...
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    3. Developing in vivo Functional Imaging Technology with Micron-Scale Resolution Using Optical Coherence Tomography

      Developing in vivo Functional Imaging Technology with Micron-Scale Resolution Using Optical Coherence Tomography
      Researchers and physicians rely on functional imaging to better understand tumors and other structures within the human body. However, imaging technologies that capture deep structures have poor resolution, while those that provide high resolution have limited depth. Positron emission tomography (PET), for example, reveals details deep within tissue but suffers from poor spatial resolution, with each voxel of a PET scan representing thousands or even millions of cells. In contrast ...
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    4. High-resolution contrast-enhanced optical coherence tomography in mice retinae

      High-resolution contrast-enhanced optical coherence tomography in mice retinae
      Optical coherence tomography (OCT) is a noninvasive interferometric imaging modality providing anatomical information at depths of millimeters and a resolution of micrometers. Conventional OCT images limit our knowledge to anatomical structures alone, without any contrast enhancement. Therefore, here we have, for the first time, optimized an OCT-based contrast-enhanced imaging system for imaging single cells and blood vessels in vivo inside the living mouse retina at subnanomolar sensitivity. We used bioconjugated ...
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    5. Feature of the Week 04/02/2016: Contrast-Enhanced Optical Coherence Tomography with Picomolar Sensitivity for Functional in vivo Imaging (with Audio)

      Feature of the Week 04/02/2016:  Contrast-Enhanced Optical Coherence Tomography with Picomolar Sensitivity for Functional in vivo Imaging (with Audio)
      ...6(6) (2015) [5] E.D. SoRelle et al, Langmuir 31(45) (2015) For more information see recent Article . Courtesy Adam de la Zerda from Stanford . Optical Coherence Tomography (OCT) enables real-time imaging of living tissue...
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    6. Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging

      Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging
      Optical Coherence Tomography (OCT) enables real-time imaging of living tissues at cell-scale resolution over millimeters in three dimensions. Despite these advantages, functional biological studies with OCT have been limited by a lack of exogenous contrast agents that can be distinguished from tissue. Here we report an approach to functional OCT imaging that implements custom algorithms to spectrally identify unique contrast agents: large gold nanorods (LGNRs). LGNRs exhibit 110-fold greater spectral ...
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    7. Quantitative contrast-enhanced optical coherence tomography

      Quantitative contrast-enhanced optical coherence tomography
      We have developed a model to accurately quantify the signals produced by exogenous scattering agents used for contrast-enhanced Optical Coherence Tomography (OCT). This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of OCT detection. Accordingly, we show that real scattering particles can be described as simplified ideal scatterers with modified scattering intensity and concentration. The relation between OCT signal and particle concentration is approximately linear at ...
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    8. Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents

      Biofunctionalization of Large Gold Nanorods Realizes Ultrahigh-Sensitivity Optical Imaging Agents
      Gold nanorods (GNRs, ~50 x 15 nm) have been used ubiquitously in biomedicine for their optical properties, and many biofunctionalization methods have been described for them. Recently, the synthesis of larger-than-usual GNRs (LGNRs, ~100 x 30 nm) has been demonstrated. However, LGNRs have not been biofunctionalized and therefore remain absent from biomedical literature to date. Here we report the first biofunctionalization of LGNRs, resulting in highly stable particles with a ...
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    9. Post-doc position at the de la Zerda Lab – Stanford Medical School

      Post-doc position at the de la Zerda Lab – Stanford Medical School
      We have several post-doc positions available for exceptional individuals with backgrounds in Optical Coherence Tomography (OCT). Starting date is flexible, but preferably during 2013 or early 2014. We are a multidisciplinary lab focusing on the development of molecular imaging technologies to study cancer and ophthalmic diseases. Our work spans both basic science and translational medicine applications. For more information about the lab, visit: http://delazerda.stanford.edu The post-doc will ...
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    10. System And Method For Molecular In Vivo Imaging And Theranostics

      System And Method For Molecular In Vivo Imaging And Theranostics
      Systems and methods of characterizing biological tissues are provided. Tn the systems and methods, a first optical coherence tomography ( OCT) image of a selected portion of biological tissues combined with a plurality of nanoparticϊs is obtained, where the plurality of nanoparticls are configured to bind to one or more types of biological molecules in the biological tissues and to produce contrast during OCT imaging. The systems and methods also include ...
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  2. About Adam de la Zerda

    Adam de la Zerda

    Adam de la Zerda is an Assistant Professor in the departments of Structural Biology and Electrical Engineering at Stanford University. He is working on the development of new medical imaging technologies to detect cancer at an early stage and guide physicians towards optimal treatment of the cancer. He has received numerous additional awards including Forbes Magazine 30-under-30 twice in Science and Healthcare (2013 and 2014), the Pew-Stewart Scholar of Cancer Research Award, the Air Force Young Investigator Award, the Dale F. Frey Award, the NIH Director’s Early Independence Award, the Damon Runyon Fellowship, and the Young Investigator Award at the World Molecular Imaging Congress. He published over 20 papers in leading journals including Nature Nanotechnology, Nature Medicine, Nano Letters, and PNAS, some of which received significant press coverage from Forbes, US News and The Washington Post. He is the founder of the medical start-ups OcuBell Inc. and Click Diagnostics.