1. Adam de la Zerda

    0 Comments Leave a Comment

    1-15 of 26 1 2 »
    1. Mentioned In 26 Articles

    2. Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation

      Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells in Vivo through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation
      By their nature, tumors pose a set of profound challenges to the immune system with respect to cellular recognition and response coordination. Recent research indicates that leukocyte subpopulations, especially tumor-associated macrophages (TAMs), can exert substantial influence on the efficacy of various cancer immunotherapy treatment strategies. To better study and understand the roles of TAMs in determining immunotherapeutic outcomes, significant technical challenges associated with dynamically monitoring single cells of interest in ...
      Read Full Article
    3. Upper limit for angular compounding speckle reduction

      Upper limit for angular compounding speckle reduction
      Angular compounding is a technique for reducing speckle noise in optical coherence tomography that is claimed to significantly improve the signal-to-noise ratio (SNR) of images without impairing their spatial resolution. Here, we examine how focal point movements caused by optical aberrations in an angular compounding system may produce unintended spatial averaging and concomitant loss of spatial resolution. Experimentally, we accounted for such aberrations by aligning our system and measuring distortions ...
      Read Full Article
    4. Gold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed In Vivo Lymphangiography

      Gold Nanobipyramids as Second Near Infrared Optical Coherence Tomography Contrast Agents for Multiplexed In Vivo Lymphangiography
      Developing contrast-enhanced optical coherence tomography (OCT) techniques is important for specific imaging of tissue lesions, molecular imaging, cell-tracking, and highly sensitive microangiography and lymphangiography. Multiplexed OCT imaging in the second near infrared (NIR-II) window is highly desirable since it allows simultaneous imaging and tracking of multiple biological events in high resolution with deeper tissue penetration in vivo. Here we demonstrate that gold nanobipyramids can function as OCT multiplexing contrast agents ...
      Read Full Article
    5. Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods

      Real-time detection of circulating tumor cells in living animals using functionalized large gold nanorods
      Optical coherence tomography (OCT) can be utilized with significant speckle reduction techniques and highly-scattering contrast agents for noninvasive, contrast-enhanced imaging of living tissues at the cellular scale. The advantages of reduced speckle noise and improved targeted contrast can be harnessed to track objects as small as 2 m in vivo, which enables applications for cell tracking and quantification in living subjects. Here we demonstrate the use of Large Gold Nanorods ...
      Read Full Article
    6. Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals

      Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near-Infrared Window for Enhanced Angiography in Live Animals
      Optical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived from the movements of red blood cells (RBCs). However, the low hematocrit and long latency between RBCs in capillaries make these OCTA signals discontinuous, leading to incomplete mapping of the vascular networks. OCTA imaging of microvascular circulation is particularly challenging in ...
      Read Full Article
    7. Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography

      Intraoperative Imaging Modalities and the Potential Role of Speckle Modulating Optical Coherence Tomography
      Maximizing extent of resection has been correlated with improved outcomes in a variety of pediatric and adult brain tumors. 1-11 While gross total resections are often achieved without the use of intraoperative adjuncts, difficulty in distinguishing tumor from normal brain can at times prevent the complete resection of brain tumors. Intraoperative imaging tools have increasingly been embraced with the goal of improving rates of gross total resection. In this review ...
      Read Full Article
    8. Developing in vivo Functional Imaging Technology with Micron-Scale Resolution Using Optical Coherence Tomography

      Developing in vivo Functional Imaging Technology with Micron-Scale Resolution Using Optical Coherence Tomography
      Researchers and physicians rely on functional imaging to better understand tumors and other structures within the human body. However, imaging technologies that capture deep structures have poor resolution, while those that provide high resolution have limited depth. Positron emission tomography (PET), for example, reveals details deep within tissue but suffers from poor spatial resolution, with each voxel of a PET scan representing thousands or even millions of cells. In contrast ...
      Read Full Article
    9. Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo

      Optical coherence tomography of lymphatic vessel endothelial hyaluronan receptors in vivo
      Optical Coherence Tomography (OCT) imaging of living subjects offers millimeters depth of penetration into tissue while maintaining high spatial resolution. However, because most molecular biomarkers do not produce inherent OCT contrast signals, exogenous contrast agents must be employed to achieve molecular imaging. Here we demonstrate that microbeads (Bs) can be used as effective contrast agents to target cellular biomarkers in lymphatic vessels and can be detected by OCT using a ...
      Read Full Article
    10. Developing in vivo Functional Imaging Technology with Micron-Scale Resolution Using Optical Coherence Tomography

      Developing in vivo Functional Imaging Technology with Micron-Scale Resolution Using Optical Coherence Tomography
      Researchers and physicians rely on functional imaging to better understand tumors and other structures within the human body. However, imaging technologies that capture deep structures have poor resolution, while those that provide high resolution have limited depth. Positron emission tomography (PET), for example, reveals details deep within tissue but suffers from poor spatial resolution, with each voxel of a PET scan representing thousands or even millions of cells. In contrast ...
      Read Full Article
    11. Speckle-modulating optical coherence tomography in living mice and humans

      Speckle-modulating optical coherence tomography in living mice and humans
      Optical coherence tomography (OCT) is a powerful biomedical imaging technology that relies on the coherent detection of backscattered light to image tissue morphology in vivo . As a consequence, OCT is susceptible to coherent noise (speckle noise), which imposes significant limitations on its diagnostic capabilities. Here we show speckle-modulating OCT (SM-OCT), a method based purely on light manipulation that virtually eliminates speckle noise originating from a sample. SM-OCT accomplishes this by ...
      Read Full Article
    12. In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors

      In Vivo Molecular Optical Coherence Tomography of Lymphatic Vessel Endothelial Hyaluronan Receptors
      Optical Coherence Tomography (OCT) imaging of living subjects offers increased depth of penetration while maintaining high spatial resolution when compared to other optical microscopy techniques. However, since most protein biomarkers do not exhibit inherent contrast detectable by OCT, exogenous contrast agents must be employed for imaging specific cellular biomarkers of interest. While a number of OCT contrast agents have been previously studied, demonstrations of molecular targeting with such agents in ...
      Read Full Article
    13. Spectral contrast-enhanced optical coherence tomography for improved detection of tumor microvasculature and functional imaging of lymphatic drainage

      Spectral contrast-enhanced optical coherence tomography for improved detection of tumor microvasculature and functional imaging of lymphatic drainage
      Optical Coherence Tomography (OCT) is well-suited to study in vivo dynamics of blood circulation and lymphatic flow because of the techniques combination of rapid image acquisition, micron spatial resolution, and penetration depth in turbid tissues. However, OCT has been historically constrained by a dearth of contrast agents that are readily distinguished from the strong scattering intrinsic to biological tissues. In this study, we demonstrate large gold nanorods (LGNRs) as optimized ...
      Read Full Article
    14. Reconstruction and Spectral Analysis for Optical Coherence Tomography

      Reconstruction and Spectral Analysis for Optical Coherence Tomography
      MATLAB code for reconstruction and spectral analysis of spectral domain OCT images. This code can be used as part of a platform for molecular imaging with OCT, which we call MOZART. This code was created to read raw interferograms from Thorlabs OCTs (SW version 4 works best, but version 3 is also supported with a few changes). It reconstructs the raw interferograms into OCT images, and supports both 2D, 3D ...
      Read Full Article
    15. A model for quantifying contrast enhancement in optical coherence tomography (OCT)

      A model for quantifying contrast enhancement in optical coherence tomography (OCT)
      We have developed a model to accurately quantify the signals produced by exogenous scattering agents used for contrast-enhanced Optical Coherence Tomography (OCT). This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of coherence-based detection. Accordingly, we show that real scattering particles can be described as simplified ideal scatterers with modified scattering intensity and concentration. The relation between OCT signal and particle concentration is approximately linear at ...
      Read Full Article
    16. 1-15 of 26 1 2 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. About Adam de la Zerda

    Adam de la Zerda

    Adam de la Zerda is an Assistant Professor in the departments of Structural Biology and Electrical Engineering at Stanford University. He is working on the development of new medical imaging technologies to detect cancer at an early stage and guide physicians towards optimal treatment of the cancer. He has received numerous additional awards including Forbes Magazine 30-under-30 twice in Science and Healthcare (2013 and 2014), the Pew-Stewart Scholar of Cancer Research Award, the Air Force Young Investigator Award, the Dale F. Frey Award, the NIH Director’s Early Independence Award, the Damon Runyon Fellowship, and the Young Investigator Award at the World Molecular Imaging Congress. He published over 20 papers in leading journals including Nature Nanotechnology, Nature Medicine, Nano Letters, and PNAS, some of which received significant press coverage from Forbes, US News and The Washington Post. He is the founder of the medical start-ups OcuBell Inc. and Click Diagnostics.

  3. Quotes

    1. We showed that you can take effectively any OCT system out there and, with minimal changes, boost its resolution to the point where it can detect anatomical features smaller than the size of a typical cell.
      In Scientists turbocharge high-resolution, 3-D imaging